Agidol Plus 1.5mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with severe muscle rigidity and confusion
- Irregular or fast heartbeat
- Fainting or loss of consciousness
- Involuntary movements of face, tongue, or limbs
- Severe allergic reaction with swelling of face, lips, or throat
- Yellowing of skin or eyes
- Severe abdominal pain with vomiting and no bowel movement
- Difficulty breathing or chest pain
If experiencing severe symptoms, call emergency services immediately.
What is ziplan ds 1.5mg/2mg tablet used for?
This medicine is a combination of haloperidol (an antipsychotic) and trihexyphenidyl (an anticholinergic) used to treat schizophrenia and other psychotic disorders while reducing movement side effects. It is available by prescription only and must be taken under medical supervision.
- Generic Name: Haloperidol (1.5mg) + Trihexyphenidyl (2mg)
- Manufacturer: Zion Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ziplan ds 1.5mg/2mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हेलोपेरिडोल और ट्राईहेक्सीफेनिडाइल का संयोजन है। इसका उपयोग सिज़ोफ्रेनिया और अन्य मानसिक विकारों के इलाज में किया जाता है। हेलोपेरिडोल मतिभ्रम और भ्रम को कम करता है, जबकि ट्राईहेक्सीफेनिडाइल दवा के कारण होने वाली मांसपेशियों की अकड़न, कंपन और ऐंठन को कम करता है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और मनोचिकित्सक की देखरेख में लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, धुंधली दृष्टि, कब्ज, नींद आना, चक्कर आना और पेशाब में कठिनाई शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, मांसपेशियों में अकड़न, भ्रम, अनियमित दिल की धड़कन और न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम शामिल हो सकते हैं। यदि आपको असामान्य हरकतें, बेहोशी या तेज धड़कन महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से दवा की मात्रा न बदलें और न ही अचानक बंद करें। शराब और अन्य नींद लाने वाली दवाओं से बचें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीन चलाने से बचें। कब्ज से बचने के लिए भरपूर पानी पिएं और रेशेदार भोजन करें। नियमित रूप से डॉक्टर से जांच कराते रहें।
💊 ziplan ds 1.5mg/2mg tablet Uses & Benefits
[{"condition":"Schizophrenia","description":"Helps reduce hallucinations, delusions, disorganized thinking, and agitation in people with schizophrenia.","evidence":"Well-established"},{"condition":"Other psychotic disorders","description":"May be used for brief psychotic disorder, schizoaffective disorder, or psychosis associated with other medical conditions.","evidence":"Established"},{"condition":"Drug-induced extrapyramidal symptoms","description":"Trihexyphenidyl helps control movement side effects caused by antipsychotic medicines, while haloperidol treats the underlying psychosis.","evidence":"Well-established"},{"condition":"Severe agitation in acute psychosis","description":"Can help calm severe agitation when used under close medical supervision.","evidence":"Established"}]
Off-label uses: [{"condition":"Tourette syndrome","description":"Haloperidol may sometimes be used off-label to reduce tics, but this combination is not a first-choice treatment.","evidence":"Limited"},{"condition":"Huntington's disease chorea","description":"Haloperidol may be used off-label to suppress involuntary movements, but trihexyphenidyl can worsen chorea in some cases.","evidence":"Limited"},{"condition":"Severe nausea and vomiting","description":"Haloperidol has antiemetic properties and may be used off-label in palliative care, but this combination is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Schizophrenia
Also treats: Schizoaffective disorder, Brief psychotic disorder, Drug-induced psychosis, Extrapyramidal symptoms
📋 Drug Information
| Generic Name(s) | Haloperidol (1.5mg) + Trihexyphenidyl (2mg) |
| Brand Name | ziplan ds 1.5mg/2mg tablet |
| Manufacturer | Zion Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a cool, dry place away from direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Haloperidol works by blocking dopamine D2 receptors in the brain, especially in the mesolimbic and mesocortical pathways, which helps reduce psychotic symptoms such as hallucinations and delusions. It also blocks D2 receptors in the nigrostriatal pathway, which can cause movement side effects. Trihexyphenidyl is a centrally acting anticholinergic that blocks muscarinic acetylcholine receptors. By reducing cholinergic activity in the striatum, it helps balance dopamine and acetylcholine, thereby reducing drug-induced extrapyramidal symptoms such as stiffness, tremor, and muscle spasms. The combination allows haloperidol to be used with better tolerability in terms of movement side effects.
Mechanism Steps
💡 How to Take ziplan ds 1.5mg/2mg tablet
Strength: Each tablet contains haloperidol 1.5 mg and trihexyphenidyl 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this combination is one tablet taken orally one to two times daily, or as directed by your psychiatrist. The dose depends on the condition being treated, your response to treatment, and your age. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or child psychiatrist. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and increase gradually under close medical supervision. Monitor for confusion, falls, and movement disorders. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney disease. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is determined by your doctor based on your condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ziplan ds 1.5mg/2mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Levodopa | Major | |
| Other antipsychotics | Major | |
| QT-prolonging drugs | Major | |
| CNS depressants | Major | |
| Anticholinergics | Major | |
| Carbamazepine | Moderate | |
| Fluoxetine | Moderate | |
| Rifampicin | Moderate | |
| Antihypertensives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Other antipsychotics (e.g., clozapine, olanzapine)
- Levodopa
- QT-prolonging drugs (e.g., amiodarone, sotalol, methadone)
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Anticholinergic drugs (e.g., benztropine, oxybutynin, tricyclic antidepressants)
⚡ Moderate Interactions
- Carbamazepine
- Fluoxetine
- Rifampicin
- Antihypertensives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases drowsiness, dizziness, and the risk of falls. It can also worsen the sedative effects of haloperidol and the anticholinergic effects of trihexyphenidyl.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Parkinson's disease","Angle-closure glaucoma","Urinary retention","Severe heart disease or recent heart attack","Severe liver disease","Known hypersensitivity to haloperidol or trihexyphenidyl","Coma or severe CNS depression","Alcohol or drug withdrawal states"]
⚠️ Warnings & Precautions
["May cause drowsiness and dizziness; avoid driving or operating machinery until you know how it affects you.","Do not stop this medicine suddenly; withdrawal can cause nausea, vomiting, insomnia, and agitation.","May cause anticholinergic effects such as dry mouth, constipation, and blurred vision.","Use with caution in elderly patients; increased risk of confusion, falls, and movement disorders.","May increase the risk of falls and fractures in elderly patients.","Avoid alcohol and other CNS depressants.","May cause QT prolongation; use with caution in patients with heart disease.","May cause neuroleptic malignant syndrome; seek immediate medical attention if symptoms occur.","May cause tardive dyskinesia with long-term use; report involuntary movements.","Use with caution in patients with liver or kidney disease.","May affect blood sugar and lipid levels; monitor if you have diabetes or high cholesterol.","Do not use in children unless prescribed by a child psychiatrist."]
🤱 Lactation Safety
Haloperidol is excreted in breast milk. Trihexyphenidyl may also pass into breast milk. Consult your doctor before breastfeeding. Monitoring of the infant for drowsiness and feeding difficulties is advised.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, coma, low blood pressure, fast or irregular heartbeat, muscle rigidity, and anticholinergic symptoms such as dry mouth, flushing, and urinary retention. Seek immediate emergency medical care. Treatment is supportive and may include activated charcoal, intravenous fluids, and monitoring in a hospital. There is no specific antidote for haloperidol or trihexyphenidyl overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop it on your own, as sudden withdrawal can cause serious problems. Avoid alcohol and other sedative medicines because they can increase drowsiness and dizziness. Use caution while driving or operating heavy machinery until you know how this medicine affects you. Drink plenty of water and eat high-fiber foods to help with constipation. Tell your doctor if you have glaucoma, prostate problems, heart disease, or liver or kidney disease. Keep all follow-up appointments so your doctor can monitor your symptoms and adjust the dose if needed. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine. They are at higher risk of confusion, falls, and movement disorders. Start with a lower dose and monitor closely. Anticholinergic effects such as dry mouth, constipation, and urinary retention may be more pronounced.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine should be used during pregnancy only if clearly needed. Haloperidol may cause withdrawal symptoms in newborns if used near delivery. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and other medicines used during surgery. Your doctor may adjust the dose or temporarily stop it before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. It may also interact with medicines used during dental procedures. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness, dizziness, and muscle stiffness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Light to moderate exercise is generally safe, but consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause difficulty concentrating. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as neuroleptic malignant syndrome, tardive dyskinesia, or severe allergic reactions, seek immediate medical attention. Your doctor will decide if and when to stop the medicine, usually by tapering the dose gradually.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of tardive dyskinesia, a condition involving involuntary movements of the face, tongue, or limbs. Regular monitoring by your doctor is important. Metabolic effects such as weight gain and changes in blood sugar and cholesterol may occur. Periodic blood tests and ECG may be needed. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine in managing psychotic symptoms.
Evidence: Well-establishedHelps family members support the patient and improve communication.
Evidence: EstablishedHelps improve social functioning and daily living skills.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from direct sunlight. If traveling across time zones, consult your doctor about adjusting the timing of doses. Check customs regulations for controlled medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Haloperidol starts reducing agitation within 1-2 hours, but full antipsychotic effects may take several days to weeks. Trihexyphenidyl starts reducing movement symptoms within 1-2 hours.
A: No, do not stop suddenly. Withdrawal can cause nausea, vomiting, insomnia, and agitation. Always consult your doctor before stopping.
A: Consult your doctor. Haloperidol may cause withdrawal symptoms in newborns if used near delivery. Use only if clearly needed under medical supervision.
A: Avoid alcohol. It increases drowsiness, dizziness, and the risk of falls.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for ziplan ds 1.5mg/2mg tablet
View AllAlternative brands with exact same active ingredient:
-
halodryl 1.5mg/2mg tabletZeelab Pharmacy Pvt Ltd ₹6.00 80% CHEAPER
-
benzydol 1.5 mg/2 mg tabletLa Pharmaceuticals ₹11.07 63.1% CHEAPER
-
haltix 1.5mg/2mg tabletZee Laboratories ₹28.03 6.6% CHEAPER
-
agidol plus 1.5mg tabletAGM Biotec ₹32.49 8.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive in the way that opioids or benzodiazepines are, but it can cause dependence and withdrawal symptoms if stopped suddenly. It should be tapered under medical supervision. - Myth: This medicine can cure schizophrenia permanently.
Fact: This medicine helps control symptoms but does not cure schizophrenia. Long-term treatment and therapy are often needed. - Myth: You can stop this medicine once you feel better.
Fact: Stopping suddenly can cause withdrawal symptoms and relapse of psychosis. Always consult your doctor before stopping. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases drowsiness, dizziness, and the risk of falls. Avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Haloperidol 1.5 mg + Trihexyphenidyl 2 mg tablet (generic)
Brand Alternatives
- Agidol Plus 1.5mg Tablet