Serenace Tablet (Haloperidol 0.25mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever, muscle rigidity, confusion, or irregular heartbeat (possible neuroleptic malignant syndrome).
- Involuntary movements of the face, tongue, or limbs (possible tardive dyskinesia).
- Fainting, palpitations, or shortness of breath (possible arrhythmia).
- Severe allergic reaction with swelling of face, lips, or throat.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (possible liver toxicity).
- Unusual bruising or bleeding, or signs of infection (possible blood dyscrasia).
- Seizures or loss of consciousness.
If experiencing severe symptoms, call emergency services immediately.
What is ziplan 0.25mg tablet used for?
Haloperidol is a typical antipsychotic used to treat schizophrenia, acute psychosis, and Tourette syndrome. It works by blocking dopamine D2 receptors in the brain. Common side effects include drowsiness, dizziness, and extrapyramidal symptoms. It requires a prescription and regular monitoring.
- Generic Name: Haloperidol (0.25mg)
- Manufacturer: Zion Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ziplan 0.25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हेलोपेरिडोल नामक सक्रिय तत्व से बनी है, जो एक एंटीसाइकोटिक दवा है। इसका उपयोग सिज़ोफ्रेनिया, तीव्र मनोविकृति, और टूरेट सिंड्रोम के इलाज में किया जाता है। यह मस्तिष्क में डोपामाइन रिसेप्टर्स को ब्लॉक करके काम करती है, जिससे मतिभ्रम, भ्रम और आंदोलन कम होते हैं। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, कब्ज, और मांसपेशियों में अकड़न शामिल हैं। गंभीर दुष्प्रभावों में टार्डिव डिस्किनेसिया, न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम, और दिल की धड़कन में गड़बड़ी हो सकती है। अगर आपको असामान्य हरकतें, तेज़ बुखार, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। अगर आपको दिल, जिगर, या गुर्दे की बीमारी है, तो डॉक्टर को बताएं। नियमित जांच कराते रहें।
💊 ziplan 0.25mg tablet Uses & Benefits
[{"condition":"Schizophrenia","description":"Reduces hallucinations, delusions, and disorganised thinking in patients with schizophrenia.","evidence":"Well-established"},{"condition":"Acute psychosis","description":"Controls severe agitation, aggression, and psychotic symptoms in acute settings.","evidence":"Well-established"},{"condition":"Tourette syndrome","description":"Helps suppress motor and vocal tics in patients with Tourette syndrome.","evidence":"Well-established"},{"condition":"Severe behavioural problems","description":"Used short-term to manage severe aggression or agitation in patients with psychiatric disorders.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Nausea and vomiting","description":"Sometimes used off-label for refractory nausea and vomiting, especially in palliative care.","evidence":"Limited"},{"condition":"Delirium","description":"May be used off-label to manage delirium in hospitalised patients, though evidence is mixed.","evidence":"Limited"},{"condition":"Huntington's disease","description":"Occasionally used off-label to control chorea and behavioural symptoms in Huntington's disease.","evidence":"Limited"}]
Primary treatment for: Schizophrenia
Also treats: Acute psychosis, Tourette syndrome, Severe behavioural problems
📋 Drug Information
| Generic Name(s) | Haloperidol (0.25mg) |
| Brand Name | ziplan 0.25mg tablet |
| Manufacturer | Zion Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Typical Antipsychotics |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Haloperidol is included in the WHO Model List of Essential Medicines for the treatment of psychotic disorders. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Haloperidol is a potent dopamine D2 receptor antagonist. It blocks dopamine receptors in the mesolimbic and mesocortical pathways, which helps reduce positive symptoms of psychosis such as hallucinations and delusions. It also blocks dopamine receptors in the nigrostriatal pathway, which can lead to extrapyramidal side effects. Additionally, haloperidol has some activity at sigma receptors and may affect other neurotransmitter systems.
Mechanism Steps
💡 How to Take ziplan 0.25mg tablet
Strength: Immediate-release tablet, 0.25 mg.
Dosage Information
| Adult Dosage | The usual starting dose for adults is 0.5 to 5 mg two to three times daily, depending on the condition being treated. For schizophrenia, doses may range from 1 to 15 mg per day. For acute agitation, doses up to 5 mg may be used. The maximum recommended daily dose is 20 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should start at a lower dose, typically 0.25 to 0.5 mg once or twice daily, and titrate slowly. They are more susceptible to extrapyramidal symptoms, sedation, and falls. |
| Renal Impairment | No specific dose adjustment is provided in the manufacturer's labelling. Use with caution in patients with renal impairment. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Haloperidol is extensively metabolised in the liver. Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 20 mg per day for oral administration. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ziplan 0.25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Amiodarone | Major | |
| Fluoxetine | Moderate | |
| Levodopa | Major | |
| Ketoconazole | Moderate | |
| Benzodiazepines | Major | |
| Antacids | Minor | |
| Caffeine | Minor | |
| Paroxetine | Moderate | |
| Methadone | Major | |
| Rifampicin | Moderate |
🚨 Major Interactions
- QT-prolonging drugs (e.g., amiodarone, sotalol, methadone)
- Central nervous system depressants (e.g., benzodiazepines, opioids, alcohol)
- Levodopa and dopamine agonists
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Anticholinergic drugs (e.g., benztropine, trihexyphenidyl)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase sedation, dizziness, and the risk of central nervous system depression. It may also worsen extrapyramidal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to haloperidol or any component of the formulation","Severe central nervous system depression","Parkinson's disease","Dementia with Lewy bodies","Prolonged QT interval or history of torsades de pointes","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Tardive dyskinesia: May be irreversible; risk increases with duration of treatment.","Neuroleptic malignant syndrome: A life-threatening emergency; discontinue immediately if suspected.","QT prolongation: Avoid in patients with risk factors; monitor ECG.","Falls: May cause drowsiness and dizziness, increasing fall risk, especially in the elderly.","Blood dyscrasias: Monitor for signs of infection or bleeding.","Hyperprolactinemia: May cause galactorrhea, gynecomastia, and sexual dysfunction.","Anticholinergic effects: May cause dry mouth, constipation, urinary retention.","Withdrawal: Do not stop abruptly; taper gradually."]
🤱 Lactation Safety
Haloperidol is excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless the potential benefit outweighs the risk. Consult your doctor.
💊 Overdose Management
Overdose of haloperidol can cause severe extrapyramidal symptoms, hypotension, sedation, and QT prolongation. There is no specific antidote. Treatment is supportive and symptomatic, including airway management, ECG monitoring, and correction of electrolyte imbalances. Activated charcoal may be considered if ingestion is recent. Contact a poison control centre immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as withdrawal symptoms may occur. Avoid driving or operating heavy machinery until you know how this medicine affects you. Avoid alcohol and other central nervous system depressants while taking this medicine. Inform your doctor if you have a history of heart problems, liver disease, kidney disease, or seizures. Tell your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. If you experience muscle stiffness, high fever, confusion, or irregular heartbeat, seek immediate medical attention. Regular blood tests and heart monitoring may be required during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially extrapyramidal symptoms, sedation, and falls. Start with a lower dose and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It may not be safe during pregnancy, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine. It may interact with anaesthetic agents and affect recovery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth and increase the risk of dental problems. Regular dental check-ups are advised.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, so avoid strenuous exercise or activities requiring alertness until you know how it affects you. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is important to avoid these activities until you know how the medicine affects you. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation can lead to withdrawal symptoms or relapse. Your doctor will gradually reduce the dose if needed.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of tardive dyskinesia, a potentially irreversible movement disorder. Regular monitoring for extrapyramidal symptoms, metabolic changes, and cardiac effects is necessary. Periodic assessment of the need for continued treatment is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for schizophrenia and psychosis.
Evidence: Well-establishedFamily therapy and supported employment can improve outcomes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If travelling across time zones, adjust dosing schedule gradually in consultation with your doctor. Check customs regulations for controlled substances before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Antipsychotic effects may begin within hours to days, but full therapeutic effect may take several weeks.
A: No, do not stop suddenly. Consult your doctor; gradual tapering is usually needed.
A: Avoid alcohol, driving, and operating heavy machinery until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for ziplan 0.25mg tablet
View AllAlternative brands with exact same active ingredient:
-
oprex 0.25mg tabletPsycormedies ₹4.03 21.9% CHEAPER
-
halocalm 0.25mg tabletTweet India Pharmaceuticals Pvt Ltd ₹5.50 6.6% COSTLIER
-
larenase 0.25mg tabletLa Pharmaceuticals ₹6.05 17.2% COSTLIER
-
haldol 0.25mg tabletEast West Pharma ₹6.47 25.4% COSTLIER
-
halidace 0.25mg tabletBaroda Pharma Pvt Ltd ₹6.61 28.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Haloperidol is only for severe mental illness.
Fact: Haloperidol is also used for Tourette syndrome, severe agitation, and sometimes nausea. - Myth: Haloperidol is addictive.
Fact: Haloperidol is not addictive, but it can cause dependence in the sense that stopping it abruptly can lead to withdrawal symptoms. - Myth: You can stop haloperidol once you feel better.
Fact: Haloperidol should be tapered gradually under medical supervision to prevent relapse or withdrawal.
🔄 Alternative Options
Generic Alternatives
- Haloperidol
Brand Alternatives
- Serenace