Amotive Syrup: Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe rash or hives
- Hallucinations or confusion
- Seizures
- Irregular heartbeat
- Severe drowsiness or inability to stay awake
- Blood in vomit or stool
If experiencing severe symptoms, call emergency services immediately.
What is yecold syrup used for?
This medicine is a combination of chlorpheniramine maleate and dextromethorphan hydrobromide used to treat dry cough and allergic symptoms. It works by suppressing the cough reflex and blocking histamine. It should be taken as directed by a doctor and is not recommended for children under 6 years without medical advice.
- Generic Name: Chlorpheniramine Maleate (1.5mg/5ml) + Dextromethorphan Hydrobromide (5mg/5ml)
- Manufacturer: Yew Biotech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 yecold syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सूखी खांसी, एलर्जी से होने वाली नाक बहना, छींक आना और आंखों में पानी आना जैसी समस्याओं के इलाज के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और डेक्सट्रोमेथोर्फन हाइड्रोब्रोमाइड दो सक्रिय तत्व होते हैं। यह खांसी की प्रतिक्रिया को दबाती है और एलर्जी के लक्षणों को कम करती है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना और धुंधली दृष्टि शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव जैसे एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, या मतिभ्रम बहुत दुर्लभ हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के अनुसार ही लें। इसकी खुराक न बढ़ाएं। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों को 6 साल से कम उम्र में बिना डॉक्टर की सलाह के न दें। यदि खांसी 7 दिनों से अधिक रहे तो डॉक्टर से मिलें।
💊 yecold syrup Uses & Benefits
[{"condition":"Dry cough","description":"This medicine suppresses the cough reflex and is used for temporary relief of dry, irritating, non-productive cough.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"The antihistamine component helps relieve sneezing, runny nose, and watery eyes associated with allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"It provides symptomatic relief of cough and nasal symptoms associated with the common cold.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Dry cough
Also treats: Allergic rhinitis, Common cold
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (1.5mg/5ml) + Dextromethorphan Hydrobromide (5mg/5ml) |
| Brand Name | yecold syrup |
| Manufacturer | Yew Biotech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby reducing allergic symptoms such as sneezing, rhinorrhea, and lacrimation. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata to raise the threshold for coughing. It is a non-opioid agent that does not cause respiratory depression at therapeutic doses.
Mechanism Steps
💡 How to Take yecold syrup
Strength: Each 5 ml of syrup contains 1.5 mg chlorpheniramine maleate and 5 mg dextromethorphan hydrobromide.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (2 teaspoons) every 4 to 6 hours, not to exceed 60 ml in 24 hours. However, the dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate beyond the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic and sedative effects of this medicine. A lower dose may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be necessary in patients with hepatic impairment. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | For adults, the maximum daily dose is 60 ml of this syrup in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of yecold syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| CNS depressants | Major | |
| SSRIs | Major | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inhibitors | Moderate | |
| Antihypertensives | Minor | |
| Levodopa | Minor | |
| Alcohol | Major | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Selective serotonin reuptake inhibitors (SSRIs)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impair motor skills. Combining alcohol with this medicine can also increase the risk of respiratory depression and other serious side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, dextromethorphan, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI therapy","Children under 6 years of age (unless directed by a doctor)","Chronic bronchitis, emphysema, or other chronic lung diseases","Cough associated with excessive phlegm","Narrow-angle glaucoma","Urinary retention","Severe liver disease"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, glaucoma, prostatic hypertrophy, or urinary retention.","Do not use for chronic cough or cough with excessive secretions unless directed by a doctor.","Consult a doctor if cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache.","Keep out of reach of children.","Do not exceed the recommended dose.","Use with caution in elderly patients who are more sensitive to anticholinergic effects."]
🤱 Lactation Safety
Chlorpheniramine and dextromethorphan may pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult a doctor before use.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, blurred vision, nausea, vomiting, hallucinations, rapid heart rate, seizures, and respiratory depression. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Additional Safety Advice
Do not exceed the recommended dose of this medicine. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine because it can increase drowsiness and dizziness. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for a chronic cough or a cough with excessive phlegm unless advised by a doctor. Keep this medicine out of the reach of children. If your cough persists for more than 7 days, worsens, or is accompanied by fever, rash, or persistent headache, stop using it and consult a doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic and sedative effects of this medicine. They may experience increased drowsiness, confusion, dry mouth, and urinary retention. A lower dose may be appropriate, and close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and it should be used only if clearly needed.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may interact with other medications and increase the risk of side effects such as drowsiness and respiratory depression.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it can cause dry mouth and may interact with medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult a doctor if your cough persists for more than 7 days, worsens, or is accompanied by fever, rash, or persistent headache. Also stop if you experience any serious side effects.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to tolerance, dependence, and increased risk of side effects such as sedation, dry mouth, and urinary retention. Regular monitoring by a doctor is advised if long-term use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion and soothe the throat.
Evidence: LimitedCan help soothe a cough and sore throat.
Evidence: ModerateHelps clear nasal passages and reduce congestion.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If you are crossing time zones, continue taking the medicine as prescribed, but adjust the timing gradually. Check the customs regulations of your destination country regarding carrying prescription medications. Always keep the medicine in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 15-30 minutes after taking it.
A: You should avoid taking other cold medicines without consulting your doctor, as they may contain similar ingredients and increase the risk of side effects.
A: This medicine is not recommended for children under 6 years without medical advice. Consult a pediatrician for appropriate dosing.
A: Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for yecold syrup
View AllAlternative brands with exact same active ingredient:
-
flunetra plus syrupNectar Biopharma Pvt Limited ₹32.81 50.7% CHEAPER
-
amotive syrupProgressive Life Care ₹46.78 29.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure a cough instantly.
Fact: This medicine provides symptomatic relief but does not cure the underlying cause. It may take some time to work. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the sedative effects and can be dangerous. Avoid alcohol while taking this medicine. - Myth: This medicine is safe for children of all ages.
Fact: It is not recommended for children under 6 years without medical advice.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate + dextromethorphan hydrobromide syrup (various manufacturers)
Brand Alternatives
- Amotive syrup