wartsrub-s paint - Podophyllum resin (25% w/v) + Benzoin (10% w/v) medicine

Podowart S Paint: Complete Medicine Guide for Wart Treatment

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🏭 Leeford Healthcare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
🤰 Pregnancy Category This medicine is contraindicated during pregnancy. Podophyllum resin is known to cause fetal harm and is not safe for use in pregnant women. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for anogenital warts; limited for other wart types.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe burning, pain, or blistering at the application site
  • Signs of infection such as pus, foul odor, or spreading redness
  • Swelling of the face, lips, or throat, or difficulty breathing
  • Unusual tiredness, easy bruising, or fever
  • Confusion, dizziness, or numbness in the hands or feet
  • Nausea, vomiting, or severe abdominal pain
  • Decreased urine output or dark urine

If experiencing severe symptoms, call emergency services immediately.

What is wartsrub-s paint used for?

This medicine is a topical prescription paint containing podophyllum resin 25% w/v and benzoin 10% w/v. It is used to treat anogenital warts by inhibiting cell division in the infected skin cells. It must be applied only by a healthcare professional or under strict medical supervision and is contraindicated in pregnancy.

  • Generic Name: Podophyllum resin (25% w/v) + Benzoin (10% w/v)
  • Manufacturer: Leeford Healthcare Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 wartsrub-s paint के बारे में (Hindi Summary)

उपयोग: यह दवा मुख्य रूप से गुप्तांगों और गुदा के आसपास होने वाले मस्सों (एनोजेनिटल वार्ट्स) के इलाज के लिए इस्तेमाल की जाती है। यह पोडोफिलम रेजिन और बेंजोइन का मिश्रण है जो मस्से के ऊतकों को नष्ट करने में मदद करता है। यह दवा केवल डॉक्टर की सलाह और निगरानी में ही लगाई जानी चाहिए। इसे गर्भवती महिलाओं, स्तनपान कराने वाली महिलाओं और छोटे बच्चों पर इस्तेमाल नहीं करना चाहिए।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में लगाने की जगह पर जलन, दर्द, लालिमा, सूजन और खुजली शामिल हैं। कभी-कभी त्वचा का छिलना या अल्सर भी हो सकता है। दुर्लभ मामलों में मतली, उल्टी, चक्कर आना या रक्त कोशिकाओं में बदलाव जैसे गंभीर दुष्प्रभाव हो सकते हैं। अगर कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को केवल बाहरी त्वचा पर ही लगाएं। इसे आंखों, नाक, मुंह या योनि के अंदर न लगाएं। दवा लगाने से पहले और बाद में हाथ अच्छी तरह धोएं। इलाज के दौरान यौन संबंध बनाने से बचें। गर्भावस्था और स्तनपान के दौरान इसका इस्तेमाल न करें। बच्चों की पहुंच से दूर रखें। अगर त्वचा पर गंभीर जलन, दर्द या संक्रमण के लक्षण दिखें तो दवा बंद करें और डॉक्टर से मिलें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 wartsrub-s paint Uses & Benefits

  • [{"condition":"Anogenital warts (condyloma acuminatum)","description":"This medicine is applied topically to treat external genital and perianal warts caused by human papillomavirus.
  • It destroys the wart tissue through its antimitotic and keratolytic actions.","evidence":"Well-established"},{"condition":"Common warts (verruca vulgaris)","description":"Sometimes used for the treatment of common warts on the hands and feet, although it is not the first-line therapy for these lesions.","evidence":"Limited"},{"condition":"Plantar warts","description":"May be used for plantar warts that have not responded to other treatments, but it requires careful application because of the thicker skin on the soles.","evidence":"Limited"}]

Off-label uses: [{"condition":"Molluscum contagiosum","description":"Occasionally used off-label to treat molluscum contagiosum lesions, but evidence for this use is not strong and it is not a standard recommendation.","evidence":"Limited"},{"condition":"Seborrheic keratosis","description":"Rarely used off-label for seborrheic keratosis, but this is not a recommended or well-studied indication.","evidence":"Insufficient"}]

Primary treatment for: Anogenital warts (condyloma acuminatum)

Also treats: Common warts, Plantar warts

📋 Drug Information

Generic Name(s)Podophyllum resin (25% w/v) + Benzoin (10% w/v)
Brand Namewartsrub-s paint
ManufacturerLeeford Healthcare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action Class
Route of AdministrationTopical
StorageStore at room temperature between 15°C and 30°C. Protect from light and moisture. Keep the container tightly closed when not in use. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine only to the wart tissue and avoid surrounding healthy skin to prevent irritation.
2
Use a cotton swab or applicator to apply the medicine precisely; do not use your fingers.
3
Wash your hands thoroughly before and after application to prevent spreading the virus or medicine.
4
Follow the 3-day application and 4-day rest cycle exactly as prescribed; do not apply more frequently.
5
Avoid sexual activity while the medicine is on the skin and until the treated area has healed completely.
6
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before using this medicine.
7
Do not cover the treated area with tight bandages unless specifically instructed by your doctor.
8
If you experience severe pain, blistering, or signs of infection, stop using the medicine and contact your doctor immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Anogenital warts
This medicine is commonly prescribed for this condition.
Likely Use
Common warts on hands
This medicine is not first-line for common warts; other treatments are preferred.
Not Primary
Fever
This medicine is not a fever reducer.
Not Primary
Skin tags
This medicine is not for skin tags and should not be used without a diagnosis.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSystemic absorption of podophyllotoxin through intact skin is generally low, but it can be significant if the medicine is applied to large areas, to broken or inflamed skin, or left on for prolonged periods. Benzoin is minimally absorbed through the skin.
DistributionNot established from the available information.
Protein BindingNot established from the available information.
MetabolismPodophyllotoxin is metabolized in the liver, primarily by cytochrome P450 enzymes, although the exact pathways are not fully characterized. Benzoin is largely inert and is not significantly metabolized.
Half-LifeNot established from the available information.
ExcretionPodophyllotoxin and its metabolites are excreted mainly in the bile and urine. Benzoin is excreted unchanged in the feces.
BioavailabilityNot established from the available information.
Onset of ActionThe onset of action is gradual. Visible effects on the wart, such as redness, swelling, and beginning of tissue breakdown, typically appear within 1 to 2 weeks after the first application.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe local effect of a single application lasts for several hours to a few days, depending on the concentration and the duration of contact. The full therapeutic effect requires multiple applications over several weeks.

How It Works

This medicine works through the combined action of podophyllum resin and benzoin. Podophyllum resin contains podophyllotoxin, which binds to tubulin and inhibits microtubule assembly. This arrests cell division in the metaphase stage, preventing the rapid proliferation of the human papillomavirus-infected keratinocytes that form the wart. Benzoin acts as a protective and mildly antiseptic agent that helps the medicine adhere to the skin and reduces local irritation. Together, these actions lead to the gradual destruction and sloughing of the wart tissue.

Mechanism Steps

1
Binding to tubulin: Podophyllotoxin, the active component of podophyllum resin, binds reversibly to tubulin, the protein that forms microtubules.
2
Inhibition of microtubule assembly: This binding prevents the polymerization of tubulin into microtubules, which are essential for cell division.
3
Arrest of mitosis: Without microtubules, the infected cells cannot complete mitosis and are arrested in the metaphase stage of the cell cycle.
4
Cell death and tissue destruction: The arrested cells eventually die, leading to the breakdown and sloughing of the wart tissue.
5
Protective and adhesive effect of benzoin: Benzoin forms a protective film over the treated area, helping the medicine stay in contact with the wart and reducing irritation to surrounding healthy skin.

💡 How to Take wartsrub-s paint

Strength: Topical paint containing podophyllum resin 25% w/v and benzoin 10% w/v.

1Wash your hands thoroughly before and after applying the medicine.
2Clean and dry the wart area gently.
3Using a cotton swab or applicator, apply a thin layer of the medicine directly to the wart. Avoid touching surrounding healthy skin.
4Allow the medicine to dry completely.
5Do not cover the area with a bandage unless instructed by your doctor.
6Wash your hands again after application.
7Avoid touching or scratching the treated area.
8Follow the prescribed schedule exactly. Do not apply more often or for longer than directed.

Dosage Information

Adult DosageThis medicine is for topical application only and must be applied by a healthcare professional or according to a doctor's specific instructions. The typical adult dose is a thin layer applied directly to the wart once or twice daily for 3 consecutive days, followed by 4 days without treatment. This cycle may be repeated weekly for up to 4 to 6 weeks. The exact dose and duration depend on the size, number, and location of the warts, as well as the patient's response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more susceptible to the irritant effects of this medicine. Use with caution and under close medical supervision. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is established for patients with renal impairment. Use with caution and monitor for signs of systemic toxicity.
Hepatic ImpairmentNo specific dose adjustment is established for patients with hepatic impairment. Use with caution and monitor for signs of systemic toxicity.
Maximum Daily DoseThe maximum daily dose is not established from available information. The amount applied should be limited to the smallest quantity that effectively covers the wart tissue, as directed by a healthcare professional.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double dose to catch up.

⚠️ Side Effects of wartsrub-s paint

✅ Common Side Effects

Local burning or stinging (Common (up to 50%))
This usually subsides after a few minutes. If it is severe or persistent, wash the area gently and inform your doctor.
Redness and swelling at the application site (Common (up to 50%))
This is an expected reaction indicating the medicine is working. Keep the area clean and avoid scratching. Consult your doctor if it becomes very painful.
Itching (Common (10-30%))
Avoid scratching. Apply a cool compress if needed. If itching is severe, contact your doctor.
Erosion or ulceration of the skin (Uncommon (1-10%))
Stop using the medicine and consult your doctor. Keep the area clean and covered to prevent infection.
Pain at the application site (Common (10-30%))
Over-the-counter pain relievers may help. If pain is severe, contact your doctor.

🚨 Serious Side Effects

Severe skin necrosis or ulceration (Rare (<0.1%))
Seek immediate medical attention if you notice blackening or extensive breakdown of the skin.
Systemic toxicity (e.g., bone marrow suppression, neurotoxicity) (Rare (<0.1%))
Seek immediate medical attention if you experience unusual tiredness, easy bruising, fever, confusion, or numbness.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services immediately if you experience swelling of the face, lips, or throat, difficulty breathing, or a widespread rash.

⚠️ Rare Side Effects

Contact dermatitis
Stop using the medicine and consult a doctor. A different treatment may be needed.
Hyperpigmentation or hypopigmentation
Usually temporary. If it persists, consult a dermatologist.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Other topical antimitotics Major
Systemic antimitotics Major
Immunosuppressants Moderate
Warfarin Moderate
Other topical products Minor

🚨 Major Interactions

  • Other topical antimitotic agents (e.g., podophyllotoxin, 5-fluorouracil)
  • Systemic antimitotic drugs (e.g., methotrexate, vincristine)

⚡ Moderate Interactions

  • Immunosuppressants (e.g., cyclosporine, tacrolimus)
  • Warfarin

🍷 Alcohol Interaction

No specific interaction between this medicine and alcohol is established. However, alcohol may worsen skin irritation or allergic reactions. It is advisable to avoid excessive alcohol consumption while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to podophyllum resin, benzoin, or any component of the formulation.","Pregnancy or planning to become pregnant.","Breastfeeding.","Application to bleeding, broken, or inflamed skin.","Use on large areas of skin or on mucous membranes.","Concurrent use with other antimitotic agents.","Children under 2 years of age.","Immunocompromised patients without medical supervision."]

⚠️ Warnings & Precautions

["For external use only. Do not swallow.","Avoid contact with eyes, nose, mouth, and other mucous membranes.","Apply only to the wart tissue and avoid surrounding healthy skin.","Wash hands thoroughly after application.","Do not cover the treated area with tight bandages unless instructed.","Avoid sexual activity while the medicine is on the skin.","Do not use for more than the recommended duration without medical advice.","Keep out of reach of children.","Discontinue use and consult a doctor if severe irritation, pain, or signs of infection occur.","Inform your doctor if you are taking any other medications, especially immunosuppressants or anticoagulants."]

🤱 Lactation Safety

This medicine should not be used during breastfeeding because podophyllotoxin may be excreted in breast milk and could harm the infant. If treatment is essential, breastfeeding should be interrupted during the treatment period.

💊 Overdose Management

Overdose with this medicine is rare but can occur if excessive amounts are applied or if the medicine is ingested. Symptoms of overdose include severe skin irritation, nausea, vomiting, abdominal pain, diarrhea, confusion, dizziness, and blood cell abnormalities. If overdose is suspected, wash the affected area thoroughly with soap and water and seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose of this medicine, apply it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

This medicine must be applied only by a qualified healthcare professional or under strict medical supervision. It is for external use on the skin only and must never be taken by mouth or applied to the eyes, inside the nose, mouth, or vagina. The treated area should be kept clean and dry, and the patient should avoid touching or scratching the wart to prevent spreading the virus. Hands must be washed thoroughly after any contact with the medicine. Patients should avoid sexual activity while the medicine is on the skin and until the treated area has completely healed. This medicine should not be used during pregnancy or while breastfeeding. It must be kept out of the reach of children. Patients should inform their doctor about all other medicines they are taking, especially other topical products or drugs that affect the immune system. If the skin becomes severely irritated, painful, or shows signs of infection, the patient should stop using the medicine and contact their doctor immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have thinner, more sensitive skin and are at higher risk of irritation and systemic absorption. Use with caution and under close medical supervision. Dose must be individualized by a qualified clinician.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, discuss alternative treatments with your doctor. Effective contraception should be used during treatment.

🏥 Post-Surgery Considerations

Avoid using this medicine on surgical wounds or areas of broken skin. Consult your doctor before using it after any surgery in the anogenital area.

🦷 Dental Procedures

This medicine is not used in the mouth and has no direct relevance to dental procedures. However, inform your dentist about all medicines you are using.

💚 Lifestyle Tips for Better Results

🏃
Keep the affected area clean and dry to prevent secondary infection.
🥗
Avoid sharing towels, clothing, or personal items to prevent spreading the virus.
😴
Practice safe sex to reduce the risk of transmitting or acquiring HPV.
💧
Maintain a healthy immune system with a balanced diet, regular exercise, and adequate sleep.
🧘
Avoid smoking and excessive alcohol, as these can weaken your immune system.
🌞
Wear loose-fitting cotton underwear to reduce friction and irritation.
🚭
Do not pick at or scratch the warts, as this can spread the virus.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that cause friction or sweating in the treated area until it has healed. Swimming should be avoided while the medicine is on the skin to prevent washing it off and contaminating the water.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables to support immune function.
Include foods high in vitamin C, zinc, and antioxidants.
Stay well hydrated by drinking plenty of water.
Limit processed foods, sugary drinks, and excessive caffeine.

💼 Impact on Daily Work & Life

This medicine is applied topically and is not expected to affect your ability to work or drive. However, if you experience dizziness or any systemic symptoms, avoid driving or operating machinery. You may need to take short breaks for application if applying during work hours.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if the warts do not improve after 6 weeks of treatment, if you experience severe skin reactions, or if you develop signs of systemic toxicity. Do not stop treatment abruptly without consulting your doctor, as the warts may recur.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged application can lead to chronic skin irritation, scarring, and rarely systemic toxicity. Regular follow-up with your doctor is important to monitor for these effects and to assess the need for continued treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cryotherapy

Freezing the warts with liquid nitrogen, performed by a healthcare professional.

Evidence: Well-established
Laser therapy

Using laser light to destroy wart tissue, often used for resistant warts.

Evidence: Well-established
Imiquimod cream

A topical immune response modifier that stimulates the body's immune system to fight the virus.

Evidence: Well-established
Sinecatechins ointment

A topical green tea extract that has antiviral and antioxidant properties.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

HPV vaccination is recommended for the prevention of anogenital warts and certain cancers. This medicine treats existing warts but does not protect against future HPV infections. Discuss HPV vaccination with your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate or freeze

✅ DO

Keep in original container with lid tightly closed

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children and pets

❌ DON'T

Do not leave within easy access

✈️ Traveling with This Medicine

When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor explaining the medical need, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. Keep it in your carry-on luggage to avoid temperature fluctuations in checked baggage. If you need to apply it during travel, ensure you have a private space and wash your hands thoroughly afterward. Be aware of customs regulations regarding prescription medicines in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old man with recurrent genital warts
He was prescribed this medicine by his dermatologist. He applied it exactly as directed for 3 days, then rested for 4 days. After 4 weeks, the warts had significantly reduced in size. He experienced mild burning during application but it subsided. He emphasized the importance of not applying it to healthy skin.
💡 Lesson: Consistent application and careful avoidance of healthy skin are key to successful treatment and minimizing side effects.
👤 A 28-year-old woman with a single anogenital wart
She was hesitant to use the medicine due to fear of pain. Her doctor applied the first dose in the clinic and taught her how to apply it at home. She followed the schedule and the wart cleared in 3 weeks. She reported mild redness and itching, which resolved after treatment ended.
💡 Lesson: Proper instruction and reassurance from a healthcare professional can help patients adhere to treatment and achieve good results.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Visible improvement usually occurs within 1 to 2 weeks, but complete clearance may take 4 to 6 weeks of regular treatment.

Q: Can I apply this medicine to my face?

A: No, this medicine is not recommended for use on the face due to the risk of severe irritation and scarring.

Q: What should I do if I miss a dose?

A: If you miss a dose, apply it as soon as you remember unless it is almost time for the next dose. Do not double the dose.

Q: Is it safe to use during pregnancy?

A: No, this medicine is contraindicated during pregnancy as it can harm the developing baby.

Q: Can I drink alcohol while using this medicine?

A: It is advisable to avoid excessive alcohol as it may worsen skin irritation.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine on my face?
  • How long will it take for the warts to disappear?
  • Will the warts come back after treatment?
  • Can I have sex while using this medicine?
  • What should I do if I accidentally apply too much?
  • Is it safe to use other creams on the same area?
  • Does this medicine affect fertility?
  • Can I use this medicine if I have sensitive skin?

🔄 Substitutes for wartsrub-s paint

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Podowart s paint can be used to remove any skin growth.
    Fact: This medicine is specifically for viral warts and should not be used on moles, skin tags, or other growths without a proper diagnosis.
  • Myth: You can apply podowart s paint as often as you like to make warts go away faster.
    Fact: Applying more than prescribed can cause severe skin damage and systemic toxicity. Always follow the prescribed schedule.
  • Myth: Podowart s paint is safe to use during pregnancy.
    Fact: This medicine is contraindicated in pregnancy because podophyllum resin can harm the developing baby.
  • Myth: Podowart s paint works immediately.
    Fact: It takes several weeks of regular application to see full results. Patience and consistency are important.

🔄 Alternative Options

Generic Alternatives

  • Podophyllum resin 25% w/v + Benzoin 10% w/v topical paint

Brand Alternatives

  • Podowart S Paint

📊 Comparison with Similar Medicines

[{"medicine":"Podowart S Paint","active_ingredient":"Podophyllum resin 25% + Benzoin 10%","route":"Topical","typical_use":"Anogenital warts","prescription_required":true},{"medicine":"Podophyllotoxin 0.5% solution","active_ingredient":"Podophyllotoxin 0.5%","route":"Topical","typical_use":"Anogenital warts","prescription_required":true},{"medicine":"Imiquimod 5% cream","active_ingredient":"Imiquimod 5%","route":"Topical","typical_use":"Anogenital warts","prescription_required":true}]

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