Astorglip M 1000mg/50mg Tablet: Comprehensive Guide
When to Call Your Doctor IMMEDIATELY
- Rapid breathing or shortness of breath
- Severe muscle pain or weakness
- Unusual tiredness or extreme fatigue
- Severe abdominal pain that may radiate to the back
- Swelling of the face, lips, tongue, or throat
- Yellowing of the skin or eyes
- Dark urine or decreased urine output
- Persistent vomiting or diarrhea leading to dehydration
If experiencing severe symptoms, call emergency services immediately.
What is vidagem-m 1gm tablet used for?
This medicine is a combination of Metformin 1000 mg and Vildagliptin 50 mg used to treat type 2 diabetes in adults. It helps lower blood sugar by improving insulin sensitivity and increasing insulin release after meals. It is taken orally with meals, usually twice daily, as prescribed by a doctor.
- Generic Name: Metformin (1000mg) + Vildagliptin (50mg)
- Manufacturer: Daxin Pharmaceutical Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vidagem-m 1gm tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेटफॉर्मिन 1000 मिलीग्राम और विल्डाग्लिप्टिन 50 मिलीग्राम का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) वाले वयस्कों में रक्त शर्करा को नियंत्रित करने के लिए किया जाता है। यह शरीर में इंसुलिन की कार्यक्षमता को बढ़ाती है और भोजन के बाद इंसुलिन के स्राव को बढ़ावा देती है। यह दवा खाने के साथ ली जाती है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट में असहजता, सिरदर्द, चक्कर आना और धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लैक्टिक एसिडोसिस, अग्नाशयशोथ (पैन्क्रियाटाइटिस), और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि आपको तेजी से सांस लेने में कठिनाई, गंभीर पेट दर्द, या चेहरे पर सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ लें ताकि पेट की परेशानी कम हो। पर्याप्त पानी पिएं। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस और लो ब्लड शुगर का खतरा बढ़ सकता है। अपनी अन्य दवाओं के बारे में डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें। नियमित रूप से ब्लड शुगर की जांच करें।
💊 vidagem-m 1gm tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on therapy to diet and exercise to improve glycemic control in adults whose blood sugar is not adequately controlled with metformin alone or vildagliptin alone.","evidence":"Well-established"},{"condition":"Improvement of glycemic control in adults with type 2 diabetes","description":"Helps lower both fasting and postprandial blood glucose levels when used as part of a comprehensive treatment plan.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prediabetes","description":"Sometimes considered off-label to delay progression to type 2 diabetes, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Polycystic ovary syndrome (PCOS) with insulin resistance","description":"Metformin component may be used off-label in PCOS, but the combination with vildagliptin is not established for this purpose.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Obesity, Dyslipidemia, Hypertension
📋 Drug Information
| Generic Name(s) | Metformin (1000mg) + Vildagliptin (50mg) |
| Brand Name | vidagem-m 1gm tablet |
| Manufacturer | Daxin Pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed. Protect from moisture and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. Guidelines from WHO generally recommend metformin as first-line therapy for type 2 diabetes, but the specific combination with vildagliptin is not addressed in WHO guidelines. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes recommend metformin as initial therapy and DPP-4 inhibitors as add-on options, but specific recommendations for this fixed-dose combination may vary. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Vildagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which normally breaks down incretin hormones such as GLP-1 and GIP. By inhibiting DPP-4, vildagliptin increases the levels of these active incretins, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon secretion from alpha cells. The combined effect is better control of blood sugar, especially after meals, with a lower risk of hypoglycemia when used alone.
Mechanism Steps
💡 How to Take vidagem-m 1gm tablet
Strength: Tablet containing Metformin 1000 mg and Vildagliptin 50 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally twice daily with meals, or as prescribed by your doctor. The dose may be adjusted based on your blood sugar levels, kidney function, and tolerability. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on kidney function. Kidney function should be monitored regularly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Metformin is contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73 m²). In moderate renal impairment (eGFR 30-45 mL/min/1.73 m²), metformin should be used with caution and dose reduction may be necessary. Vildagliptin dose should be reduced to 50 mg once daily in moderate to severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Vildagliptin should not be used in patients with severe hepatic impairment. In mild to moderate hepatic impairment, no dose adjustment is required for vildagliptin, but metformin should be used with caution. Regular monitoring of liver function is advised. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is Metformin 2000 mg and Vildagliptin 100 mg, but the exact dose depends on the prescribed regimen. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vidagem-m 1gm tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast media | Major | |
| Alcohol | Major | |
| Diuretics | Moderate | |
| Insulin | Moderate | |
| Sulfonylureas | Moderate | |
| ACE inhibitors | Moderate | |
| Corticosteroids | Moderate | |
| Cationic drugs | Moderate | |
| Sympathomimetics | Minor | |
| Thyroid hormones | Minor |
🚨 Major Interactions
- Iodinated contrast media
- Alcohol
- Diuretics (e.g., furosemide)
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, vancomycin)
⚡ Moderate Interactions
- Insulin and insulin secretagogues (e.g., sulfonylureas, meglitinides)
- ACE inhibitors
- Thiazide diuretics and other diuretics
- Corticosteroids
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause unpredictable drops in blood sugar. If you choose to drink, do so only occasionally and in moderation, and always with food. Discuss safe limits with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR < 30 mL/min/1.73 m²)","Acute or chronic metabolic acidosis","Hypersensitivity to metformin, vildagliptin, or any component","Severe hepatic impairment","Acute conditions that may alter renal function (e.g., dehydration, severe infection, shock)","Use of iodinated contrast media (temporarily stop)"]
⚠️ Warnings & Precautions
["Lactic acidosis: rare but serious; risk increases with renal impairment, dehydration, sepsis, alcohol use, and liver disease.","Pancreatitis: has been reported with vildagliptin; monitor for severe abdominal pain.","Hypoglycemia: risk increases when combined with insulin or sulfonylureas.","Renal function: assess before and during treatment; dose adjustment may be needed.","Hepatic function: monitor liver enzymes; discontinue if significant elevation occurs.","Vitamin B12 deficiency: long-term metformin use may reduce B12 levels.","Surgery: temporarily stop before surgery and restart after kidney function is confirmed normal.","Alcohol: avoid excessive intake due to risk of lactic acidosis.","Elderly: greater risk of renal impairment; monitor kidney function closely.","Pregnancy and lactation: consult doctor before use."]
🤱 Lactation Safety
Not established from the available information. Metformin is excreted in human milk in small amounts. Vildagliptin is also excreted in animal milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause lactic acidosis, hypoglycemia, or pancreatitis. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include dialysis for metformin removal. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Take it with meals to reduce stomach upset. Drink plenty of water throughout the day. Avoid excessive alcohol because it increases the risk of lactic acidosis and low blood sugar. Inform your doctor about all other medicines, especially those for blood pressure, cholesterol, or infections. Check your blood sugar regularly as advised. Do not stop this medicine suddenly without consulting your doctor. If you are scheduled for a surgery or a contrast X-ray procedure, tell your doctor because this medicine may need to be temporarily stopped. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney impairment and lactic acidosis. Kidney function should be assessed before starting and monitored regularly. Dose adjustment may be necessary based on renal function. Elderly patients should also be monitored for hypoglycemia, especially if taking other glucose-lowering drugs.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine is not recommended during pregnancy unless clearly needed. Your doctor may switch you to insulin or another suitable treatment. Good blood sugar control before and during pregnancy is important for the health of both mother and baby.
🏥 Post-Surgery Considerations
This medicine should be temporarily stopped before surgery and restarted only after your kidney function is confirmed normal by your doctor. This is to reduce the risk of lactic acidosis. Follow your surgeon's and doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. No specific precautions are usually needed for routine dental procedures, but if you are having surgery or a procedure requiring contrast media, your doctor may advise temporary discontinuation. Maintain good oral hygiene as diabetes can increase the risk of gum disease.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is encouraged while taking this medicine, but monitor your blood sugar before and after exercise, especially if you also take insulin or sulfonylureas. Carry fast-acting sugar in case of hypoglycemia. Stay hydrated during exercise. If you experience dizziness or weakness, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work routine. Inform your employer about your condition if necessary, especially if you work in a safety-sensitive role.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, pancreatitis, or severe allergic reactions, seek immediate medical attention and your doctor will decide whether to stop the medicine. If your blood sugar is well controlled and you wish to stop, discuss with your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. Metformin may cause vitamin B12 deficiency over years, so periodic monitoring is advised. Kidney function should be checked regularly. Vildagliptin may rarely affect the liver, so liver enzymes should be monitored. The combination helps reduce the risk of diabetes-related complications when blood sugar is well controlled. Regular follow-up with your doctor is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can reduce the need for medication.
Evidence: Well-establishedSulfonylureas, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives based on individual needs.
Evidence: Well-establishedMay be required if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, people with diabetes are at higher risk of complications from infections, so ensure you are up to date with recommended vaccinations such as influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within days, but the full effect on HbA1c may take 2-3 months. Your doctor will monitor your progress.
A: It depends on the severity of your kidney problems. Your doctor will check your kidney function and may adjust the dose or choose a different medicine.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop without consulting your doctor. Diabetes is a chronic condition, and stopping medicine can cause blood sugar to rise again.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be continued along with lifestyle changes. - Myth: You can eat anything while taking this medicine.
Fact: A healthy diet and regular exercise are essential for effective blood sugar control. - Myth: This medicine causes weight gain.
Fact: Unlike some other diabetes medicines, this combination is generally weight-neutral. - Myth: You can stop taking this medicine once your blood sugar is normal.
Fact: Diabetes is a chronic condition. Stopping medicine without consulting your doctor can cause blood sugar to rise again.
🔄 Alternative Options
Generic Alternatives
- Metformin + Vildagliptin generic
Brand Alternatives
- Zomelis Met
- Jalra M
- Galvus Met