vexigest 100mg soft gelatin capsule - Progesterone (Natural Micronized) (100mg) medicine

Aurich 100mg Capsule: Complete Medicine Guide

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🏭 Vexilla Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Progesterone is not classified by the old FDA pregnancy letter categories. When used as prescribed for luteal support or to prevent miscarriage, it is considered acceptable. However, it should only be used during pregnancy if clearly needed and under medical supervision. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden shortness of breath or chest pain
  • Swelling, redness, or pain in one leg
  • Severe headache with vision changes
  • Yellowing of the skin or eyes
  • Heavy or unexpected vaginal bleeding
  • Severe allergic reaction with swelling of the face, lips, or throat
  • Persistent vomiting or severe abdominal pain

If experiencing severe symptoms, call emergency services immediately.

What is vexigest 100mg soft gelatin capsule used for?

This medicine is a natural micronized progesterone capsule used to treat menstrual problems, protect the uterine lining during hormone replacement therapy, and support early pregnancy. It is taken by mouth, usually at bedtime, and must be used under a doctor's supervision.

  • Generic Name: Progesterone (Natural Micronized) (100mg)
  • Manufacturer: Vexilla Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 vexigest 100mg soft gelatin capsule के बारे में (Hindi Summary)

उपयोग: यह दवा प्राकृतिक माइक्रोनाइज़्ड प्रोजेस्टेरोन 100 मिलीग्राम कैप्सूल है। यह महिलाओं में प्रोजेस्टेरोन हार्मोन की कमी से होने वाली समस्याओं के इलाज के लिए इस्तेमाल की जाती है। इसका उपयोग अनियमित मासिक धर्म, अत्यधिक रक्तस्राव, और हार्मोन रिप्लेसमेंट थेरेपी में गर्भाशय की परत की सुरक्षा के लिए किया जाता है। यह गर्भधारण में सहायता के लिए भी दी जाती है। यह दवा डॉक्टर की सलाह के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, स्तनों में कोमलता, मनोदशा में बदलाव, पेट में सूजन, मतली और अनियमित रक्तस्राव शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के सामान्य होने पर ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर पैर में सूजन या दर्द, सांस लेने में कठिनाई, सीने में दर्द, या त्वचा और आंखों का पीला पड़ना हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पानी के साथ पूरा निगलें, चबाएं नहीं। इसे रात को सोने से पहले लेना बेहतर होता है क्योंकि इससे नींद आ सकती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी चलाने या मशीन चलाने से बचें। अपने डॉक्टर को अपनी सभी दवाओं और स्वास्थ्य समस्याओं के बारे में बताएं। गर्भावस्था में इस दवा को डॉक्टर की सलाह के बिना शुरू या बंद न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 vexigest 100mg soft gelatin capsule Uses & Benefits

[{"condition":"Abnormal uterine bleeding due to hormonal imbalance","description":"This medicine helps regulate the menstrual cycle and control abnormal bleeding when progesterone levels are low.","evidence":"Well-established"},{"condition":"Secondary amenorrhea","description":"Used to restart menstrual periods in women who have stopped menstruating due to low progesterone.","evidence":"Well-established"},{"condition":"Hormone replacement therapy in postmenopausal women with a uterus","description":"Protects the uterine lining from the effects of estrogen alone and reduces the risk of endometrial hyperplasia.","evidence":"Well-established"},{"condition":"Luteal phase support in assisted reproduction","description":"Supports the lining of the uterus after ovulation induction or embryo transfer to improve the chance of pregnancy.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage due to luteal phase defect","description":"May be prescribed to support early pregnancy when progesterone production is inadequate.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Catamenial epilepsy","description":"Sometimes used to reduce seizure frequency linked to the menstrual cycle, but evidence is limited.","evidence":"Limited"},{"condition":"Premenstrual syndrome","description":"Occasionally prescribed for severe premenstrual symptoms, though results vary.","evidence":"Limited"}]

Primary treatment for: Progesterone deficiency

Also treats: Abnormal uterine bleeding, Secondary amenorrhea, Endometrial hyperplasia, Infertility due to luteal phase defect

📋 Drug Information

Generic Name(s)Progesterone (Natural Micronized) (100mg)
Brand Namevexigest 100mg soft gelatin capsule
ManufacturerVexilla Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassNatural Progesterone
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at bedtime to minimize daytime drowsiness.
2
Take it with food, preferably a meal containing some fat, to improve absorption.
3
Do not drive or operate heavy machinery until you know how this medicine affects you.
4
Inform your doctor if you have a history of blood clots, liver disease, or breast cancer.
5
Do not stop this medicine suddenly, especially if you are pregnant or on hormone replacement therapy.
6
Keep a record of your menstrual bleeding pattern to help your doctor adjust the dose.
7
Report any unusual vaginal bleeding, leg swelling, or shortness of breath immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Irregular menstrual periods
This medicine is commonly prescribed for this.
Likely Use
Abnormal uterine bleeding
This medicine helps regulate bleeding due to hormonal imbalance.
Likely Use
Infertility due to luteal phase defect
This medicine supports the luteal phase.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMicronized progesterone is absorbed from the gastrointestinal tract. Absorption is improved when the capsule is taken with food, especially a fatty meal, because progesterone is a fat-soluble hormone. The micronized form increases the surface area for absorption compared with non-micronized progesterone.
DistributionProgesterone is widely distributed in the body. It is highly bound to plasma proteins, mainly albumin and corticosteroid-binding globulin. It crosses the blood-brain barrier and the placenta, and it is excreted in breast milk.
Protein BindingApproximately 96% to 99% bound to plasma proteins, mainly albumin and corticosteroid-binding globulin.
MetabolismProgesterone is extensively metabolized in the liver. The main metabolic pathways involve reduction and hydroxylation, producing metabolites such as pregnanediol and pregnanolone. Some metabolites have sedative effects.
Half-LifeThe elimination half-life of micronized progesterone is approximately 5 to 20 hours, depending on the individual and the formulation.
ExcretionMetabolites are excreted mainly in the urine as glucuronide and sulfate conjugates. A small amount is excreted in the bile and feces.
BioavailabilityThe oral bioavailability of micronized progesterone is variable and low, roughly 5% to 10%, because of extensive first-pass metabolism in the liver. Taking it with food increases absorption.
Onset of ActionSedative effects may be noticed within 1 to 2 hours after taking a dose. Effects on the menstrual cycle and uterine lining usually take several days to weeks to become apparent.
Peak Plasma TimePeak plasma levels are usually reached 1 to 3 hours after taking the capsule with food.
Duration of ActionThe sedative effect may last for several hours. The hormonal effects on the uterus persist as long as the medicine is taken regularly.

How It Works

This medicine works by binding to and activating progesterone receptors in the nucleus of target cells. Once bound, the hormone-receptor complex interacts with specific DNA sequences and changes the production of certain proteins. In the uterus, this leads to a secretory transformation of the endometrium, which is needed for a healthy menstrual cycle and for implantation of a fertilized egg. It also reduces the growth-promoting effects of estrogen on the uterine lining. In the brain, it has a calming effect that can cause drowsiness. Because the progesterone in this medicine is micronized, it is absorbed more efficiently from the gut than ordinary progesterone.

Mechanism Steps

1
Absorption and transport: After swallowing, the micronized progesterone is absorbed from the intestine and travels through the bloodstream bound to albumin and other proteins.
2
Entry into target cells: The hormone enters cells of the uterus, breast, and brain, where it binds to the progesterone receptor.
3
Receptor activation: Binding changes the shape of the receptor, allowing it to move into the nucleus and attach to specific DNA regions.
4
Gene regulation: This alters the production of proteins that control the menstrual cycle, prepare the uterine lining for pregnancy, and influence brain activity.
5
Clinical effects: The result is regulation of bleeding, protection of the uterine lining, support of early pregnancy, and a mild calming effect.

💡 How to Take vexigest 100mg soft gelatin capsule

Strength: Capsule, 100 mg

1Swallow the capsule whole with a glass of water.
2Take it at the same time each day, preferably at bedtime.
3Take it with food to improve absorption and reduce stomach upset.
4Do not crush, chew, or open the capsule.
5If you miss a dose, follow the missed dose instructions.
6Do not stop taking this medicine without talking to your doctor.

Dosage Information

Adult DosageThe dose of this medicine is individualized by a qualified clinician based on the condition being treated, your age, weight, liver function, and response to therapy. For menstrual irregularities, a common regimen is 200 to 300 mg taken once daily at bedtime for 10 to 12 days each month. For hormone replacement therapy, 100 mg once daily at bedtime may be used. For luteal support in assisted reproduction, doses of 200 to 600 mg daily in divided doses may be prescribed. Always follow your doctor's instructions exactly. Do not change the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageThere is no specific dose adjustment for elderly patients, but they may be more sensitive to the sedative effects. Use with caution and follow your doctor's advice.
Renal ImpairmentNo dose adjustment is usually needed for mild to moderate kidney problems. Consult your doctor if you have severe kidney disease.
Hepatic ImpairmentThis medicine is not recommended for patients with severe liver disease. For mild to moderate liver impairment, your doctor may adjust the dose and monitor liver function.
Maximum Daily DoseThe maximum daily dose is determined by your doctor based on the indication. Doses up to 600 mg per day have been used in clinical practice for luteal support. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Improves absorption and reduces stomach upset.
Grapefruit
Avoid
May increase drug levels by affecting liver enzymes.
Alcohol
Avoid
May increase drowsiness and dizziness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of vexigest 100mg soft gelatin capsule

✅ Common Side Effects

Drowsiness or sleepiness (Common (up to 30%))
Take the dose at bedtime. Avoid driving or operating machinery until you know how it affects you.
Dizziness (Common (10-20%))
Rise slowly from sitting or lying down. Avoid alcohol. If it persists, consult your doctor.
Headache (Common (10-20%))
Rest, stay hydrated, and use a mild pain reliever if needed. Consult your doctor if headaches are severe or frequent.
Breast tenderness (Common (10-20%))
Wear a supportive bra. Usually improves with continued use. Consult your doctor if severe.
Mood changes or irritability (Common (5-10%))
Discuss with your doctor if it affects your daily life. Do not stop the medicine on your own.
Abdominal bloating or nausea (Common (5-10%))
Take with food. Eat small, frequent meals. Consult your doctor if it continues.
Spotting or irregular vaginal bleeding (Common (5-10%))
Report to your doctor if bleeding is heavy or persistent.

🚨 Serious Side Effects

Blood clots in the legs or lungs (Rare (<0.1%))
Seek immediate medical attention if you notice swelling or pain in one leg, sudden shortness of breath, or chest pain.
Severe allergic reaction (Rare (<0.1%))
Stop the medicine and get emergency help if you have rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing.
Liver problems (Rare (<0.1%))
Report yellowing of the eyes or skin, dark urine, or severe abdominal pain to your doctor immediately.
Unusual vaginal bleeding (Uncommon (0.1-1%))
Contact your doctor if you have heavy or unexpected bleeding that does not stop.

⚠️ Rare Side Effects

Jaundice
Seek medical attention if you notice yellowing of the skin or eyes.
Depression
Talk to your doctor if you feel persistently sad or hopeless.
Seizures
Get emergency help if you have a seizure.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ketoconazole Major
Rifampicin Major
Carbamazepine Moderate
Phenytoin Moderate
St. John's wort Moderate
Grapefruit juice Minor
Alcohol Minor

🚨 Major Interactions

  • Warfarin
  • Ketoconazole
  • Rifampicin

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin
  • St. John's wort

🍷 Alcohol Interaction

Alcohol can increase the drowsiness and dizziness caused by this medicine. It is best to avoid alcohol while taking this medicine, especially if you need to drive or operate machinery.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to progesterone or any ingredient in the capsule","Undiagnosed vaginal bleeding","Known or suspected breast cancer","Known or suspected progesterone-sensitive tumors","Severe liver disease","Active or history of blood clots in the legs, lungs, or brain","Missed abortion"]

⚠️ Warnings & Precautions

["This medicine may cause drowsiness. Avoid driving or operating machinery until you know how it affects you.","Do not use this medicine as a contraceptive. It does not prevent pregnancy.","Tell your doctor if you have a history of depression, epilepsy, migraine, or heart disease.","This medicine may increase the risk of blood clots. Seek immediate medical help if you notice symptoms.","Do not stop this medicine suddenly without consulting your doctor, especially during pregnancy.","Keep all appointments for monitoring and follow-up."]

🤱 Lactation Safety

Progesterone is excreted in breast milk. The amount is small and it is generally considered safe for breastfeeding mothers, but it should only be used if prescribed by a doctor. Monitor the infant for any unusual drowsiness or poor feeding.

💊 Overdose Management

Overdose of this medicine is unlikely to cause serious harm. Symptoms may include severe drowsiness, dizziness, nausea, and vomiting. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Swallow the capsule whole with water; do not crush or chew it. Taking it at bedtime is often advised because it can cause drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you. Tell your doctor about all other medicines, supplements, and herbal products you take, especially anticoagulants, antifungals, and epilepsy medicines. Do not start or stop this medicine during pregnancy without medical advice. Keep all follow-up appointments so your doctor can monitor your response and adjust the dose if needed. Store the capsules in their original container, away from heat, moisture, and direct light. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly women may be more sensitive to the sedative effects of this medicine. Use with caution and follow your doctor's advice. Regular monitoring for blood clots and liver function may be advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. It may be prescribed to support early pregnancy in certain cases. Do not use this medicine without medical advice if you are trying to conceive.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery to reduce the risk of blood clots. Follow your doctor's instructions.

🦷 Dental Procedures

Tell your dentist that you are taking this medicine. It is generally safe for dental procedures, but your dentist may take precautions if you have a history of blood clots or are on other medications.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to support hormonal balance.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice stress-reducing techniques such as yoga or meditation.
💧
Get adequate sleep to help regulate hormones.
🧘
Avoid smoking and limit alcohol intake.
🌞
Eat a balanced diet rich in fruits, vegetables, and whole grains.

🏋️ Exercise Considerations

This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. If you feel dizzy during exercise, stop and rest.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce processed and high-sugar foods.
Stay well hydrated.
Eat small, frequent meals if you experience nausea.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is best to take it at bedtime. If you have a job that requires alertness, discuss with your doctor about adjusting the timing. Most women can continue their normal activities with caution.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects such as blood clots, severe allergic reaction, or liver problems, stop the medicine and seek immediate medical attention. Your doctor will advise you on when and how to stop safely.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when taken under medical supervision. However, prolonged use may increase the risk of blood clots, breast tenderness, and mood changes. Regular follow-up with your doctor is recommended to monitor your response and adjust the dose. Liver function tests may be advised if you have a history of liver disease.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Regular exercise, balanced diet, and stress management can help improve hormonal balance.

Evidence: Well-established
Other progestogens

Synthetic progestogens like dydrogesterone may be used as alternatives, but they have different side effect profiles.

Evidence: Well-established
Non-hormonal treatments

For some conditions, non-hormonal options may be considered.

Evidence: Varies by condition

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations as recommended by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor for specific advice. Do not pack it in checked luggage; keep it in your carry-on bag.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with irregular periods
She was prescribed this medicine for 10 days each month. She took it at bedtime as advised. After two cycles, her periods became more regular. She noted that taking it with a small snack helped reduce nausea.
💡 Lesson: Taking the medicine at bedtime and with food improves tolerability and helps regulate the cycle.
👤 A 38-year-old woman undergoing IVF
She was given this medicine for luteal support after embryo transfer. She experienced mild drowsiness and breast tenderness but continued as prescribed. She was advised not to stop the medicine until her doctor confirmed the pregnancy test result.
💡 Lesson: Adherence to the prescribed regimen is crucial for supporting early pregnancy, and side effects are usually manageable.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The sedative effect may be noticed within 1-2 hours. Effects on the menstrual cycle may take several weeks to become apparent.

Q: Can I take this medicine with food?

A: Yes, taking it with food, especially a fatty meal, improves absorption and reduces stomach upset.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: This medicine is sometimes prescribed during pregnancy to support early pregnancy. However, it should only be used under medical supervision.

Q: Can I stop taking this medicine suddenly?

A: No, do not stop this medicine suddenly without consulting your doctor, especially if you are pregnant or on hormone replacement therapy.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my fertility?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will it cause weight gain?
  • Is it safe during breastfeeding?

🔄 Substitutes for vexigest 100mg soft gelatin capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a contraceptive.
    Fact: This medicine is not a contraceptive and does not prevent pregnancy.
  • Myth: This medicine causes weight gain in everyone.
    Fact: Weight gain is not a common side effect. Some women may experience bloating, but significant weight gain is rare.
  • Myth: This medicine can be taken at any time of day.
    Fact: It is best taken at bedtime because it can cause drowsiness.
  • Myth: This medicine is safe to take without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Natural micronized progesterone 100 mg capsules from other manufacturers

Brand Alternatives

  • Aurich 100mg capsule

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredient":"Natural micronized progesterone","strength":"100 mg","form":"Capsule","route":"Oral","notes":"Identical to natural progesterone; may cause drowsiness."},{"medicine":"Dydrogesterone","active_ingredient":"Dydrogesterone","strength":"10 mg","form":"Tablet","route":"Oral","notes":"Synthetic progestogen; less sedating; different side effect profile."},{"medicine":"Medroxyprogesterone acetate","active_ingredient":"Medroxyprogesterone acetate","strength":"2.5 mg, 5 mg, 10 mg","form":"Tablet","route":"Oral","notes":"Synthetic progestogen; not identical to natural progesterone."}]

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