Myrest Forte Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or stool
- Severe abdominal pain
- Yellowing of skin or eyes
- Difficulty breathing or swelling of face
- High fever with muscle rigidity
- Uncontrolled movements of tongue or face
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is vertex plus 650mg/5mg tablet used for?
This medicine is a combination of Paracetamol (650 mg) and Prochlorperazine (5 mg) used to treat pain and nausea, especially in migraines. It works by relieving pain and blocking nausea signals in the brain. It is taken orally as prescribed by a doctor.
- Generic Name: Paracetamol (650mg) + Prochlorperazine (5mg)
- Manufacturer: Ultramark Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vertex plus 650mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल और प्रोक्लोरपेराज़ीन का संयोजन है, जिसका उपयोग दर्द और मतली, विशेषकर माइग्रेन में किया जाता है। यह दर्द को कम करती है और उल्टी को रोकती है।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, यकृत क्षति और रक्त विकार हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अधिक मात्रा में न लें। गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। यकृत या गुर्दे की समस्या हो तो डॉक्टर को बताएं।
💊 vertex plus 650mg/5mg tablet Uses & Benefits
[{"condition":"Migraine headache","description":"Relieves pain and reduces nausea and vomiting associated with migraines.","evidence":"Well-established"},{"condition":"Tension headache with nausea","description":"Provides pain relief and controls nausea.","evidence":"Moderate"},{"condition":"Post-operative nausea and vomiting","description":"Used to prevent or treat nausea and vomiting after surgery.","evidence":"Well-established"},{"condition":"General pain with nausea","description":"Used for various painful conditions when nausea is also present.","evidence":"Limited"}]
Off-label uses: [{"condition":"Vertigo","description":"Sometimes used to relieve vertigo due to its antiemetic and sedative effects.","evidence":"Limited"},{"condition":"Anxiety-associated nausea","description":"May be used off-label for nausea related to anxiety.","evidence":"Limited"}]
Primary treatment for: Migraine headache
Also treats: Tension headache, Post-operative nausea and vomiting, General pain with nausea
📋 Drug Information
| Generic Name(s) | Paracetamol (650mg) + Prochlorperazine (5mg) |
| Brand Name | vertex plus 650mg/5mg tablet |
| Manufacturer | Ultramark Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Paracetamol works centrally to reduce pain and fever by inhibiting prostaglandin synthesis in the brain. Prochlorperazine blocks dopamine D2 receptors in the chemoreceptor trigger zone, reducing nausea and vomiting. It also has anticholinergic and sedative effects.
Mechanism Steps
💡 How to Take vertex plus 650mg/5mg tablet
Strength: Tablet: Paracetamol 650 mg + Prochlorperazine 5 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain and nausea, not to exceed 4 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects, especially drowsiness and extrapyramidal symptoms. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | Paracetamol: 4000 mg per day; Prochlorperazine: 40 mg per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vertex plus 650mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| Anticholinergics | Moderate | |
| Levodopa | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Other CNS depressants (e.g., opioids, benzodiazepines)
⚡ Moderate Interactions
- Anticholinergics (e.g., benztropine)
- Levodopa
🍷 Alcohol Interaction
Avoid alcohol consumption while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of liver damage, especially due to the paracetamol component.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to paracetamol or prochlorperazine","Severe liver disease","Severe kidney disease","Blood dyscrasias","Parkinson's disease","Children under 2 years (prochlorperazine)"]
⚠️ Warnings & Precautions
["Avoid driving or operating machinery until you know how this medicine affects you.","Do not consume alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with liver or kidney disease.","Do not exceed the recommended dose of paracetamol to avoid liver damage.","Prochlorperazine may cause extrapyramidal symptoms; report any unusual muscle movements."]
🤱 Lactation Safety
Paracetamol is considered safe during breastfeeding. Prochlorperazine may pass into breast milk and could cause drowsiness in the infant. Consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and severe drowsiness, hypotension, and extrapyramidal symptoms from prochlorperazine. Seek emergency medical attention immediately. Treatment includes activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine as it can increase drowsiness and the risk of liver damage. Inform your doctor if you have liver or kidney problems, or if you are pregnant or breastfeeding. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and extrapyramidal effects of prochlorperazine. Use with caution and monitor closely. Dose adjustment may be needed.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine. Paracetamol is generally considered safe, but prochlorperazine should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain and nausea. Inform your surgeon and anesthesiologist about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with anesthetics and other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy after taking this medicine. Light activities are fine if you feel well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also affect your concentration at work.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately. For short-term use, stop when symptoms resolve as advised.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. Prolonged use of prochlorperazine can cause tardive dyskinesia. Regular monitoring of liver and kidney function may be needed. Do not use for extended periods without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help reduce migraine frequency and nausea.
Evidence: ModerateMay help with pain and nausea.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. Consult your doctor before vaccination if you are on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It usually starts working within 30-60 minutes after taking it.
A: It is best taken with food to reduce stomach upset.
A: Consult your doctor before combining with other painkillers, as paracetamol overdose can occur.
🤔 Common Patient Concerns
🔄 Substitutes for vertex plus 650mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
neurosia forte 650mg/5mg tabletAmbrosia Pharma ₹18.75 45.1% CHEAPER
-
nuropar plus 650mg/5mg tabletModgal Pharmaceuticals Pvt Ltd ₹24.38 28.6% CHEAPER
-
redirest forte tabletMac Millon Pharmaceuticals Pvt Ltd ₹37.13 8.8% COSTLIER
-
myrest forte tabletMedishri Healthcare ₹49.00 43.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: It is specifically for pain with nausea, such as migraine. It is not a general painkiller for all conditions. - Myth: It is safe to take extra doses if pain persists.
Fact: Taking more than the recommended dose can cause serious liver damage and other side effects.
🔄 Alternative Options
Generic Alternatives
- Paracetamol + Prochlorperazine combination tablets
Brand Alternatives
- Myrest Forte Tablet