vasoprin 60 mg/75 mg tablet - Isosorbide Mononitrate (60mg) + Aspirin (75mg) medicine

Vasoprin 60 mg/75 mg Tablet: Comprehensive Medicine Guide

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🏭 Torrent Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is vasoprin 60 mg/75 mg tablet used for?

This medicine is a combination of Isosorbide Mononitrate and Aspirin used to prevent and treat angina and reduce the risk of heart attack and stroke. It works by widening blood vessels and preventing blood clots.

  • Generic Name: Isosorbide Mononitrate (60mg) + Aspirin (75mg)
  • Manufacturer: Torrent Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 vasoprin 60 mg/75 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एंजाइना (सीने में दर्द) के इलाज और रोकथाम के लिए इस्तेमाल की जाती है। यह दिल के दौरे और स्ट्रोक के खतरे को कम करने में भी मदद करती है। यह रक्त वाहिकाओं को फैलाकर और रक्त के थक्के बनने से रोककर काम करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर लालिमा और मतली शामिल हैं। गंभीर दुष्प्रभावों में गंभीर निम्न रक्तचाप, जीआई रक्तस्राव और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन न करें। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें। दवा को ठंडी और सूखी जगह पर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 vasoprin 60 mg/75 mg tablet Uses & Benefits

[{"condition":"Angina pectoris","description":"Used for the prevention and treatment of angina attacks by reducing cardiac workload and improving coronary blood flow.","evidence":"Well-established"},{"condition":"Secondary prevention of myocardial infarction","description":"Aspirin component helps prevent recurrent heart attacks in patients with a history of cardiovascular events.","evidence":"Well-established"},{"condition":"Secondary prevention of stroke","description":"Low-dose aspirin reduces the risk of recurrent ischemic stroke.","evidence":"Well-established"},{"condition":"Coronary artery disease","description":"Used in combination to manage symptoms and prevent complications in patients with coronary artery disease.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Prevention of preeclampsia","description":"Low-dose aspirin is sometimes used off-label to reduce the risk of preeclampsia in high-risk pregnancies.","evidence":"Limited"},{"condition":"Prevention of colorectal cancer","description":"Aspirin has been studied for chemoprevention of colorectal cancer, but this is not a standard indication.","evidence":"Limited"}]

Primary treatment for: Angina pectoris

Also treats: Coronary artery disease, Myocardial infarction prevention, Stroke prevention

📋 Drug Information

Generic Name(s)Isosorbide Mononitrate (60mg) + Aspirin (75mg)
Brand Namevasoprin 60 mg/75 mg tablet
ManufacturerTorrent Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels.
2
Take with food to reduce stomach upset.
3
Avoid alcohol while taking this medicine.
4
Do not stop taking this medicine abruptly without consulting your doctor.
5
Report any unusual bleeding, bruising, or severe headache to your doctor immediately.
6
Inform your doctor if you are scheduled for surgery or dental procedures.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain (angina)
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIsosorbide Mononitrate is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Aspirin is also well absorbed, with peak levels occurring within 1-2 hours.
DistributionIsosorbide Mononitrate has a volume of distribution of approximately 0.6 L/kg. Aspirin is widely distributed throughout body tissues, including crossing the placental barrier and appearing in breast milk.
Protein BindingIsosorbide Mononitrate is less than 5% bound to plasma proteins. Aspirin is approximately 80-90% bound to plasma proteins, mainly albumin.
MetabolismIsosorbide Mononitrate undergoes extensive hepatic metabolism via denitration, with no significant first-pass effect. Aspirin is rapidly hydrolyzed to salicylic acid in the liver and other tissues.
Half-LifeThe elimination half-life of Isosorbide Mononitrate is approximately 5 hours. The half-life of aspirin is about 15-20 minutes, while its active metabolite salicylate has a half-life of 2-3 hours at low doses and up to 15-30 hours at high doses.
ExcretionIsosorbide Mononitrate is excreted primarily in the urine as metabolites. Aspirin metabolites are excreted mainly in the urine, with excretion influenced by urine pH.
BioavailabilityIsosorbide Mononitrate has a bioavailability of approximately 100% due to lack of first-pass metabolism. Aspirin has a bioavailability of about 50-75% due to first-pass metabolism.
Onset of ActionIsosorbide Mononitrate: onset of action is within 30-60 minutes for oral tablets. Aspirin: onset of antiplatelet effect is within 30-60 minutes.
Peak Plasma TimeIsosorbide Mononitrate: 1-2 hours. Aspirin: 1-2 hours for immediate-release formulations.
Duration of ActionIsosorbide Mononitrate: up to 12-24 hours depending on formulation. Aspirin: antiplatelet effect lasts for the lifespan of platelets (7-10 days).

How It Works

Isosorbide Mononitrate acts by releasing nitric oxide, which activates guanylate cyclase, leading to increased cyclic GMP levels. This results in relaxation of vascular smooth muscle, particularly in veins, causing vasodilation and reduced preload. Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) and COX-2 enzymes, thereby reducing the synthesis of thromboxane A2, a potent platelet aggregator and vasoconstrictor. The combined effect reduces cardiac workload and prevents thrombus formation.

Mechanism Steps

1
Nitric oxide release: Isosorbide Mononitrate is metabolized to release nitric oxide, which diffuses into vascular smooth muscle cells.
2
Guanylate cyclase activation: Nitric oxide binds to and activates guanylate cyclase, increasing cyclic GMP levels.
3
Vascular smooth muscle relaxation: Elevated cyclic GMP leads to relaxation of vascular smooth muscle, causing vasodilation, especially of veins.
4
Reduced preload and afterload: Vasodilation reduces venous return (preload) and systemic vascular resistance (afterload), decreasing cardiac workload.
5
COX inhibition by aspirin: Aspirin irreversibly acetylates cyclooxygenase enzymes, inhibiting thromboxane A2 production.
6
Platelet inhibition: Reduced thromboxane A2 leads to decreased platelet aggregation and vasoconstriction, lowering thrombotic risk.

💡 How to Take vasoprin 60 mg/75 mg tablet

Strength: Tablet containing Isosorbide Mononitrate 60 mg and Aspirin 75 mg.

1Take the tablet by mouth with a full glass of water.
2Swallow the tablet whole; do not crush, chew, or break it.
3Take it at the same time each day to maintain consistent blood levels.
4Take with food to reduce stomach upset.
5Do not take with alcohol or grapefruit juice.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally once daily or as directed by your physician. The dose may be adjusted based on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially hypotension and dizziness. Dose adjustment may be necessary. Consult your doctor.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be required. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be required. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (60 mg isosorbide mononitrate + 75 mg aspirin) or as prescribed by your doctor. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Alcohol
Avoid
Increases risk of hypotension and bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of vasoprin 60 mg/75 mg tablet

✅ Common Side Effects

Headache (Common (10-30%))
Usually resolves with continued use. If persistent or severe, consult your doctor.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid driving if affected.
Flushing (Common (5-10%))
Usually temporary. Stay hydrated.
Nausea (Common (5-10%))
Take with food to reduce stomach upset.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or blurred vision.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools or vomit blood.
Allergic reactions (Rare (<0.1%))
Seek emergency help if you develop rash, itching, swelling, or difficulty breathing.

⚠️ Rare Side Effects

Methemoglobinemia
Seek immediate medical attention if you experience bluish discoloration of lips, nails, or skin, or shortness of breath.
Thrombocytopenia
Report unusual bruising or bleeding to your doctor immediately.
Bronchospasm
Seek medical help if you experience wheezing or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major
Warfarin Major
Ibuprofen Major
Lisinopril Moderate
Prednisone Moderate
Antacid Minor

🚨 Major Interactions

  • Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
  • Anticoagulants (e.g., warfarin)
  • Other NSAIDs

⚡ Moderate Interactions

  • Antihypertensives
  • Corticosteroids

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine as it can potentiate the blood pressure-lowering effect and increase the risk of gastrointestinal bleeding.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nitrates or aspirin","Severe hypotension","Active bleeding disorders","Severe liver or kidney disease","Concurrent use of phosphodiesterase-5 inhibitors","History of asthma induced by aspirin or NSAIDs"]

⚠️ Warnings & Precautions

["Avoid abrupt discontinuation of isosorbide mononitrate as it may cause rebound angina.","Use with caution in patients with glaucoma or increased intracranial pressure.","Aspirin may cause gastrointestinal bleeding; use with caution in patients with peptic ulcer disease.","Avoid alcohol consumption.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe hypotension, headache, flushing, dizziness, and tachycardia. Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. Avoid alcohol while taking this medicine as it can increase the risk of low blood pressure and gastrointestinal bleeding. Inform your doctor about all other medications you are taking, especially blood thinners, other nitrates, and erectile dysfunction drugs. Do not use this medicine if you are pregnant or breastfeeding without medical advice. Store at room temperature away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to hypotension and dizziness. Dose adjustment and close monitoring are advised.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine may not be safe during pregnancy.

🏥 Post-Surgery Considerations

Inform your surgeon about this medicine before surgery. It may need to be stopped temporarily due to bleeding risk.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce heart strain.
🥗
Regular low-impact exercise like walking or swimming.
😴
Practice stress-reduction techniques like meditation.
💧
Include heart-healthy foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you, as it may cause dizziness or low blood pressure.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Limit salt and alcohol

💼 Impact on Daily Work & Life

This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. It should not interfere with most daily activities if taken as prescribed.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately for guidance.

📅 Long-Term Use Effects

Long-term use may lead to tolerance to nitrates, requiring dose adjustment or a nitrate-free interval. Aspirin long-term use increases risk of gastrointestinal bleeding. Regular monitoring of blood pressure, renal function, and signs of bleeding is recommended.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medicine for heart health.

Evidence: Well-established
Other antianginal medications

Beta-blockers or calcium channel blockers may be alternatives or additions.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. Consult your doctor for routine vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, consult your doctor for dose adjustment. Keep enough supply for the entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with a history of angina
He was prescribed this medicine for angina prevention. He experienced mild headache initially, which subsided after a week. He was advised to take it with food and avoid alcohol. His angina attacks reduced significantly over a month.
💡 Lesson: Consistency and adherence to prescribed dosage are key to managing angina effectively.
👤 A 65-year-old woman with coronary artery disease
She started this medicine after a heart attack. She was monitored for bleeding and blood pressure. She reported dizziness initially, which improved with slow position changes. She was advised not to stop the medicine without consulting her doctor.
💡 Lesson: Regular monitoring and reporting side effects help in safe long-term use.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Isosorbide Mononitrate starts working within 30-60 minutes, while Aspirin's antiplatelet effect begins within 30-60 minutes. Full benefits may take days to weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop without consulting your doctor. Abrupt discontinuation can worsen angina.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for vasoprin 60 mg/75 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.
  • Myth: It is safe to stop this medicine suddenly.
    Fact: Abrupt discontinuation can worsen angina. Always consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Isosorbide Mononitrate + Aspirin combination generics

Brand Alternatives

  • Vasoprin 60 mg/75 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Vasoprin 60 mg/75 mg tablet","composition":"Isosorbide Mononitrate 60 mg + Aspirin 75 mg","release_type":"Immediate release","usual_frequency":"Once daily"},{"medicine":"Isosorbide Dinitrate + Aspirin","composition":"Isosorbide Dinitrate 20 mg + Aspirin 75 mg","release_type":"Immediate release","usual_frequency":"Twice daily"}]

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