varnmic d 10mg/250mg tablet - Dicyclomine (10mg) + Mefenamic Acid (250mg) medicine

Anglospas 10 mg/250 mg Tablet: Complete Medicine Guide

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🏭 SB Lifesciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding
  • High fever with sore throat

If experiencing severe symptoms, call emergency services immediately.

What is varnmic d 10mg/250mg tablet used for?

This medicine is a combination of dicyclomine and mefenamic acid used to treat abdominal cramps, menstrual pain, and irritable bowel syndrome. It works by relaxing gut muscles and reducing inflammation.

  • Generic Name: Dicyclomine (10mg) + Mefenamic Acid (250mg)
  • Manufacturer: SB Lifesciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 varnmic d 10mg/250mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइसाइक्लोमिन और मेफेनैमिक एसिड का संयोजन है, जिसका उपयोग पेट की ऐंठन, मासिक धर्म के दर्द और इरिटेबल बाउल सिंड्रोम (IBS) के इलाज के लिए किया जाता है। यह आंतों की मांसपेशियों को आराम देकर और सूजन को कम करके दर्द से राहत देती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, चक्कर आना, नींद आना, जी मिचलाना, पेट दर्द, कब्ज और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में गंभीर रक्तस्राव, गुर्दे की समस्या, एलर्जी प्रतिक्रिया और रक्त विकार हो सकते हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, चेहरे या गले में सूजन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अधिक मात्रा में या लंबे समय तक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की परेशानी कम हो। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट में रक्तस्राव और नींद आने की समस्या बढ़ सकती है। यदि आपको चक्कर या नींद आती है तो वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 varnmic d 10mg/250mg tablet Uses & Benefits

[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal cramps and pain associated with IBS by reducing smooth muscle spasms and inflammation.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Reduces menstrual cramps and pelvic pain by decreasing prostaglandin production and relaxing uterine muscles.","evidence":"Well-established"},{"condition":"Gastrointestinal spasms","description":"Used for short-term relief of spasms in the stomach and intestines due to various causes.","evidence":"Moderate"},{"condition":"Biliary colic","description":"May help relieve pain from gallbladder spasms, but should be used under medical supervision.","evidence":"Limited"}]

Off-label uses: [{"condition":"Urinary tract spasms","description":"Sometimes prescribed off-label to relieve bladder spasms, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Irritable bowel syndrome

Also treats: Primary dysmenorrhea, Gastrointestinal spasms, Biliary colic

📋 Drug Information

Generic Name(s)Dicyclomine (10mg) + Mefenamic Acid (250mg)
Brand Namevarnmic d 10mg/250mg tablet
ManufacturerSB Lifesciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid alcohol while taking this medicine to prevent stomach bleeding and drowsiness.
3
Do not drive or operate heavy machinery if you feel dizzy or drowsy.
4
Do not take this medicine for longer than prescribed without consulting your doctor.
5
Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, or asthma.
6
Report any unusual bleeding, bruising, or severe abdominal pain immediately.
7
Stay well hydrated throughout the day to help prevent constipation.
8
Do not take other NSAIDs or pain relievers without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
Menstrual cramps
This medicine is effective for primary dysmenorrhea.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Headache
This medicine is not intended for headache relief.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDicyclomine is well absorbed from the gastrointestinal tract after oral administration. Mefenamic acid is also absorbed from the gastrointestinal tract, but absorption may be delayed if taken with food. Not established from the available information for specific bioavailability values.
DistributionDicyclomine is widely distributed in the body, including the central nervous system. Mefenamic acid is highly bound to plasma proteins and distributes into synovial fluid. Not established from the available information for specific volume of distribution values.
Protein BindingMefenamic acid is highly bound to plasma proteins (approximately 90% or more). Dicyclomine is also bound to plasma proteins, but the exact percentage is not established from the available information.
MetabolismDicyclomine is metabolized in the liver. Mefenamic acid is metabolized in the liver, primarily by cytochrome P450 enzymes, including CYP2C9. Not established from the available information for specific metabolic pathways.
Half-LifeThe elimination half-life of dicyclomine is approximately 1.8 hours. The elimination half-life of mefenamic acid is approximately 2 to 4 hours. Not established from the available information for the combination product.
ExcretionDicyclomine is excreted mainly in the urine and feces. Mefenamic acid is excreted primarily in the urine as metabolites and conjugates. Not established from the available information for specific percentages.
BioavailabilityNot established from the available information.
Onset of ActionThe onset of action for dicyclomine is within 1 to 2 hours after oral administration. Mefenamic acid typically begins to relieve pain within 1 to 2 hours. Not established from the available information for the combination product.
Peak Plasma TimePeak plasma concentrations of dicyclomine are reached within 1 to 2 hours. Peak plasma concentrations of mefenamic acid are reached within 2 to 4 hours. Not established from the available information for the combination product.
Duration of ActionThe duration of action for dicyclomine is approximately 4 to 6 hours. Mefenamic acid provides pain relief for approximately 4 to 6 hours. Not established from the available information for the combination product.

How It Works

This medicine combines two active ingredients with complementary actions. Dicyclomine is an anticholinergic and antispasmodic agent that blocks muscarinic acetylcholine receptors on smooth muscle cells in the gastrointestinal tract. This reduces muscle contractions and helps relieve spasms. Mefenamic acid is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased production of prostaglandins, which are mediators of pain, inflammation, and fever. The combination provides both antispasmodic and analgesic effects, targeting both the muscle spasm and the inflammatory pain component.

Mechanism Steps

1
Dicyclomine blocks muscarinic receptors: Dicyclomine binds to muscarinic acetylcholine receptors on smooth muscle cells, preventing acetylcholine from stimulating muscle contractions.
2
Reduced smooth muscle spasm: By blocking these receptors, dicyclomine decreases excessive contractions and spasms in the gastrointestinal tract, relieving cramping pain.
3
Mefenamic acid inhibits cyclooxygenase: Mefenamic acid blocks the COX-1 and COX-2 enzymes, which are responsible for converting arachidonic acid into prostaglandins.
4
Decreased prostaglandin production: Lower prostaglandin levels reduce inflammation, pain, and uterine contractions, which helps relieve menstrual cramps and inflammatory pain.
5
Combined symptomatic relief: The antispasmodic and anti-inflammatory actions work together to provide relief from both muscle spasm and pain.

💡 How to Take varnmic d 10mg/250mg tablet

Strength: Each tablet contains dicyclomine 10 mg and mefenamic acid 250 mg.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it with food or milk to reduce stomach upset.
4Do not crush, chew, or break the tablet unless advised by your doctor.
5Do not take more than the prescribed dose.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken two to three times a day, as needed for pain and spasms. The exact dose and duration depend on the condition being treated and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially anticholinergic effects like confusion, dry mouth, and urinary retention. Use with caution and lower doses may be needed. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney disease. Dose adjustment may be necessary. Consult your doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose adjustment may be necessary. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of stomach bleeding and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of varnmic d 10mg/250mg tablet

✅ Common Side Effects

Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Common (5-10%))
Avoid alcohol and activities requiring alertness. Consult doctor if severe.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Stomach pain (Common (5-10%))
Take with food. If pain persists or worsens, consult doctor.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor immediately.
Allergic reactions (Rare (<0.1%))
Seek emergency help if you experience rash, itching, swelling of face or throat, or difficulty breathing.
Blood disorders (Rare (<0.1%))
Report unusual bruising, bleeding, fever, or sore throat to your doctor.

⚠️ Rare Side Effects

Liver toxicity
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Severe skin reactions
Stop the medicine and seek immediate medical help if you develop a rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Anticholinergics Major
Lithium Moderate
Methotrexate Moderate
ACE inhibitors Moderate
Diuretics Moderate
Antacids Minor
Corticosteroids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., aspirin, ibuprofen)
  • Anticholinergic drugs (e.g., atropine, antihistamines)

⚡ Moderate Interactions

  • Lithium
  • Methotrexate
  • ACE inhibitors and ARBs
  • Diuretics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may worsen drowsiness and dizziness caused by dicyclomine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or history of recurrent ulcers","Severe kidney disease","Severe liver disease","Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease)","Asthma triggered by aspirin or other NSAIDs","Known allergy to dicyclomine, mefenamic acid, or other NSAIDs","Breastfeeding","Children under 12 years of age","Patients with myasthenia gravis","Patients with obstructive uropathy or gastrointestinal obstruction"]

⚠️ Warnings & Precautions

["Take with food or milk to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not drive or operate machinery if you feel dizzy or drowsy.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for longer than prescribed without medical advice.","Inform your doctor if you have a history of kidney or liver disease, asthma, or bleeding disorders.","Stop the medicine and consult your doctor if you experience severe abdominal pain, black stools, or vomiting blood.","This medicine may cause dry mouth, constipation, and blurred vision. Report persistent symptoms to your doctor.","Do not take this medicine if you are pregnant or planning to become pregnant without consulting your doctor."]

🤱 Lactation Safety

Dicyclomine may pass into breast milk and could cause serious side effects in a nursing infant. Mefenamic acid also passes into breast milk. This medicine is not recommended during breastfeeding. Consult your doctor for alternative options.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, confusion, dry mouth, fast heartbeat, nausea, vomiting, stomach pain, and bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than advised. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding and drowsiness. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not use this medicine if you are pregnant, especially in the last trimester, or breastfeeding without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the anticholinergic effects of dicyclomine, such as confusion, dry mouth, constipation, and urinary retention. They are also at higher risk of NSAID-related gastrointestinal bleeding and kidney problems. Use with caution and lower doses may be needed.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy, especially in the third trimester, as mefenamic acid may cause premature closure of the ductus arteriosus in the fetus. If you are planning to become pregnant, consult your doctor for alternative treatments.

🏥 Post-Surgery Considerations

This medicine should not be used for peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. For other surgeries, consult your doctor before taking this medicine as it may increase bleeding risk.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on your digestive system.
🥗
Eat a balanced diet rich in fiber to prevent constipation.
😴
Stay well hydrated by drinking plenty of water.
💧
Practice stress-reducing techniques like yoga or meditation.
🧘
Get adequate sleep to help your body recover.
🌞
Avoid trigger foods that worsen your abdominal cramps.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or drowsy after taking this medicine. Mild to moderate exercise like walking may be beneficial, but listen to your body and stop if you feel unwell.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds to reduce inflammation.
Reduce intake of processed and spicy foods that can irritate the stomach.
Eat smaller, more frequent meals to ease digestion.
Stay well hydrated with water and clear fluids.
Avoid caffeine and carbonated drinks if they worsen your symptoms.

💼 Impact on Daily Work & Life

This medicine may cause dizziness and drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth and constipation, which can be managed with fluids and dietary changes.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor immediately if you experience severe abdominal pain, black or bloody stools, vomiting blood, signs of an allergic reaction, or any other serious side effect. Do not stop taking it abruptly if you have been on it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, and liver toxicity. It is not recommended for prolonged use without regular monitoring by a doctor. If you need to take it for more than a few days, your doctor may monitor your kidney and liver function and blood counts.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary modifications

Avoiding trigger foods and eating a high-fiber diet can help manage IBS symptoms.

Evidence: Well-established
Stress management

Yoga, meditation, and counseling can reduce stress-related abdominal cramps.

Evidence: Moderate
Heat therapy

Applying a heating pad to the abdomen can help relieve menstrual cramps.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. This medicine is not known to interact with vaccines. Consult your doctor for specific advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to maintain consistent intervals. Check local customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with severe menstrual cramps
She was prescribed this medicine for primary dysmenorrhea. She took one tablet with food twice a day during her periods. Within a few hours, her cramps reduced significantly. She experienced mild dry mouth but it was manageable. She was advised not to take it on an empty stomach.
💡 Lesson: Taking this medicine with food improves tolerability and provides effective relief from menstrual cramps.
👤 A 45-year-old man with irritable bowel syndrome
He had frequent abdominal cramps and bloating. His doctor prescribed this medicine to be taken as needed. He found that taking it at the first sign of cramps helped prevent severe episodes. He also made dietary changes and practiced stress management.
💡 Lesson: This medicine can be effective for IBS-related cramps when taken early, along with lifestyle modifications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving cramps within 1 to 2 hours after taking it with food.

Q: Can I take this medicine on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset and bleeding.

Q: Is it safe to take this medicine every day?

A: This medicine is generally for short-term use. Long-term use should only be done under a doctor's supervision due to potential side effects.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Can I take this medicine with alcohol?

A: No, avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and drowsiness.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • Can I take it with other pain relievers?

🔄 Substitutes for varnmic d 10mg/250mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: This medicine is specifically for abdominal cramps and menstrual pain. It is not a general pain reliever for headaches or muscle aches.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This is a prescription medicine. It should only be taken under a doctor's supervision due to potential side effects and interactions.
  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce the risk of stomach upset and bleeding.

🔄 Alternative Options

Generic Alternatives

  • Dicyclomine + Mefenamic Acid combination (generic)

Brand Alternatives

  • Anglospas 10 mg/250 mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Dicyclomine 10 mg + Mefenamic Acid 250 mg","primary_use":"Abdominal cramps, IBS, dysmenorrhea","onset":"1-2 hours"},{"medicine":"Dicyclomine + Paracetamol","composition":"Dicyclomine 10 mg + Paracetamol 500 mg","primary_use":"Abdominal cramps with pain","onset":"30-60 minutes"},{"medicine":"Mefenamic Acid alone","composition":"Mefenamic Acid 250 mg","primary_use":"Pain and inflammation","onset":"1-2 hours"}]

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