valporate chrono 200 tablet - Sodium Valproate (133.5mg) + Valproic Acid (58mg) medicine

Alprotic 133.5mg/58mg Tablet CR: Complete Medicine Guide

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🏭 Crescent Therapeutics Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, valproate is known to cause serious harm to the unborn baby when taken during pregnancy. It is associated with neural tube defects, other major congenital malformations, and neurodevelopmental disorders. It should not be used during pregnancy for epilepsy or bipolar disorder unless absolutely necessary and no other effective treatment is available. Women of childbearing potential must use effective contraception while taking this medicine. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for epilepsy, bipolar disorder, and migraine prophylaxis.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain radiating to the back
  • Persistent vomiting or loss of appetite
  • Unusual bleeding or bruising
  • Sore throat, fever, or mouth ulcers
  • Suicidal thoughts or behavior
  • Severe skin rash, blisters, or peeling
  • Confusion, lethargy, or increased sleepiness
  • Seizures that worsen or new types of seizures

If experiencing severe symptoms, call emergency services immediately.

What is valporate chrono 200 tablet used for?

This medicine is a controlled-release tablet containing sodium valproate and valproic acid. It is used to treat epilepsy, bipolar disorder, and prevent migraines. It works by increasing GABA levels in the brain. It carries serious risks including liver damage, pancreatitis, and birth defects. It must be taken exactly as prescribed and never stopped suddenly.

  • Generic Name: Sodium Valproate (133.5mg) + Valproic Acid (58mg)
  • Manufacturer: Crescent Therapeutics Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 valporate chrono 200 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मिर्गी (एपिलेप्सी), बाइपोलर डिसऑर्डर और माइग्रेन के इलाज के लिए इस्तेमाल की जाती है। यह दौरे को नियंत्रित करने, मूड को स्थिर करने और माइग्रेन के दर्द को कम करने में मदद करती है। यह दवा मस्तिष्क में GABA नामक रसायन को बढ़ाती है, जिससे दौरे और मूड स्विंग्स कम होते हैं। इसे डॉक्टर के निर्देशानुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट दर्द, भूख न लगना, वजन बढ़ना, बाल झड़ना, कंपन, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में लिवर की समस्या, पैंक्रियाटाइटिस, खून की बीमारी, आत्महत्या के विचार और त्वचा पर गंभीर रैश शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे भोजन के साथ या बिना भोजन के ले सकते हैं। अचानक दवा बंद न करें, इससे दौरे पड़ सकते हैं। शराब न पिएं। गर्भवती हों या गर्भधारण की योजना बना रही हों तो डॉक्टर को बताएं। नियमित रूप से लिवर और खून की जांच कराएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 valporate chrono 200 tablet Uses & Benefits

[{"condition":"Epilepsy (generalized tonic-clonic seizures)","description":"This medicine is used alone or with other medicines to control generalized tonic-clonic seizures in adults and children.","evidence":"Well-established"},{"condition":"Epilepsy (absence seizures)","description":"It is effective in reducing the frequency of absence seizures, especially in children.","evidence":"Well-established"},{"condition":"Epilepsy (myoclonic seizures)","description":"This medicine helps control myoclonic seizures, which are brief muscle jerks.","evidence":"Well-established"},{"condition":"Bipolar disorder (manic episodes)","description":"It is used to treat acute manic or mixed episodes and for maintenance therapy to prevent mood swings.","evidence":"Well-established"},{"condition":"Migraine prophylaxis","description":"This medicine helps reduce the frequency of migraine headaches in adults.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label for certain types of nerve pain, though evidence is limited.","evidence":"Limited"},{"condition":"Agitation in dementia","description":"Occasionally used off-label to manage agitation in elderly patients with dementia, but with caution due to side effects.","evidence":"Limited"}]

Primary treatment for: Epilepsy

Also treats: Bipolar disorder, Migraine prophylaxis

📋 Drug Information

Generic Name(s)Sodium Valproate (133.5mg) + Valproic Acid (58mg)
Brand Namevalporate chrono 200 tablet
ManufacturerCrescent Therapeutics Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food to reduce stomach upset.
2
Do not crush, chew, or break the controlled-release tablet; swallow it whole.
3
Never stop this medicine suddenly without consulting your doctor, as it can cause withdrawal seizures.
4
Avoid alcohol completely while taking this medicine to prevent liver damage and excessive drowsiness.
5
Keep all scheduled appointments for liver function tests, blood counts, and valproate level monitoring.
6
Inform your doctor immediately if you experience symptoms of liver problems such as yellowing of eyes or skin, dark urine, or severe abdominal pain.
7
Use effective contraception if you are a woman of childbearing age, as this medicine can harm the unborn baby.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Seizures
This medicine is commonly prescribed for epilepsy.
Likely Use
✅
Mood swings
Used for bipolar disorder.
Likely Use
✅
Migraine headaches
Used for migraine prevention.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is absorbed from the gastrointestinal tract. The controlled-release formulation is designed to slow the absorption, leading to a more gradual increase in plasma levels compared to immediate-release formulations. Food may affect the rate but not the extent of absorption.
DistributionValproate is widely distributed throughout the body, including the brain and cerebrospinal fluid. It crosses the placenta and is excreted in breast milk.
Protein BindingValproate is highly bound to plasma proteins, primarily albumin. Protein binding is concentration-dependent and can become saturated at higher therapeutic levels.
MetabolismValproate is extensively metabolized in the liver, primarily through glucuronidation and beta-oxidation. Some metabolites may have anticonvulsant activity. The metabolism can be affected by other drugs and liver disease.
Half-LifeThe elimination half-life of valproate is typically 9 to 16 hours in adults. In controlled-release formulations, the half-life may appear longer due to slower absorption.
ExcretionValproate and its metabolites are primarily excreted in the urine, with a small amount eliminated in feces and expired air.
BioavailabilityThe bioavailability of valproate from this controlled-release tablet is high, approximately 90% or more, similar to other oral formulations.
Onset of ActionThe onset of action for seizure control may take several days to weeks, depending on the indication and individual response. For acute mania, effects may be seen within a few days.
Peak Plasma TimePeak plasma concentrations for this controlled-release formulation are typically reached 3 to 8 hours after oral administration.
Duration of ActionThe duration of action is related to the dosing interval. With controlled-release, effects are maintained over 12 to 24 hours, allowing for once or twice daily dosing.

How It Works

This medicine works by increasing the availability of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that reduces excessive electrical activity in the brain. Valproate achieves this by inhibiting the enzymes that break down GABA and by enhancing its synthesis. Additionally, it blocks voltage-gated sodium channels, which further stabilizes neuronal membranes and prevents the spread of seizure activity. In bipolar disorder, the mood-stabilizing effects are thought to be related to these same mechanisms, although the exact way it stabilizes mood is not fully understood.

Mechanism Steps

1
Inhibition of GABA transaminase: This medicine inhibits the enzyme GABA transaminase, which is responsible for breaking down GABA. This leads to increased levels of GABA in the brain.
2
Increased GABA synthesis: It also enhances the activity of glutamic acid decarboxylase, the enzyme that synthesizes GABA, further increasing GABA concentrations.
3
Blockade of voltage-gated sodium channels: This medicine blocks voltage-gated sodium channels, which reduces the ability of neurons to fire rapidly and repetitively, thereby preventing seizure spread.
4
Modulation of other neurotransmitter systems: It may also affect other neurotransmitters such as dopamine and serotonin, contributing to its mood-stabilizing effects.

💡 How to Take valporate chrono 200 tablet

Strength: Controlled-release tablet containing Sodium Valproate 133.5 mg and Valproic Acid 58 mg.

1Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
2Take it at the same time(s) each day, with or without food.
3If it upsets your stomach, take it with a meal or snack.
4Do not stop taking this medicine suddenly without talking to your doctor.
5Keep track of your doses and refill your prescription before it runs out.

Dosage Information

Adult DosageThe dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. For epilepsy, the usual starting dose is 10-15 mg/kg/day, increased gradually. For bipolar disorder, typical starting dose is 750 mg/day in divided doses. For migraine prophylaxis, 500-1000 mg/day. The controlled-release formulation is usually taken once or twice daily. Do not adjust the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. Valproate is used in children for epilepsy, but the dose is based on weight and must be carefully titrated. It is contraindicated in children under 2 years due to high risk of liver toxicity.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and tremor. Doses should be started low and increased slowly. Renal and hepatic function should be monitored. Falls risk may be increased due to drowsiness.
Renal ImpairmentValproate is primarily metabolized by the liver, so renal impairment usually does not require dose adjustment. However, in severe renal impairment, metabolites may accumulate. Monitor for side effects and consider dose reduction.
Hepatic ImpairmentThis medicine is contraindicated in patients with significant hepatic impairment. In mild to moderate impairment, dose reduction and close monitoring of liver function are required. Avoid use in active liver disease.
Maximum Daily DoseThe maximum daily dose is typically 60 mg/kg/day. However, the exact maximum must be determined by a qualified clinician based on individual factors.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Alcohol
Avoid
Increases risk of liver damage and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of valporate chrono 200 tablet

✅ Common Side Effects

Nausea (Common (up to 20%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Tremor (Common (10-20%))
Report to your doctor if it interferes with daily activities. Dose adjustment may help.
Weight gain (Common (10-20%))
Monitor your weight and discuss diet and exercise with your doctor.
Hair loss (Common (5-10%))
Usually reversible. Discuss with your doctor; sometimes zinc or selenium supplements may help.
Drowsiness (Common (5-15%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Liver failure (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, severe nausea, or abdominal pain.
Pancreatitis (Rare (<0.1%))
Seek immediate care if you have severe abdominal pain that may radiate to the back, with nausea and vomiting.
Blood dyscrasias (e.g., thrombocytopenia) (Uncommon (0.1-1%))
Report unusual bleeding, bruising, or signs of infection. Regular blood tests are needed.
Suicidal thoughts (Uncommon (0.1-1%))
Seek immediate help if you have thoughts of harming yourself. Contact your doctor or a crisis line.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Stop the medicine and seek emergency care if you develop a rash, blisters, or peeling skin.

⚠️ Rare Side Effects

Kidney problems (e.g., Fanconi syndrome)
Report changes in urination or flank pain to your doctor.
Hearing loss
Inform your doctor if you notice any hearing changes.
Low body temperature (hypothermia)
Seek medical advice if you feel unusually cold or have chills.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Carbapenem antibiotics Major
Lamotrigine Major
Aspirin Major
Warfarin Major
Phenytoin Moderate
Rifampicin Moderate
Tricyclic antidepressants Moderate
Cimetidine Minor
Erythromycin Minor
Alcohol Major

🚨 Major Interactions

  • Carbapenem antibiotics (e.g., meropenem)
  • Lamotrigine
  • Aspirin
  • Warfarin

⚡ Moderate Interactions

  • Phenytoin
  • Rifampicin
  • Tricyclic antidepressants

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. Both alcohol and valproate can cause liver damage and central nervous system depression. Combining them increases the risk of drowsiness, dizziness, and liver toxicity. If you consume alcohol regularly, discuss it with your doctor.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to valproate or any component of the formulation","Active liver disease or significant hepatic impairment","Urea cycle disorders","Mitochondrial disorders caused by POLG gene mutations","Pregnancy for epilepsy or bipolar disorder unless no alternative","Women of childbearing potential not using effective contraception"]

⚠️ Warnings & Precautions

["Hepatotoxicity: Can cause severe liver damage, especially in children under 2 and those with mitochondrial disorders. Monitor liver function closely.","Pancreatitis: Cases have been reported. Discontinue if suspected.","Suicidal thoughts: Increased risk in patients taking antiepileptic drugs. Monitor mood.","Hyperammonemia: Can occur even with normal liver function. Monitor ammonia if symptoms.","Thrombocytopenia: May cause low platelet count. Monitor CBC.","Withdrawal: Do not stop abruptly; may cause seizures.","Driving and operating machinery: May cause drowsiness or dizziness.","Pregnancy: Causes birth defects and neurodevelopmental disorders. Use effective contraception."]

🤱 Lactation Safety

Valproate is excreted in breast milk. The amount is generally low, and it is considered compatible with breastfeeding in most cases, but the infant should be monitored for potential side effects such as drowsiness, poor feeding, or jaundice. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of this medicine can cause serious symptoms including deep coma, respiratory depression, and metabolic acidosis. There is no specific antidote. Treatment is supportive and may include gastric lavage if taken recently, activated charcoal, and hemodialysis in severe cases. Naloxone has been used in some cases but is not routinely recommended. Seek immediate medical attention if overdose is suspected.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the controlled-release tablet; swallow it whole with a glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Do not stop taking this medicine suddenly, as it can cause withdrawal seizures or mood changes. If you need to stop, your doctor will gradually reduce the dose. Avoid alcohol while taking this medicine, as it can increase drowsiness and the risk of liver damage. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Keep all appointments for blood tests to monitor liver function, blood counts, and drug levels. Store this medicine at room temperature, away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to side effects such as drowsiness, dizziness, and tremor. Doses should be started low and increased slowly. Regular monitoring of liver and kidney function is important. Falls risk may be increased due to drowsiness. Caregivers should be informed about the medicine and its side effects.

🤰 Pregnancy Planning (TTC)

This medicine is harmful to the unborn baby. Women of childbearing potential must use effective contraception. If you are planning pregnancy, consult your doctor well in advance to discuss alternative treatments. Do not stop the medicine suddenly without medical advice. Preconception counseling and folic acid supplementation are recommended.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect bleeding risk. Your doctor may adjust the dose before surgery. Monitor for seizures or mood changes after surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause bleeding tendencies due to low platelets. Your dentist may take precautions to control bleeding. Maintain good oral hygiene to prevent dental problems.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through diet and exercise to manage weight gain.
🥗
Take calcium and vitamin D supplements if advised to protect bone health.
😴
Get regular sleep and manage stress to reduce seizure triggers.
💧
Avoid alcohol and recreational drugs.
🧘
Wear a medical alert bracelet to inform others of your condition and medicine.
🌞
Keep a seizure diary or mood journal to track your progress.

🏋️ Exercise Considerations

Exercise is generally safe while taking this medicine. However, if you experience dizziness or drowsiness, avoid activities that require balance or coordination, such as cycling or swimming, until you know how the medicine affects you. Stay hydrated during exercise. Consult your doctor before starting a new exercise program.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.
Include adequate protein to support liver function.
Limit high-fat and high-sugar foods to manage weight.
Stay well hydrated.
Avoid alcohol completely.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to concentrate. Discuss any work-related concerns with your doctor. With proper dose adjustment, most people can continue their normal activities.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal seizures or mood relapse. Your doctor will gradually taper the dose over weeks or months. If you experience serious side effects such as liver problems, pancreatitis, or severe rash, stop the medicine and seek immediate medical attention.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to weight gain, hair loss, tremor, and bone density loss. It can also affect liver function, blood counts, and hormone levels. Regular monitoring of liver function, complete blood count, and valproate levels is essential. Some patients may experience cognitive effects. The risk of side effects increases with higher doses and longer duration. Periodic review with your doctor is necessary to assess the benefit-risk balance.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Ketogenic diet

A high-fat, low-carbohydrate diet that can help control seizures in some patients, especially children.

Evidence: Well-established for certain types of epilepsy
Vagus nerve stimulation

A device implanted under the skin that sends electrical signals to the vagus nerve to reduce seizures.

Evidence: Well-established for refractory epilepsy
Cognitive behavioral therapy

Can help manage mood symptoms in bipolar disorder alongside medication.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific contraindications for vaccinations while taking this medicine. However, live vaccines should be avoided in patients on immunosuppressive doses of any medication. Consult your doctor before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Carry enough supply for the entire trip and a little extra in case of delays. Check customs regulations for controlled substances before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with epilepsy
She was started on this medicine for generalized tonic-clonic seizures. After a few weeks, her seizure frequency decreased significantly. She experienced mild hair loss and weight gain, but these were managed with dietary changes and reassurance. She emphasizes the importance of taking the medicine regularly and attending follow-up visits.
💡 Lesson: Consistent use and regular monitoring lead to better seizure control and management of side effects.
👤 A 45-year-old man with bipolar disorder
He was prescribed this medicine for acute mania. His mood stabilized over several weeks, and he was able to return to work. He initially felt drowsy but this improved. He learned to avoid alcohol and to take the medicine with food to prevent nausea.
💡 Lesson: Adherence to the prescribed regimen and lifestyle adjustments greatly improve outcomes in bipolar disorder.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: For seizures, it may take several weeks to achieve full effect. For mania, improvement may be seen within days. For migraine prevention, it may take a few weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop suddenly. Your doctor will gradually reduce the dose to prevent withdrawal seizures or mood relapse.

Q: What should I avoid while taking this medicine?

A: Avoid alcohol, driving until you know how it affects you, and other medications that interact with it without consulting your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my other medicines?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • Will it cause weight gain?

🔄 Substitutes for valporate chrono 200 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is only for epilepsy.
    Fact: It is also used for bipolar disorder and migraine prevention.
  • Myth: You can stop taking this medicine once you feel better.
    Fact: Stopping suddenly can cause seizures or mood relapse. Always taper under medical supervision.
  • Myth: This medicine is safe during pregnancy.
    Fact: It can cause serious birth defects and developmental problems. It should be avoided in pregnancy unless absolutely necessary.

🔄 Alternative Options

Generic Alternatives

  • Sodium valproate + valproic acid controlled-release tablets (various manufacturers)

Brand Alternatives

  • Alprotic 133.5mg/58mg Tablet CR

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Sodium Valproate 133.5mg + Valproic Acid 58mg","release_type":"Controlled-release","frequency":"Once or twice daily"},{"medicine":"Divalproex sodium","composition":"Divalproex sodium (equivalent to valproic acid)","release_type":"Delayed-release or extended-release","frequency":"Once or twice daily"}]

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