Applygen Forte Soft Gelatin Vaginal Suppository: Complete Information
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction (swelling, difficulty breathing)
- Severe diarrhea or abdominal pain
- High fever with chills
- Persistent vaginal bleeding
- No improvement after 7 days
If experiencing severe symptoms, call emergency services immediately.
What is vagikrem vaginal capsule used for?
This medicine is a vaginal suppository containing clindamycin and clotrimazole, used to treat mixed vaginal infections caused by bacteria and fungi.
- Generic Name: Clindamycin (100mg) + Clotrimazole (100mg)
- Manufacturer: CRMS Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vagikrem vaginal capsule के बारे में (Hindi Summary)
उपयोग: यह दवा योनि संक्रमण के इलाज के लिए उपयोग की जाती है, जिसमें बैक्टीरिया और फंगस दोनों शामिल होते हैं। यह क्लिंडामाइसिन और क्लोट्रिमाजोल का संयोजन है।
साइड इफेक्ट्स: आम दुष्प्रभावों में योनि में जलन, खुजली या हल्की परेशानी शामिल है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया या गंभीर दस्त हो सकते हैं।
सुरक्षा सलाह: इस दवा का उपयोग डॉक्टर के निर्देशानुसार करें। उपयोग से पहले हाथ धोएं। रात को सोने से पहले इसे योनि में डालें। उपचार के दौरान संभोग से बचें।
💊 vagikrem vaginal capsule Uses & Benefits
[{"condition":"Bacterial vaginosis","description":"Clindamycin treats bacterial vaginosis by inhibiting bacterial protein synthesis.","evidence":"Well-established"},{"condition":"Vaginal candidiasis","description":"Clotrimazole treats vaginal yeast infections by disrupting fungal cell membranes.","evidence":"Well-established"},{"condition":"Mixed vaginal infections","description":"The combination is used when both bacterial and fungal infections are present.","evidence":"Commonly used"}]
Off-label uses: []
Primary treatment for: Mixed vaginal infections
Also treats: Bacterial vaginosis, Vaginal candidiasis
📋 Drug Information
| Generic Name(s) | Clindamycin (100mg) + Clotrimazole (100mg) |
| Brand Name | vagikrem vaginal capsule |
| Manufacturer | CRMS Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | |
| Route of Administration | Vaginal |
| Storage | Store below 25°C in a dry place. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clindamycin binds to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis and causing bacterial cell death. Clotrimazole inhibits the synthesis of ergosterol, a key component of fungal cell membranes, leading to increased permeability and cell death.
Mechanism Steps
💡 How to Take vagikrem vaginal capsule
Strength: Soft gelatin vaginal suppository containing Clindamycin 100mg and Clotrimazole 100mg.
Dosage Information
| Adult Dosage | The usual adult dose is one suppository inserted vaginally once or twice daily, usually at bedtime, for 3 to 7 days. The exact dose and duration must be individualized by a qualified clinician based on the type and severity of infection, age, and renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but use with caution. |
| Renal Impairment | No dose adjustment is typically needed for renal impairment, but consult your doctor. |
| Hepatic Impairment | Use with caution in severe hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | One suppository twice daily (200mg clindamycin + 200mg clotrimazole). |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vagikrem vaginal capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Erythromycin | Major | |
| Warfarin | Moderate |
🚨 Major Interactions
- Erythromycin
⚡ Moderate Interactions
- Warfarin
🍷 Alcohol Interaction
No known interaction with alcohol, but alcohol may worsen vaginal irritation.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clindamycin or clotrimazole","First trimester of pregnancy (relative)"]
⚠️ Warnings & Precautions
["Do not use orally.","Avoid contact with eyes.","Use with caution in patients with liver disease.","May cause vaginal irritation.","Do not use during menstruation."]
🤱 Lactation Safety
Clindamycin is excreted in breast milk. Clotrimazole is minimally absorbed. Consult your doctor before use.
💊 Overdose Management
Overdose is unlikely due to vaginal route. If accidental ingestion, seek medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double dose.
Additional Safety Advice
Use this medicine exactly as prescribed by your doctor. Wash your hands before and after inserting the suppository. Insert it high into the vagina while lying on your back with your knees bent. It is best used at bedtime to allow the medicine to stay in place. Avoid sexual intercourse during treatment, as it may reduce effectiveness and cause irritation. Do not use tampons or douches while using this medicine. If you are pregnant or breastfeeding, consult your doctor before use. Do not use this medicine if you have a history of allergy to clindamycin or clotrimazole. Keep out of reach of children. If symptoms do not improve within a few days, contact your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects. Use with caution and monitor for adverse reactions.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is generally not recommended in the first trimester.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after any vaginal or pelvic surgery.
🦷 Dental Procedures
No specific considerations for dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions, but avoid strenuous activities if you feel discomfort.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. You can continue normal activities, but avoid intercourse during treatment.
🛑 When to Stop This Medicine
Stop using this medicine only after completing the prescribed course or as directed by your doctor. If you experience severe side effects, stop and consult your doctor immediately.
📅 Long-Term Use Effects
Long-term use of clindamycin can lead to bacterial resistance and rarely pseudomembranous colitis. Prolonged use of clotrimazole may cause local irritation. Use only as prescribed and for the recommended duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used for systemic treatment but with different side effect profiles.
Evidence: Well-establishedCan help restore vaginal flora but not a primary treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interaction with vaccines.
📦 Storage Guide
✅ DO
Store below 25°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat. If traveling across time zones, continue your regular schedule. Inform customs if carrying more than personal use quantity.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief within 1-2 days, but complete the full course as prescribed.
A: It is recommended to avoid sexual intercourse during treatment to prevent irritation and ensure effectiveness.
A: Consult your doctor. It is generally not recommended in the first trimester unless clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for vagikrem vaginal capsule
View AllAlternative brands with exact same active ingredient:
-
vagid cl suppositoryBliss Gvs Pharma Limited ₹67.50 75.9% CHEAPER
-
canison c vaginal pessariesAGIO Pharmaceuticals Ltd ₹70.00 75% CHEAPER
-
clenol lb 100mg/100mg tablet vtAkesiss Pharma Pvt Ltd ₹83.44 70.2% CHEAPER
-
metrogyl v 100mg/100mg vaginal suppositoryJ B Chemicals and Pharmaceuticals Ltd ₹87.00 69% CHEAPER
-
vezynda soft gelatin suppositoryDemax Biotech Pvt Ltd ₹87.00 69% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: It can be taken orally.
Fact: It is for vaginal use only. - Myth: It can cure all vaginal infections.
Fact: It only treats bacterial and fungal infections.