Uniprogestin 50mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Severe headache with vision changes
- Swelling or pain in one leg
- Yellowing of skin or eyes
- Severe allergic reaction (rash, itching, swelling of face or throat)
- Persistent vomiting or severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is uniprogestin 50mg injection used for?
This medicine is a hydroxyprogesterone injection used to support pregnancy in women with a history of recurrent miscarriage or preterm birth. It works by mimicking natural progesterone to maintain the uterine lining and reduce contractions.
- Generic Name: Hydroxyprogesterone (50mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 uniprogestin 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा हाइड्रॉक्सीप्रोजेस्टेरोन का इंजेक्शन है, जिसका उपयोग गर्भावस्था को सहारा देने के लिए किया जाता है। यह उन महिलाओं के लिए है जिन्हें बार-बार गर्भपात होता है या समय से पहले प्रसव का खतरा होता है। यह दवा प्राकृतिक प्रोजेस्टेरोन की तरह काम करती है और गर्भाशय की परत को बनाए रखती है। यह इंजेक्शन के रूप में डॉक्टर द्वारा दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, सूजन या लालिमा शामिल है। कुछ महिलाओं को मतली, सिरदर्द या स्तनों में कोमलता हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन रक्त के थक्के, एलर्जी या यकृत की समस्या हो सकती है। यदि सांस लेने में कठिनाई, सीने में दर्द या त्वचा का पीलापन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर द्वारा दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी पूरी मेडिकल हिस्ट्री बताएं, खासकर यदि आपको रक्त के थक्के, यकृत रोग या कैंसर है। नियमित जांच के लिए डॉक्टर के पास जाएं। लंबे समय तक बैठने से बचें। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 uniprogestin 50mg injection Uses & Benefits
[{"condition":"Recurrent miscarriage","description":"Used to support early pregnancy in women with a history of recurrent miscarriages due to luteal phase defect or progesterone deficiency.","evidence":"Well-established"},{"condition":"Preterm birth prevention","description":"Prescribed to reduce the risk of preterm delivery in women with a history of spontaneous preterm birth.","evidence":"Well-established"},{"condition":"Luteal phase support","description":"Used in assisted reproductive technology cycles to support the luteal phase and improve implantation rates.","evidence":"Well-established"},{"condition":"Menstrual irregularities","description":"Helps regulate menstrual cycles in women with progesterone deficiency.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Endometrial hyperplasia","description":"Sometimes used off-label to treat endometrial hyperplasia, but evidence is limited.","evidence":"Limited"},{"condition":"Hormone replacement therapy","description":"Occasionally used in combination with estrogen for hormone replacement therapy in postmenopausal women.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency
Also treats: Recurrent miscarriage, Preterm birth, Luteal phase defect
📋 Drug Information
| Generic Name(s) | Hydroxyprogesterone (50mg) |
| Brand Name | uniprogestin 50mg injection |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Progestins (First generation) |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to progesterone receptors in the uterus and other reproductive tissues. Hydroxyprogesterone is a synthetic progestin that mimics the action of natural progesterone. By binding to these receptors, it helps maintain the endometrial lining, reduces uterine contractility, and supports the maintenance of pregnancy. It also inhibits the release of gonadotropin-releasing hormone, which can suppress ovulation. The exact mechanism for preventing preterm birth is not fully understood but is thought to involve relaxation of uterine smooth muscle and reduction of inflammatory mediators.
Mechanism Steps
💡 How to Take uniprogestin 50mg injection
Strength: Injection: 50mg
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, age, weight, and clinical response. For recurrent miscarriage, a common dose is 250-500 mg intramuscularly once weekly or as directed. For preterm birth prevention, 250 mg intramuscularly once weekly is typical. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are established for elderly patients. Use with caution and monitor closely. |
| Renal Impairment | No specific dosage adjustments are established for renal impairment. Use with caution. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. |
| Maximum Daily Dose | Not established from the available information. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of uniprogestin 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Rifampicin | Major | |
| Carbamazepine | Moderate | |
| St. John's Wort | Moderate |
🚨 Major Interactions
- Warfarin
- Rifampicin
⚡ Moderate Interactions
- Carbamazepine
- St. John's Wort
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and worsen side effects such as drowsiness or mood changes. It is advisable to avoid alcohol while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to hydroxyprogesterone or any component of the formulation","History of blood clots (thrombophlebitis, pulmonary embolism)","Liver disease","Breast cancer","Undiagnosed vaginal bleeding"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of blood clots.","May cause fluid retention; use with caution in patients with heart or kidney disease.","May affect blood sugar levels; monitor in diabetic patients.","May cause mood changes; advise patients to report persistent depression.","Not for use in men or children."]
🤱 Lactation Safety
Hydroxyprogesterone is excreted in breast milk. Consult your doctor before using this medicine while breastfeeding. It may affect milk production.
💊 Overdose Management
Overdose is unlikely due to intramuscular administration. If overdose is suspected, seek immediate medical attention. Treatment is symptomatic and supportive.
⏰ Missed Dose
If you miss a scheduled injection, contact your doctor as soon as possible to reschedule. Do not double the dose.
Additional Safety Advice
This medicine must only be given by a healthcare professional. Do not attempt to self-administer. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Before starting treatment, provide a complete medical history, especially if you have had blood clots, liver disease, or cancer. Regular follow-up visits are necessary to monitor your response and check for any complications. Avoid prolonged sitting or immobility, as this can increase the risk of blood clots. If you miss an appointment for your injection, contact your doctor to reschedule as soon as possible. Do not stop treatment without consulting your doctor, as sudden discontinuation may cause withdrawal bleeding or other hormonal imbalances. Keep all appointments for blood tests and ultrasounds as recommended.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not typically used in elderly women unless specifically indicated. Use with caution and monitor for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. It may be prescribed to support early pregnancy in certain conditions.
🏥 Post-Surgery Considerations
Inform your surgeon if you are taking this medicine, as it may affect blood clotting. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may increase the risk of bleeding during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase the risk of falls or injury. Light to moderate exercise is generally safe, but consult your doctor before starting any new routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery if you feel affected. Most women can continue their normal activities, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping suddenly may cause hormonal imbalances or withdrawal bleeding. Your doctor will advise you on the appropriate duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of blood clots, liver problems, and fluid retention. Regular monitoring of liver function and blood pressure is recommended. Discuss with your doctor if you need to use it for more than a few months.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used as an alternative, but consult your doctor before switching.
Evidence: LimitedStress reduction and adequate rest can complement medical therapy.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light. If traveling across time zones, consult your doctor about adjusting injection timing. Keep a cool pack if necessary but do not freeze. Declare it to customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 24-48 hours after injection, but its full effects may take several days to weeks.
A: Yes, it is used to support pregnancy in specific conditions. However, it should only be used under medical supervision.
A: No, this medicine is only available as an injection and must be given by a healthcare professional.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an injection and must be given by a healthcare professional. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in certain conditions such as liver disease and blood clotting disorders.
🔄 Alternative Options
Generic Alternatives
- Hydroxyprogesterone injection
Brand Alternatives
- Uniprogestin 50mg injection