Bonflox-n Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Sudden tendon pain or swelling
- Numbness or tingling in hands or feet
- Seizures or severe confusion
If experiencing severe symptoms, call emergency services immediately.
What is unin-nz dry syrup used for?
This medicine is a prescription oral suspension containing Nitazoxanide (100 mg) and Ofloxacin (50 mg). It is used to treat certain infectious diarrheas caused by susceptible bacteria and parasites. It works by killing the pathogens through two different mechanisms. It should be taken exactly as prescribed by a doctor.
- Generic Name: Nitazoxanide (100mg) + Ofloxacin (50mg)
- Manufacturer: Shinto Organics (P) Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 unin-nz dry syrup के बारे में (Hindi Summary)
उपयोग: यह दवा नाइटाज़ोक्सानाइड और ऑफ़लोक्सासिन का संयोजन है, जिसका उपयोग कुछ प्रकार के संक्रामक दस्त के इलाज के लिए किया जाता है। यह उन रोगजनकों को मारती है जो दस्त का कारण बनते हैं। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, टेंडन टूटना, और तंत्रिका क्षति शामिल हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। दवा लेने से पहले बोतल को अच्छी तरह हिलाएं। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ इस दवा को न लें, कम से कम 2 घंटे का अंतराल रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 unin-nz dry syrup Uses & Benefits
[{"condition":"Infectious diarrhea","description":"Used for the treatment of diarrhea caused by susceptible bacteria and parasites, such as Giardia lamblia, Entamoeba histolytica, and certain bacteria.","evidence":"Established for specific pathogens"},{"condition":"Giardiasis","description":"Nitazoxanide component is effective against Giardia lamblia, a common cause of watery diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Amebiasis","description":"Nitazoxanide is used for intestinal amebiasis caused by Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Bacterial enteritis","description":"Ofloxacin component targets susceptible bacterial pathogens causing enteritis, such as Escherichia coli and Salmonella species.","evidence":"Established for susceptible strains"}]
Off-label uses: [{"condition":"Cryptosporidiosis","description":"Nitazoxanide has been used off-label for cryptosporidiosis in immunocompetent patients, but efficacy varies.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Sometimes included in combination regimens, but not a standard first-line approach.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea
Also treats: Giardiasis, Amebiasis, Bacterial enteritis
📋 Drug Information
| Generic Name(s) | Nitazoxanide (100mg) + Ofloxacin (50mg) |
| Brand Name | unin-nz dry syrup |
| Manufacturer | Shinto Organics (P) Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed when not in use. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. The World Health Organization does not have specific guidelines for this fixed-dose combination. Treatment should follow local guidelines and clinical judgment. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research does not have specific guidelines for this combination. Use should be based on clinical diagnosis and local resistance patterns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two agents with distinct mechanisms. Nitazoxanide is a prodrug that is rapidly metabolized to tizoxanide, which inhibits pyruvate:ferredoxin oxidoreductase (PFOR), an enzyme essential for anaerobic energy metabolism in susceptible parasites and anaerobic bacteria. This disruption leads to impaired energy production and cell death. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This inhibition leads to double-strand DNA breaks and bacterial cell death. Together, they target both parasitic and bacterial components of mixed gastrointestinal infections.
Mechanism Steps
💡 How to Take unin-nz dry syrup
Strength: Each 5 mL of suspension contains Nitazoxanide 100 mg and Ofloxacin 50 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the specific indication, severity of infection, patient age, weight, renal and hepatic function, and clinical response. Typically, it is taken orally twice daily for a duration determined by the doctor. Do not self-adjust the dose. Complete the full course as prescribed even if symptoms improve. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. The ofloxacin component is generally not recommended for children under 18 years due to potential effects on cartilage development, unless the benefit outweighs the risk as determined by a specialist. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of fluoroquinolone-related adverse effects, including tendon rupture and central nervous system effects. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment due to the ofloxacin component. For creatinine clearance less than 50 mL/min, the dose or frequency may need to be reduced. Consult a clinician for specific guidance based on renal function tests. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. However, nitazoxanide is metabolized in the liver, and caution is advised in patients with severe liver disease. Monitor liver function if used in such patients. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by a qualified clinician based on the individual patient's condition and response. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of unin-nz dry syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Warfarin | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Major | |
| Probenecid | Moderate | |
| Cimetidine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc, or multivitamins containing divalent cations
- Warfarin
- Theophylline
- NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
⚡ Moderate Interactions
- Probenecid
- Cimetidine
- Oral hypoglycemics (e.g., glibenclamide)
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can worsen dizziness, drowsiness, and gastrointestinal side effects. It may also increase the risk of central nervous system effects such as seizures. Additionally, alcohol can dehydrate you, which is particularly harmful if you have diarrhea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nitazoxanide, ofloxacin, or other fluoroquinolones","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may worsen muscle weakness)","Children under 18 years for ofloxacin component (unless specifically indicated)","Pregnancy and breastfeeding (unless clearly needed and advised by doctor)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, can cause disabling and potentially irreversible serious adverse reactions involving tendons, muscles, joints, nerves, and central nervous system. Reserve use for patients with no alternative treatment options.","Tendon rupture can occur during or after therapy; risk is increased in elderly patients, those with kidney disease, and those on corticosteroids.","Peripheral neuropathy may occur; discontinue if symptoms develop.","Central nervous system effects including seizures, confusion, and hallucinations have been reported. Use with caution in patients with epilepsy.","Avoid excessive sunlight and use sunscreen due to photosensitivity risk.","May exacerbate muscle weakness in patients with myasthenia gravis.","Clostridioides difficile-associated diarrhea may occur; if suspected, discontinue and treat appropriately.","Do not use in patients with a history of tendon disorders with fluoroquinolones."]
🤱 Lactation Safety
Not established from the available information. It is not known whether nitazoxanide or ofloxacin are excreted in human milk. Ofloxacin is excreted in breast milk and may cause serious adverse reactions in nursing infants. Breastfeeding is not recommended while taking this medicine. Consult your doctor for guidance.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs, renal function, and electrolyte balance. Activated charcoal may be considered if ingestion is recent. Hemodialysis may be considered for ofloxacin overdose but is not effective for nitazoxanide.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not share it with others, even if they have similar symptoms. Complete the full course even if you feel better, to prevent resistance. Shake the suspension well before each use. Measure the dose with the provided measuring device, not a household spoon. Avoid alcohol while taking this medicine. Inform your doctor if you have kidney or liver problems, epilepsy, or tendon disorders. Do not take antacids or mineral supplements within 2 hours of this medicine, as they can reduce its absorption. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of fluoroquinolone-related side effects, including tendon rupture, kidney impairment, and central nervous system effects. Dose adjustment may be needed based on renal function. Monitor closely for any signs of tendon pain, confusion, or worsening kidney function. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy unless clearly needed and advised by a doctor. Ofloxacin may affect fetal development, and nitazoxanide safety in pregnancy is not well established. Discuss alternative treatments with your doctor if you are pregnant or trying to conceive.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Ofloxacin can interact with certain anesthetics and may increase the risk of tendon rupture. Your doctor may advise you to stop the medicine before surgery or adjust the dose.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no specific contraindications, but your dentist may need to know to avoid prescribing interacting medications. Maintain good oral hygiene to prevent secondary infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous exercise or high-impact activities, as fluoroquinolones can increase the risk of tendon injury. If you experience any tendon pain, stop exercising and consult your doctor immediately. Light activities like walking are generally safe if you feel well enough.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion in some people. Avoid driving, operating heavy machinery, or performing tasks that require mental alertness until you know how the medicine affects you. If you have diarrhea, you may need to take time off work to rest and prevent spreading the infection to others.
🛑 When to Stop This Medicine
Stop taking this medicine and seek immediate medical attention if you experience any serious side effects such as severe allergic reaction, tendon pain or swelling, numbness or tingling, seizures, or severe diarrhea. Do not stop the medicine early just because you feel better; complete the full course as prescribed. If you need to stop for any reason, consult your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless specifically directed by a doctor. Prolonged use of antibiotics can lead to bacterial resistance and superinfections. Ofloxacin can rarely cause persistent tendon damage, nerve damage, or central nervous system effects. Regular monitoring of kidney and liver function may be required if used for extended periods. Always consult your doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration caused by diarrhea, regardless of the cause.
Evidence: Well-establishedMay help restore gut flora and reduce diarrhea duration, but should be taken separately from antibiotics.
Evidence: ModerateRecommended for children with diarrhea in some settings to reduce severity and duration.
Evidence: Well-established for children💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, if you are due for any live vaccines, consult your doctor as antibiotics may affect the immune response to certain vaccines. Generally, antibiotics do not interfere with most vaccines, but it is best to inform your healthcare provider.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed color or consistency
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but you must complete the full course as prescribed.
A: Yes, taking it with food can help reduce stomach upset. However, avoid taking it with dairy products or antacids within 2 hours.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The ofloxacin component is generally not recommended for children under 18 years unless specifically indicated by a specialist. Consult a pediatrician.
A: It is best to avoid alcohol as it can worsen side effects like dizziness and nausea, and may increase the risk of seizures.
🤔 Common Patient Concerns
🔄 Substitutes for unin-nz dry syrup
View AllAlternative brands with exact same active ingredient:
-
Flagynor Oral SuspensionAbbott ₹22.50 65.2% CHEAPER
-
nizanof dry syrupMolekule India Pvt Ltd ₹40.18 37.9% CHEAPER
-
ose n oral suspensionCureways Remedies ₹42.19 34.8% CHEAPER
-
Siloc Aid Oral SuspensionColors Life Sciences ₹42.19 34.8% CHEAPER
-
oflee-nt dry syrupLeeMed Pharmaceuticals ₹44.00 32% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is only effective against specific bacterial and parasitic infections. It is not effective for viral diarrhea or diarrhea caused by other non-infectious conditions. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to ensure the infection is fully treated and to prevent resistance. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for everyone. It should be avoided in certain conditions such as myasthenia gravis, pregnancy, and in children unless specifically indicated.
🔄 Alternative Options
Generic Alternatives
- Nitazoxanide + Ofloxacin suspension (generic versions may be available)
Brand Alternatives
- Bonflox-N Suspension