unifen 75mg injection - Diclofenac (75mg) medicine

NAC SR 75 Tablet: Complete Medicine Guide

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Diclofenac (75mg)
🏭 Uniword Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac should be avoided during the third trimester due to risk of premature closure of the ductus arteriosus and other complications. Use in early pregnancy only if clearly needed and after consulting a doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is unifen 75mg injection used for?

This medicine is a sustained-release tablet containing Diclofenac 75 mg, an NSAID used to relieve pain and inflammation in conditions like arthritis, gout, and musculoskeletal injuries. It works by blocking COX enzymes and reducing prostaglandins. Take it with food, swallow whole, and do not exceed 150 mg per day.

  • Generic Name: Diclofenac (75mg)
  • Manufacturer: Uniword Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 unifen 75mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक 75 मिलीग्राम का सस्टेन्ड-रिलीज़ टैबलेट है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह ऑस्टियोआर्थराइटिस, रूमेटॉइड आर्थराइटिस, गाउट, और मांसपेशियों की चोटों में प्रभावी है। यह शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करके दर्द और सूजन को कम करती है। इसे भोजन के साथ लें और टैबलेट को चबाएं नहीं।

साइड इफेक्ट्स: आम दुष्प्रभावों में पेट दर्द, जलन, मतली, उल्टी, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, दिल का दौरा, स्ट्रोक, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि काला मल, खून की उल्टी, तेज पेट दर्द, सीने में दर्द, सांस लेने में कठिनाई, या चेहरे/होंठ/गले में सूजन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें। टैबलेट को पूरा निगलें, चबाएं या तोड़ें नहीं। दवा लेने के बाद तुरंत न लेटें। शराब और अन्य दर्द निवारक दवाओं से बचें। यदि आपको पेट अल्सर, हृदय रोग, गुर्दे या यकृत की समस्या है, या आप रक्त पतला करने वाली दवाएं ले रहे हैं, तो अपने डॉक्टर को बताएं। खुराक न बढ़ाएं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 unifen 75mg injection Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate back pain and stiffness associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute gout","description":"Provides rapid relief from pain and inflammation during acute gout attacks.","evidence":"Well-established"},{"condition":"Musculoskeletal injuries","description":"Used for pain and swelling following sprains, strains, and sports injuries.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Postoperative pain","description":"May be used off-label for short-term management of postoperative pain.","evidence":"Limited"}]

Primary treatment for: Osteoarthritis

Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Acute gout, Musculoskeletal injuries

📋 Drug Information

Generic Name(s)Diclofenac (75mg)
Brand Nameunifen 75mg injection
ManufacturerUniword Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe the lowest effective dose for the shortest duration.
2
Advise patients to take the tablet with food or milk to minimize GI upset.
3
Warn patients about the increased risk of cardiovascular events with long-term use.
4
Monitor renal and hepatic function periodically, especially in elderly patients.
5
Avoid concomitant use with other NSAIDs or anticoagulants unless necessary.
6
Instruct patients not to crush or chew the sustained-release tablet.
7
Educate patients about the signs of GI bleeding and when to seek help.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Acute gout attack
This medicine can provide rapid relief.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly and completely absorbed from the gastrointestinal tract after oral administration. However, due to first-pass metabolism, only about 50-60% of the dose reaches systemic circulation. The sustained-release formulation slows the absorption rate, leading to a lower peak plasma concentration but a more prolonged therapeutic effect.
DistributionDiclofenac is highly bound to plasma proteins (approximately 99%) and has a volume of distribution of about 0.55 L/kg. It penetrates well into synovial fluid, where it can remain for up to 12 hours after a single dose.
Protein BindingApproximately 99% bound to plasma proteins, primarily albumin.
MetabolismDiclofenac is extensively metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C9, to several metabolites, including 4'-hydroxydiclofenac and 5-hydroxydiclofenac. Some metabolites may have weak anti-inflammatory activity.
Half-LifeThe terminal half-life of diclofenac from the sustained-release formulation is approximately 4-6 hours, but the therapeutic effect lasts longer due to slow release.
ExcretionDiclofenac and its metabolites are excreted primarily in urine (about 65%) and bile/feces (about 35%).
BioavailabilityThe bioavailability of diclofenac from the sustained-release tablet is approximately 50-60% due to first-pass metabolism.
Onset of ActionPain relief typically begins within 30-60 minutes after oral administration, but the sustained-release formulation may have a slightly delayed onset compared to immediate-release forms.
Peak Plasma TimePeak plasma concentration is reached approximately 4-6 hours after oral administration of the sustained-release tablet.
Duration of ActionThe analgesic and anti-inflammatory effects last for approximately 12-24 hours, allowing for once or twice daily dosing.

How It Works

This medicine works by inhibiting the cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for converting arachidonic acid into prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By blocking their production, this medicine reduces pain and swelling. It also has antipyretic properties. The sustained-release formulation allows for a slower absorption and prolonged duration of action, which helps maintain consistent pain relief over 24 hours.

Mechanism Steps

1
Absorption: The sustained-release tablet is swallowed and absorbed slowly from the gastrointestinal tract.
2
Distribution: Diclofenac binds extensively to plasma proteins and distributes to inflamed tissues.
3
COX inhibition: It inhibits COX-1 and COX-2 enzymes, blocking prostaglandin synthesis.
4
Reduced pain and inflammation: Decreased prostaglandins lead to reduced pain, swelling, and fever.
5
Metabolism and excretion: The drug is metabolized in the liver and excreted mainly in urine and bile.

💡 How to Take unifen 75mg injection

Strength: Sustained-release tablet, 75 mg.

1Take the tablet with a full glass of water.
2Swallow the tablet whole; do not crush, chew, or break it.
3Take with food or milk to reduce stomach upset.
4Stay upright for at least 30 minutes after taking.
5Do not take on an empty stomach.
6Follow the prescribed schedule exactly.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one 75 mg sustained-release tablet taken orally once or twice daily, depending on the condition being treated. The maximum recommended daily dose is 150 mg. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Take with food or milk to reduce stomach upset.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) are at increased risk of side effects, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely.
Renal ImpairmentIn patients with mild to moderate renal impairment, no dose adjustment is usually necessary, but caution is advised. In severe renal impairment, diclofenac is contraindicated. Consult a doctor for individualized dosing.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, use with caution and consider lower doses. In severe hepatic impairment, diclofenac is contraindicated.
Maximum Daily Dose150 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of GI bleeding and liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of unifen 75mg injection

✅ Common Side Effects

Stomach pain (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Heartburn (Common (5-10%))
Avoid lying down immediately after taking. Antacids may help, but consult your doctor.
Nausea (Common (5-10%))
Take with a meal. If severe or persistent, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Heart attack or stroke (Rare (<0.1%))
Call emergency services if you experience chest pain, shortness of breath, weakness on one side, or slurred speech.
Kidney failure (Rare (<0.1%))
Report decreased urine output, swelling, or sudden weight gain to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you develop rash, itching, swelling of face/lips/tongue, or difficulty breathing.

⚠️ Rare Side Effects

Hepatitis
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor.
Pancreatitis
Seek immediate care for severe upper abdominal pain radiating to the back.
Aseptic meningitis
Seek immediate care for severe headache, stiff neck, fever, and sensitivity to light.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Aspirin Major
Methotrexate Major
Lithium Major
ACE inhibitors Major
Corticosteroids Moderate
Diuretics Moderate
SSRIs Moderate
Cyclosporine Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Aspirin
  • Methotrexate
  • Lithium
  • ACE inhibitors

⚡ Moderate Interactions

  • Corticosteroids
  • Diuretics
  • SSRIs
  • Cyclosporine

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also enhance the central nervous system side effects such as dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to diclofenac or other NSAIDs","History of asthma, urticaria, or allergic reaction after aspirin or NSAID use","Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney impairment","Severe liver impairment","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery perioperative period"]

⚠️ Warnings & Precautions

["Take with food to reduce GI upset.","Do not crush or chew the sustained-release tablet.","Avoid alcohol and other NSAIDs.","Use with caution in elderly patients.","Monitor for signs of GI bleeding.","May increase risk of cardiovascular events.","May impair kidney function.","May cause liver toxicity.","Avoid in pregnancy unless directed.","Do not use for more than 10 days without medical advice."]

🤱 Lactation Safety

Diclofenac is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but consult your doctor before use. Monitor the infant for any unusual signs.

💊 Overdose Management

Overdose may cause nausea, vomiting, abdominal pain, gastrointestinal bleeding, headache, dizziness, drowsiness, and in severe cases, acute kidney failure, liver damage, and coma. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. Activated charcoal may be administered if within 1-2 hours of ingestion. Hemodialysis is not effective for removing diclofenac.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach upset. Swallow the tablet whole; do not crush, chew, or break it, as this can release the entire dose at once and increase the risk of side effects. Do not lie down immediately after taking it; stay upright for at least 30 minutes. Avoid alcohol and other NSAIDs while on this medicine. Inform your doctor if you have a history of stomach ulcers, heart disease, kidney or liver problems, or if you are taking blood thinners, corticosteroids, or antidepressants. Do not use this medicine for more than the prescribed duration without medical advice. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store at room temperature away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely. Avoid concomitant use with other NSAIDs or anticoagulants.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is not recommended during the third trimester. Use effective contraception if you are taking this medicine and do not wish to become pregnant.

🏥 Post-Surgery Considerations

This medicine may be used for postoperative pain, but it should be avoided in patients undergoing coronary artery bypass graft (CABG) surgery. Consult your surgeon before taking this medicine after any surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Avoid smoking and excessive alcohol.

🏋️ Exercise Considerations

Avoid high-impact exercises that may worsen joint pain. Consult a physiotherapist for a tailored exercise plan. Stop exercise if you experience severe pain, dizziness, or shortness of breath.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Eat plenty of fruits and vegetables

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Inform your employer if you need to take it during work hours.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as black stools, vomiting blood, severe abdominal pain, chest pain, or allergic reactions. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney problems, liver toxicity, and cardiovascular events. Regular monitoring of renal and hepatic function, blood pressure, and complete blood count is recommended. Use the lowest effective dose for the shortest duration possible.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Acupuncture

May help with pain relief in some patients.

Evidence: Limited
Topical NSAIDs

May provide localized pain relief with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, if you are scheduled for vaccination, inform your doctor about this medicine. There is no need to stop this medicine before vaccination unless advised.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with acute gout attack
Experienced severe pain in his big toe. His doctor prescribed this medicine. He took it with food and noticed relief within a few hours. He was advised to avoid alcohol and to monitor for stomach upset.
💡 Lesson: Prompt use of this medicine during a gout attack can provide rapid pain relief, but lifestyle modifications are essential to prevent future attacks.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief typically begins within 30-60 minutes after taking the tablet, but the full anti-inflammatory effect may take a few days.

Q: Can I take it on an empty stomach?

A: No, it should be taken with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take with other NSAIDs unless directed by your doctor. Paracetamol may be taken with caution, but consult your doctor first.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for unifen 75mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce stomach upset.
  • Myth: It is safe to double the dose if pain is severe.
    Fact: Never double the dose. Exceeding the recommended dose increases the risk of serious side effects.
  • Myth: This medicine is not addictive.
    Fact: It is not addictive, but it can cause dependence if used for a long time without medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac sodium 75 mg sustained-release tablet
  • Diclofenac potassium 75 mg sustained-release tablet

Brand Alternatives

  • Voveran SR 75
  • Dynapar SR 75
  • Reactin SR 75
  • Nac SR 75

📊 Comparison with Similar Medicines

[{"medicine":"Diclofenac SR 75 mg","class":"NSAID","half_life":"4-6 hours","common_uses":"Arthritis, gout, musculoskeletal pain","gi_risk":"Moderate to high"},{"medicine":"Aceclofenac 100 mg SR","class":"NSAID","half_life":"3-4 hours","common_uses":"Arthritis, pain","gi_risk":"Moderate"},{"medicine":"Etoricoxib 90 mg","class":"COX-2 selective NSAID","half_life":"22 hours","common_uses":"Arthritis, pain","gi_risk":"Lower"}]

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