Ujvira 100mg Injection (Trastuzumab): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Chest pain or a fast, irregular heartbeat
- Sudden weight gain or swelling of the legs or ankles
- Fever with chills or a severe infection-like feeling
- New or worsening cough
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is ujvira 100mg injection used for?
This medicine is a targeted cancer treatment given by intravenous infusion. It contains trastuzumab, which attaches to the HER2 protein on certain cancer cells and helps stop their growth. It is used mainly for HER2-positive breast and stomach cancers and requires regular heart monitoring.
- Generic Name: Trastuzumab (100mg)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ujvira 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रास्टुज़ुमैब नामक सक्रिय तत्व वाला एक इंजेक्शन है, जिसे HER2-पॉज़िटिव स्तन कैंसर और पेट के कैंसर के इलाज में इस्तेमाल किया जाता है। यह कैंसर कोशिकाओं की सतह पर मौजूद HER2 प्रोटीन से जुड़कर उनकी वृद्धि को धीमा करती है और शरीर की प्रतिरक्षा प्रणाली को उन्हें नष्ट करने में मदद करती है। यह दवा केवल डॉक्टर की देखरेख में नस के माध्यम से ड्रिप द्वारा दी जाती है। इलाज से पहले यह जांचना ज़रूरी है कि ट्यूमर में HER2 की मात्रा अधिक है या नहीं।
साइड इफेक्ट्स: इस दवा से कुछ सामान्य दुष्प्रभाव हो सकते हैं, जैसे बुखार, ठंड लगना, सिरदर्द, जी मिचलाना, उल्टी, दस्त, थकान और ड्रिप के दौरान चकत्ते या चक्कर आना। कुछ गंभीर दुष्प्रभाव भी हो सकते हैं, जैसे दिल की कार्यक्षमता कम होना, सांस लेने में तकलीफ, फेफड़ों में सूजन, गंभीर एलर्जी या संक्रमण। कोई भी नया या बढ़ता लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या कैंसर डे-केयर सेंटर में योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इलाज से पहले और इलाज के दौरान दिल की जांच कराना बहुत ज़रूरी है। अपने डॉक्टर को अपनी सभी दवाओं, सप्लीमेंट्स और पुरानी बीमारियों के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का इस्तेमाल न करें। बुखार, सांस फूलना, पैरों में सूजन या अत्यधिक थकान होने पर तुरंत डॉक्टर से संपर्क करें।
💊 ujvira 100mg injection Uses & Benefits
[{"condition":"HER2-positive early breast cancer","description":"Used as part of a treatment plan, often with chemotherapy, to reduce the risk of the cancer coming back after surgery.","evidence":"Well-established"},{"condition":"HER2-positive metastatic breast cancer","description":"Used to slow the growth of cancer that has spread to other parts of the body and to help control symptoms.","evidence":"Well-established"},{"condition":"HER2-positive metastatic gastric or gastro-oesophageal junction cancer","description":"Used in combination with chemotherapy for cancers of the stomach or the area where the food pipe meets the stomach that have high HER2 levels.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Other HER2-positive solid tumours","description":"Occasionally used in selected HER2-positive cancers such as certain salivary, lung, or bladder cancers, based on specialist judgement.","evidence":"Limited"}]
Primary treatment for: HER2-positive breast cancer
Also treats: HER2-positive metastatic breast cancer, HER2-positive metastatic gastric or gastro-oesophageal junction cancer
📋 Drug Information
| Generic Name(s) | Trastuzumab (100mg) |
| Brand Name | ujvira 100mg injection |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | HER2/neu (ErbB2) Inhibitor- Monoclonal antibody |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C. Do not freeze. Keep the vial in its original carton to protect it from light. Once prepared for infusion, use it as directed by the healthcare professional. |
| Shelf Life | The shelf life is usually 24 to 36 months from the date of manufacture when stored correctly. Check the expiry date on the vial before use. |
| WHO Guideline | Trastuzumab is included in World Health Organization essential medicines lists for certain HER2-positive cancers. Specific recommendations should be confirmed with the latest WHO guidance and your treating specialist. |
| ICMR Guideline | Indian Council of Medical Research guidelines for breast and gastric cancer management include HER2 testing and trastuzumab-based therapy for HER2-positive disease. Always follow the advice of your treating oncologist. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a monoclonal antibody that binds with high affinity to the extracellular part of the human epidermal growth factor receptor 2, known as HER2. By attaching to HER2, it blocks the signals that tell cancer cells to grow and divide. It also marks the cancer cells so that the body's immune system can attack and destroy them through a process called antibody-dependent cellular cytotoxicity. In some patients, this medicine also helps to prevent HER2 from being cut off the cell surface, which further reduces growth signals.
Mechanism Steps
💡 How to Take ujvira 100mg injection
Strength: 100 mg single-use vial for intravenous infusion
Dosage Information
| Adult Dosage | The dose of this medicine is decided by a cancer specialist and depends on the type of cancer, the treatment plan, and whether it is given weekly or every three weeks. It is given as an intravenous infusion, often over 30 to 90 minutes, with the first dose given more slowly. Dose must be individualized by a qualified clinician based on indication, age, weight, heart function, and other treatments being used. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults can receive this medicine, but they may be more sensitive to its effects, especially on the heart. Heart function should be checked carefully before and during treatment. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is usually needed for kidney problems, but your doctor will consider your overall health. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is usually needed for liver problems, but your doctor will consider your overall health. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | Not applicable, as this medicine is given on a scheduled basis rather than daily. The maximum dose is determined by the treating specialist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ujvira 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Doxorubicin | Major | |
| Paclitaxel | Moderate |
🚨 Major Interactions
- Anthracycline chemotherapy medicines such as doxorubicin
⚡ Moderate Interactions
- Paclitaxel
🍷 Alcohol Interaction
There is no known direct interaction between this medicine and alcohol. However, alcohol can worsen tiredness, nausea, and liver strain, so it is best to avoid or limit alcohol during cancer treatment. Always ask your treating doctor for personal advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe allergic reaction to trastuzumab or any ingredient of this product","Severe uncontrolled heart failure or other serious heart conditions","Pregnancy, unless the potential benefit clearly outweighs the risk, as decided by the treating specialist"]
⚠️ Warnings & Precautions
["This medicine must only be given by a healthcare professional in a setting equipped to manage emergencies.","Heart function must be checked before and regularly during treatment.","Infusion-related reactions can occur, especially with the first dose, and need close observation.","Tell your doctor about all other medicines, including chemotherapy, before starting treatment.","Avoid pregnancy during treatment and for several months after the last dose.","Do not breastfeed during treatment and for several months after the last dose.","Report any new or worsening symptoms such as breathlessness, fever, or swelling without delay."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for harm to the baby, breastfeeding is not recommended during treatment and for several months after the last dose. Discuss feeding options with your doctor.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. Because it is given by a healthcare professional, overdose is unlikely. If too much is given, the patient should be monitored closely for side effects, especially heart and infusion-related effects, and treated supportively.
⏰ Missed Dose
If you miss a scheduled appointment for this injection, contact your cancer care team as soon as possible to arrange a new appointment. Do not try to make up for a missed dose on your own. Your doctor will decide the best time for the next dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting where emergency equipment is available. Always inform your doctor about all other medicines, supplements, and herbal products you are taking, and about any history of heart disease, lung disease, or allergies. Regular heart tests, usually an echocardiogram or MUGA scan, are needed before and during treatment. Do not try to self-administer this injection. If you are pregnant, planning pregnancy, or breastfeeding, tell your doctor before starting treatment. Keep all follow-up appointments and report any fever, chills, breathlessness, chest discomfort, swelling of the legs, or unusual tiredness without delay.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the heart effects of this medicine. Heart function should be checked carefully before and during treatment. Your doctor will also consider other health conditions and medicines you are taking when deciding on treatment.
🤰 Pregnancy Planning (TTC)
This medicine may harm an unborn baby. Women who could become pregnant should use effective contraception during treatment and for several months after the last dose. If you are planning pregnancy, discuss it with your cancer specialist before stopping contraception. Men should also use contraception during treatment and for several months after the last dose.
🏥 Post-Surgery Considerations
This medicine is often used after surgery as part of adjuvant treatment for HER2-positive breast cancer. Follow your surgeon's and oncologist's advice about wound care, activity, and when to start or continue treatment after surgery.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine. There is no direct interaction with dental procedures, but your overall health and any blood count changes should be considered. Your dentist may consult your cancer doctor before doing any procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise such as walking is usually encouraged, but avoid strenuous activity if you feel tired or breathless. If you have heart problems, ask your doctor what level of exercise is safe for you. Stop exercising and seek medical advice if you develop chest pain, severe breathlessness, or dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may feel tired after infusions, so plan rest days around your treatment schedule. Most people can continue light work, but avoid driving or operating machinery if you feel dizzy or unwell. Discuss your work schedule with your doctor and employer to make adjustments as needed.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your cancer specialist will decide when to stop based on your response to treatment, side effects, and heart function. If you develop serious side effects such as heart problems or severe infusion reactions, your doctor may pause or stop treatment. Always discuss any concerns before making changes.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with a small ongoing risk of heart problems, so heart function is usually checked periodically even after treatment ends. Most other side effects improve after treatment is stopped. Some patients may experience lasting tiredness. Your doctor will advise on how long to continue treatment and what follow-up is needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another HER2-targeted medicine that may be used in combination with trastuzumab for some patients.
Evidence: Well-establishedA medicine that combines trastuzumab with a chemotherapy payload, used in certain settings.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Talk to your doctor before receiving any vaccine while on this medicine. Live vaccines should generally be avoided during cancer treatment because the immune system may be weakened. Inactivated vaccines may be given, but their effectiveness can vary. Follow your doctor's advice.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze the vial
✅ DO
Keep the vial in its original carton to protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Check the expiry date before use
❌ DON'T
Do not use if the solution is cloudy or contains particles
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, carry a copy of your prescription and a letter from your doctor explaining your treatment. This medicine is given in a hospital or clinic, so plan your travel around your infusion schedule. Keep the medicine in its original packaging and store it in a refrigerator at 2°C to 8°C if you are carrying it. Do not freeze it. Check airline and customs rules for carrying prescription medicines, and carry enough supply for your trip. Inform your doctor before travelling so that arrangements can be made for your next dose.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given by a healthcare professional as an intravenous infusion, usually in a hospital or cancer day-care setting. It is not given as a tablet or at home.
A: The schedule is decided by your cancer specialist. It may be given once a week or once every three weeks, depending on your treatment plan.
A: You may feel feverish, chilly, or dizzy during or shortly after the infusion. Tell your nurse immediately if you feel unwell, as the drip can be slowed and medicines can be given to help.
A: This medicine can reduce the heart's pumping ability in some people. Heart function is checked before and during treatment. Report breathlessness, leg swelling, or unusual tiredness right away.
A: This medicine may harm an unborn baby. Use effective contraception during treatment and for several months after the last dose. Talk to your doctor if you are planning pregnancy.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet at home.
Fact: This medicine is given only as an intravenous infusion by a healthcare professional in a hospital or cancer day-care setting. - Myth: This medicine works for all types of breast cancer.
Fact: This medicine works only for cancers that have high levels of HER2. Your tumour must be tested before treatment. - Myth: Once you feel better, you can stop treatment.
Fact: Stopping treatment early can reduce its benefit. Always discuss any changes with your cancer specialist.
🔄 Alternative Options
Generic Alternatives
- Trastuzumab
Brand Alternatives
- Ujvira 100mg injection