i nem 500mg/500mg Injection: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Difficulty breathing or swelling of face, lips, or throat
- Severe or persistent diarrhea, especially with blood or mucus
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is ufimep cl 500mg/500mg injection used for?
This medicine is a combination antibiotic containing imipenem and cilastatin, used to treat serious bacterial infections. It is administered intravenously in a hospital setting. It works by killing bacteria and preventing their growth.
- Generic Name: Imipenem (500mg) + Cilastatin (500mg)
- Manufacturer: Elkos Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ufimep cl 500mg/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा इमिपेनम और सिलास्टेटिन का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में नस के माध्यम से दी जाती है। यह निमोनिया, पेट के संक्रमण, मूत्र मार्ग संक्रमण, त्वचा संक्रमण और रक्त संक्रमण जैसी स्थितियों में प्रभावी है। यह दवा केवल डॉक्टर की देखरेख में दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, चकत्ते और इंजेक्शन स्थल पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में दौरे, एलर्जी, और गंभीर दस्त हो सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे स्वयं न लें। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और एलर्जी के बारे में बताएं। उपचार के दौरान शराब न पिएं। यदि दौरे, सांस लेने में कठिनाई, या गंभीर दस्त हो तो तुरंत चिकित्सा सहायता लें।
💊 ufimep cl 500mg/500mg injection Uses & Benefits
[{"condition":"Complicated intra-abdominal infections","description":"Used to treat serious infections within the abdomen, such as peritonitis and abscesses, often caused by mixed aerobic and anaerobic bacteria.","evidence":"Well-established"},{"condition":"Severe pneumonia","description":"Effective against hospital-acquired and community-acquired pneumonia caused by susceptible organisms, including multidrug-resistant strains.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Treats severe kidney and urinary tract infections, including pyelonephritis, especially when resistant bacteria are suspected.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for complicated skin infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA) and mixed anaerobic infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts, often after chemotherapy.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible bacteria.","evidence":"Established"},{"condition":"Endocarditis","description":"Sometimes used for treating heart valve infections, often in combination with other antibiotics.","evidence":"Established"}]
Off-label uses: [{"condition":"Melioidosis","description":"May be used as part of combination therapy for melioidosis, a bacterial infection caused by Burkholderia pseudomallei.","evidence":"Limited"},{"condition":"Nocardiosis","description":"Occasionally used for treating nocardiosis, a rare infection caused by Nocardia species.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Complicated intra-abdominal infections, Severe pneumonia, Complicated urinary tract infections, Skin and soft tissue infections, Febrile neutropenia, Bone and joint infections, Endocarditis
📋 Drug Information
| Generic Name(s) | Imipenem (500mg) + Cilastatin (500mg) |
| Brand Name | ufimep cl 500mg/500mg injection |
| Manufacturer | Elkos Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store the unreconstituted vial at 20-25°C (68-77°F). Once reconstituted, the solution should be used immediately or stored as per manufacturer's instructions (typically refrigerated at 2-8°C for up to 24 hours). Do not freeze. |
| Shelf Life | 24 months from the date of manufacture for the unreconstituted vial. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Imipenem is a carbapenem antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), particularly PBP-2 and PBP-1a/1b, leading to bacterial lysis and death. Cilastatin is a dehydropeptidase-I inhibitor that blocks the renal metabolism of imipenem, thereby increasing its urinary recovery and reducing potential nephrotoxicity. The combination ensures high and sustained antibacterial activity against a broad spectrum of pathogens.
Mechanism Steps
💡 How to Take ufimep cl 500mg/500mg injection
Strength: 500 mg imipenem + 500 mg cilastatin per vial, powder for injection.
Dosage Information
| Adult Dosage | The usual adult dose ranges from 250 mg to 1000 mg of imipenem, administered intravenously every 6 to 8 hours, depending on the severity and type of infection. For complicated infections, 500 mg every 6 hours or 1000 mg every 8 hours is common. The maximum daily dose is 4000 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For children over 3 months, doses typically range from 15-25 mg/kg every 6 hours, but must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Use with caution and monitor renal function closely. |
| Renal Impairment | Dose adjustment is required for patients with renal impairment. For creatinine clearance 20-40 mL/min, reduce dose by 50%. For creatinine clearance <20 mL/min, reduce dose by 75%. For patients on hemodialysis, dose after dialysis. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment alone. However, monitor liver function closely. |
| Maximum Daily Dose | 4000 mg per day (as imipenem component). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ufimep cl 500mg/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ganciclovir | Major | |
| Valproic acid | Major | |
| Probenecid | Major | |
| Cyclosporine | Moderate | |
| Aminoglycosides | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- Ganciclovir
- Valproic acid
- Probenecid
⚡ Moderate Interactions
- Cyclosporine
- Aminoglycosides
- Warfarin
🍷 Alcohol Interaction
Avoid alcohol consumption while receiving this medicine, as it may increase the risk of seizures and exacerbate central nervous system side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to imipenem, cilastatin, or other carbapenems","Severe allergy to beta-lactam antibiotics (penicillins, cephalosporins)","History of seizures (relative contraindication; use with caution)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Seizures have been reported, especially in patients with CNS disorders or renal impairment. Use with caution.","Clostridioides difficile-associated diarrhea may occur. Monitor for persistent diarrhea.","Serious hypersensitivity reactions, including anaphylaxis, can occur. Have emergency treatment available.","Prolonged use may lead to superinfection with resistant organisms.","Use with caution in patients with renal impairment; dose adjustment is necessary.","May interact with valproic acid, reducing its efficacy. Avoid combination if possible.","Not recommended for pediatric patients under 3 months of age due to lack of safety data."]
🤱 Lactation Safety
Imipenem and cilastatin are excreted in breast milk in low amounts. Caution is advised when administering to nursing mothers. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose may cause nausea, vomiting, seizures, and hypotension. Treatment is symptomatic and supportive. Imipenem and cilastatin can be removed by hemodialysis. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a hospital setting. If a dose is missed, inform your nurse or doctor immediately. Do not attempt to self-administer. The dosing schedule will be adjusted by the healthcare team.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a hospital setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially kidney disease, epilepsy, or allergies to antibiotics. Your kidney function will be monitored during treatment, and the dose may be adjusted accordingly. Avoid alcohol during treatment as it may worsen side effects. If you experience seizures, severe diarrhea, or signs of an allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe rash, seek emergency medical help immediately. Do not stop treatment early without consulting your doctor, even if you feel better, as this can lead to antibiotic resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of renal impairment and seizures. Dose adjustment based on creatinine clearance is essential. Monitor renal function and neurological status closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is classified as Pregnancy Category B, but use only if clearly needed. Discuss risks and benefits.
🏥 Post-Surgery Considerations
This medicine is often used to treat or prevent infections after surgery. It is administered intravenously in a hospital setting. Follow your surgeon's instructions for wound care and monitoring.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may interact with other medications used during dental procedures. No specific precautions are established, but consult your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you experience dizziness or fatigue. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it may require hospitalization. You should not drive or operate machinery if you experience dizziness or seizures. Plan for rest and recovery during treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine the appropriate duration based on your infection and clinical response.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, blood dyscrasias or liver enzyme elevations. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of renal, hepatic, and hematologic parameters is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another carbapenem antibiotic with similar spectrum but lower seizure risk.
Evidence: Well-establishedBeta-lactam/beta-lactamase inhibitor combination for serious infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, live vaccines should be avoided during antibiotic therapy. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store unreconstituted vial at 20-25°C
❌ DON'T
Do not freeze
✅ DO
Use reconstituted solution immediately or refrigerate at 2-8°C for up to 24 hours
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and discharge summary. Store any remaining medication as instructed. Consult your doctor before travel if you have ongoing infection concerns.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working immediately after intravenous administration, but clinical improvement may take 24-72 hours.
A: No, this medicine is only available as an intravenous injection and must be given by a healthcare professional.
A: It may be used in children over 3 months of age under a pediatrician's supervision. Dosing is weight-based.
A: Seek immediate medical attention. Your doctor may adjust the dose or switch to a different antibiotic.
🤔 Common Patient Concerns
🔄 Substitutes for ufimep cl 500mg/500mg injection
View AllAlternative brands with exact same active ingredient:
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imilan 500mg/500mg injectionMylan Pharmaceuticals Pvt Ltd ₹467.81 66.6% CHEAPER
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Zilamac 500 mg/500 mg InjectionMacleods Pharmaceuticals Pvt Ltd ₹502.35 64.1% CHEAPER
-
imici 500mg/500mg injectionServo Healthcare ₹556.88 60.2% CHEAPER
-
cilareach 500mg/500mg injectionFusion Healthcare Pvt Ltd ₹599.00 57.2% CHEAPER
-
micromax injectionMicro Labs Ltd ₹612.19 56.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given intravenously by a healthcare professional. - Myth: This medicine is safe for viral infections.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent resistance and relapse.
🔄 Alternative Options
Generic Alternatives
- Imipenem and Cilastatin Injection
Brand Alternatives
- I Nem 500mg/500mg Injection