Nextril 50 Tablet (Tofisopam 50mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- New or worsening depression, suicidal thoughts, or unusual behavioural changes.
- Severe dizziness, fainting, or confusion.
- Unusual bruising or bleeding.
- Persistent vomiting or inability to keep fluids down.
- Seizures or severe muscle twitching.
If experiencing severe symptoms, call emergency services immediately.
What is tolrina 50mg tablet used for?
This medicine contains Tofisopam 50 mg, an atypical anxiolytic used to treat generalised anxiety and stress-related symptoms. It is taken orally, usually one to three times daily, and must be prescribed by a doctor. It causes less sedation than traditional benzodiazepines but can still cause drowsiness, so avoid driving until you know how it affects you.
- Generic Name: Tofisopam (50mg)
- Manufacturer: Arinna Lifescience Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 tolrina 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टोफिसोपम 50 मिलीग्राम युक्त एक टैबलेट है, जिसका उपयोग मुख्य रूप से चिंता, तनाव और घबराहट के इलाज में किया जाता है। यह मस्तिष्क में कुछ रासायनिक संकेतों को संतुलित करके मन को शांत करने में मदद करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें। यह दवा आमतौर पर दिन में एक से तीन बार ली जाती है, लेकिन सही खुराक डॉक्टर तय करते हैं। इस दवा से नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन बिल्कुल न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, थकान, चक्कर आना, सूखा मुँह, जी मिचलाना और हल्का सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी मूड में बदलाव या नींद की समस्या हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, पीलिया, या गंभीर त्वचा पर दाने दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। खुराक को अपने आप न बढ़ाएं, न घटाएं और न ही बंद करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। अपने डॉक्टर को अन्य सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। गर्भावस्था, गर्भधारण की योजना या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा को बच्चों की पहुंच से दूर रखें।
💊 tolrina 50mg tablet Uses & Benefits
[{"condition":"Generalised anxiety disorder","description":"This medicine is used to reduce excessive worry, tension, and nervousness in adults with generalised anxiety, often as part of a broader treatment plan.","evidence":"Moderate"},{"condition":"Stress-related tension and psychosomatic complaints","description":"It may help relieve anxiety-driven physical symptoms such as tension headaches, palpitations, and digestive discomfort linked to stress.","evidence":"Limited"},{"condition":"Functional gastrointestinal disorders with anxiety component","description":"Sometimes prescribed when anxiety contributes to irritable bowel-like symptoms or functional dyspepsia.","evidence":"Limited"},{"condition":"Autonomic nervous system imbalance","description":"Used in some regions for symptoms attributed to autonomic dysfunction, such as sweating, palpitations, and mild tremor.","evidence":"Limited"}]
Off-label uses: [{"condition":"Alcohol withdrawal support","description":"Occasionally used in some clinical settings to ease anxiety during alcohol withdrawal, but this is not a standard first-line approach.","evidence":"Limited"},{"condition":"Premenstrual syndrome with anxiety","description":"May be tried for anxiety-related premenstrual symptoms, though robust evidence is lacking.","evidence":"Limited"}]
Primary treatment for: Generalised anxiety disorder
Also treats: Stress-related disorders, Functional gastrointestinal disorders, Autonomic nervous system imbalance
📋 Drug Information
| Generic Name(s) | Tofisopam (50mg) |
| Brand Name | tolrina 50mg tablet |
| Manufacturer | Arinna Lifescience Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepines |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original packaging. |
| Shelf Life | Typically 24 months from the date of manufacture, but refer to the packaging for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Tofisopam is a 2,3-benzodiazepine that differs structurally from classical 1,4-benzodiazepines. It does not bind strongly to the classical benzodiazepine site on GABA-A receptors and therefore produces less sedation and muscle relaxation. Instead, it appears to modulate the activity of benzodiazepine receptors in a unique way and influences dopaminergic and serotonergic neurotransmission. This medicine is thought to help restore balance in brain circuits involved in anxiety and stress responses, leading to a calmer state without heavy sedation.
Mechanism Steps
💡 How to Take tolrina 50mg tablet
Strength: Tofisopam 50 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is individualized by a qualified clinician based on the indication, severity of symptoms, age, and liver and kidney function. A common starting dose is 50 mg taken one to three times daily, but the exact regimen must be determined by your doctor. Do not adjust the dose without medical advice. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness and dizziness. A lower starting dose may be advised by the doctor, and close monitoring is recommended. |
| Renal Impairment | Dose adjustment may be necessary in patients with significant kidney impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose reduction or avoidance may be necessary in patients with liver impairment. This medicine should be used with caution and under medical supervision in such cases. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing doctor based on individual patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of tolrina 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| CNS depressants | Major | |
| Alcohol | Major | |
| CYP3A4 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- CNS depressants (e.g., opioids, barbiturates, other benzodiazepines)
- Alcohol
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because it can significantly increase sedation, impair coordination, and raise the risk of respiratory depression. Combining alcohol with this medicine may also worsen anxiety and mood symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Tofisopam or any component of the tablet","Severe liver impairment","Myasthenia gravis","Severe respiratory insufficiency","Sleep apnoea syndrome","Pregnancy and breastfeeding unless specifically advised by a doctor"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not consume alcohol while taking this medicine.","Use with caution in elderly patients, who may be more sensitive to side effects.","Do not stop this medicine abruptly without medical advice, as withdrawal symptoms may occur.","Inform your doctor if you have a history of substance abuse, liver disease, kidney disease, or mental health conditions.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether Tofisopam passes into breast milk. Breastfeeding mothers should consult their doctor before using this medicine, as alternative treatments may be preferred.
💊 Overdose Management
If you suspect an overdose, seek emergency medical attention immediately. Symptoms of overdose may include excessive drowsiness, confusion, dizziness, or slowed breathing. Treatment is supportive and symptomatic, as there is no specific antidote. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase, decrease, or stop the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you, because it may cause drowsiness or reduced concentration. Do not drink alcohol while taking this medicine, as it can increase sedation and impair judgement. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially those affecting the liver or brain. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Keep this medicine out of the reach of children and store it in its original packaging. If you experience any unusual symptoms such as severe dizziness, mood changes, or signs of an allergic reaction, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the sedative and dizzying effects of this medicine. A lower starting dose and close monitoring are recommended. Falls and confusion are of particular concern.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before continuing this medicine. The safety profile during pregnancy is not well established, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It may interact with anaesthetic agents and increase sedation. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. It may increase drowsiness when combined with certain sedatives or anaesthetics used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness, so avoid strenuous exercise or activities requiring high coordination until you know how it affects you. Light to moderate exercise is generally safe and can help reduce anxiety.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and reduced concentration, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Discuss with your doctor if your job involves such activities. It is important to follow safety precautions until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or wish to discontinue, your doctor will guide you on a gradual tapering schedule to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine should be reviewed regularly by your doctor. Some patients may develop tolerance or dependence, and withdrawal symptoms can occur if stopped abruptly. Periodic monitoring of liver and kidney function may be advised. The need for continued treatment should be reassessed periodically.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured psychological therapy that can be highly effective for anxiety and may reduce the need for medication.
Evidence: Well-establishedCan help manage stress and anxiety as a complementary approach.
Evidence: ModeratePhysical activity has been shown to reduce anxiety symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about how to adjust the dosing schedule. Store it at room temperature and away from direct sunlight. Check customs regulations for controlled medicines before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some people notice improvement within a few days, but full therapeutic benefits usually develop over one to two weeks. Individual response varies.
A: No, you should not stop this medicine abruptly as it can cause withdrawal symptoms. Always consult your doctor for a gradual tapering plan.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor to weigh the benefits and risks.
A: No, alcohol should be strictly avoided as it can increase sedation and impair coordination.
🤔 Common Patient Concerns
🔄 Substitutes for tolrina 50mg tablet
View AllAlternative brands with exact same active ingredient:
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tofisern 50mg tabletConsern Pharma Limited ₹135.94 21.7% CHEAPER
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tofiryd 50 tabletRyon Pharma ₹135.94 21.7% CHEAPER
-
toficalm 50 tabletSun Pharmaceutical Industries Ltd ₹169.69 2.3% CHEAPER
-
nextril 50 tabletTorrent Pharmaceuticals Ltd ₹194.05 11.8% COSTLIER
-
tofypeace 50 tabletPsychocare Health Pvt Ltd ₹209.06 20.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is primarily an anxiolytic and is not intended as a sleeping aid, although it may help with anxiety-related sleep problems. - Myth: This medicine is the same as other benzodiazepines.
Fact: This medicine belongs to a different subclass (2,3-benzodiazepine) and has a distinct profile with less sedation and muscle relaxation. - Myth: You can stop this medicine anytime without problems.
Fact: Abrupt discontinuation can cause withdrawal symptoms. Always taper under medical supervision.