Imore Gel: Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Signs of gastrointestinal bleeding: black stools, vomiting blood, severe abdominal pain.
- Cardiovascular symptoms: chest pain, shortness of breath, weakness.
- Renal symptoms: decreased urine output, swelling in legs, fatigue.
- Severe skin reaction: blistering, peeling, or widespread rash.
- Neurological symptoms: confusion, seizures, irregular heartbeat (signs of lidocaine toxicity).
If experiencing severe symptoms, call emergency services immediately.
What is synofia gel used for?
This medicine is a topical gel containing diclofenac (3% w/w) and lidocaine (2.5% w/w). It is used to relieve pain and inflammation in muscles and joints. Apply a thin layer to the affected area 3-4 times daily, or as directed by your doctor.
- Generic Name: Diclofenac (3% w/w) + Lidocaine (2.5% w/w)
- Manufacturer: Rauwolfia Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 synofia gel के बारे में (Hindi Summary)
उपयोग: यह दवा दर्द और सूजन को कम करने के लिए एक टॉपिकल जेल है। इसमें डाइक्लोफेनाक (3% w/w) और लिडोकेन (2.5% w/w) होते हैं। यह मांसपेशियों और जोड़ों के दर्द, मोच, अकड़न और गठिया के दर्द में राहत देती है। इसे प्रभावित जगह पर दिन में 3-4 बार लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में त्वचा पर जलन, लालिमा, खुजली या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, या गंभीर त्वचा दाने हो सकते हैं। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल स्वस्थ त्वचा पर लगाएं। आंखों, म्यूकस झिल्ली और खुले घावों से बचें। उपयोग के बाद हाथ धोएं। पट्टी या गर्मी न लगाएं। धूप से बचें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। 7 दिनों से अधिक उपयोग न करें।
💊 synofia gel Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation from strains, sprains, and sports injuries.","evidence":"Well-established"},{"condition":"Osteoarthritis of superficial joints","description":"Reduces pain and improves mobility in knee and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Localized back pain","description":"Provides targeted relief for acute or chronic back pain of musculoskeletal origin.","evidence":"Moderate"},{"condition":"Soft tissue injuries","description":"Helps reduce pain and swelling in contusions, tendinitis, and bursitis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes used off-label for localized neuropathic pain due to lidocaine's numbing effect.","evidence":"Limited"},{"condition":"Postherpetic neuralgia","description":"May provide symptomatic relief in some patients, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain
Also treats: Osteoarthritis, Soft tissue injuries, Back pain
📋 Drug Information
| Generic Name(s) | Diclofenac (3% w/w) + Lidocaine (2.5% w/w) |
| Brand Name | synofia gel |
| Manufacturer | Rauwolfia Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Keep the tube tightly closed when not in use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased production of prostaglandins, which are mediators of inflammation and pain. Lidocaine is an amide-type local anesthetic that blocks voltage-gated sodium channels on nerve membranes, preventing the initiation and conduction of nerve impulses, thereby producing local numbness. Together, they reduce both inflammation and pain perception in the applied area.
Mechanism Steps
💡 How to Take synofia gel
Strength: Topical gel containing diclofenac 3% w/w and lidocaine 2.5% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer of this medicine to the affected area 3 to 4 times daily, or as directed by your physician. The dose and frequency depend on the condition being treated and the size of the affected area. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and follow the doctor's instructions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Renal Impairment | No specific dosage adjustment is established for topical use. However, use with caution in patients with renal impairment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Hepatic Impairment | No specific dosage adjustment is established for topical use. However, use with caution in patients with hepatic impairment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Maximum Daily Dose | The maximum daily dose depends on the size of the affected area and the frequency of application. Do not exceed the recommended frequency of 3 to 4 times daily. The total daily dose should not exceed 16 grams of gel per day (which corresponds to 480 mg diclofenac and 400 mg lidocaine) unless otherwise directed by a physician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of synofia gel
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Major | |
| Methotrexate | Major | |
| Corticosteroids | Moderate | |
| Beta-blockers | Moderate |
🚨 Major Interactions
- Oral NSAIDs (e.g., ibuprofen, naproxen)
- Anticoagulants (e.g., warfarin)
- Antiplatelet agents (e.g., clopidogrel)
- ACE inhibitors and ARBs
- Diuretics
- Lithium
- Methotrexate
- Corticosteroids
- Other topical products
- Class I antiarrhythmics (e.g., tocainide)
⚡ Moderate Interactions
- Beta-blockers
- Cimetidine
🍷 Alcohol Interaction
No specific interaction is established between this topical medicine and alcohol. However, alcohol may increase the risk of gastrointestinal bleeding if the medicine is absorbed systemically. It is advisable to limit alcohol consumption while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diclofenac, lidocaine, or any component of the formulation.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Application to broken skin, mucous membranes, or eyes.","Third trimester of pregnancy.","Active peptic ulcer disease or history of recurrent ulcers.","Severe renal impairment.","Severe hepatic impairment.","Children under 12 years of age (unless directed by a physician)."]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes and mucous membranes.","Do not apply to large areas of the body or use with occlusive dressings.","Discontinue use if severe skin reactions occur.","Use with caution in patients with a history of gastrointestinal bleeding or ulcers.","Use with caution in patients with cardiovascular disease or risk factors.","Use with caution in elderly patients who may be more susceptible to side effects.","Do not use for more than 7 days without medical advice.","Keep out of reach of children.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
It is not known whether diclofenac or lidocaine are excreted in human milk after topical application. Because many drugs are excreted in human milk, caution should be exercised when this medicine is used by a nursing woman. Avoid application to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose with topical application is unlikely due to low systemic absorption. If accidental ingestion occurs, seek immediate medical attention. Symptoms of systemic toxicity may include nausea, vomiting, drowsiness, seizures, or cardiac arrhythmias. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply this medicine only to intact skin and avoid contact with eyes, mucous membranes, and open wounds. Wash your hands thoroughly after each application unless the hands are the treated area. Do not cover the treated area with airtight dressings or apply heat, as this can increase absorption and the risk of side effects. Avoid exposure to sunlight or tanning beds on treated skin. Do not use this medicine for more than the recommended duration without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Do not use this medicine in children under 12 years of age unless directed by a physician. Keep this medicine out of reach of children. If you have a history of stomach ulcers, kidney disease, heart disease, or asthma, inform your doctor before using this medicine. Do not apply this medicine to large areas of the body or use it more frequently than prescribed. If symptoms persist or worsen after 7 days, discontinue use and seek medical advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects due to reduced renal and hepatic function. Use with caution and monitor for signs of irritation or systemic effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Avoid use in the third trimester. Discuss alternative pain relief options.
🏥 Post-Surgery Considerations
Consult your surgeon before using this medicine on surgical wounds. It should not be applied to healing incisions unless approved by your doctor.
🦷 Dental Procedures
This medicine is not intended for oral or dental use. For dental pain, consult a dentist for appropriate treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While using this medicine, you can continue gentle exercises as tolerated. Avoid strenuous activities that may worsen the injury. If pain increases with activity, stop and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you feel normal.
🛑 When to Stop This Medicine
Stop using this medicine if you experience severe skin reactions, signs of allergic reaction, or if your symptoms worsen. Do not stop prescribed treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine over large areas may lead to systemic absorption and potential side effects similar to oral NSAIDs, including gastrointestinal, renal, and cardiovascular risks. Regular monitoring may be required if used for extended periods. It is advisable to use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: ModerateProvide counter-irritant effect for mild pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. This medicine can be used around the time of vaccination if needed for pain relief.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, keep it in its original packaging with the prescription label intact. Carry a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. If flying, pack it in your carry-on luggage to avoid temperature fluctuations in checked baggage. No time zone adjustments are needed for topical use.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The lidocaine component provides numbing within 30 minutes, while the anti-inflammatory effect of diclofenac may take several hours to days.
A: No, it should not be applied to the face or near eyes and mucous membranes unless specifically directed by a doctor.
A: Avoid use in the third trimester. Consult your doctor before using this medicine during pregnancy.
A: Consult your doctor before combining with oral NSAIDs, as it may increase the risk of side effects.
A: Do not use for more than 7 days without medical advice. If symptoms persist, consult a doctor.
🤔 Common Patient Concerns
🔄 Substitutes for synofia gel
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used on open wounds.
Fact: No, it should only be applied to intact skin. Application to broken skin can increase absorption and risk of side effects. - Myth: More gel means faster relief.
Fact: Using more than the recommended amount does not improve efficacy and may increase the risk of side effects. - Myth: This medicine is completely free of systemic side effects.
Fact: Although systemic absorption is low, side effects similar to oral NSAIDs can occur, especially with prolonged use over large areas.
🔄 Alternative Options
Generic Alternatives
- Diclofenac 3% w/w + Lidocaine 2.5% w/w topical gel