Entacom Plus 150 Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with severe muscle stiffness or confusion
- Sudden swelling of the face, lips, tongue, or throat
- Severe eye pain or sudden vision changes
- Fainting or severe dizziness
- Unusual bruising or bleeding
- Chest pain or irregular heartbeat
- Hallucinations or severe mood changes
If experiencing severe symptoms, call emergency services immediately.
What is syncapone 150 tablet used for?
This medicine is a combination of levodopa and carbidopa used to treat Parkinson's disease. It works by increasing dopamine levels in the brain, which helps reduce tremors, stiffness, and slowness of movement.
- Generic Name: Levodopa (150mg) + Carbidopa (37.5mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 syncapone 150 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पार्किंसन रोग के इलाज के लिए इस्तेमाल की जाती है। यह लेवोडोपा और कार्बिडोपा का संयोजन है, जो मस्तिष्क में डोपामाइन के स्तर को बढ़ाकर कंपन, अकड़न और चलने-फिरने की धीमी गति जैसे लक्षणों को कम करती है। यह दवा डॉक्टर की सलाह पर ही लेनी चाहिए और अचानक बंद नहीं करनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, चक्कर आना, मुँह सूखना, भूख कम लगना और शरीर में अनैच्छिक हरकतें शामिल हैं। कुछ लोगों को मानसिक भ्रम, मूड में बदलाव या नींद की समस्या भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको तेज बुखार, मांसपेशियों में अकड़न, सांस लेने में तकलीफ या आँखों में तेज दर्द हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे गंभीर समस्या हो सकती है। अगर दवा से जी मिचलाता है तो हल्के नाश्ते के साथ लें, लेकिन प्रोटीन युक्त भारी भोजन के साथ न लें। दवा लेने के बाद चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। नियमित जांच के लिए डॉक्टर के पास जाते रहें।
💊 syncapone 150 tablet Uses & Benefits
[{"condition":"Parkinson's disease","description":"This medicine is used to reduce tremors, rigidity, bradykinesia, and postural instability in patients with idiopathic Parkinson's disease.","evidence":"Well-established"},{"condition":"Parkinsonism due to other causes","description":"It may be used in some patients with parkinsonian symptoms caused by conditions other than classic Parkinson's disease, as determined by a specialist.","evidence":"Moderate"},{"condition":"Restless legs syndrome","description":"In selected cases, this medicine may be prescribed off-label for severe restless legs syndrome when other treatments are not effective.","evidence":"Limited"}]
Off-label uses: [{"condition":"Restless legs syndrome","description":"Sometimes used off-label for refractory restless legs syndrome under specialist supervision.","evidence":"Limited"},{"condition":"Dopa-responsive dystonia","description":"May be used off-label in some inherited forms of dystonia that respond to dopamine therapy.","evidence":"Limited"}]
Primary treatment for: Parkinson's disease
Also treats: Parkinsonism due to other causes, Restless legs syndrome (off-label)
📋 Drug Information
| Generic Name(s) | Levodopa (150mg) + Carbidopa (37.5mg) |
| Brand Name | syncapone 150 tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Refer to the package label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by supplying the brain with levodopa, which is a precursor of dopamine. Dopamine itself cannot cross the blood-brain barrier, but levodopa can. Once levodopa reaches the brain, it is converted into dopamine by an enzyme called aromatic L-amino acid decarboxylase. Carbidopa blocks this enzyme outside the brain, so more levodopa reaches the brain and less is converted to dopamine in the body. This reduces peripheral side effects such as nausea and vomiting and allows a lower dose of levodopa to be effective. The restored dopamine levels help balance the movement control circuits in the brain, improving symptoms of Parkinson's disease.
Mechanism Steps
💡 How to Take syncapone 150 tablet
Strength: Tablet containing levodopa 150 mg and carbidopa 37.5 mg, immediate release.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's condition, response, and other factors. It is usually started at a low dose and increased gradually. The typical starting dose is one tablet of this strength taken two to three times a day, but the exact dose and frequency must be determined by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness, low blood pressure, and confusion. Doses are usually started low and increased slowly under close medical supervision. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney disease. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing clinician based on the patient's condition and tolerance. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of syncapone 150 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Non-selective MAOIs | Major | |
| Antipsychotics | Major | |
| Iron supplements | Moderate | |
| Antihypertensives | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Metoclopramide | Moderate | |
| Vitamin B6 | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Non-selective monoamine oxidase inhibitors (MAOIs)
- Antipsychotics (e.g., haloperidol, risperidone)
- Iron supplements
⚡ Moderate Interactions
- Antihypertensives
- Tricyclic antidepressants
- Metoclopramide
🍷 Alcohol Interaction
Alcohol may increase dizziness, drowsiness, and low blood pressure while taking this medicine. It is best to avoid alcohol or limit it strictly and discuss with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Narrow-angle glaucoma","Unexplained skin lesions or a history of melanoma","Concurrent use of non-selective MAO inhibitors","Known hypersensitivity to levodopa or carbidopa"]
⚠️ Warnings & Precautions
["Do not stop this medicine suddenly; withdrawal can cause a serious reaction.","May cause drowsiness or sudden sleep attacks; avoid driving if affected.","May cause low blood pressure; stand up slowly.","May cause or worsen mental disturbances; report mood or behavior changes.","Use with caution in patients with heart, liver, kidney, or lung disease.","May darken urine, sweat, and saliva; this is harmless."]
🤱 Lactation Safety
Levodopa is excreted in breast milk and may suppress prolactin and affect milk production. Carbidopa may also pass into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, irregular heartbeat, low blood pressure, confusion, and involuntary movements. Seek immediate medical attention. Treatment is supportive and symptomatic, as there is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop the medicine suddenly, because abrupt withdrawal can cause a serious condition called neuroleptic malignant syndrome. Take it with food if it upsets your stomach, but avoid a high-protein meal right before a dose because protein can reduce its absorption. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause dizziness or sudden sleepiness. Tell your doctor about all other medicines you take, especially blood pressure medicines, antidepressants, and antipsychotics. Keep your appointments for regular monitoring of blood pressure, movement symptoms, and mental health. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to experience dizziness, low blood pressure, confusion, and hallucinations. Doses are usually started low and increased slowly. Regular monitoring is essential.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be adjusted around the time of surgery. Do not stop it without medical advice.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine. It may interact with certain dental anesthetics or medications. Your dentist may need to consult your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial, but avoid overexertion. If you experience dizziness or sudden sleepiness, stop and rest. Always warm up before exercise and cool down after. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can improve your ability to perform daily activities and work. However, it may cause dizziness or sudden sleepiness, so avoid driving or operating heavy machinery until you know how it affects you. Discuss any work-related challenges with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may adjust or stop it based on your condition, side effects, or other factors. Abrupt withdrawal can cause serious problems.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to motor complications such as dyskinesias and wearing-off effects. Regular monitoring by a neurologist is important to adjust the dose and manage these complications. Some patients may also experience mood changes or impulse control disorders. The medicine does not stop the progression of Parkinson's disease.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve balance, flexibility, and mobility in Parkinson's disease.
Evidence: Well-establishedA surgical option for advanced Parkinson's disease when medicines are not effective enough.
Evidence: Well-establishedHelps with daily living activities and adaptive strategies.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known for this medicine. However, always inform your healthcare provider about all medicines you take before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If traveling across time zones, discuss with your doctor how to adjust the timing of doses. Store it at room temperature and away from direct sunlight. Check customs regulations for carrying prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement may begin within 30 to 60 minutes after a dose, but the full benefit may take several days to weeks of regular use.
A: No, stopping suddenly can cause a serious reaction. Always consult your doctor before stopping.
A: If you remember within half the dosing interval, take it. Otherwise, skip it and continue your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for syncapone 150 tablet
View AllAlternative brands with exact same active ingredient:
-
tidomet e 150mg/37.5mg/200mg tabletTorrent Pharmaceuticals Ltd ₹59.06 60.1% CHEAPER
-
entacom plus 150 tabletIntas Pharmaceuticals Ltd ₹161.72 9.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine cures Parkinson's disease.
Fact: This medicine controls symptoms but does not cure the disease. - Myth: You can stop the medicine once you feel better.
Fact: Stopping suddenly can cause serious problems. Always consult your doctor. - Myth: It is safe to take with any other medicine.
Fact: It can interact with many medicines, so always inform your doctor.
🔄 Alternative Options
Generic Alternatives
- Levodopa and carbidopa combination tablets from other manufacturers
Brand Alternatives
- Entacom Plus 150 Tablet