Kuff-D Syrup: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Fast, irregular, or pounding heartbeat
- Severe dizziness or fainting
- Difficulty urinating or inability to urinate
- Yellowing of skin or eyes
- Severe headache or blurred vision
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is synabron d syrup used for?
This medicine is a combination of phenylpropanolamine (a decongestant) and chlorpheniramine maleate (an antihistamine) used to relieve symptoms of allergic rhinitis and common cold such as nasal congestion, sneezing, and runny nose. It works by reducing swelling in the nasal passages and blocking histamine effects.
- Generic Name: Phenylpropanolamine (1.5mg/5ml) + Chlorpheniramine Maleate (12.5mg/5ml)
- Manufacturer: Concept Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 synabron d syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी राइनाइटिस और सामान्य सर्दी के लक्षणों जैसे नाक बंद होना, छींक आना, नाक बहना और आंखों में पानी आना के इलाज के लिए उपयोग की जाती है। यह फेनिलप्रोपेनॉलामाइन और क्लोरफेनिरामाइन मेलिएट का संयोजन है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी प्रतिक्रिया, दिल की धड़कन तेज होना या पेशाब करने में कठिनाई हो सकती है।
सुरक्षा सलाह: दवा की खुराक से अधिक न लें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाते समय या मशीन चलाते समय सावधानी बरतें। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, थायरॉइड या ग्लूकोमा है तो डॉक्टर को बताएं। 7 दिनों से अधिक उपयोग न करें।
💊 synabron d syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itching, and watery eyes associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief of nasal congestion and sneezing due to upper respiratory tract infections.","evidence":"Well-established"},{"condition":"Vasomotor rhinitis","description":"Helps reduce nasal congestion and discharge in non-allergic rhinitis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Urticaria","description":"Sometimes used off-label for relief of itching and hives due to allergic reactions.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Common cold, Vasomotor rhinitis
📋 Drug Information
| Generic Name(s) | Phenylpropanolamine (1.5mg/5ml) + Chlorpheniramine Maleate (12.5mg/5ml) |
| Brand Name | synabron d syrup |
| Manufacturer | Concept Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Phenylpropanolamine is a sympathomimetic amine that stimulates alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa and reducing swelling and congestion. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby reducing allergic symptoms such as sneezing, itching, and runny nose. The combination provides both decongestant and antihistaminic effects.
Mechanism Steps
💡 How to Take synabron d syrup
Strength: Each 5 ml contains Phenylpropanolamine 1.5 mg and Chlorpheniramine Maleate 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 5-10 ml (1-2 teaspoons) every 4-6 hours as needed, not to exceed 4 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and consult a doctor for appropriate dosing. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult a doctor. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. Consult a doctor. |
| Maximum Daily Dose | Not established from the available information. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of synabron d syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Moderate | |
| Antihypertensives | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other sympathomimetics
⚡ Moderate Interactions
- Alcohol and CNS depressants
- Antihypertensives
🍷 Alcohol Interaction
Alcohol increases the sedative effects of chlorpheniramine and may enhance cardiovascular effects of phenylpropanolamine. Avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to phenylpropanolamine or chlorpheniramine","Uncontrolled hypertension","Severe coronary artery disease","Hyperthyroidism","Glaucoma","Urinary retention","MAOI therapy within 14 days"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Use with caution in patients with cardiovascular disease.","Use with caution in patients with diabetes mellitus.","Use with caution in patients with prostatic hypertrophy.","Do not use for more than 7 days without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor.
💊 Overdose Management
Overdose may cause severe drowsiness, tachycardia, hypertension, hallucinations, and seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants while taking this medicine. Use caution when driving or operating heavy machinery until you know how this medicine affects you. Inform your doctor if you have high blood pressure, heart disease, diabetes, thyroid problems, or glaucoma. Do not use for more than 7 days without consulting a doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and urinary retention. Use with caution and consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination in pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may interact with other medications or affect recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. Avoid such activities until you know how it affects you. It may also reduce alertness, so plan your work accordingly.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if symptoms persist beyond 7 days, worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to tolerance, dependence, and increased risk of side effects such as elevated blood pressure and sedation. Regular monitoring of blood pressure and heart rate is advised if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help relieve nasal congestion without medication.
Evidence: Well-establishedReducing exposure to allergens can decrease symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after taking a dose.
A: Consult your doctor first. Phenylpropanolamine can increase blood pressure.
A: Pediatric dosing is not established. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for synabron d syrup
View AllAlternative brands with exact same active ingredient:
-
coform p syrupAjanta Pharma Ltd ₹17.81 54.9% CHEAPER
-
kuff-d syrupIntas Pharmaceuticals Ltd ₹78.75 99.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only provides symptomatic relief; it does not cure the underlying infection. - Myth: It is safe to take this medicine for long periods.
Fact: Prolonged use without medical supervision can lead to side effects and is not recommended.