Nitnib 12.5 Capsule (Sunitinib 12.5 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain, shortness of breath, or swelling of the legs.
- Severe headache, confusion, seizures, or vision changes.
- Vomiting blood, black stools, or bleeding that will not stop.
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain.
- Decreased urine output or sudden weight gain.
- Fever above 100.4°F (38°C) with chills or sore throat.
- Sudden swelling of the face, lips, or throat.
- Severe skin rash or blistering.
If experiencing severe symptoms, call emergency services immediately.
What is sutib 12.5 capsule used for?
This medicine is a targeted cancer medicine containing Sunitinib 12.5 mg. It is used to treat advanced kidney cancer, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. It works by blocking enzymes that help cancer grow and form blood vessels. It is taken by mouth once daily, usually in cycles, and requires regular monitoring by a cancer specialist.
- Generic Name: Sunitinib (12.5mg)
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sutib 12.5 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा सुनिटिनिब 12.5 मिलीग्राम कैप्सूल है, जिसका उपयोग कैंसर के इलाज के लिए किया जाता है। यह मुख्य रूप से गुर्दे के उन्नत कैंसर, गैस्ट्रोइंटेस्टाइनल स्ट्रोमल ट्यूमर और अग्नाशय के न्यूरोएंडोक्राइन ट्यूमर के लिए दी जाती है। यह दवा कैंसर कोशिकाओं की वृद्धि और रक्त वाहिकाओं के निर्माण को रोककर काम करती है। इसे मुँह से एक बार प्रतिदिन लिया जाता है, आमतौर पर चक्रों में। इसका उपयोग केवल कैंसर विशेषज्ञ की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में थकान, जी मिचलाना, दस्त, मुँह के छाले, भूख में कमी, उच्च रक्तचाप, त्वचा का रंग बदलना और स्वाद में बदलाव शामिल हैं। कुछ लोगों में रक्त कोशिकाओं की संख्या कम हो सकती है, जिससे संक्रमण या रक्तस्राव का खतरा बढ़ जाता है। गंभीर दुष्प्रभावों में हृदय विफलता, यकृत की क्षति, गंभीर रक्तस्राव और रक्त के थक्के शामिल हो सकते हैं। कोई भी नया या बिगड़ता लक्षण दिखने पर तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को अपने कैंसर विशेषज्ञ के निर्देशानुसार ही लें। कैप्सूल को पानी के साथ पूरा निगलें, इसे खोलें, चबाएं या तोड़ें नहीं। हर दिन एक ही समय पर दवा लें। अंगूर और अंगूर का रस न लें क्योंकि इससे दवा का स्तर बढ़ सकता है। अपने डॉक्टर को सभी अन्य दवाओं, विटामिन और हर्बल उत्पादों के बारे में बताएं। उपचार के दौरान और बाद में गर्भनिरोधक का उपयोग करें। स्तनपान न कराएं। नियमित रक्त परीक्षण, रक्तचाप की जांच और हृदय की निगरानी के लिए अपॉइंटमेंट न चूकें। सीने में दर्द, सांस लेने में कठिनाई, गंभीर सिरदर्द, दृष्टि में बदलाव, असामान्य रक्तस्राव या पैरों में सूजन होने पर तुरंत डॉक्टर से संपर्क करें।
💊 sutib 12.5 capsule Uses & Benefits
[{"condition":"Advanced renal cell carcinoma","description":"Used as a first-line or subsequent treatment for advanced kidney cancer that cannot be removed by surgery.","evidence":"Well-established"},{"condition":"Gastrointestinal stromal tumor after imatinib failure","description":"Used for a rare tumor of the stomach and bowel when another targeted medicine called imatinib no longer works or cannot be tolerated.","evidence":"Well-established"},{"condition":"Pancreatic neuroendocrine tumors","description":"Used for advanced pancreatic neuroendocrine tumors that are progressing and cannot be cured by surgery.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Other advanced solid tumors","description":"Sometimes studied or used in selected patients with other advanced cancers, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Advanced renal cell carcinoma
Also treats: Gastrointestinal stromal tumor, Pancreatic neuroendocrine tumors
📋 Drug Information
| Generic Name(s) | Sunitinib (12.5mg) |
| Brand Name | sutib 12.5 capsule |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep the capsules in their original container, tightly closed, and away from moisture and direct sunlight. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture. Check the expiry date on the pack. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a small-molecule tyrosine kinase inhibitor that blocks several receptor enzymes involved in cancer growth and blood vessel formation. By inhibiting these receptors, it reduces the supply of blood and nutrients to the tumor and slows the multiplication of cancer cells. This dual action helps control tumor growth in cancers that depend on these signaling pathways.
Mechanism Steps
💡 How to Take sutib 12.5 capsule
Strength: This medicine is available as a 12.5 mg immediate-release capsule for oral use.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 50 mg taken by mouth once daily for 4 weeks, followed by 2 weeks off, for kidney cancer and gastrointestinal stromal tumor. For pancreatic neuroendocrine tumors, the usual dose is 37.5 mg taken by mouth once daily without a planned break. This 12.5 mg capsule is a smaller strength that may be used to adjust the dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and side effects. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially heart problems, high blood pressure, and tiredness. Your doctor will monitor you closely and adjust the dose if needed. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is usually needed for mild to moderate kidney problems. This medicine has not been studied in patients with severe kidney problems or those on dialysis. Your doctor will decide if this medicine is suitable for you. |
| Hepatic Impairment | No dose adjustment is usually needed for mild to moderate liver problems. This medicine has not been studied in patients with severe liver problems. Your doctor will decide if this medicine is suitable for you and will monitor your liver function closely. |
| Maximum Daily Dose | The maximum daily dose is 50 mg for kidney cancer and gastrointestinal stromal tumor, and 37.5 mg for pancreatic neuroendocrine tumors. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sutib 12.5 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Moderate | |
| Amlodipine | Moderate | |
| St. John's wort | Major |
🚨 Major Interactions
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Strong CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin, and St. John's wort
⚡ Moderate Interactions
- Blood pressure medicines
- Blood thinners such as warfarin
🍷 Alcohol Interaction
Alcohol may worsen some side effects of this medicine, such as tiredness, dizziness, and stomach upset. It is best to avoid alcohol or limit it to very small amounts while taking this medicine. Talk to your doctor about what is safe for you.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to Sunitinib or any other ingredient in this medicine.","Pregnancy or planning to become pregnant.","Breastfeeding without talking to your doctor first."]
⚠️ Warnings & Precautions
["This medicine can cause serious heart problems. Tell your doctor if you have a history of heart disease.","This medicine can raise blood pressure. Check your blood pressure regularly and take medicines as prescribed.","This medicine can increase the risk of bleeding. Tell your doctor if you notice unusual bruising or bleeding.","This medicine can cause liver injury. Regular blood tests are needed.","This medicine can affect kidney function. Regular blood tests are needed.","This medicine can cause severe skin reactions. Tell your doctor about any rash.","This medicine can affect wound healing. Tell your doctor if you are planning surgery.","This medicine can cause tiredness and dizziness. Be careful when driving or operating machinery.","This medicine can interact with many other medicines. Always tell your doctor about all medicines you take.","Do not donate blood while taking this medicine and for several weeks after the last dose."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because it may harm a nursing infant, women should not breastfeed while taking this medicine and for at least 4 weeks after the last dose. Talk to your doctor about safe feeding options for your baby.
💊 Overdose Management
If you take too much of this medicine, contact your doctor or go to the nearest emergency room right away. Take the medicine bottle with you. Treatment is supportive, meaning doctors will manage your symptoms and monitor your vital signs. There is no specific antidote for an overdose of this medicine.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, call your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as your cancer specialist prescribes. Swallow the capsule whole with a glass of water, with or without food, at the same time each day. Do not open, crush, or chew the capsule. If you miss a dose, follow your doctor's instructions and never double the next dose. Avoid grapefruit and grapefruit juice because they can raise the level of this medicine in your body. Tell your doctor about all other medicines, vitamins, and herbal products you take, especially blood thinners, blood pressure medicines, and medicines that affect liver enzymes. Use effective contraception during treatment and for several weeks after the last dose. Do not breastfeed while taking this medicine. Keep all appointments for blood tests, blood pressure checks, and heart monitoring. Contact your doctor right away if you develop chest pain, shortness of breath, severe headache, vision changes, unusual bleeding, or swelling of the legs.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, especially heart problems, high blood pressure, and tiredness. Your doctor will monitor you closely and may adjust your dose. Regular blood tests and heart checks are important. Tell your doctor about all other medicines you take, as interactions are more common in older adults.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Both men and women should use effective contraception during treatment and for several weeks after the last dose. If you are planning to become pregnant, talk to your doctor before starting this medicine. Do not breastfeed while taking this medicine.
🏥 Post-Surgery Considerations
This medicine can affect wound healing and increase the risk of bleeding. Tell your surgeon and doctor that you are taking this medicine before any surgery. Your doctor may ask you to stop taking this medicine for a short time before and after surgery. Do not stop taking it without your doctor's advice.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental work. This medicine can increase the risk of bleeding and infection. Your dentist may recommend extra precautions. Do not stop taking this medicine without talking to your doctor first.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause tiredness, dizziness, and high blood pressure. Avoid strenuous exercise until you know how this medicine affects you. Light activities like walking are usually safe, but talk to your doctor before starting any new exercise program. If you feel chest pain, shortness of breath, or severe tiredness during exercise, stop and seek medical help.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, dizziness, and high blood pressure, which may affect your ability to drive or operate machinery. Avoid driving or using heavy machinery until you know how this medicine affects you. You may need to adjust your work schedule to accommodate treatment cycles and doctor visits. Talk to your employer about flexible working arrangements if needed. Many people are able to continue working during treatment with some modifications.
🛑 When to Stop This Medicine
Do not stop taking this medicine without talking to your doctor. Your doctor will decide when it is safe to stop based on your response to treatment, side effects, and overall health. If you experience severe side effects, your doctor may temporarily stop the medicine or reduce the dose. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to ongoing side effects such as tiredness, high blood pressure, thyroid problems, and skin changes. Regular monitoring of your heart, liver, kidneys, and blood counts is needed throughout treatment. Some side effects may improve after treatment ends, but others may require ongoing management. Your doctor will review your treatment regularly to decide if you should continue.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Ask your doctor if there are any clinical trials for your condition that may offer other treatment options.
Evidence: VariesPalliative care can help manage symptoms and improve quality of life alongside cancer treatment.
Evidence: Well-establishedA dietitian can help you maintain your strength and manage side effects like nausea and weight loss.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Talk to your doctor before receiving any vaccines while taking this medicine. Live vaccines should be avoided because this medicine can weaken your immune system. Inactivated vaccines may be safe but may not work as well. Your doctor can advise you on the best vaccination schedule.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a letter from your doctor explaining that you are taking this medicine for cancer treatment. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes. Store it at room temperature and away from direct sunlight. If you are crossing time zones, talk to your doctor about how to adjust your dosing schedule. Check the customs rules of your destination country for controlled or prescription medicines. Carry enough medicine for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working soon after you begin taking it, but it may take several weeks to months before any benefit is seen on scans or in symptoms. Your doctor will monitor your progress with regular tests.
A: Yes, you can take this medicine with or without food. However, avoid grapefruit and grapefruit juice, as they can increase the level of this medicine in your body.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
A: No, you should never stop taking this medicine without talking to your doctor first. Stopping suddenly can allow the cancer to grow again.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for several weeks after the last dose. If you are pregnant or think you may be pregnant, contact your doctor immediately.
🤔 Common Patient Concerns
🔄 Substitutes for sutib 12.5 capsule
View AllAlternative brands with exact same active ingredient:
-
sunixar 12.5 capsuleSun Pharmaceutical Industries Ltd ₹386.00 16.1% CHEAPER
-
nitnib 12.5 capsuleZydus Cadila ₹495.00 7.6% COSTLIER
-
Rcnet 12.5 CapsuleBDR Pharmaceuticals Internationals Pvt ₹495.00 7.6% COSTLIER
-
svitinib 12.5 capsuleMylan Pharmaceuticals Pvt Ltd ₹550.00 19.6% COSTLIER
-
sunitax 12.5 capsuleAureate Healthcare Pvt Ltd ₹750.00 63% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer completely.
Fact: This medicine can slow or stop cancer growth and help people live longer, but it is not a guaranteed cure. It is used to control advanced cancer. - Myth: This medicine is safe to take without regular blood tests.
Fact: This medicine can affect the heart, liver, kidneys, and blood counts. Regular blood tests and monitoring are essential for safe use. - Myth: You can stop taking this medicine whenever you feel better.
Fact: You should never stop taking this medicine without talking to your doctor. Stopping suddenly can allow the cancer to grow again. - Myth: This medicine is a type of chemotherapy.
Fact: This medicine is a targeted therapy, not traditional chemotherapy. It works differently by blocking specific enzymes that cancer cells need to grow.
🔄 Alternative Options
Generic Alternatives
- Sunitinib 12.5 mg capsule
Brand Alternatives
- Nitnib 12.5 capsule