sustrone 50mg injection - Testosterone Propionate (50mg/1ml) medicine

Testanon 50mg/1ml Injection: Comprehensive Medicine Guide

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🏭 Taj Pharma India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category This medicine is contraindicated in pregnancy. Testosterone and its esters can cause virilisation of a female fetus and are not recommended for use during pregnancy. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for male hypogonadism and delayed puberty; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Chest pain or shortness of breath
  • Sudden swelling or pain in the calf
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Prolonged painful erection
  • Severe allergic reaction with facial swelling
  • Unexplained weight gain or swelling

If experiencing severe symptoms, call emergency services immediately.

What is sustrone 50mg injection used for?

This medicine is a testosterone propionate injection used for testosterone replacement in men with hypogonadism and for delayed puberty in boys. It is given by intramuscular injection under medical supervision.

  • Generic Name: Testosterone Propionate (50mg/1ml)
  • Manufacturer: Taj Pharma India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 sustrone 50mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा टेस्टोस्टेरोन प्रोपियोनेट इंजेक्शन है, जिसका उपयोग पुरुषों में टेस्टोस्टेरोन की कमी (हाइपोगोनाडिज्म) के इलाज के लिए किया जाता है। यह किशोर लड़कों में देर से होने वाले यौवन को शुरू करने में भी मदद कर सकती है। यह दवा मांसपेशियों, हड्डियों और पुरुष यौन विशेषताओं को बनाए रखने में सहायक होती है। यह केवल डॉक्टर की सलाह और निगरानी में ही दी जानी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, सूजन, मुँहासे, तैलीय त्वचा, मनोदशा में बदलाव, और शरीर में पानी का जमाव शामिल हैं। गंभीर दुष्प्रभावों में रक्त के थक्के बनना, लीवर की समस्या, और हृदय की विफलता का बिगड़ना शामिल हो सकता है। महिलाओं में आवाज भारी होना और अत्यधिक बाल बढ़ना जैसे प्रभाव हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर की देखरेख में ही लेनी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को सभी दवाओं और स्वास्थ्य स्थितियों के बारे में बताएं। नियमित रूप से रक्त जांच, लीवर फंक्शन और प्रोस्टेट की जांच कराते रहें। गर्भवती या स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। किसी भी असामान्य लक्षण जैसे सीने में दर्द, सांस लेने में कठिनाई, या पैर में सूजन हो तो तुरंत डॉक्टर को बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 sustrone 50mg injection Uses & Benefits

[{"condition":"Male hypogonadism","description":"Used as testosterone replacement therapy in men with confirmed low testosterone due to primary or secondary hypogonadism.","evidence":"Well-established"},{"condition":"Delayed puberty in boys","description":"May be used to induce pubertal development in adolescent boys with delayed puberty, under specialist supervision.","evidence":"Well-established"},{"condition":"Advanced breast cancer in women","description":"Historically used as hormonal therapy in selected postmenopausal women with advanced breast cancer, now less common.","evidence":"Limited"},{"condition":"Cachexia or muscle wasting","description":"Sometimes considered to promote anabolism in selected patients with severe catabolic illness, though evidence is limited.","evidence":"Limited"}]

Off-label uses: [{"condition":"Male osteoporosis","description":"Occasionally used to support bone mineral density in hypogonadal men, but not a first-line therapy.","evidence":"Limited"},{"condition":"Anaemia of chronic disease","description":"May improve erythropoiesis in some hypogonadal patients, but not standard therapy.","evidence":"Limited"}]

Primary treatment for: Male hypogonadism

Also treats: Delayed puberty in boys, Advanced breast cancer in women, Cachexia

📋 Drug Information

Generic Name(s)Testosterone Propionate (50mg/1ml)
Brand Namesustrone 50mg injection
ManufacturerTaj Pharma India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassAndrogens
Route of AdministrationParenteral (intramuscular injection)
StorageStore in a cool, dry place away from direct sunlight. Do not freeze. Keep the vial in its original carton to protect from light. Store at room temperature (15-30°C).
Shelf LifeRefer to the expiry date on the packaging. Do not use after the expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Administer this medicine only under medical supervision; do not self-inject.
2
Monitor liver function, blood counts, and prostate health regularly during treatment.
3
Assess cardiovascular risk before starting and monitor for fluid retention.
4
In women, watch for signs of virilisation and discontinue if they occur.
5
In adolescents, monitor growth and bone age to avoid premature epiphyseal closure.
6
Advise patients to report any calf pain, chest pain, or breathing difficulty immediately.
7
Adjust dose based on clinical response and serum testosterone levels.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Low testosterone symptoms in men
This medicine is commonly prescribed for this.
Likely Use
✅
Delayed puberty in boys
This medicine may be used under specialist supervision.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered by intramuscular injection and is absorbed from the injection site into the bloodstream. The propionate ester is relatively short-acting compared with longer-chain testosterone esters.
DistributionTestosterone distributes widely into body tissues, including muscle, skin, prostate, and adipose tissue. It is highly bound to plasma proteins, mainly sex hormone-binding globulin and albumin.
Protein BindingApproximately 98% bound to plasma proteins, primarily sex hormone-binding globulin and albumin.
MetabolismTestosterone is metabolised in the liver, mainly by reduction and oxidation, to inactive metabolites including androsterone and etiocholanolone, with some conversion to dihydrotestosterone and estradiol in peripheral tissues.
Half-LifeThe elimination half-life of testosterone propionate is approximately 20 to 30 hours after intramuscular injection, though this can vary between individuals.
ExcretionMetabolites are excreted mainly in urine as glucuronide and sulfate conjugates, with a small amount in faeces.
BioavailabilityBioavailability is high after intramuscular injection because the first-pass hepatic metabolism is bypassed.
Onset of ActionOnset of clinical effects is gradual, with early hormonal effects within hours and noticeable clinical changes over days to weeks.
Peak Plasma TimePeak plasma testosterone levels typically occur within 24 to 48 hours after intramuscular injection.
Duration of ActionThe duration of action is relatively short for an injectable testosterone ester, usually requiring administration every 2 to 3 days or as directed by the clinician.

How It Works

Testosterone propionate is an esterified form of testosterone that acts as an agonist at androgen receptors. After injection, esterases release free testosterone, which enters target cells and binds to cytoplasmic androgen receptors. The receptor-ligand complex translocates to the nucleus and modulates gene transcription, leading to masculinising and anabolic effects in tissues such as muscle, bone, prostate, and skin. It also suppresses gonadotropin secretion through negative feedback on the hypothalamus and pituitary.

Mechanism Steps

1
Ester cleavage: After intramuscular injection, esterases in blood and tissues cleave the propionate ester to release free testosterone.
2
Androgen receptor binding: Free testosterone diffuses into target cells and binds to the cytoplasmic androgen receptor.
3
Nuclear translocation: The testosterone-receptor complex moves into the nucleus and binds to androgen response elements on DNA.
4
Gene transcription: This binding alters transcription of multiple genes, producing masculinising and anabolic effects.
5
Feedback suppression: Increased androgen levels suppress luteinising hormone and follicle-stimulating hormone secretion from the pituitary.

💡 How to Take sustrone 50mg injection

Strength: Injection: 50 mg per 1 mL

1This medicine is given by intramuscular injection by a healthcare professional.
2Do not self-administer unless trained and instructed by your doctor.
3The injection is usually given into a large muscle such as the buttock or thigh.
4Follow your doctor's schedule for injections; do not change the frequency without advice.
5Attend regular follow-up appointments for monitoring.

Dosage Information

Adult DosageThe dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, and clinical response. For male hypogonadism, typical regimens may involve intramuscular injections of 25 to 50 mg two to three times per week, but exact dosing varies. For delayed puberty, specialist guidance is required. Do not self-administer; this medicine is given by a healthcare professional.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more susceptible to fluid retention, cardiac effects, and prostate enlargement. Dose must be individualized by a qualified clinician with close monitoring.
Renal ImpairmentNo specific dose adjustment is established for renal impairment. Use with caution and monitor fluid balance and renal function.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary based on liver function tests. Consult a clinician.
Maximum Daily DoseNot established from the available information. The maximum dose must be determined by a qualified clinician based on the individual patient's needs and response.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
No specific timing required
This medicine is given by injection, so food timing does not affect it.
High-salt foods
Limit intake
May worsen fluid retention.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Contact your healthcare provider for guidance.
💡 Do not self-administer a missed dose without medical advice.
📌 More than half the dosing interval has passed
→ Skip the missed dose and resume your regular schedule.
💡 Do not double the dose to catch up.

⚠️ Side Effects of sustrone 50mg injection

✅ Common Side Effects

Injection site pain or swelling (Common (5-10%))
Apply a cold compress and avoid massaging the site. Consult a doctor if redness or swelling worsens.
Acne or oily skin (Common (5-10%))
Keep skin clean and use non-comedogenic products. Consult a dermatologist if severe.
Increased or decreased libido (Common (5-10%))
Discuss with your doctor if this becomes bothersome.
Mood changes (Common (5-10%))
Report persistent mood swings or irritability to your doctor.
Fluid retention (Common (5-10%))
Reduce salt intake and inform your doctor if swelling persists.

🚨 Serious Side Effects

Thromboembolic events (deep vein thrombosis, pulmonary embolism) (Rare (<0.1%))
Seek immediate medical attention if you experience calf pain, chest pain, or shortness of breath.
Severe liver injury (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain immediately.
Worsening of heart failure (Rare (<0.1%))
Contact your doctor if you notice increased swelling, weight gain, or breathing difficulty.
Prostate cancer progression (Rare (<0.1%))
Attend regular prostate monitoring as advised by your doctor.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care for rash, swelling of face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Priapism
Seek emergency medical attention for prolonged painful erection.
Hepatic peliosis
Report abdominal pain or unexplained bruising to your doctor.
Severe virilisation in women
Discuss with your doctor if you notice voice deepening or excessive hair growth.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Insulin Major
Corticosteroids Major
Cyclosporine Moderate
Oxyphenbutazone Moderate
Propranolol Minor

🚨 Major Interactions

  • Warfarin
  • Insulin
  • Corticosteroids

⚡ Moderate Interactions

  • Cyclosporine
  • Oxyphenbutazone

🍷 Alcohol Interaction

Alcohol may worsen liver toxicity and increase the risk of mood changes and fluid retention. It is advisable to avoid or minimise alcohol consumption while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known or suspected prostate cancer","Male breast cancer","Pregnancy or breastfeeding","Severe liver disease","Uncontrolled heart failure","Hypersensitivity to testosterone or any component of the formulation"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease, hypertension, or heart failure.","Monitor for thromboembolic events, especially in patients with risk factors.","May worsen sleep apnoea; evaluate if symptoms occur.","Can cause virilisation in women; discuss risks before use.","May accelerate bone maturation and cause premature epiphyseal closure in adolescents.","Regular monitoring of liver function, blood counts, and prostate health is required.","Avoid use in patients with a history of drug abuse or dependence."]

🤱 Lactation Safety

This medicine is not recommended during breastfeeding because it may pass into breast milk and affect the infant. Consult a doctor for alternative options.

💊 Overdose Management

Overdose may cause severe virilisation, fluid retention, or thromboembolic events. Treatment is supportive and symptomatic. Seek immediate medical attention if overdose is suspected. Do not attempt to manage at home.

⏰ Missed Dose

If you miss a dose, contact your healthcare provider for guidance. Do not double the dose to catch up. The dosing schedule for this medicine is usually determined by your doctor, and adjustments should only be made under medical supervision.

Additional Safety Advice

General Safety

This medicine must only be used under the supervision of a qualified clinician. Do not self-inject or adjust the dose without medical advice. Inform your doctor about all medicines, supplements, and herbal products you take, especially blood thinners, insulin, or corticosteroids. Regular monitoring of blood counts, liver function, prostate health in men, and lipid profile is important during treatment. Avoid sharing this medicine with anyone else. Pregnant or breastfeeding women must not handle or use this medicine. Report any calf pain, chest pain, breathing difficulty, or sudden vision changes immediately. Store the injection as directed and never use a damaged or expired vial. Keep all follow-up appointments so your doctor can assess benefits and risks.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of fluid retention, cardiac effects, and prostate enlargement. Close monitoring is required, and dose adjustments may be necessary.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated in pregnancy and should not be used by women planning to conceive. If you are planning pregnancy, consult your doctor to discuss safe alternatives.

🏥 Post-Surgery Considerations

Inform your surgeon and anaesthesiologist about this medicine before any surgery. It may affect fluid balance, blood clotting, and cardiovascular function during and after surgery.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may affect bleeding risk and wound healing.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce cardiovascular strain.
🥗
Engage in regular low-impact exercise as advised by your doctor.
😴
Avoid alcohol to reduce liver toxicity risk.
💧
Follow a balanced diet low in salt to manage fluid retention.
🧘
Get adequate sleep and manage stress.
🌞
Attend all follow-up appointments for monitoring.

🏋️ Exercise Considerations

Consult your doctor before starting any new exercise regimen. Avoid strenuous activities if you experience joint pain, swelling, or cardiovascular symptoms. Regular moderate exercise is generally beneficial but should be tailored to your condition.

🥗 Diet Recommendations

Limit high-salt foods to reduce fluid retention.
Include plenty of fruits and vegetables.
Choose lean proteins and whole grains.
Stay well hydrated unless advised otherwise.
Avoid excessive alcohol.

💼 Impact on Daily Work & Life

This medicine may cause mood changes, dizziness, or fluid retention that could affect your ability to drive or operate machinery. Avoid driving until you know how it affects you. Discuss any work-related concerns with your doctor.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects such as chest pain, breathing difficulty, or severe allergic reactions, seek immediate medical attention. Your doctor will determine if and when to discontinue treatment based on your response and monitoring results.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to increased red blood cell count, fluid retention, liver enzyme changes, and prostate enlargement. Regular monitoring of blood counts, liver function, and prostate health is essential. In adolescents, prolonged use can cause premature closure of growth plates. Women may experience irreversible virilising effects. Periodic review with your doctor is necessary to ensure safe continuation.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Regular exercise, healthy diet, and weight management can support testosterone levels and overall health.

Evidence: Well-established
Other testosterone formulations

Testosterone gels, patches, or longer-acting injections may be alternatives under medical guidance.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, inform your doctor about this medicine before receiving any vaccine, especially live vaccines, as your immune response may be affected.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not freeze

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in hand luggage if travelling by air. Store at room temperature and protect from light. Check customs regulations for controlled substances before travelling internationally. If crossing time zones, consult your doctor about adjusting injection timing.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with confirmed hypogonadism
He was prescribed this medicine by his endocrinologist after blood tests confirmed low testosterone. He received intramuscular injections two to three times per week. Over several weeks, he noticed improved energy, mood, and muscle strength. He attended regular follow-ups for blood tests and prostate checks.
💡 Lesson: Regular monitoring and adherence to the prescribed schedule are essential for safe and effective testosterone replacement.
👤 A 14-year-old boy with delayed puberty
He was referred to a pediatric endocrinologist who prescribed this medicine to induce puberty. The injections were given under supervision, and his growth and development were closely monitored. His parents were advised to report any behavioural changes or side effects.
💡 Lesson: In adolescents, testosterone therapy must be carefully monitored to avoid premature closure of growth plates and other adverse effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Clinical effects may begin within days to weeks, but full benefits may take several weeks to months. Your doctor will monitor your response.

Q: Is this medicine safe for long-term use?

A: Long-term use requires regular monitoring of liver function, blood counts, and prostate health. Your doctor will assess the benefits and risks periodically.

Q: Can women use this medicine?

A: This medicine is generally not recommended for women except in specific specialist settings, as it can cause virilising effects. It is contraindicated in pregnancy.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for sustrone 50mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a safe way to build muscle for bodybuilding.
    Fact: This medicine is a prescription drug for medical conditions and should not be used for bodybuilding without medical supervision due to serious health risks.
  • Myth: This medicine is safe to use during pregnancy.
    Fact: This medicine is contraindicated in pregnancy as it can harm the developing fetus.

🔄 Alternative Options

Generic Alternatives

  • Testosterone propionate injection (generic)

Brand Alternatives

  • Testanon 50mg/1ml injection

📊 Comparison with Similar Medicines

[{"medicine":"Testosterone propionate","strength":"50 mg/mL","route":"Intramuscular","half_life":"20-30 hours","frequency":"Every 2-3 days"},{"medicine":"Testosterone enanthate","strength":"100-250 mg/mL","route":"Intramuscular","half_life":"4-5 days","frequency":"Every 2-4 weeks"}]

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