Magnakof Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of face, lips, or throat
- Irregular or fast heartbeat
- Severe dizziness or fainting
- Inability to urinate
- Confusion or hallucinations
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is superhist 50 mg/2.5 mg/5 mg syrup used for?
This medicine is a combination of guaifenesin (expectorant) and chlorpheniramine maleate (antihistamine) used to relieve cough, nasal congestion, and allergic symptoms. It works by thinning mucus and blocking histamine. It is for short-term use and may cause drowsiness.
- Generic Name: Guaifenesin (50mg) + Chlorpheniramine Maleate (2.5mg)
- Manufacturer: Overseas Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 superhist 50 mg/2.5 mg/5 mg syrup के बारे में (Hindi Summary)
उपयोग: यह दवा गुआइफेनेसिन और क्लोरफेनिरामाइन मेलिएट का संयोजन है, जिसका उपयोग खांसी, नाक बंद होना, छींक आना और एलर्जी के लक्षणों से राहत के लिए किया जाता है। यह बलगम को पतला करके खांसी को आसान बनाती है और एलर्जी के कारण होने वाले लक्षणों को कम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुँह सूखना, चक्कर आना और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या दिल की धड़कन अनियमित हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। दवा लेने के बाद वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आपको ग्लूकोमा, प्रोस्टेट की समस्या, थायरॉइड या हृदय रोग है तो डॉक्टर को बताएं। 7 दिनों से अधिक उपयोग से पहले डॉक्टर से सलाह लें।
💊 superhist 50 mg/2.5 mg/5 mg syrup Uses & Benefits
[{"condition":"Productive cough associated with upper respiratory tract infections","description":"Helps loosen mucus and makes cough more productive, providing symptomatic relief.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, runny nose, and watery eyes due to allergic reactions.","evidence":"Well-established"},{"condition":"Common cold with cough and nasal congestion","description":"Provides temporary relief of cough and nasal symptoms.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Vasomotor rhinitis","description":"Sometimes used off-label for non-allergic rhinitis symptoms.","evidence":"Limited"}]
Primary treatment for: Cough and allergic rhinitis
Also treats: Common cold, Upper respiratory tract infection
📋 Drug Information
| Generic Name(s) | Guaifenesin (50mg) + Chlorpheniramine Maleate (2.5mg) |
| Brand Name | superhist 50 mg/2.5 mg/5 mg syrup |
| Manufacturer | Overseas Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Guaifenesin is an expectorant that increases the volume and reduces the viscosity of respiratory tract secretions, promoting ciliary action and making coughs more productive. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms such as sneezing, rhinorrhea, and lacrimation. It also has anticholinergic properties that contribute to dry mouth and urinary retention.
Mechanism Steps
💡 How to Take superhist 50 mg/2.5 mg/5 mg syrup
Strength: Each 5 mL syrup contains Guaifenesin 50 mg and Chlorpheniramine Maleate 2.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 5-10 mL (1-2 teaspoons) every 4-6 hours as needed, not to exceed 60 mL in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of chlorpheniramine, especially drowsiness and anticholinergic effects. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be needed in renal impairment. Consult your doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | For adults: maximum 60 mL in 24 hours. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of superhist 50 mg/2.5 mg/5 mg syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Alcohol | Major | |
| Benzodiazepines | Moderate | |
| Opioids | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Fluoxetine | Moderate | |
| Paroxetine | Moderate | |
| Atropine | Moderate | |
| Antihypertensives | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
⚡ Moderate Interactions
- Anticholinergics (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impair motor skills. Combining alcohol with chlorpheniramine can also increase the risk of respiratory depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to guaifenesin or chlorpheniramine","Narrow-angle glaucoma","Urinary retention","Severe liver disease","Acute asthma attack","MAO inhibitor therapy within 14 days"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of confusion and falls.","Do not use for chronic cough without medical evaluation.","Consult doctor if symptoms persist beyond 7 days or worsen."]
🤱 Lactation Safety
Chlorpheniramine may pass into breast milk and cause drowsiness in the infant. Guaifenesin is generally considered safe but consult your doctor before use during breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, anticholinergic effects, seizures, and respiratory depression. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1-2 hours of ingestion. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness. Inform your doctor if you have glaucoma, prostate enlargement, thyroid problems, or heart disease. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to drowsiness, confusion, and anticholinergic effects like urinary retention and constipation. Use with caution and lower doses may be needed.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are pregnant, planning pregnancy, or breastfeeding. The safety profile is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may interact with anesthetics and other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel drowsy or dizzy from this medicine. Light activity is fine if you feel well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also reduce alertness, so take caution during work.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if symptoms persist beyond 7 days, worsen, or if you experience severe side effects. Do not stop prescribed medications without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and increased anticholinergic effects. Regular monitoring of liver and kidney function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and relieve congestion.
Evidence: Well-establishedMoisturizes nasal passages and relieves congestion.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination timing if you are ill.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, continue your regular dosing schedule as prescribed. Check customs regulations for carrying medications. Keep it in your carry-on luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after taking a dose.
A: Consult your doctor before combining with other cold medicines to avoid overlapping ingredients and side effects.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for superhist 50 mg/2.5 mg/5 mg syrup
View AllAlternative brands with exact same active ingredient:
-
magnakof syrupMankind Pharma Ltd ₹42.18 34.6% CHEAPER
-
namiphylate-d syrupNamigo Pharma Pvt Ltd ₹80.00 24% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is for productive cough and allergic symptoms; it is not effective for all cough types. - Myth: It is safe to take this medicine for a long time.
Fact: Prolonged use without medical supervision is not recommended; consult a doctor if symptoms persist beyond 7 days.
🔄 Alternative Options
Generic Alternatives
- Guaifenesin + Chlorpheniramine Maleate syrup (generic)
Brand Alternatives
- Magnakof syrup