Iocef-CS 1.5gm Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe diarrhea with blood or mucus
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
- Unusual bleeding or bruising
- High fever with chills that does not improve
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is sulwak 1.5gm injection used for?
This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections of the lungs, urine, abdomen, skin, and blood. It works by killing bacteria and is given by a healthcare professional.
- Generic Name: Cefoperazone (1gm) + Sulbactam (0.5gm)
- Manufacturer: Waksmed Lifescience Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sulwak 1.5gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफोपेराज़ोन और सल्बैक्टम का संयोजन है, जिसे इंजेक्शन के रूप में दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे कि फेफड़ों का संक्रमण (निमोनिया), मूत्र मार्ग का संक्रमण, पेट का संक्रमण, त्वचा का संक्रमण, और खून का संक्रमण। यह दवा बैक्टीरिया को मारती है और केवल डॉक्टर की देखरेख में अस्पताल या क्लिनिक में ही दी जानी चाहिए। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, चकत्ते, खुजली, और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। कुछ लोगों को सिरदर्द, चक्कर आना, या मुँह में धातु जैसा स्वाद भी महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज एलर्जी प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर त्वचा प्रतिक्रिया, और खून की समस्या शामिल हो सकती है। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य कर्मियों द्वारा ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी के बारे में बताएं, खासकर पेनिसिलिन या सेफलोस्पोरिन एंटीबायोटिक्स से। अगर आपको किडनी या लीवर की बीमारी है, तो डॉक्टर को जरूर बताएं। इलाज के दौरान शराब का सेवन बिल्कुल न करें। बेहतर महसूस होने पर भी दवा का कोर्स पूरा करें। अपने सभी फॉलो-अप अपॉइंटमेंट समय पर लें ताकि डॉक्टर आपकी प्रगति की निगरानी कर सकें।
💊 sulwak 1.5gm injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat pneumonia and bronchitis caused by susceptible bacteria, especially when resistant organisms are suspected.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used for peritonitis, cholecystitis, and other abdominal infections, often in combination with other antibiotics or surgical drainage.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and endometritis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in bloodstream infections caused by susceptible Gram-negative and some Gram-positive bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used for bacterial meningitis when the causative organism is susceptible and the medicine can cross into the cerebrospinal fluid.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as part of empirical therapy in cancer patients with fever and low white blood cell counts, though other agents are often preferred.","evidence":"Limited"},{"condition":"Surgical prophylaxis","description":"Occasionally used before certain surgeries to prevent infection, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infection, Intra-abdominal infection, Skin infection, Septicemia, Gynecological infection
📋 Drug Information
| Generic Name(s) | Cefoperazone (1gm) + Sulbactam (0.5gm) |
| Brand Name | sulwak 1.5gm injection |
| Manufacturer | Waksmed Lifescience Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unopened vial at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Once reconstituted, the solution should be used within the time specified by the manufacturer, usually within 24 hours if stored at room temperature or up to 72 hours if refrigerated. Do not freeze. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. Do not use if the expiry date has passed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the synthesis of the bacterial cell wall. Cefoperazone binds to specific proteins called penicillin-binding proteins on the inner membrane of the bacterial cell, which stops the cross-linking of peptidoglycan strands. Without proper cross-linking, the bacterial cell wall becomes weak and cannot withstand the internal pressure of the cell, leading to cell lysis and death. Sulbactam is a beta-lactamase inhibitor that protects cefoperazone from being broken down by beta-lactamase enzymes produced by certain bacteria. By inactivating these enzymes, sulbactam extends the antibacterial spectrum of cefoperazone to include many beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take sulwak 1.5gm injection
Strength: Each vial contains cefoperazone sodium equivalent to 1 gram of cefoperazone and sulbactam sodium equivalent to 0.5 gram of sulbactam, total 1.5 grams. It is a sterile powder for injection.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 grams to 3 grams every 12 hours, given by intravenous or intramuscular injection. For severe infections, doses up to 12 grams per day may be used in divided doses. The exact dose and duration depend on the type and severity of the infection, the patient's kidney and liver function, and the doctor's judgment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, the dose for children is calculated based on body weight and the severity of the infection, but this must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney and liver function, which can affect how this medicine is cleared from the body. The dose may need to be adjusted based on kidney function tests. Elderly patients should be monitored closely for side effects, especially kidney problems and bleeding. |
| Renal Impairment | In patients with reduced kidney function, the dose of this medicine may need to be reduced or the dosing interval lengthened. This is because sulbactam is mainly excreted by the kidneys. Your doctor will adjust the dose based on your creatinine clearance. Regular monitoring of kidney function is recommended. |
| Hepatic Impairment | In patients with liver disease, the dose may need to be adjusted because cefoperazone is partly excreted in bile. If both liver and kidney function are impaired, dose reduction is usually necessary. Your doctor will determine the appropriate dose based on your liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 grams per day in divided doses for adults with normal kidney function. Doses above this are not recommended. The exact maximum dose must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sulwak 1.5gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Major | |
| Alcohol | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Vitamin K | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, amikacin)
- Loop diuretics (e.g., furosemide)
- Warfarin
- Alcohol
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
- Methotrexate
🍷 Alcohol Interaction
Alcohol should be completely avoided while receiving this medicine and for at least 72 hours after the last dose. Combining alcohol with this medicine can cause a disulfiram-like reaction, which includes flushing, severe nausea, vomiting, sweating, headache, and a rapid heartbeat. Alcohol can also increase the risk of liver problems and may worsen side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefoperazone, sulbactam, or any other cephalosporin or beta-lactam antibiotic","Previous severe allergic reaction to penicillin","Use in patients with a history of anaphylaxis to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Before starting treatment, tell your doctor about all your allergies, especially to antibiotics.","Use with caution in patients with kidney disease; dose adjustment may be needed.","Use with caution in patients with liver disease; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause false-positive results in certain urine glucose tests.","May increase the risk of bleeding when used with blood thinners.","Avoid alcohol during treatment.","Safety and effectiveness in children have not been fully established for all infections."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in human breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by healthcare professionals. If an overdose occurs, it may cause severe nausea, vomiting, diarrhea, and electrolyte imbalances. Treatment is supportive and symptomatic. There is no specific antidote. In case of accidental overdose, seek immediate medical attention. Hemodialysis may help remove the drug from the blood in severe cases.
⏰ Missed Dose
Because this medicine is given by a healthcare professional, missed doses are managed by the medical team. If you miss a scheduled dose, inform your nurse or doctor as soon as possible. They will adjust the schedule to ensure you receive the correct total dose. Do not try to self-administer extra doses to make up for a missed one.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional. Before receiving this medicine, tell your doctor about all your allergies, especially any allergy to penicillin or cephalosporin antibiotics. Inform your doctor if you have kidney disease, liver disease, or a history of bleeding problems. Do not breastfeed while receiving this medicine without consulting your doctor, as it may pass into breast milk. Avoid alcohol during treatment because it may worsen side effects and put extra stress on your liver. Do not stop treatment early even if you feel better, because incomplete treatment can allow the infection to return and may lead to resistance. If you miss a scheduled dose, inform the nursing staff or your doctor so that the schedule can be adjusted safely. Keep all follow-up appointments so your doctor can monitor your response and check for side effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney and liver function, which can affect how this medicine is cleared from the body. They may be more sensitive to side effects, especially kidney problems and bleeding. Close monitoring of kidney function and blood counts is recommended. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. This medicine is classified as Pregnancy Category B, but it should be used during pregnancy only if clearly needed. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. It is important to complete the prescribed course. If you have surgery while on this medicine, inform your surgeon and anesthesiologist. They will monitor you for any interactions with anesthesia or other medications.
🦷 Dental Procedures
If you have a dental procedure while on this medicine, inform your dentist. This medicine may increase the risk of bleeding, so your dentist should take precautions. Also, antibiotics can affect the balance of bacteria in your mouth, so maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered. Light activities like walking are fine if you feel up to it. If you experience dizziness or shortness of breath, stop and rest. Consult your doctor before resuming your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work during treatment. You may feel tired or have side effects like dizziness, so avoid driving or operating heavy machinery until you know how the medicine affects you. Once you are discharged, you may need a few days to regain your strength before returning to work.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your response to treatment and the type of infection. Stopping early can allow the infection to return and may lead to antibiotic resistance. If you experience severe side effects, your doctor may stop the medicine and switch you to another antibiotic.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to overgrowth of resistant bacteria or fungi, such as Candida infections. It may also cause changes in blood counts, liver enzymes, and kidney function. Prolonged use should be avoided unless necessary, and regular monitoring is required. If you need to use this medicine for more than 2 weeks, your doctor will monitor you closely for side effects and adjust the dose as needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria causing the infection, other antibiotics such as ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.
Evidence: Well-establishedFor abscesses or infected collections, surgical drainage may be needed in addition to antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live vaccines. If you need to receive a live vaccine, such as the oral typhoid vaccine, consult your doctor about the timing. In general, antibiotics do not interfere with most vaccines, but it is best to inform your doctor about all medicines you are taking before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Use reconstituted solution within the recommended time
❌ DON'T
Do not use if the solution is cloudy or has particles
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, it is usually given in a hospital setting, so travel is unlikely. However, if you are discharged and need to continue injections, carry the medicine in its original packaging with the prescription. Keep it at room temperature and protect it from extreme heat or cold. Carry a copy of your prescription and medical records. Check with the airline about carrying injectable medicines. If traveling across time zones, consult your doctor about adjusting the dosing schedule.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working soon after the first dose, but you may not feel better for 24 to 48 hours. It is important to complete the full course prescribed by your doctor.
A: No, this medicine is given by injection and must be administered by a healthcare professional in a hospital or clinic setting.
A: Tell your doctor or nurse about any side effects you experience. Do not try to treat them yourself without medical advice.
A: This medicine is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed and prescribed by your doctor.
A: This medicine passes into breast milk in small amounts. Consult your doctor before breastfeeding.
🤔 Common Patient Concerns
🔄 Substitutes for sulwak 1.5gm injection
View AllAlternative brands with exact same active ingredient:
-
Salbazone 1gm/0.5gm InjectionNV Lifecare Pvt Ltd ₹117.19 46.2% CHEAPER
-
cefobest-s 1gm/0.5gm injectionNectar Biopharma Pvt Limited ₹125.00 42.7% CHEAPER
-
Sizowin-S 1gm/0.5gm InjectionZenacts Pharma ₹163.00 25.2% CHEAPER
-
cefozen d 1gm/0.5gm injectionZentis Drugs Pvt Ltd ₹165.00 24.3% CHEAPER
-
iocef-cs 1.5gm injectionIncus Pharmaceuticals Pvt Ltd ₹215.63 1.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop this medicine as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor, even if you feel better, to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to take without a doctor's supervision.
Fact: This medicine is a prescription injectable antibiotic and must only be given by a healthcare professional. Self-medication is dangerous.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone and Sulbactam Injection
Brand Alternatives
- Iocef-CS 1.5gm Injection