Dimpizon-S 1gm/500mg Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or persistent diarrhea
- Blood in stool or vomit
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe skin rash or blistering
If experiencing severe symptoms, call emergency services immediately.
What is epojen injection used for?
This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections. It works by killing bacteria and preventing them from destroying the antibiotic. It is given by a healthcare professional in a hospital or clinic setting.
- Generic Name: Cefoperazone (1gm) + Sulbactam (500mg)
- Manufacturer: Jenfer Biosciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 epojen injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयोजन एंटीबायोटिक इंजेक्शन है जिसमें सेफोपेराज़ोन और सल्बैक्टम शामिल हैं। इसका उपयोग निमोनिया, मूत्र पथ के संक्रमण, त्वचा के संक्रमण, पेट के संक्रमण और रक्त के संक्रमण जैसे गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारती है और उन्हें एंटीबायोटिक को नष्ट करने से रोकती है। यह केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, मतली, उल्टी, पेट दर्द, दाने और इंजेक्शन की जगह पर दर्द या सूजन शामिल हैं। कुछ रोगियों को सिरदर्द, चक्कर आना या स्वाद में बदलाव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज एलर्जी, गंभीर त्वचा प्रतिक्रियाएं, रक्त विकार, यकृत या गुर्दे की समस्याएं और गंभीर दस्त शामिल हो सकते हैं। यदि आपको असामान्य रक्तस्राव, पीलिया, पेशाब में कमी या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, विशेष रूप से पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। इलाज के दौरान अपने रक्त, यकृत और गुर्दे की कार्यप्रणाली की निगरानी करवाएं। बेहतर महसूस होने पर भी इलाज बीच में न रोकें। शराब से बचें। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं।
💊 epojen injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat pneumonia and bronchitis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used for peritonitis, cholecystitis, and other abdominal infections.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in bloodstream infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and endometritis caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in immunocompromised patients with fever and low white blood cell counts.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used in some cases when other options are not suitable, but not a first-line agent.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Septicemia
📋 Drug Information
| Generic Name(s) | Cefoperazone (1gm) + Sulbactam (500mg) |
| Brand Name | epojen injection |
| Manufacturer | Jenfer Biosciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature (15-30°C) in a dry place, protected from light. After reconstitution, use immediately or store as directed by the manufacturer. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Cefoperazone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial cell death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, preventing them from destroying cefoperazone. This combination extends the antibacterial spectrum of cefoperazone to include many beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take epojen injection
Strength: Injection: Cefoperazone 1 gram + Sulbactam 500 milligrams per vial.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 to 2 grams of cefoperazone with 0.5 to 1 gram of sulbactam every 12 hours, administered intravenously or intramuscularly. The dose and frequency depend on the severity of the infection, the site of infection, and the patient's kidney and liver function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and may require dose adjustment. Dose must be individualized by a qualified clinician based on renal function. |
| Renal Impairment | In patients with reduced kidney function (creatinine clearance less than 30 mL/min), dose adjustment may be necessary. Monitor kidney function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with severe liver disease, dose adjustment may be needed. Monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is typically 4 grams of cefoperazone and 2 grams of sulbactam, but this may vary based on the severity of infection and clinical judgment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of epojen injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Probenecid | Moderate | |
| Gentamicin | Moderate | |
| Furosemide | Moderate | |
| Alcohol | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Warfarin
- Probenecid
- Aminoglycosides (e.g., gentamicin)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine and for at least 72 hours after the last dose, as it may cause a disulfiram-like reaction with symptoms such as flushing, nausea, vomiting, and headache.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to penicillins or cephalosporins","Previous anaphylactic reaction to beta-lactam antibiotics","Use in patients with a history of serious beta-lactam-associated allergic reactions"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of penicillin allergy.","May cause Clostridioides difficile-associated diarrhea; monitor for severe diarrhea.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","May cause false-positive results in certain urine glucose tests.","Avoid alcohol during treatment due to disulfiram-like reactions."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine. The benefits may outweigh risks in some cases.
💊 Overdose Management
Overdose may cause severe gastrointestinal symptoms, seizures, or other neurological effects. Treatment is supportive and symptomatic. Hemodialysis may be considered in severe cases. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for instructions. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a hospital or clinic setting. Inform your doctor about all your allergies, especially to penicillins or cephalosporins, before receiving this medicine. Tell your doctor about all other medicines you are taking, including blood thinners, probenecid, and other antibiotics. Your doctor may monitor your blood counts, liver function, and kidney function during treatment. Do not stop treatment early even if you feel better, as this can lead to resistant infections. Avoid alcohol during treatment. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before receiving this medicine. Keep all follow-up appointments and report any new symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and may require dose adjustment. They are also at higher risk of side effects. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, inform your doctor before receiving this medicine. The safety of this medicine in pregnancy is not well established. Use only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. It is often given before or during surgery. Follow your surgeon's instructions regarding its use.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used to prevent infection after dental procedures in certain cases. However, it is not routinely prescribed for dental infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may feel weak or dizzy while on this medicine. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so it may require hospitalization or frequent visits. You may need to take time off work to recover. Avoid driving or operating machinery if you feel dizzy or weak.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to recurrence of infection and antibiotic resistance. Your doctor will decide when to stop based on your clinical response.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, blood, liver, or kidney problems. It is usually prescribed for a short duration. Regular monitoring of blood counts, liver, and kidney function is advised during prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and sensitivity, other antibiotics like ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.
Evidence: Well-establishedRest, hydration, and fever control are important adjuncts to antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interact with vaccines. However, if you are acutely ill, vaccination may be postponed until you recover. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medicine as directed. Inform your doctor if you plan to travel to areas with high risk of infections.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after administration, but you may not feel better for 24 to 48 hours. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Inform your doctor before receiving this medicine. It may still be used with caution if necessary, but close monitoring is required.
🤔 Common Patient Concerns
🔄 Substitutes for epojen injection
View AllAlternative brands with exact same active ingredient:
-
cefones s injectionFitwel Pharmaceuticals Private Limited ₹160.00 387.7% COSTLIER
-
zobeta 1gm/500mg injectionStallion Laboratories Pvt Ltd ₹175.00 433.4% COSTLIER
-
magnamax s 1gm/500mg injectionApus Life Pvt Ltd ₹182.81 457.2% COSTLIER
-
sepraz 1.5gm injectionNimbus Health Care Pvt Ltd ₹182.81 457.2% COSTLIER
-
varpraz-s injectionVarenyam Healthcare Pvt Ltd ₹185.63 465.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone + Sulbactam injection
Brand Alternatives
- Dimpizon-S 1gm/500mg injection