Avspas 20mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is subospas 20mg/250mg tablet used for?
This medicine is a combination of dicyclomine and mefenamic acid used to relieve abdominal cramps and pain associated with irritable bowel syndrome and menstrual cramps. It works by relaxing gut muscles and reducing inflammation.
- Generic Name: Dicyclomine (20mg) + Mefenamic Acid (250mg)
- Manufacturer: Prime Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 subospas 20mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेट की ऐंठन, दर्द और सूजन को कम करने के लिए इस्तेमाल की जाती है। यह डिसाइक्लोमिन और मेफेनैमिक एसिड का संयोजन है। यह इरिटेबल बाउल सिंड्रोम (IBS), मासिक धर्म के दर्द, और पेट की मरोड़ में राहत देती है। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, चक्कर आना, नींद आना, जी मिचलाना, कब्ज और पेट दर्द शामिल हैं। गंभीर दुष्प्रभावों में पेट में खून आना, अल्सर, किडनी की समस्या, और एलर्जी प्रतिक्रिया हो सकती है। अगर काला मल, खून की उल्टी, तेज पेट दर्द, या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खाने के साथ लें ताकि पेट खराब न हो। शराब न पिएं। अगर नींद या चक्कर आए तो वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दूसरी दर्द निवारक दवाओं के साथ न लें।
💊 subospas 20mg/250mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Helps relieve abdominal cramps and pain associated with IBS by reducing smooth muscle spasms and inflammation.","evidence":"Well-established"},{"condition":"Menstrual cramps (dysmenorrhea)","description":"Reduces pain and inflammation associated with menstrual periods.","evidence":"Well-established"},{"condition":"Gastrointestinal spasms","description":"Used to relieve spasms in conditions like gastroenteritis, diverticulitis, and biliary colic.","evidence":"Moderate"},{"condition":"Abdominal pain due to functional bowel disorders","description":"Provides symptomatic relief of cramping and discomfort.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for preventing migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Urinary tract spasms","description":"Occasionally used to relieve bladder spasms, but not a standard indication.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome
Also treats: Menstrual cramps, Gastrointestinal spasms, Functional bowel disorders
📋 Drug Information
| Generic Name(s) | Dicyclomine (20mg) + Mefenamic Acid (250mg) |
| Brand Name | subospas 20mg/250mg tablet |
| Manufacturer | Prime Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Dicyclomine is an anticholinergic and antispasmodic agent that blocks muscarinic acetylcholine receptors in the gastrointestinal smooth muscle, leading to relaxation and relief of spasms. Mefenamic acid is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combination provides both antispasmodic and anti-inflammatory effects, targeting abdominal pain and cramps.
Mechanism Steps
💡 How to Take subospas 20mg/250mg tablet
Strength: Tablet containing dicyclomine 20 mg and mefenamic acid 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times a day, preferably with food. The exact dose and duration depend on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially anticholinergic effects and gastrointestinal bleeding. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (dicyclomine 40 mg + mefenamic acid 500 mg) in divided doses, but this may vary based on clinical judgment. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of subospas 20mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Anticholinergics | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Anticholinergic drugs (e.g., atropine, antihistamines)
- Lithium
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics
- Corticosteroids
- SSRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen drowsiness and dizziness caused by dicyclomine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers","Severe kidney disease","Severe liver disease","Known allergy to dicyclomine, mefenamic acid, or other NSAIDs","Third trimester of pregnancy","Patients with myasthenia gravis","Patients with obstructive uropathy","Patients with paralytic ileus","Severe heart failure"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of side effects.","Avoid in patients with a history of gastrointestinal bleeding.","Use with caution in patients with asthma, as NSAIDs may precipitate bronchospasm.","Do not use for more than 7 days without medical advice.","May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol consumption.","Consult doctor before use in pregnancy or breastfeeding.","May interact with other medications; inform your doctor about all medicines you take."]
🤱 Lactation Safety
Dicyclomine may pass into breast milk and could cause anticholinergic effects in the infant. Mefenamic acid also passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe drowsiness, dry mouth, flushing, rapid heartbeat, nausea, vomiting, and abdominal pain. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and drowsiness. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, asthma, or bleeding disorders. Do not take other pain relievers or anti-inflammatory drugs without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects such as confusion, dry mouth, constipation, and gastrointestinal bleeding. Use with caution and lower doses may be needed. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally avoided during pregnancy, especially in the third trimester, due to potential risks to the fetus.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may increase the risk of bleeding and interfere with healing.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy. Mild to moderate exercise like walking may help with digestion and overall well-being.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also cause dry mouth, so keep water handy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or if your symptoms do not improve within 7 days. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, and liver damage. Regular monitoring of kidney and liver function is advised. It should be used for the shortest duration necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedAvoiding trigger foods can reduce IBS symptoms.
Evidence: Well-establishedYoga, meditation, and counseling can help reduce stress-related symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Consult your doctor for routine vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving symptoms within 1-2 hours after taking it.
A: It is best taken with food or milk to reduce stomach upset.
A: Consult your doctor. It is generally avoided in the third trimester.
A: Avoid other NSAIDs as they increase the risk of bleeding and ulcers.
🤔 Common Patient Concerns
🔄 Substitutes for subospas 20mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
-
dimef 20mg/250mg tabletSymet Drugs Ltd ₹13.13 7.3% CHEAPER
-
mefsun spas 20mg/250mg tabletSunrise Remedies Pvt Ltd ₹13.78 2.7% CHEAPER
-
cyclofen 20 mg/250 mg tabletBiochem Pharmaceutical Industries ₹14.37 1.5% COSTLIER
-
meftace 20mg/250mg tabletStanford Biotech Pvt Ltd ₹14.58 3% COSTLIER
-
spasmocare 20mg/250mg tabletBiocare Remedies ₹15.94 12.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure irritable bowel syndrome.
Fact: It provides symptomatic relief but does not cure the underlying condition. - Myth: It is safe to take for long periods without monitoring.
Fact: Long-term use requires medical supervision due to risks of kidney, liver, and gastrointestinal problems. - Myth: It can be taken with other painkillers.
Fact: Combining with other NSAIDs increases the risk of bleeding and ulcers.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine + Mefenamic Acid combination generics