strumedin-p tablet - Gabapentin (300mg) + Nortriptyline (10mg) medicine

Gabaneuron NT Tablet: A Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Rostrumed Biotech Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for neuropathic pain based on clinical experience and studies of individual components.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Thoughts of self-harm or suicide
  • Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
  • Irregular heartbeat or palpitations
  • Severe dizziness or fainting
  • Confusion or hallucinations
  • Yellowing of skin or eyes (jaundice)
  • Decreased urine output or inability to urinate

If experiencing severe symptoms, call emergency services immediately.

What is strumedin-p tablet used for?

This medicine is a combination of gabapentin and nortriptyline used to treat neuropathic pain. It works by reducing abnormal nerve signals and enhancing pain inhibition in the brain. It is taken orally, usually once or twice daily, and should not be stopped suddenly.

  • Generic Name: Gabapentin (300mg) + Nortriptyline (10mg)
  • Manufacturer: Rostrumed Biotech Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 strumedin-p tablet के बारे में (Hindi Summary)

उपयोग: यह दवा गैबापेंटिन और नॉर्ट्रिप्टिलाइन का संयोजन है, जिसका उपयोग न्यूरोपैथिक दर्द (तंत्रिका दर्द) के इलाज के लिए किया जाता है। यह मधुमेह से होने वाले तंत्रिका दर्द, दाद के बाद होने वाले दर्द, और अन्य तंत्रिका संबंधी दर्द में प्रभावी है। यह दर्द को कम करने और मूड को बेहतर बनाने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि, कब्ज और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको आत्महत्या के विचार, तेज़ धड़कन, या गंभीर एलर्जी हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। दवा लेते समय वाहन चलाने या मशीनरी चलाने से बचें, क्योंकि इससे नींद और चक्कर आ सकते हैं। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 strumedin-p tablet Uses & Benefits

[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, shooting, and tingling pain in the feet and hands caused by diabetes-related nerve damage.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It reduces the persistent, often severe pain that can linger after a shingles outbreak.","evidence":"Well-established"},{"condition":"Neuropathic pain of mixed origin","description":"Used for chronic nerve pain due to various causes, such as spinal cord injury or chemotherapy-induced neuropathy.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed to prevent migraines, though not FDA-approved for this use.","evidence":"Limited"},{"condition":"Chronic musculoskeletal pain","description":"Occasionally used for pain that has a neuropathic component, but evidence is not strong.","evidence":"Limited"}]

Primary treatment for: Neuropathic pain

Also treats: Diabetic neuropathy, Postherpetic neuralgia, Chronic musculoskeletal pain with neuropathic component

📋 Drug Information

Generic Name(s)Gabapentin (300mg) + Nortriptyline (10mg)
Brand Namestrumedin-p tablet
ManufacturerRostrumed Biotech Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at bedtime initially to minimize daytime drowsiness.
2
Do not stop this medicine abruptly; always taper under medical supervision.
3
Avoid alcohol and other CNS depressants while on this medicine.
4
Monitor for mood changes or suicidal thoughts, especially in young adults.
5
Inform your doctor if you have kidney or liver problems before starting this medicine.
6
Use caution while driving or operating machinery until you know how this medicine affects you.
7
Keep all follow-up appointments to monitor your response and adjust the dose if needed.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Burning or shooting nerve pain
This medicine is commonly prescribed for this.
Likely Use
✅
Tingling or numbness in hands/feet
This medicine can help with neuropathic pain.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not for ordinary headaches.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGabapentin is absorbed from the gastrointestinal tract via a saturable transport mechanism, with bioavailability decreasing as the dose increases. Nortriptyline is well absorbed from the gastrointestinal tract. Food does not significantly affect the absorption of either component.
DistributionGabapentin distributes widely throughout the body, including the central nervous system, but does not bind significantly to plasma proteins. Nortriptyline is highly lipophilic and distributes extensively into tissues, including the brain.
Protein BindingGabapentin is less than 3% bound to plasma proteins. Nortriptyline is approximately 90-95% bound to plasma proteins, primarily albumin.
MetabolismGabapentin is not metabolized by the liver and is excreted unchanged by the kidneys. Nortriptyline is metabolized in the liver primarily by CYP2D6 and CYP1A2 enzymes into active and inactive metabolites.
Half-LifeThe elimination half-life of gabapentin is approximately 5-7 hours in patients with normal renal function. The elimination half-life of nortriptyline ranges from 16 to 40 hours, with an average of about 25 hours.
ExcretionGabapentin is excreted unchanged in the urine. Nortriptyline and its metabolites are excreted primarily in the urine and to a lesser extent in feces.
BioavailabilityThe bioavailability of gabapentin is dose-dependent, ranging from about 60% at 300 mg to 33% at 1600 mg. Nortriptyline has a bioavailability of approximately 50-60% due to first-pass metabolism.
Onset of ActionPain relief from this medicine is not immediate; it may take several days to weeks of regular use to notice significant improvement.
Peak Plasma TimeGabapentin reaches peak plasma concentrations within 2-3 hours after oral administration. Nortriptyline reaches peak plasma concentrations within 7-8 hours.
Duration of ActionThe analgesic effect of this medicine is sustained with regular dosing, but the duration of action for a single dose is not well-defined due to the need for steady-state levels.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system, reducing the release of excitatory neurotransmitters and dampening abnormal pain signaling. Nortriptyline, a tricyclic antidepressant, inhibits the reuptake of serotonin and norepinephrine in the brain and spinal cord, which enhances descending pain inhibition and helps modulate pain perception. Together, they provide a synergistic effect in managing neuropathic pain.

Mechanism Steps

1
Gabapentin binding: Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels on presynaptic neurons, reducing calcium influx and subsequent release of pain neurotransmitters.
2
Nortriptyline reuptake inhibition: Nortriptyline blocks the reuptake of serotonin and norepinephrine, increasing their availability in the synaptic cleft and enhancing descending pain inhibitory pathways.
3
Synergistic analgesia: The combined actions reduce abnormal pain signaling and improve pain tolerance, leading to relief in neuropathic pain conditions.

💡 How to Take strumedin-p tablet

Strength: Each tablet contains Gabapentin 300 mg and Nortriptyline 10 mg.

1Take this medicine by mouth with or without food.
2Swallow the tablet whole with a glass of water.
3Do not crush, chew, or break the tablet unless your doctor advises.
4Take it at the same time each day to maintain consistent levels.
5If you experience stomach upset, take it with a meal or snack.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on your response and tolerability. It is important to follow your doctor's prescription exactly. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and anticholinergic effects. Start with a lower dose and titrate slowly. Renal function should be assessed before initiating therapy, and dose adjustments may be necessary.
Renal ImpairmentGabapentin requires dose reduction in patients with impaired renal function. For creatinine clearance 30-59 mL/min, the maximum daily dose is 600 mg; for 15-29 mL/min, 300 mg; for <15 mL/min, 150 mg. Nortriptyline does not require renal dose adjustment, but caution is advised. Consult your doctor for personalized dosing.
Hepatic ImpairmentNortriptyline should be used with caution in patients with hepatic impairment; dose reduction may be necessary. Gabapentin does not undergo hepatic metabolism, so no adjustment is needed for hepatic impairment alone. Consult your doctor.
Maximum Daily DoseThe maximum daily dose of this medicine is generally 2 tablets (600 mg gabapentin + 20 mg nortriptyline) per day, but this may vary based on individual patient factors. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with or without food
Food does not significantly affect absorption, but taking with food may reduce stomach upset.
Grapefruit
Avoid
May increase nortriptyline levels by inhibiting CYP3A4.
Alcohol
Avoid
Increases sedation and impairs psychomotor performance.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of strumedin-p tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery until you know how it affects you. If persistent, consult your doctor.
Dizziness (Common (10-20%))
Rise slowly from sitting or lying positions. Report if severe or persistent.
Dry mouth (Common (10-20%))
Sip water frequently, chew sugar-free gum, or use saliva substitutes.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Consult doctor if it persists.
Weight gain (Common (5-10%))
Monitor weight and maintain a balanced diet. Consult a dietitian if needed.

🚨 Serious Side Effects

Suicidal thoughts or behavior (Rare (<0.1%))
Seek immediate medical help if you experience any thoughts of self-harm.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you have swelling of face, lips, throat, or difficulty breathing.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, chest pain, or shortness of breath.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop the medicine and seek emergency care if you develop a rash with blisters or peeling skin.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis)
Report any signs of infection, fever, or unusual bleeding to your doctor immediately.
Liver enzyme elevation
Regular liver function tests may be needed. Report yellowing of eyes or skin.
Hyponatremia (low sodium)
Report symptoms like confusion, headache, or seizures.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
Opioids Major
Benzodiazepines Major
Alcohol Major
CYP2D6 inhibitors Moderate
Anticholinergics Moderate
Sympathomimetics Moderate
Antacids Minor
Cimetidine Minor
Warfarin Moderate

🚨 Major Interactions

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • CNS depressants (e.g., opioids, benzodiazepines, alcohol)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., antihistamines, antipsychotics)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • Sympathomimetic drugs (e.g., pseudoephedrine)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can enhance the sedative effects of both gabapentin and nortriptyline, leading to increased drowsiness, dizziness, and impaired judgment. It may also worsen depression and increase the risk of central nervous system depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to gabapentin, nortriptyline, or any component of the formulation","Use of MAO inhibitors within the past 14 days","Uncontrolled narrow-angle glaucoma","Acute recovery phase after myocardial infarction","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["May cause drowsiness and dizziness; avoid driving or operating machinery until effects are known.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","May increase risk of suicidal thoughts and behaviors; monitor closely, especially in young adults.","Use with caution in patients with a history of seizures, as both drugs can affect seizure threshold.","Can cause anticholinergic effects; use with caution in patients with benign prostatic hyperplasia or urinary retention.","May impair cognitive and motor function; supervise elderly patients.","Avoid alcohol and other CNS depressants.","Consult doctor before use in pregnancy, lactation, or if planning pregnancy."]

🤱 Lactation Safety

Gabapentin and nortriptyline are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.

💊 Overdose Management

Overdose of this medicine can cause severe drowsiness, confusion, tachycardia, hypotension, cardiac arrhythmias, and respiratory depression. Seek immediate medical attention. Treatment is supportive and symptomatic, including gastric lavage if recent ingestion, activated charcoal, and monitoring of vital signs and cardiac rhythm. There is no specific antidote. Hemodialysis may be considered for gabapentin overdose in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms such as anxiety, insomnia, and nausea. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and dizziness. Do not consume alcohol while taking this medicine, as it can increase sedation and impair your ability to think clearly. Inform your doctor about all other medications you are taking, especially MAOIs, as dangerous interactions can occur. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and anticholinergic effects. They may also have reduced renal function, requiring dose adjustment. Close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Both gabapentin and nortriptyline may pose risks to the fetus. Your doctor will weigh the benefits and risks and may consider alternative treatments.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and increase sedation. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it can cause dry mouth and increase the risk of dental problems. It may also interact with local anesthetics or sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on nerves.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice relaxation techniques to manage chronic pain.
💧
Get adequate sleep to help your body recover.
🧘
Avoid smoking and limit caffeine intake.
🌞
Join a support group for chronic pain management.

🏋️ Exercise Considerations

This medicine can cause drowsiness and dizziness, so avoid activities that require alertness, such as heavy lifting or high-impact exercises, until you know how it affects you. Gentle stretching and walking are generally safe.

🥗 Diet Recommendations

Include foods rich in omega-3 fatty acids, such as fish and flaxseeds.
Eat plenty of fruits and vegetables for antioxidants.
Stay hydrated to help with dry mouth and constipation.
Limit processed foods and added sugars.
Consider a balanced diet to manage weight.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. It may also impact concentration. Discuss with your employer if you need accommodations. Avoid driving until you know how the medicine affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to discontinue, they will gradually reduce the dose to prevent withdrawal symptoms. Seek immediate medical attention if you have suicidal thoughts or severe allergic reactions.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of renal and hepatic function, as well as mood and suicidal ideation. Some patients may develop tolerance or dependence. Regular follow-up with your doctor is essential to assess the continued benefit and adjust the dose. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Cognitive behavioral therapy

Helps manage chronic pain and associated depression.

Evidence: Moderate
Transcutaneous electrical nerve stimulation (TENS)

May provide additional pain relief for some patients.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations regarding controlled substances, as some countries may have restrictions.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with diabetic neuropathy
He had been suffering from burning pain in his feet for years. His doctor prescribed this medicine. After 3 weeks, he noticed a significant reduction in pain, especially at night. He experienced mild drowsiness initially, which improved after a few days. He was advised to take it at bedtime.
💡 Lesson: Consistent use and taking the medicine at bedtime can improve tolerability and sleep quality.
👤 A 62-year-old woman with postherpetic neuralgia
After a shingles outbreak, she had persistent shooting pain in her chest. This medicine was added to her regimen. She found relief within a month, but experienced dry mouth and constipation. Her doctor advised increased fluid intake and fiber, which helped manage these side effects.
💡 Lesson: Side effects can often be managed with simple lifestyle adjustments; report them to your doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It may take several days to weeks to notice significant pain relief. Continue taking it as prescribed and follow up with your doctor.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop suddenly. Always consult your doctor before stopping, as abrupt discontinuation can cause withdrawal symptoms.

Q: Is it safe to take with other painkillers?

A: Consult your doctor before combining with other painkillers, as interactions may occur.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for strumedin-p tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a simple painkiller for any type of pain.
    Fact: This medicine is specifically for neuropathic pain and is not effective for ordinary headaches or muscle pain.
  • Myth: You can stop taking this medicine as soon as you feel better.
    Fact: Stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision.
  • Myth: This medicine is addictive.
    Fact: Gabapentin and nortriptyline are not considered addictive in the traditional sense, but they can cause dependence if misused. Follow your doctor's instructions.

🔄 Alternative Options

Generic Alternatives

  • Gabapentin 300 mg + Nortriptyline 10 mg tablets from other manufacturers

Brand Alternatives

  • Gabaneuron NT Tablet (Aristo Pharmaceuticals Pvt Ltd)

📊 Comparison with Similar Medicines

[{"medicine":"Gabapentin + Nortriptyline","composition":"Gabapentin 300 mg + Nortriptyline 10 mg","uses":"Neuropathic pain","notes":"Combination provides synergistic analgesia."},{"medicine":"Gabapentin alone","composition":"Gabapentin 300 mg","uses":"Neuropathic pain, epilepsy","notes":"May be less effective for mood component."},{"medicine":"Nortriptyline alone","composition":"Nortriptyline 10 mg","uses":"Neuropathic pain, depression","notes":"May cause more anticholinergic side effects."}]

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