Ranolazine 500 mg Sustained-Release Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fainting or loss of consciousness
- Fast, irregular, or pounding heartbeat
- Severe dizziness or lightheadedness
- Swelling of face, lips, or throat
- Difficulty breathing or chest tightness
- Yellowing of skin or eyes
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is stozina 500mg tablet used for?
This medicine is a sustained-release tablet containing Ranolazine 500 mg, used to treat chronic stable angina by reducing the frequency of chest pain attacks. It works by inhibiting the late sodium current in heart cells, improving oxygen balance without significantly lowering heart rate or blood pressure. It is not for immediate relief of an acute angina attack.
- Generic Name: Ranolazine (500mg)
- Manufacturer: Katzung Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stozina 500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रैनोलाज़िन 500 मिलीग्राम का एक सस्टेन्ड-रिलीज़ टैबलेट है, जिसका उपयोग पुरानी स्थिर एंजाइना (दिल की धमनियों में रक्त के प्रवाह में कमी के कारण होने वाले सीने के दर्द) के हमलों की आवृत्ति को कम करने के लिए किया जाता है। यह दिल की मांसपेशियों में सोडियम और कैल्शियम के असंतुलन को कम करके दिल की मांसपेशियों के तनाव और ऑक्सीजन की मांग को घटाती है। यह दवा दिल की धड़कन या रक्तचाप को बहुत कम नहीं करती, इसलिए उन रोगियों के लिए उपयोगी है जो अन्य दवाओं को सहन नहीं कर पाते। यह दवा तीव्र एंजाइना हमले के तत्काल उपचार के लिए नहीं है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, कब्ज, जी मिचलाना और कमजोरी शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के अभ्यस्त होने पर कम हो सकते हैं। कुछ लोगों को धड़कन तेज होना, धुंधली दृष्टि या कानों में घंटी बजना महसूस हो सकता है। गंभीर लेकिन दुर्लभ दुष्प्रभावों में बेहोशी, तेज या अनियमित दिल की धड़कन और निम्न रक्तचाप के लक्षण शामिल हैं। यदि आपको चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई या गंभीर त्वचा प्रतिक्रिया हो, तो तुरंत आपातकालीन चिकित्सा सहायता लें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें, आमतौर पर दिन में दो बार भोजन के साथ या बिना। सस्टेन्ड-रिलीज़ टैबलेट को चबाएं या तोड़ें नहीं, इसे पूरा निगल लें। इस दवा के साथ अंगूर का रस न पिएं क्योंकि इससे दवा का स्तर बढ़ सकता है और दुष्प्रभावों का खतरा बढ़ सकता है। कोई भी अन्य दवा, जड़ी-बूटी या सप्लीमेंट शुरू या बंद करने से पहले अपने डॉक्टर से सलाह लें। यदि आपको लीवर या किडनी की समस्या, दिल की धड़कन की गड़बड़ी या लंबे क्यूटी सिंड्रोम का इतिहास है, तो अपने डॉक्टर को बताएं। इस दवा से चक्कर आ सकते हैं, इसलिए तब तक वाहन न चलाएं जब तक आपको इसका असर पता न चल जाए। तीव्र एंजाइना हमले के लिए इस दवा का उपयोग न करें।
💊 stozina 500mg tablet Uses & Benefits
[{"condition":"Chronic stable angina pectoris","description":"This medicine is used to reduce the frequency of angina attacks in adults with chronic stable angina who remain symptomatic despite other anti-anginal therapies.","evidence":"Well-established"},{"condition":"Microvascular angina","description":"Sometimes prescribed for chest pain due to small vessel disease of the heart when standard treatments are not effective.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diabetic neuropathy pain","description":"Occasionally used off-label for nerve pain in diabetes, but evidence is limited and it is not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Chronic stable angina pectoris
Also treats: Microvascular angina, Coronary artery disease
📋 Drug Information
| Generic Name(s) | Ranolazine (500mg) |
| Brand Name | stozina 500mg tablet |
| Manufacturer | Katzung Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Late Sodium channel blocker- angina |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, and protect from light and moisture. |
| Shelf Life | The shelf life is not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the late inward sodium current in cardiac myocytes. By blocking this current, it reduces intracellular sodium accumulation, which in turn decreases calcium overload through the sodium-calcium exchanger. This leads to reduced diastolic wall tension and improved myocardial oxygen supply-demand balance. Unlike beta-blockers or calcium channel blockers, it does not significantly lower heart rate or blood pressure, making it useful in patients who cannot tolerate those effects.
Mechanism Steps
💡 How to Take stozina 500mg tablet
Strength: Sustained-release tablet, 500 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg taken twice daily by mouth. Your doctor may increase the dose to 1000 mg twice daily if needed and if tolerated. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines you are taking. Do not adjust your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects such as dizziness and QT prolongation. Dose should be individualized by a qualified clinician based on renal and hepatic function and other medicines. |
| Renal Impairment | For patients with severe renal impairment (creatinine clearance less than 30 mL/min), this medicine should be used with caution. Dose adjustment may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe hepatic impairment (Child-Pugh class C). In patients with moderate hepatic impairment (Child-Pugh class B), the dose should not exceed 500 mg twice daily. In mild hepatic impairment, no dose adjustment is typically needed, but individualization by a clinician is required. |
| Maximum Daily Dose | The maximum recommended daily dose is 1000 mg twice daily (2000 mg per day). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stozina 500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Simvastatin | Major | |
| Quinidine | Major | |
| Diltiazem | Moderate | |
| Verapamil | Moderate | |
| Grapefruit juice | Moderate | |
| Cyclosporine | Moderate | |
| Cimetidine | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Class Ia and III antiarrhythmics (e.g., quinidine, dofetilide, sotalol)
- Simvastatin
⚡ Moderate Interactions
- Moderate CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin)
- P-glycoprotein inhibitors (e.g., cyclosporine)
- Grapefruit juice
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and low blood pressure while taking this medicine. It is best to avoid alcohol or limit its intake and discuss with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe hepatic impairment (Child-Pugh class C)","Concomitant use with strong CYP3A inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir","Known hypersensitivity to ranolazine or any component of the formulation","History of long QT syndrome","Concomitant use with Class Ia or Class III antiarrhythmics except amiodarone"]
⚠️ Warnings & Precautions
["This medicine may prolong the QT interval; use with caution in patients with a history of QT prolongation or those taking other QT-prolonging drugs.","Avoid use in patients with severe hepatic impairment.","Dose adjustment may be needed in patients with moderate hepatic impairment or severe renal impairment.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use this medicine to treat an acute angina attack; use your rescue medicine as prescribed.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not start or stop any other medicine without consulting your doctor."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many medicines are excreted in breast milk, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
If you suspect an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe dizziness, fainting, fast or irregular heartbeat, and low blood pressure. Treatment is supportive and may include ECG monitoring and management of symptoms. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually twice daily with or without food. Do not crush, chew, or break the sustained-release tablet; swallow it whole. Avoid drinking grapefruit juice while taking this medicine because it can increase the amount of medicine in your blood and raise the risk of side effects. Do not start or stop any other medicine, including over-the-counter products and herbal supplements, without consulting your doctor. Inform your doctor if you have liver or kidney problems, heart rhythm disorders, or a history of long QT syndrome. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Keep all follow-up appointments and get regular electrocardiograms and blood tests as advised. Do not use this medicine to treat an acute angina attack; use your rescue medicine as instructed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and QT prolongation. Dose should be individualized based on renal and hepatic function and other medicines. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. There are no adequate studies in pregnant women. The medicine should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be stopped temporarily, especially if you are undergoing heart surgery or procedures that affect heart rhythm. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain medicines used in dentistry, such as local anesthetics containing epinephrine. Your dentist may need to adjust the treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness. Avoid strenuous exercise until you know how it affects you. Start any new exercise program gradually and under your doctor's guidance. If you experience chest pain during exercise, stop and use your rescue medicine as prescribed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It should not interfere with most desk jobs, but discuss any specific work requirements with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as fainting, irregular heartbeat, or severe allergic reactions, seek immediate medical attention. Your doctor may adjust or stop the medicine based on your condition and response.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated. However, it can cause QT prolongation, so periodic ECG monitoring is advised. Liver and kidney function should be monitored in patients with impairment. Do not stop the medicine without consulting your doctor, as angina may worsen.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.
Evidence: Well-establishedSupervised exercise and education programs can improve cardiovascular health and reduce angina symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, patients with heart disease should discuss vaccination schedules, including influenza and pneumococcal vaccines, with their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, consult your doctor about adjusting dosing times. Check local customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several days to weeks to show its full effect. It is not for immediate relief of an acute angina attack.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: Avoid grapefruit and grapefruit juice. Avoid alcohol as it may increase dizziness. Do not start any new medicine without consulting your doctor.
A: This medicine is used for chronic stable angina and is generally safe when taken as prescribed. It can affect heart rhythm (QT prolongation), so regular monitoring may be needed.
🤔 Common Patient Concerns
🔄 Substitutes for stozina 500mg tablet
View AllAlternative brands with exact same active ingredient:
-
rozo 500 er tabletZeelab Pharmacy Pvt Ltd ₹48.00 58.2% CHEAPER
-
davaindia ranolazine 500mg tablet srDavaindia Generic Pharmacy ₹50.00 56.5% CHEAPER
-
randear 500mg tablet erAlkem Laboratories Ltd ₹59.06 48.6% CHEAPER
-
nefazor xr 500 tabletTaj Pharma India Ltd ₹63.56 44.7% CHEAPER
-
corvela 500mg tabletCipla Ltd ₹63.75 44.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to relieve an acute angina attack.
Fact: This medicine is for prevention of angina attacks and is not a rescue medicine. Use sublingual nitroglycerin for acute attacks as prescribed. - Myth: This medicine lowers blood pressure significantly.
Fact: This medicine does not significantly lower blood pressure or heart rate, unlike beta-blockers or calcium channel blockers. - Myth: You can stop this medicine once you feel better.
Fact: This medicine is usually taken long-term to control angina. Do not stop without consulting your doctor.
🔄 Alternative Options
Generic Alternatives
- Ranolazine 500 mg sustained-release tablet
Brand Alternatives
- Davaindia Ranolazine 500 mg Tablet SR