corvela 500mg tablet

4.6 (19 reviews)

Ranolazine (500mg)

🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is corvela 500mg tablet used for?

Angidil 500mg Tablet SR (Ranolazine) is used to treat CARDIAC. It contains Ranolazine (500mg), which Inhibits the late sodium current (INa) in cardiac cells, reducing intracellular . Always consult your doctor before use. Take as prescribed.

Generic Name: Ranolazine
Manufacturer: Cipla Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 corvela 500mg tablet Uses & Benefits

Chronic angina (as add-on therapy when other antianginals are inadequate).

Off-label uses: Atrial fibrillation, ventricular arrhythmias (limited evidence).

📋 Drug Information

Generic Name(s)	Ranolazine
Brand Name	Angidil 500mg Tablet SR
Manufacturer	Cipla Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Late Sodium channel blocker- angina
Route of Administration	Oral (sustained-release tablet).
Storage	Store at 20-25°C (68-77°F); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed after oral administration; peak plasma concentrations achieved within 2-6 hours. Food does not affect absorption.

DistributionVolume of distribution approximately 1.5 L/kg; extensively distributed to tissues.

Protein BindingApproximately 62% bound to plasma proteins.

MetabolismExtensively metabolized in the liver, primarily by CYP3A4 and CYP2D6; also by CYP2C8 and CYP2C19.

Half-LifeApproximately 7 hours (range 5-12 hours) in healthy subjects; prolonged in hepatic impairment.

ExcretionPrimarily excreted in urine (75%) and feces (25%); less than 5% excreted unchanged.

BioavailabilityApproximately 30-50% due to first-pass metabolism.

Onset of ActionNot well-defined; therapeutic effects may take several days to weeks.

Peak Plasma Time2-6 hours after oral administration.

Duration of ActionApproximately 12 hours with sustained-release formulation.

How It Works

Inhibits the late sodium current (INa) in cardiac cells, reducing intracellular sodium and calcium overload, thereby improving myocardial oxygen supply-demand balance.

Mechanism Steps

1Inhibits late sodium current (INa) in cardiac myocytes

2Reduces intracellular sodium accumulation

3Decreases calcium overload via Na+/Ca2+ exchanger

💡 How to Take corvela 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of corvela 500mg tablet

✅ Common Side Effects

Dizziness
Headache
Constipation
Nausea

🚨 Serious Side Effects

QT prolongation
Torsades de pointes
Syncope
Renal failure

⚠️ Rare Side Effects

Hepatotoxicity
Thrombocytopenia
Angioedema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased ranolazine levels; contraindicated
Rifampin	Major	Decreased ranolazine efficacy
Amiodarone	Major	Increased risk of QT prolongation
Paroxetine	Moderate	Increased ranolazine levels
Metoprolol	Moderate	Increased metoprolol levels
Digoxin	Moderate	Increased digoxin levels
Cimetidine	Minor	Slight increase in ranolazine levels
Grapefruit juice	Minor	Increased ranolazine levels

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
CYP3A4 inducers (e.g., rifampin)
QT-prolonging drugs (e.g., amiodarone, sotalol)

⚡ Moderate Interactions

CYP2D6 inhibitors (e.g., paroxetine)
CYP2D6 substrates (e.g., metoprolol)
Digoxin

ℹ️ Minor Interactions

Cimetidine
Grapefruit juice

🍽️ Food Interactions

Grapefruit juice may increase ranolazine levels; avoid concurrent use.

🍷 Alcohol Interaction

No significant interaction reported.

🛡️ Safety & Warnings

🚫 Contraindications

Severe hepatic impairment, QT prolongation, concurrent use with strong CYP3A4 inhibitors or inducers.

📊 Monitoring Parameters

ECG (QT interval), renal and hepatic function, serum electrolytes.

🤱 Lactation Safety

Not recommended; unknown if excreted in breast milk.

💊 Overdose Management

Supportive care; monitor ECG for QT prolongation; no specific antidote.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

🔗 View Profile

🔄 Substitutes for corvela 500mg tablet

View All

Alternative brands with exact same active ingredient (Ranolazine (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

corvela 500mg tablet

What is corvela 500mg tablet used for?

💊 corvela 500mg tablet Uses & Benefits

📋 Drug Information

🔬 Pharmacology (PK/PD)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take corvela 500mg tablet

⚠️ Side Effects of corvela 500mg tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

ℹ️ Minor Interactions

🍽️ Food Interactions

🍷 Alcohol Interaction

🛡️ Safety & Warnings

🚫 Contraindications

📊 Monitoring Parameters

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

🔄 Substitutes for corvela 500mg tablet

⭐ User Reviews

😊 Was this information helpful?

Browse Medicines A-Z