Letrozole 5 mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Swelling, redness, or pain in one leg
- Severe headache with vision changes
- Yellowing of skin or eyes (jaundice)
- Unusual vaginal bleeding
- Severe allergic reaction (rash, itching, swelling of face/lips/throat)
- Persistent nausea or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is stimucor 5 tablet used for?
Letrozole 5 mg tablet is an aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women and to induce ovulation in women with PCOS. It works by lowering estrogen levels in the body.
- Generic Name: Letrozole (5mg)
- Manufacturer: Corona Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stimucor 5 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से स्तन कैंसर (ब्रेस्ट कैंसर) के इलाज में उपयोग की जाती है, विशेष रूप से उन महिलाओं में जो रजोनिवृत्ति के बाद की अवस्था में हैं। यह हार्मोन रिसेप्टर पॉजिटिव स्तन कैंसर के पुनरावृत्ति के जोखिम को कम करती है। इसके अलावा, यह पॉलीसिस्टिक ओवरी सिंड्रोम (PCOS) वाली महिलाओं में ओव्यूलेशन को प्रेरित करने के लिए भी इस्तेमाल की जाती है। यह शरीर में एस्ट्रोजन के स्तर को कम करके काम करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में गर्म लहरें (हॉट फ्लैश), थकान, जोड़ों में दर्द, सिरदर्द, मतली और वजन बढ़ना शामिल हैं। कुछ रोगियों को बाल पतले होना, त्वचा पर दाने या योनि में सूखापन भी हो सकता है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन हड्डियों के फ्रैक्चर, हृदय संबंधी समस्याएं और लीवर एंजाइम में वृद्धि हो सकती है। यदि आपको कोई गंभीर या लगातार लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। दवा की खुराक बदलें या बंद करने से पहले डॉक्टर से सलाह लें। इसे हर दिन एक ही समय पर लें। यदि आपको चक्कर या थकान महसूस हो, तो वाहन चलाने या मशीनरी चलाने से बचें। अपने डॉक्टर को अन्य सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। गर्भावस्था के दौरान यह दवा न लें क्योंकि यह भ्रूण को नुकसान पहुंचा सकती है। स्तनपान कराने वाली महिलाओं को भी इस दवा से बचना चाहिए।
💊 stimucor 5 tablet Uses & Benefits
[{"condition":"Hormone receptor-positive breast cancer in postmenopausal women","description":"Used as adjuvant therapy to reduce the risk of recurrence, or as first-line treatment for advanced disease.","evidence":"Well-established"},{"condition":"Ovulation induction in polycystic ovary syndrome","description":"Stimulates ovulation in women with PCOS who are infertile.","evidence":"Well-established"},{"condition":"Endometrial cancer","description":"Sometimes used off-label for hormone-sensitive endometrial cancer.","evidence":"Limited"},{"condition":"Precocious puberty","description":"Rarely used off-label to delay puberty in boys with peripheral precocious puberty.","evidence":"Limited"}]
Off-label uses: [{"condition":"Male infertility","description":"Sometimes prescribed off-label to improve sperm production in men with low testosterone-to-estrogen ratio.","evidence":"Limited"},{"condition":"Uterine fibroids","description":"May be used off-label to reduce fibroid size by lowering estrogen levels.","evidence":"Limited"}]
Primary treatment for: Hormone receptor-positive breast cancer
Also treats: Polycystic ovary syndrome, Endometrial cancer, Precocious puberty
📋 Drug Information
| Generic Name(s) | Letrozole (5mg) |
| Brand Name | stimucor 5 tablet |
| Manufacturer | Corona Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Aromatase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Letrozole is included in WHO essential medicines list for breast cancer treatment. WHO recommends aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer. |
| ICMR Guideline | ICMR guidelines recommend letrozole as first-line therapy for ovulation induction in PCOS and as adjuvant treatment for breast cancer in postmenopausal women. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a potent and selective non-steroidal aromatase inhibitor. It binds reversibly to the heme iron of the aromatase enzyme (CYP19A1), thereby blocking the conversion of androgens such as androstenedione and testosterone into estrogens like estrone and estradiol. This leads to a significant reduction in circulating estrogen levels, which can inhibit the growth of estrogen-dependent tissues, including certain breast cancers.
Mechanism Steps
💡 How to Take stimucor 5 tablet
Strength: Each tablet contains 5 mg of letrozole. Available as immediate-release tablets.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for breast cancer is 2.5 mg once daily, but this product contains 5 mg. For ovulation induction, the dose is typically 2.5 mg to 5 mg once daily for 5 days, starting on day 3 to 5 of the menstrual cycle. The exact dose and duration depend on the indication, patient's response, and other factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more susceptible to side effects such as bone loss and cardiovascular events. Monitor closely. |
| Renal Impairment | No dose adjustment is needed for mild to moderate renal impairment. In severe renal impairment (creatinine clearance <30 mL/min), use with caution and monitor closely. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is needed. In severe hepatic impairment, reduce dose by 50% or use with caution. |
| Maximum Daily Dose | The maximum recommended daily dose is 5 mg for the 5 mg tablet. For breast cancer, the usual dose is 2.5 mg daily, but this product is 5 mg, so it should be used as prescribed by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stimucor 5 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tamoxifen | Major | |
| Estrogen | Major | |
| Rifampicin | Moderate | |
| Ketoconazole | Moderate | |
| Warfarin | Minor |
🚨 Major Interactions
- Tamoxifen
- Estrogen-containing products
⚡ Moderate Interactions
- CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and dizziness when taken with this medicine. It is advisable to limit or avoid alcohol consumption during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to letrozole or any excipients","Premenopausal women (unless used with ovarian suppression)","Pregnancy","Breastfeeding","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in patients with hepatic impairment; dose reduction may be necessary.","Patients with severe renal impairment should be monitored closely.","Letrozole may reduce bone mineral density and increase fracture risk; calcium and vitamin D supplementation should be considered.","Patients should be advised to report any signs of thromboembolic events immediately.","Letrozole may cause dizziness and fatigue; patients should avoid driving or operating machinery until they know how it affects them.","Use effective contraception during treatment and for at least 3 weeks after the last dose.","Do not use in premenopausal women unless ovarian suppression is achieved."]
🤱 Lactation Safety
It is not known whether letrozole is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended during treatment.
💊 Overdose Management
There is limited experience with letrozole overdose. In case of suspected overdose, symptomatic and supportive care should be initiated. Contact a poison control center or emergency department immediately. Hemodialysis is not expected to be effective due to high protein binding.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine is usually taken once daily, with or without food, but taking it at the same time each day helps maintain steady levels. Avoid driving or operating heavy machinery if you feel dizzy or fatigued. Inform your doctor about all other medicines, supplements, or herbal products you are taking, as interactions may occur. Regular monitoring of bone health, liver function, and cholesterol levels may be required during long-term treatment. This medicine can harm an unborn baby, so use effective contraception during treatment and for at least three weeks after the last dose if you are of childbearing potential. Do not breastfeed while taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to bone loss and cardiovascular events. Regular monitoring of bone density, liver function, and cardiovascular health is recommended. Dose adjustment is not required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women planning to conceive should stop this medicine and consult their doctor for alternative treatments. Use effective contraception during treatment and for at least 3 weeks after the last dose.
🏥 Post-Surgery Considerations
This medicine may be used as adjuvant therapy after breast cancer surgery. It does not typically interfere with surgical recovery, but inform your surgeon about all medications you are taking.
🦷 Dental Procedures
No specific precautions are required for dental procedures. However, inform your dentist about this medicine, especially if you have bleeding disorders or are on anticoagulants.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Weight-bearing exercises are beneficial for bone health, but patients with joint pain should opt for low-impact activities like swimming or cycling. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Most patients can continue their normal daily activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or wish to discontinue, discuss with your healthcare provider to explore alternatives and manage withdrawal safely.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to decreased bone mineral density and increased risk of fractures. Regular monitoring of bone health with DEXA scans is recommended. It may also cause elevated liver enzymes and lipid abnormalities. Cardiovascular risk should be assessed periodically. Patients should be monitored for signs of thromboembolic events.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another aromatase inhibitor used for breast cancer.
Evidence: Well-establishedA steroidal aromatase inhibitor for breast cancer.
Evidence: Well-establishedAlternative for ovulation induction in PCOS.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For breast cancer, it may take several weeks to months to see full benefits. For ovulation induction, effects are seen within one cycle.
A: No, this medicine is contraindicated in pregnancy as it can harm the fetus.
A: Take it as soon as you remember if less than 12 hours have passed. If more than 12 hours, skip the dose and continue with your regular schedule.
🤔 Common Patient Concerns
🔄 Substitutes for stimucor 5 tablet
View AllAlternative brands with exact same active ingredient:
-
letzcan 5mg tabletBageo Pharmaceuticals Pvt Ltd ₹154.69 49.8% CHEAPER
-
herlet 5mg tabletZydus Cadila ₹167.00 45.8% CHEAPER
-
ovastim lz 5mg tabletMMC Healthcare Ltd ₹168.75 45.2% CHEAPER
-
anolet 5mg tabletManeesh Pharmaceuticals Ltd ₹186.56 39.4% CHEAPER
-
kavifol 5mg tabletKaviva Life Sciences ₹186.56 39.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Letrozole is a contraceptive pill.
Fact: Letrozole is not a contraceptive; it is used for ovulation induction and breast cancer treatment. - Myth: Letrozole can be taken during pregnancy.
Fact: Letrozole is contraindicated in pregnancy as it can harm the fetus. - Myth: Letrozole is safe for premenopausal women with breast cancer.
Fact: Letrozole is generally not used in premenopausal women unless ovarian suppression is achieved.
🔄 Alternative Options
Generic Alternatives
- Letrozole 2.5 mg tablet
- Letrozole 5 mg tablet (other manufacturers)
Brand Alternatives
- Femara
- Letroz
- Ovaras