Mostim Injection (Plerixafor): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe abdominal pain, especially in the left upper quadrant
- Chest pain or palpitations
- Decreased urine output or swelling in the legs
- Severe dizziness or fainting
- Signs of infection such as fever, chills, or sore throat
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is stemfor injection used for?
This medicine is a plerixafor injection used to mobilize stem cells from the bone marrow into the bloodstream for collection in patients with multiple myeloma or lymphoma. It is given subcutaneously in combination with G-CSF.
- Generic Name: Plerixafor (20mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stemfor injection के बारे में (Hindi Summary)
उपयोग: यह दवा प्लेरिक्साफोर इंजेक्शन के रूप में उपलब्ध है और मल्टीपल मायलोमा या लिम्फोमा वाले रोगियों में स्टेम सेल को बोन मैरो से रक्त में लाने के लिए उपयोग की जाती है। यह दवा स्टेम सेल ट्रांसप्लांट से पहले स्टेम सेल इकट्ठा करने में मदद करती है। यह आमतौर पर जी-सीएसएफ के साथ मिलकर दी जाती है। यह दवा डॉक्टर की देखरेख में ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, थकान, सिरदर्द, इंजेक्शन स्थल पर प्रतिक्रिया और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, प्लीहा का फटना और कुछ रक्त कैंसर में ट्यूमर कोशिकाओं का मोबिलाइजेशन शामिल हो सकता है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। उपचार के दौरान पर्याप्त पानी पिएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। स्तनपान कराने वाली महिलाओं को भी इससे बचना चाहिए। यदि आपको चक्कर आना या थकान महसूस हो तो वाहन न चलाएं। किडनी की कार्यप्रणाली की नियमित जांच कराएं। एलर्जी के लक्षण जैसे दाने, खुजली, सूजन या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर को बताएं।
💊 stemfor injection Uses & Benefits
[{"condition":"Autologous stem cell mobilization in multiple myeloma","description":"This medicine is used in combination with G-CSF to mobilize hematopoietic stem cells into the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma.","evidence":"Well-established"},{"condition":"Autologous stem cell mobilization in lymphoma","description":"This medicine is used in combination with G-CSF to mobilize hematopoietic stem cells into the peripheral blood for collection and subsequent autologous transplantation in patients with lymphoma.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Allogeneic stem cell mobilization","description":"Sometimes used off-label for mobilizing stem cells from healthy donors for allogeneic transplantation, but this is not an approved indication.","evidence":"Limited"},{"condition":"Mobilization in other hematologic malignancies","description":"Occasionally used in other conditions requiring stem cell collection, such as amyloidosis or certain solid tumors, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Multiple myeloma and lymphoma (for stem cell mobilization)
Also treats: Autologous stem cell transplantation
📋 Drug Information
| Generic Name(s) | Plerixafor (20mg) |
| Brand Name | stemfor injection |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Hematopoietic stem cell mobilizer |
| Route of Administration | Parenteral (subcutaneous injection) |
| Storage | Store this medicine refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep in the original carton to protect from light. Once removed from refrigeration, it should be used within a certain time as specified by the manufacturer. Do not use if the solution is discolored or contains particulate matter. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored under recommended conditions. Refer to the product label for the exact expiration date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a selective antagonist of the CXCR4 chemokine receptor. By blocking the binding of stromal cell-derived factor-1 (SDF-1) to CXCR4, it disrupts the retention of hematopoietic stem cells in the bone marrow microenvironment. This leads to the release of stem cells into the peripheral blood circulation, where they can be collected for transplantation.
Mechanism Steps
💡 How to Take stemfor injection
Strength: This medicine is available as a 20 mg strength injection for subcutaneous use.
Dosage Information
| Adult Dosage | The recommended dose of this medicine for adults is based on body weight and is individualized by a qualified clinician. It is typically given as a subcutaneous injection once daily, starting 6 to 11 hours before apheresis, usually for 1 to 4 days. The dose may be adjusted based on renal function and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustments are recommended for elderly patients based on age alone. However, elderly patients may have reduced renal function, and dose should be adjusted accordingly. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Renal Impairment | For patients with moderate to severe renal impairment (creatinine clearance ≤50 mL/min), the dose of this medicine should be reduced. The exact dose adjustment should be determined by a qualified clinician based on the patient's renal function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Hepatic Impairment | No specific dose adjustments are recommended for patients with hepatic impairment. However, as this medicine is not extensively metabolized by the liver, hepatic impairment is unlikely to significantly affect its pharmacokinetics. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is not established from the available information. Dosing is individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stemfor injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| G-CSF | Moderate | |
| Nephrotoxic drugs | Major |
🚨 Major Interactions
- Other drugs that affect renal function
⚡ Moderate Interactions
- G-CSF
🍷 Alcohol Interaction
There is no known interaction between this medicine and alcohol. However, alcohol may worsen side effects such as dizziness or fatigue. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to plerixafor or any component of the formulation","Pregnancy","Breastfeeding","Leukemia (due to potential tumor cell mobilization)"]
⚠️ Warnings & Precautions
["This medicine should be administered under the supervision of a qualified healthcare professional.","Patients should be monitored for signs of allergic reactions, including anaphylaxis.","Splenic rupture has been reported; monitor for abdominal pain.","Tumor cell mobilization may occur in patients with leukemia; this medicine is not recommended for these patients.","Renal function should be assessed before and during treatment; dose adjustment is needed for renal impairment.","Women of childbearing potential should use effective contraception during treatment.","Breastfeeding should be discontinued during treatment.","Patients should be adequately hydrated during treatment.","This medicine may cause dizziness or fatigue; patients should avoid driving or operating machinery until they know how it affects them."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, treatment should be symptomatic and supportive. Patients should be monitored for signs of toxicity, including excessive leukocytosis and potential for splenic rupture. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. If a dose is missed, contact your healthcare provider as soon as possible to reschedule. Do not attempt to self-administer a missed dose.
Additional Safety Advice
This medicine must be administered by a healthcare professional in a clinical setting. Patients should inform their doctor about all medical conditions, especially kidney disease, heart problems, or a history of allergies. Adequate hydration is important during treatment. Women of childbearing potential should use effective contraception during and after treatment. Breastfeeding should be avoided during treatment. Patients should not drive or operate machinery if they experience dizziness or fatigue after receiving this medicine. Regular monitoring of blood counts and kidney function is necessary. Report any signs of allergic reactions, such as rash, itching, swelling, or difficulty breathing, immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on renal function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
This medicine may harm the fetus. Women of childbearing potential should use effective contraception during treatment and for a period after. If you are planning pregnancy, consult your doctor before starting this medicine.
🏥 Post-Surgery Considerations
This medicine is not typically used in the post-surgery setting unless part of a stem cell transplant protocol. Follow your healthcare provider's instructions.
🦷 Dental Procedures
There are no specific precautions for dental procedures with this medicine. However, inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that could cause injury, especially if you experience dizziness or fatigue. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is usually given in a clinical setting, so you may need to take time off work for the procedure.
🛑 When to Stop This Medicine
This medicine is given for a short, defined period. Do not stop or change the schedule without consulting your healthcare provider. If you experience severe side effects, seek medical attention immediately.
📅 Long-Term Use Effects
The long-term effects of this medicine are not well established. It is used for a short duration (typically 1 to 4 days) as part of a stem cell mobilization regimen. There is no evidence of long-term toxicity when used as indicated. Patients should be monitored for any delayed adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Some patients can mobilize stem cells with G-CSF alone, but this medicine is added for poor mobilizers.
Evidence: Well-establishedIn some cases, chemotherapy is used to mobilize stem cells, but this is less common.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, live vaccines should be avoided during immunosuppressive therapy. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C (36°F to 46°F)
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not remove from carton until ready to use
✅ DO
Use within the specified time after removal from refrigeration
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep it refrigerated using a cooler bag with ice packs, but do not freeze. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Check airline and customs regulations for carrying injectable medicines. If traveling across time zones, consult your healthcare provider for timing adjustments. Always declare the medicine at security checkpoints.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts mobilizing stem cells within 1 to 2 hours after injection, with peak effect at 6 to 11 hours.
A: It is given as a subcutaneous injection by a healthcare professional, usually in the abdomen, thigh, or upper arm.
A: Common side effects include diarrhea, nausea, fatigue, headache, injection site reactions, and dizziness.
A: No, this medicine may harm the fetus and is not recommended during pregnancy. Use effective contraception during treatment.
A: It is not known if this medicine passes into breast milk. Breastfeeding should be discontinued during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for stemfor injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer.
Fact: This medicine does not treat cancer itself; it is used to mobilize stem cells for transplantation as part of cancer treatment. - Myth: This medicine can be self-administered at home.
Fact: This medicine must be administered by a healthcare professional in a clinical setting. - Myth: This medicine is safe during pregnancy.
Fact: This medicine may harm the fetus and is not recommended during pregnancy.
🔄 Alternative Options
Generic Alternatives
- Plerixafor
Brand Alternatives
- Mozobil