Davapride MF 0.5mg/500mg Tablet SR: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Symptoms of lactic acidosis: muscle pain, difficulty breathing, stomach discomfort, extreme tiredness.
- Severe hypoglycemia: confusion, seizures, loss of consciousness, or inability to eat or drink.
- Allergic reactions: rash, itching, swelling of face, lips, or throat, difficulty breathing.
- Signs of liver problems: yellowing of skin or eyes, dark urine, severe abdominal pain.
- Persistent nausea, vomiting, or diarrhea leading to dehydration.
- Unusual bleeding or bruising, fever, sore throat, or mouth ulcers.
If experiencing severe symptoms, call emergency services immediately.
What is stayhappi glimepiride+metformin 0.5mg/500mg tablet used for?
This medicine is a combination of Glimepiride 0.5 mg and Metformin 500 mg used to treat type 2 diabetes. It helps lower blood sugar by increasing insulin release and improving insulin sensitivity. Take it with meals as prescribed by your doctor.
- Generic Name: Glimepiride (0.5mg) + Metformin (500mg)
- Manufacturer: Sarvagunaushdhi Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stayhappi glimepiride+metformin 0.5mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ग्लिमेपिराइड 0.5 मिलीग्राम और मेटफॉर्मिन 500 मिलीग्राम का संयोजन है, जिसका उपयोग टाइप 2 मधुमेह (डायबिटीज) के इलाज के लिए किया जाता है। यह रक्त शर्करा (ब्लड शुगर) को नियंत्रित करने में मदद करती है। ग्लिमेपिराइड अग्न्याशय से इंसुलिन निकालने में मदद करता है, जबकि मेटफॉर्मिन शरीर में इंसुलिन की कार्यक्षमता को बढ़ाता है और लीवर में ग्लूकोज बनने को कम करता है। यह दवा उन वयस्कों के लिए है जिनका मधुमेह आहार और व्यायाम से नियंत्रित नहीं हो पाता या जो पहले से ही इस संयोजन पर हैं। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए। इस दवा का उपयोग टाइप 1 मधुमेह या डायबिटिक कीटोएसिडोसिस में नहीं किया जाना चाहिए। गुर्दे या लीवर की गंभीर बीमारी वाले लोगों को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में रक्त शर्करा का कम होना (हाइपोग्लाइसीमिया), जी मिचलाना, दस्त, पेट दर्द, और मुँह में धातु जैसा स्वाद शामिल हैं। कुछ लोगों को सिरदर्द, चक्कर आना, या वजन में बदलाव भी हो सकता है। गंभीर लेकिन दुर्लभ दुष्प्रभावों में लैक्टिक एसिडोसिस (मांसपेशियों में दर्द, सांस लेने में कठिनाई, पेट में परेशानी, और अत्यधिक थकान) और गंभीर हाइपोग्लाइसीमिया शामिल हैं। लंबे समय तक उपयोग से विटामिन बी12 की कमी हो सकती है। यदि कोई भी दुष्प्रभाव गंभीर हो या लंबे समय तक बना रहे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बदलें और न ही दवा लेना बंद करें। इसे भोजन के साथ लें ताकि पेट की परेशानी और रक्त शर्करा कम होने का खतरा कम हो। गोली को पूरा निगलें, चबाएं या तोड़ें नहीं। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। नियमित रूप से अपनी रक्त शर्करा की जांच करें। यदि आपको गुर्दे या लीवर की समस्या है तो डॉक्टर को बताएं। सर्जरी या कंट्रास्ट इमेजिंग से पहले डॉक्टर को सूचित करें। इस दवा को बच्चों की पहुंच से दूर रखें।
💊 stayhappi glimepiride+metformin 0.5mg/500mg tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes who are not adequately controlled on monotherapy or who are already on combination therapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Metformin component may be used off-label to improve insulin sensitivity and restore menstrual cycles in women with PCOS, but the combination with glimepiride is not standard for this indication.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Glimepiride (0.5mg) + Metformin (500mg) |
| Brand Name | stayhappi glimepiride+metformin 0.5mg/500mg tablet |
| Manufacturer | Sarvagunaushdhi Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend metformin as first-line therapy for type 2 diabetes, with sulfonylureas as add-on therapy. The combination is used when monotherapy fails to achieve glycemic targets. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes recommend individualized therapy, with metformin as first-line and sulfonylureas as second-line agents. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Glimepiride, a sulfonylurea, binds to ATP-sensitive potassium channels on pancreatic beta cells, causing depolarization and calcium influx, which triggers insulin release. Metformin, a biguanide, decreases hepatic glucose production, reduces intestinal glucose absorption, and enhances peripheral insulin sensitivity by increasing AMP-activated protein kinase activity. Together, they lower blood glucose levels by addressing both insulin secretion and insulin resistance.
Mechanism Steps
💡 How to Take stayhappi glimepiride+metformin 0.5mg/500mg tablet
Strength: Sustained-release tablet containing Glimepiride 0.5 mg and Metformin 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet taken once daily with a meal, typically the first meal of the day. The dose may be adjusted by your doctor based on your blood glucose levels and tolerance. The maximum recommended dose is generally 4 tablets per day (glimepiride 2 mg and metformin 2000 mg). Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the hypoglycemic effects of glimepiride and may have reduced renal function, increasing the risk of metformin accumulation and lactic acidosis. Start with a low dose and titrate slowly. Monitor renal function regularly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Assess renal function before starting and periodically during treatment. In patients with eGFR 30-45 mL/min/1.73 m², metformin should be used with caution and the dose may need to be reduced. This medicine is contraindicated if eGFR is below 30 mL/min/1.73 m². Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Glimepiride may accumulate and increase the risk of hypoglycemia. Metformin may increase the risk of lactic acidosis. Dose adjustment may be necessary. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is glimepiride 2 mg and metformin 2000 mg, usually taken as 4 tablets of this strength per day. However, the exact maximum dose must be determined by your doctor based on your condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stayhappi glimepiride+metformin 0.5mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Diuretics | Major | |
| Corticosteroids | Major | |
| Beta-blockers | Major | |
| ACE inhibitors | Moderate | |
| NSAIDs | Moderate | |
| MAOIs | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Diuretics (loop and thiazide)
- Corticosteroids
- Beta-blockers
⚡ Moderate Interactions
- ACE inhibitors
- NSAIDs
- Monoamine oxidase inhibitors (MAOIs)
- Fluconazole
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can increase the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause severe hypoglycemia by impairing gluconeogenesis. If you consume alcohol, do so in moderation and only after consulting your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to glimepiride, metformin, or any component of the formulation","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Risk of hypoglycemia, especially with skipped meals, alcohol, or strenuous exercise.","Risk of lactic acidosis with metformin, particularly in renal impairment, liver disease, or conditions causing tissue hypoxia.","Temporarily discontinue before contrast imaging procedures.","May cause vitamin B12 deficiency with long-term use.","Use with caution in elderly patients due to increased risk of hypoglycemia and renal impairment.","Avoid alcohol consumption.","Monitor renal function regularly.","Not for use in type 1 diabetes or diabetic ketoacidosis."]
🤱 Lactation Safety
Not established from the available information. Glimepiride and metformin are excreted in human milk in small amounts. Because of the potential for hypoglycemia in a breastfed infant, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor.
💊 Overdose Management
Overdose can cause severe hypoglycemia and lactic acidosis. Symptoms of hypoglycemia include shakiness, sweating, confusion, and loss of consciousness. Lactic acidosis may present with muscle pain, difficulty breathing, and stomach pain. If overdose is suspected, seek emergency medical attention immediately. Treatment includes supportive care, monitoring of blood glucose and electrolytes, and hemodialysis if needed for metformin removal. Glimepiride-induced hypoglycemia may require intravenous glucose and close monitoring.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Take the tablet with a meal to reduce stomach upset and lower the risk of low blood sugar. Swallow the tablet whole; do not crush, chew, or break it. Avoid drinking alcohol while on this medicine, as it can increase the risk of lactic acidosis and low blood sugar. Check your blood sugar regularly as advised. Inform your doctor if you have kidney or liver problems, as the dose may need adjustment. Tell your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. If you are scheduled for surgery or a contrast-enhanced imaging procedure, inform your doctor because this medicine may need to be temporarily stopped. Do not share this medicine with anyone else. Keep it out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to hypoglycemia and renal impairment. Start with a low dose and titrate slowly. Monitor renal function regularly. Avoid using this medicine if eGFR is below 30 mL/min/1.73 m². Educate patients and caregivers about recognizing and managing hypoglycemia.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative, usually insulin. Good blood sugar control before and during pregnancy is crucial to prevent complications for both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery due to the risk of lactic acidosis and hypoglycemia. Inform your surgeon and anesthesiologist about your diabetes and medicines. Blood sugar levels should be monitored closely during the perioperative period, and insulin may be used instead.
🦷 Dental Procedures
Inform your dentist about your diabetes and the medicines you take. Dental procedures can cause stress and affect blood sugar levels. You may need to adjust your dose or monitor blood sugar more frequently around the procedure. Good oral hygiene is important for people with diabetes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar levels and increase the risk of hypoglycemia, especially when taking glimepiride. Check your blood sugar before and after exercise, and carry a fast-acting sugar source. Avoid strenuous exercise if your blood sugar is low. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause hypoglycemia, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery if you experience symptoms of low blood sugar. Take regular breaks and snacks if your work involves physical activity. Inform your employer about your condition and the medicine you are taking in case of an emergency.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like lactic acidosis or severe hypoglycemia, seek immediate medical attention and follow your doctor's advice. Your doctor may stop the medicine temporarily before surgery or contrast imaging procedures. Always consult your doctor before making any changes to your treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, which can cause anemia and nerve damage. Regular monitoring of vitamin B12 levels is recommended. Metformin can also cause lactic acidosis in rare cases, especially in patients with kidney or liver disease. Glimepiride may cause weight gain and increase the risk of hypoglycemia. Long-term use requires periodic monitoring of blood glucose, kidney function, and liver function. Your doctor may adjust the dose or add other medicines as needed to maintain good control.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can help reduce the need for medicines.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be used as alternatives or in combination.
Evidence: Well-establishedMay be required if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of infections and should receive recommended vaccines such as influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor about the appropriate vaccination schedule. This medicine does not interact with vaccines, but blood sugar control should be stable before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your doses to maintain blood sugar control. Store at room temperature and protect from moisture. Carry a doctor's note if traveling internationally, especially if you need to carry syringes or other diabetes supplies. Always have a fast-acting sugar source with you in case of hypoglycemia.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few hours, but the full effect may take 1 to 2 weeks. Your doctor will monitor your progress and adjust the dose as needed.
A: It depends on the severity of your kidney problems. This medicine is contraindicated in severe renal impairment. Your doctor will assess your kidney function and decide if it is safe for you.
A: If you feel symptoms like shakiness, sweating, or confusion, immediately take a fast-acting sugar source like glucose tablets, fruit juice, or candy. If symptoms persist or you lose consciousness, seek emergency medical help.
A: No, do not stop taking this medicine without consulting your doctor. Diabetes is a chronic condition, and stopping treatment can cause your blood sugar to rise again.
🤔 Common Patient Concerns
🔄 Substitutes for stayhappi glimepiride+metformin 0.5mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
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davapride mf 0.5mg/500mg tablet srDavaindia Generic Pharmacy ₹17.00 32.8% CHEAPER
-
glimison-m 0.5mg/500mg tabletUnison Pharmaceuticals Pvt Ltd ₹22.50 11.1% CHEAPER
-
glyzanda m 0.5mg/500mg tabletGPA Exim Private Limited ₹28.13 11.1% COSTLIER
-
gemprime m 0.5mg/500mg tablet srCrassula Pharmaceuticals Pvt Ltd ₹35.63 40.8% COSTLIER
-
glucoryl-m 0.5mg/500mg tabletAlkem Laboratories Ltd ₹36.96 46% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. It must be continued along with diet and exercise. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Diabetes is a chronic condition. Stopping the medicine without medical advice can cause blood sugar levels to rise again. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for people with type 1 diabetes, severe kidney or liver disease, or during pregnancy. Always consult a doctor.
🔄 Alternative Options
Generic Alternatives
- Glimepiride 0.5 mg + Metformin 500 mg sustained-release tablet