Spasmindon Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow, or difficult breathing
- Severe dizziness or fainting
- Chest pain or palpitations
- Swelling of face, lips, or throat
- Yellowing of skin or eyes
- Severe abdominal pain or vomiting blood
- Decreased urine output
- Extreme drowsiness or difficulty waking up
If experiencing severe symptoms, call emergency services immediately.
What is spasmindon injection used for?
This medicine is a prescription injectable combining Codeine (an opioid pain reliever) and Papaverine (a smooth muscle relaxant). It is used in hospitals for short-term relief of acute pain and spasms, such as renal or biliary colic. It must be given by a healthcare professional and is not for self-administration.
- Generic Name: Codeine (20mg) + Papaverine (11mg)
- Manufacturer: Zydus Healthcare Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 spasmindon injection के बारे में (Hindi Summary)
उपयोग: यह दवा कोडीन और पैपावेरिन का संयोजन है, जिसका उपयोग अस्पताल में तीव्र दर्द और मांसपेशियों की ऐंठन के इलाज के लिए किया जाता है। यह गुर्दे की पथरी, पित्त की पथरी, या पेट और आंतों की ऐंठन से होने वाले दर्द में राहत देती है। यह इंजेक्शन के रूप में दी जाती है और इसे केवल डॉक्टर या नर्स द्वारा ही लगाया जाता है। मरीज को इसे खुद नहीं लगाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, जी मिचलाना, उल्टी, कब्ज, पसीना आना और चेहरे पर लालिमा शामिल हैं। कुछ मामलों में सांस धीमी होना, ब्लड प्रेशर कम होना, दिल की धड़कन अनियमित होना, या एलर्जी जैसी गंभीर समस्याएं हो सकती हैं। अगर कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे घर पर खुद न लगाएं। अगर आपको सांस की बीमारी, दिल की बीमारी, लीवर या किडनी की समस्या, या नशे की लत है तो डॉक्टर को पहले बताएं। इस दवा के साथ शराब बिल्कुल न लें। गाड़ी चलाने या मशीन चलाने से बचें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 spasmindon injection Uses & Benefits
[{"condition":"Acute pain associated with smooth muscle spasm","description":"Used for short-term relief of moderate to severe pain caused by spasms in the gastrointestinal, biliary, or urinary tracts.","evidence":"Established"},{"condition":"Renal colic","description":"Helps relieve pain and spasm associated with kidney stones.","evidence":"Established"},{"condition":"Biliary colic","description":"Provides relief from pain due to gallbladder or bile duct spasms.","evidence":"Established"},{"condition":"Gastrointestinal spasm","description":"Relaxes smooth muscle in the gut to reduce cramping and pain.","evidence":"Established"}]
Off-label uses: [{"condition":"Peripheral vascular disease","description":"Papaverine has been used off-label to improve blood flow in certain vascular conditions, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Acute pain associated with smooth muscle spasm
Also treats: Renal colic, Biliary colic, Gastrointestinal spasm, Urinary tract spasm
📋 Drug Information
| Generic Name(s) | Codeine (20mg) + Papaverine (11mg) |
| Brand Name | spasmindon injection |
| Manufacturer | Zydus Healthcare Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection). Must be administered by a qualified healthcare professional |
| Storage | Store in a cool, dry place, protected from light. Do not freeze. Keep out of reach of children. Follow the manufacturer's instructions on the label. |
| Shelf Life | Not established from the available information. Refer to the product packaging for the expiration date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Codeine is a prodrug that is metabolized by the liver into morphine, which then binds to mu-opioid receptors in the central nervous system to inhibit pain signal transmission and alter the perception of pain. Papaverine is an opium alkaloid that acts as a smooth muscle relaxant by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic AMP and cyclic GMP. This results in relaxation of smooth muscle, particularly in the walls of blood vessels and internal organs, and produces vasodilation. Together, they provide both analgesic and antispasmodic effects.
Mechanism Steps
💡 How to Take spasmindon injection
Strength: Injection: Codeine 20mg + Papaverine 11mg per dose unit.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, severity of pain and spasm, patient age, weight, and renal and hepatic function. It is typically administered as a single intramuscular or intravenous injection in a hospital or clinic setting. The usual adult dose is one injection, which may be repeated every 4 to 6 hours if needed, not exceeding the maximum daily dose recommended by the prescribing doctor. Do not self-administer. The exact dose and frequency will be determined by your treating physician. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in children under 12 years of age due to the risk of severe respiratory depression. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially respiratory depression, sedation, and hypotension. Doses should be reduced and administered with caution. Close monitoring is required. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Monitor renal function and adjust dose as advised by a clinician. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Monitor liver function and adjust dose as advised by a clinician. |
| Maximum Daily Dose | The maximum daily dose must be determined by the prescribing clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of spasmindon injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Benzodiazepines | Major | |
| Alcohol | Major | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Antihypertensives | Moderate | |
| Anticholinergics | Moderate | |
| Levodopa | Moderate | |
| Diuretics | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., benzodiazepines, alcohol, opioids)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
⚡ Moderate Interactions
- Antihypertensives
- Anticholinergics
- Levodopa
🍷 Alcohol Interaction
Alcohol should be strictly avoided while receiving this medicine. It can potentiate the sedative and respiratory depressant effects of codeine, leading to dangerous slowing of breathing, excessive drowsiness, and increased risk of overdose. Even small amounts of alcohol can enhance central nervous system depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to codeine, papaverine, or any component of the formulation","Severe respiratory depression or acute asthma attack","Paralytic ileus or suspected gastrointestinal obstruction","Severe liver impairment","Concurrent use with MAO inhibitors or within 14 days of stopping MAO inhibitor","Children under 12 years of age (risk of respiratory depression)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine contains an opioid and carries a risk of addiction, abuse, and misuse.","Respiratory depression is a serious risk, especially with high doses or in patients with compromised respiratory function.","Use with caution in elderly, debilitated, or cachectic patients.","Avoid use in patients with head injury or increased intracranial pressure.","May cause hypotension; monitor blood pressure closely.","Papaverine can cause arrhythmias; administer slowly and monitor cardiac status.","Do not use in patients with severe renal or hepatic impairment without dose adjustment.","Concurrent use with CNS depressants can cause profound sedation and respiratory depression.","Prolonged use can lead to tolerance, dependence, and withdrawal syndrome.","Not for self-administration; must be given by a healthcare professional."]
🤱 Lactation Safety
Codeine passes into breast milk and may cause serious adverse effects in a nursing infant, including excessive sleepiness, difficulty feeding, and breathing problems. Breastfeeding is not recommended while receiving this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can cause severe respiratory depression, extreme drowsiness, coma, hypotension, and cardiac arrhythmias. If overdose is suspected, seek emergency medical attention immediately. Treatment includes supportive care, maintenance of airway and breathing, and administration of an opioid antagonist such as naloxone for codeine toxicity. There is no specific antidote for papaverine; management is symptomatic and supportive. Monitor vital signs and cardiac rhythm closely.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. Missed doses are unlikely to occur outside of a hospital environment. If a scheduled dose is missed, the healthcare provider will determine the appropriate timing for the next dose. Do not attempt to self-administer or double the dose.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a monitored setting. Do not attempt to self-administer. Inform your doctor if you have a history of drug or alcohol abuse, breathing problems, liver or kidney disease, heart conditions, or low blood pressure. Avoid alcohol and other central nervous system depressants while receiving this medicine, as they can increase sedation and respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. If you are pregnant, planning pregnancy, or breastfeeding, tell your doctor before receiving this medicine. Do not stop or change the dose without medical advice. Keep all follow-up appointments and report any new or worsening symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of codeine and papaverine, including sedation, respiratory depression, hypotension, and constipation. Doses should be reduced, and patients should be monitored closely. Falls risk is increased due to dizziness and drowsiness.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, inform your doctor before receiving this medicine. Codeine may cause respiratory depression in the newborn if used near term, and papaverine safety in pregnancy is not well established. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
This medicine may be used for postoperative pain associated with smooth muscle spasm, but it should be used with caution due to the risk of respiratory depression and sedation. Monitor vital signs closely and use the lowest effective dose.
🦷 Dental Procedures
This medicine is not typically used for dental pain. If you are scheduled for dental work, inform your dentist if you are receiving this medicine, as it may interact with anesthetics or sedatives.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that require mental alertness while under the effects of this medicine. Drowsiness and dizziness can increase the risk of falls or injury. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and impaired coordination, affecting your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is usually given in a hospital setting, and you should not return to work until the effects have fully worn off and your doctor approves.
🛑 When to Stop This Medicine
This medicine is typically given as a single dose or for a short duration in a hospital setting. Do not stop or change the dose without consulting your doctor. If you experience serious side effects, seek immediate medical attention. Long-term use should be avoided, and discontinuation should be done under medical supervision to prevent withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of opioid dependence, tolerance, and withdrawal symptoms. Prolonged use can also lead to chronic constipation, hormonal changes, and increased sensitivity to pain. Regular monitoring of liver and kidney function, as well as respiratory status, is advised if extended use is necessary. It should be used only for the shortest duration that provides benefit.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medications like NSAIDs or acetaminophen may be used for mild to moderate pain without the risks of opioids.
Evidence: Well-establishedDrugs like dicyclomine or hyoscine can relax smooth muscle without opioid effects.
Evidence: Well-establishedFor musculoskeletal pain, physical therapy can complement or reduce the need for medication.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are acutely ill, vaccination may be deferred until you recover. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store in a cool, dry place, protected from light
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiration date
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting and is not typically self-administered during travel. If you are prescribed this medicine for use during travel, carry it in its original packaging with a copy of your prescription. Store it as directed, away from extreme temperatures. Check customs regulations for controlled substances before traveling internationally. Since this medicine contains an opioid, it may be subject to strict regulations. Always declare it if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 5 to 15 minutes after injection, with peak effects in about 30 to 60 minutes.
A: The pain relief and antispasmodic effects typically last for 4 to 6 hours.
A: No, this medicine must be administered by a healthcare professional in a clinical setting.
A: Yes, it contains codeine, an opioid, which can lead to dependence if used for prolonged periods. It should be used only for short-term treatment under medical supervision.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine is an injectable prescription drug that must only be given by a qualified healthcare professional in a clinical setting. - Myth: This medicine is safe to use for long periods.
Fact: This medicine contains an opioid and is intended for short-term use only. Prolonged use can lead to dependence and other serious side effects. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol should be strictly avoided as it can dangerously increase sedation and respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Codeine + Papaverine injection
Brand Alternatives
- Spasmindon Injection