Febrex Plus Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or stool
- Severe abdominal pain
- Yellowing of skin or eyes
- Difficulty breathing or swelling of face, lips, or throat
- Seizures or severe drowsiness
- Unusual bruising or bleeding
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is sinarest new tablet used for?
This medicine is a combination of Chlorpheniramine Maleate (an antihistamine) and Paracetamol (a pain reliever and fever reducer). It is used to treat symptoms of common cold and allergies such as runny nose, sneezing, and mild fever. It may cause drowsiness, so avoid driving. Do not exceed the recommended dose.
- Generic Name: Chlorpheniramine Maleate (2mg) + Paracetamol (500mg)
- Manufacturer: Centaur Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sinarest new tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल का संयोजन है। इसका उपयोग सर्दी-जुकाम, एलर्जी, नाक बहना, छींक आना, आंखों में पानी आना और हल्के बुखार व दर्द के इलाज में किया जाता है। यह दवा एलर्जी के लक्षणों को कम करने में मदद करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और पेट में गड़बड़ी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, या यकृत की क्षति हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसके साथ शराब न लें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। यदि आपको यकृत या गुर्दे की बीमारी, ग्लूकोमा, प्रोस्टेट की समस्या या सांस की बीमारी है तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें। बच्चों से दूर रखें।
💊 sinarest new tablet Uses & Benefits
[{"condition":"Common cold","description":"Relieves runny nose, sneezing, and mild fever associated with common cold.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, rhinorrhea, and itching of nose and eyes due to allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Helps relieve itching and hives of allergic origin.","evidence":"Well-established"},{"condition":"Mild pain and fever","description":"Paracetamol component provides relief from mild to moderate pain and reduces fever.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects to aid sleep, but not recommended due to side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"May be used off-label for motion sickness due to antihistamine effects, but not a first-line option.","evidence":"Limited"}]
Primary treatment for: Common cold and allergic rhinitis
Also treats: Urticaria, Allergic conjunctivitis, Mild pain and fever
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2mg) + Paracetamol (500mg) |
| Brand Name | sinarest new tablet |
| Manufacturer | Centaur Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby preventing histamine-mediated allergic responses such as vasodilation, increased vascular permeability, and sensory nerve stimulation. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which results in analgesic and antipyretic effects. The combination provides symptomatic relief from allergic and cold symptoms.
Mechanism Steps
💡 How to Take sinarest new tablet
Strength: Each tablet contains Chlorpheniramine Maleate 2 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 tablet taken orally every 6 to 8 hours as needed for symptoms, not to exceed 4 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use for the shortest duration necessary. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and anticholinergic effects. Use with caution and consider lower doses. Consult a doctor for appropriate dosing. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | Maximum daily dose: 4 tablets in 24 hours (providing 2000 mg paracetamol and 8 mg chlorpheniramine maleate). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sinarest new tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Warfarin | Major | |
| Alcohol | Major | |
| Anticholinergics | Moderate | |
| Opioids | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol and other CNS depressants
- Warfarin
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, benztropine)
- Opioid analgesics
- Carbamazepine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can increase drowsiness, dizziness, and the risk of liver damage, especially due to the paracetamol component. Concurrent use may also impair judgment and coordination.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, paracetamol, or any component of the formulation","Newborns and premature infants","Severe liver disease or severe active liver disease","Severe kidney disease","Narrow-angle glaucoma","Urinary retention due to prostatic hypertrophy","Concurrent use with MAOIs or within 14 days of stopping MAOIs"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until effects are known.","Avoid alcohol and other CNS depressants.","Do not exceed recommended dose of paracetamol; risk of severe liver damage.","Use with caution in patients with glaucoma, enlarged prostate, asthma, or COPD.","Consult doctor before use in pregnancy or breastfeeding.","Do not use for more than 7 days without medical advice.","Keep out of reach of children.","In case of overdose, seek immediate medical attention even if symptoms are not apparent."]
🤱 Lactation Safety
Chlorpheniramine and paracetamol are excreted in breast milk. Use with caution during breastfeeding. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and severe anticholinergic effects due to chlorpheniramine. Symptoms of paracetamol overdose may include nausea, vomiting, abdominal pain, and liver failure. Chlorpheniramine overdose may cause drowsiness, confusion, seizures, and respiratory depression. If overdose is suspected, seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, glaucoma, enlarged prostate, or breathing problems such as asthma or COPD. Do not use this medicine for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. If you are pregnant or breastfeeding, consult your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, particularly drowsiness, dizziness, confusion, and anticholinergic effects. Use with caution and consider lower doses. Consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may interact with anesthetics and other medications. It may also increase the risk of bleeding or drowsiness.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth and drowsiness, and interact with sedatives or anesthetics used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you experience drowsiness or dizziness. Light activities like walking are generally safe. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can impair your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also reduce your concentration, so take precautions at work.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as severe allergic reactions, liver problems, or unusual bleeding. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of paracetamol can increase the risk of liver damage, especially with high doses or alcohol consumption. Chlorpheniramine may cause tolerance and dependence. Regular monitoring of liver and kidney function may be required if used for extended periods. Consult your doctor for alternative treatments if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion without medication.
Evidence: Well-establishedCan ease nasal congestion and soothe airways.
Evidence: LimitedTargeted relief for allergic rhinitis with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are sick with a fever, consult your doctor before receiving any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing schedule accordingly, but do not exceed the maximum daily dose. Check customs regulations for carrying medications. Keep it in your carry-on luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: It is intended for short-term use. Do not use for more than 7 days without consulting a doctor.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Consult your doctor before taking with other cold medicines to avoid duplicate ingredients and potential overdose.
🤔 Common Patient Concerns
🔄 Substitutes for sinarest new tablet
View AllAlternative brands with exact same active ingredient:
-
active 2mg/500mg tabletAcichem Laboratories ₹2.25 98.2% CHEAPER
-
cp mol 2mg/500mg tabletSunrise International Labs ₹4.69 96.2% CHEAPER
-
c.p. mol tabletSun Pharmaceutical Industries Ltd ₹6.85 94.5% CHEAPER
-
specold tabletBen Pharmaceuticals ₹13.50 89.1% CHEAPER
-
anacold tabletMagnum Laboratories Pvt Ltd ₹13.51 89.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take extra doses for faster relief.
Fact: Taking more than the recommended dose can cause severe liver damage and other serious side effects. - Myth: This medicine is safe for children without doctor's advice.
Fact: Pediatric dosing is not established; consult a pediatrician before giving to children.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine Maleate + Paracetamol tablet
Brand Alternatives
- Febrex Plus Tablet