Rifampicin and Isoniazid Combination: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the right upper quadrant
- Persistent nausea and vomiting
- Sudden swelling of the face, lips, tongue, or throat
- Difficulty breathing or severe skin rash
- Unusual bruising or bleeding
- Confusion, seizures, or severe headache
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is scc 3 lw 300 mg/150 mg/550 mg tablet used for?
This medicine is a combination of rifampicin and isoniazid used to treat tuberculosis. It works by killing the bacteria that cause the infection. It must be taken exactly as prescribed for the full duration to prevent resistance.
- Generic Name: Rifampicin (300mg) + Isoniazid (150mg)
- Manufacturer: Maneesh Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 scc 3 lw 300 mg/150 mg/550 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रिफैम्पिसिन और आइसोनियाजिड का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज के लिए किया जाता है। यह टीबी के बैक्टीरिया को मारती है और संक्रमण को फैलने से रोकती है। यह दवा फेफड़ों की टीबी, लिम्फ नोड्स की टीबी, हड्डियों की टीबी और दिमाग की टीबी के इलाज में प्रभावी है। इसे डॉक्टर के निर्देशानुसार पूरा कोर्स करना बहुत जरूरी है, भले ही लक्षण ठीक हो जाएं। अधूरा इलाज टीबी को दवा-प्रतिरोधी बना सकता है, जिसका इलाज मुश्किल होता है। इस दवा को खाली पेट लेना चाहिए, आमतौर पर भोजन से 1 घंटा पहले या 2 घंटे बाद। शराब का सेवन बिल्कुल न करें क्योंकि इससे लिवर को नुकसान हो सकता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, भूख न लगना और सिरदर्द शामिल हैं। रिफैम्पिसिन के कारण पेशाब, पसीना और आंसू नारंगी-लाल रंग के हो सकते हैं, जो हानिरहित है लेकिन कपड़ों और कॉन्टैक्ट लेंस पर दाग लगा सकता है। कुछ लोगों को हाथ-पैरों में झुनझुनी या सुन्नपन महसूस हो सकता है, जिसे पेरिफेरल न्यूरोपैथी कहते हैं। गंभीर दुष्प्रभावों में लिवर की सूजन, आंखों और त्वचा का पीला पड़ना, गहरे रंग का पेशाब और पेट के ऊपरी हिस्से में दर्द शामिल हैं। अगर आपको त्वचा पर गंभीर दाने, सूजन या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, रोज एक ही समय पर, और पूरा कोर्स पूरा करें। बीच में दवा बंद न करें, वरना टीबी के बैक्टीरिया दवा के प्रति प्रतिरोधी हो सकते हैं। शराब का सेवन बिल्कुल न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, क्योंकि यह दवा कई दवाओं के साथ क्रिया करती है। गर्भनिरोधक गोलियों का असर कम हो सकता है, इसलिए अन्य तरीके अपनाएं। लिवर की जांच नियमित रूप से कराएं। अगर आंख या त्वचा पीली पड़े, पेशाब गहरा हो, या लगातार उल्टी हो, तो तुरंत डॉक्टर से संपर्क करें।
💊 scc 3 lw 300 mg/150 mg/550 mg tablet Uses & Benefits
[{"condition":"Active pulmonary tuberculosis","description":"Used as part of a multi-drug regimen to treat tuberculosis infection of the lungs, helping to kill the bacteria and prevent relapse.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Effective in tuberculosis affecting lymph nodes, bones, joints, urinary tract, and other organs when combined with other antitubercular drugs.","evidence":"Well-established"},{"condition":"Latent tuberculosis infection","description":"Sometimes used to prevent progression to active disease in people with evidence of prior exposure, but only under specialist guidance.","evidence":"Established in specific regimens"},{"condition":"Tuberculous meningitis","description":"Included in treatment regimens for tuberculosis of the central nervous system, often with additional medicines.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Atypical mycobacterial infections","description":"Occasionally used in combination regimens for certain non-tuberculous mycobacterial infections under specialist care.","evidence":"Limited"},{"condition":"Brucellosis","description":"Rifampicin component may be used in combination therapy for brucellosis in some guidelines.","evidence":"Limited"}]
Primary treatment for: Tuberculosis
Also treats: Latent tuberculosis infection, Extrapulmonary tuberculosis, Tuberculous meningitis
📋 Drug Information
| Generic Name(s) | Rifampicin (300mg) + Isoniazid (150mg) |
| Brand Name | scc 3 lw 300 mg/150 mg/550 mg tablet |
| Manufacturer | Maneesh Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place, away from direct sunlight and moisture. Keep in the original container or pouch to protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | The World Health Organization recommends rifampicin and isoniazid as first-line antitubercular medicines for the treatment of drug-susceptible tuberculosis. The combination is part of standard regimens for both intensive and continuation phases. Treatment must be given under directly observed therapy (DOT) or equivalent support to ensure adherence and prevent resistance. |
| ICMR Guideline | The Indian Council of Medical Research and the Revised National Tuberculosis Control Programme (RNTCP) in India recommend weight-based dosing of rifampicin and isoniazid for tuberculosis treatment. Daily regimen is preferred, and fixed-dose combinations are used to simplify treatment and improve adherence. Regular monitoring for adverse effects is advised. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular agents with complementary mechanisms. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, blocking the transcription of RNA and preventing protein synthesis, which leads to bacterial death. Isoniazid is a prodrug activated by the bacterial enzyme KatG and then inhibits InhA, an enzyme needed for mycolic acid synthesis in the bacterial cell wall. The combination is bactericidal against Mycobacterium tuberculosis and helps prevent the emergence of resistant strains.
Mechanism Steps
💡 How to Take scc 3 lw 300 mg/150 mg/550 mg tablet
Strength: Each pouch contains immediate-release oral dosage units of rifampicin 300 mg and isoniazid 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this combination is based on body weight and is typically given once daily on an empty stomach, at least 1 hour before or 2 hours after meals. For tuberculosis treatment, the standard regimen includes rifampicin 10 mg/kg and isoniazid 5 mg/kg daily, but the exact dose and duration depend on the specific treatment protocol and whether it is for active or latent tuberculosis. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines being taken. Never adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially liver toxicity and peripheral neuropathy. Dosing should be individualized by a clinician, and liver function should be monitored closely. Pyridoxine supplementation is often recommended. |
| Renal Impairment | For patients with mild to moderate renal impairment, no dose adjustment is usually necessary. In severe renal impairment (creatinine clearance less than 30 mL/min), rifampicin may accumulate, and dose reduction or increased dosing interval may be considered. Isoniazid does not require adjustment in renal failure but may require monitoring for neurotoxicity. Consult a nephrologist or specialist. |
| Hepatic Impairment | This medicine is contraindicated in severe hepatic impairment. In mild to moderate liver disease, use with caution and under close monitoring of liver function. Dose reduction may be necessary. Avoid alcohol and other hepatotoxic drugs. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribed regimen, typically not exceeding rifampicin 600 mg and isoniazid 300 mg per day for adults. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of scc 3 lw 300 mg/150 mg/550 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Protease inhibitors | Major | |
| Methadone | Major | |
| Phenytoin | Moderate | |
| Corticosteroids | Moderate | |
| Ketoconazole | Major | |
| Theophylline | Moderate | |
| Verapamil | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Protease inhibitors (e.g., ritonavir, atazanavir)
- Warfarin
- Oral contraceptives
- Ketoconazole, itraconazole
- Methadone
⚡ Moderate Interactions
- Phenytoin
- Corticosteroids
- Oral hypoglycemics (sulfonylureas)
- Theophylline
- Verapamil
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both rifampicin and isoniazid can cause liver damage, and alcohol significantly increases this risk. Alcohol may also worsen stomach upset and dizziness. If you have a history of alcohol use, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to rifampicin, isoniazid, or any component of the formulation","Acute liver disease or severe hepatic impairment","Previous drug-induced hepatitis from isoniazid or rifampicin","Concurrent use with certain protease inhibitors or other highly interacting drugs where alternative regimens are available","Acute porphyria"]
⚠️ Warnings & Precautions
["This medicine can cause serious liver injury. Report yellowing of eyes or skin, dark urine, or abdominal pain immediately.","Rifampicin may cause orange-red discoloration of body fluids, which is harmless but can stain clothing and contact lenses.","Use effective non-hormonal contraception during treatment and for at least 4 weeks after stopping, as hormonal contraceptives may fail.","Avoid alcohol completely to reduce the risk of liver damage.","Patients with diabetes may experience difficulty in controlling blood sugar; monitor glucose closely.","Isoniazid can cause peripheral neuropathy; pyridoxine supplementation may be prescribed.","This medicine may interact with many other drugs; always inform your doctor about all medicines you take.","Do not stop treatment early, as this can lead to drug-resistant tuberculosis."]
🤱 Lactation Safety
Rifampicin and isoniazid are excreted in breast milk in small amounts. The American Academy of Pediatrics considers both compatible with breastfeeding. However, monitor the infant for jaundice, drowsiness, or poor feeding, and consult a doctor if any concerns arise.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, abdominal pain, dizziness, and liver damage. In case of suspected overdose, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal if taken recently, monitoring of liver and kidney function, and management of symptoms. There is no specific antidote. Hemodialysis may be considered for severe isoniazid toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, at the same time each day, and complete the full course even if you feel better. Do not skip doses or stop early, because that can allow the tuberculosis bacteria to become resistant. Avoid alcohol completely while taking this medicine, as it increases the risk of liver damage. Tell your doctor about all other medicines you take, including over-the-counter products, because rifampicin interacts with many drugs. Use a non-hormonal method of contraception if you are sexually active, as this medicine can make hormonal birth control less effective. Your doctor will monitor your liver function with blood tests before and during treatment. If you notice yellowing of the skin or eyes, dark urine, or persistent nausea, contact your doctor immediately. Keep all appointments for follow-up and sputum tests.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver toxicity, peripheral neuropathy, and drug interactions. Liver function should be monitored closely, and pyridoxine supplementation is often recommended. Doses may need adjustment based on kidney and liver function. Falls due to dizziness should be prevented.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. Tuberculosis treatment is important for both mother and baby, but the regimen may need adjustment. Use effective non-hormonal contraception during treatment, as this medicine can harm a developing fetus and reduce the effectiveness of hormonal contraceptives.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and other medications. It may affect liver function and blood clotting. Your doctor may recommend monitoring liver function before and after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth and increase the risk of oral candidiasis. It may also interact with medications used in dental procedures. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine, but listen to your body. If you experience dizziness, fatigue, or shortness of breath, avoid strenuous activities. Consult your doctor before starting any new exercise regimen, especially if you have liver or heart conditions.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is important to take the medicine at the same time each day, which may require adjusting your work schedule. Inform your employer about your treatment if you work in healthcare or food handling, as tuberculosis can be contagious. Most people can continue their normal activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure and drug-resistant tuberculosis. If you experience severe side effects such as jaundice, severe rash, or difficulty breathing, seek immediate medical attention. Your doctor may adjust the regimen or stop the medicine if necessary.
📅 Long-Term Use Effects
Long-term use of this medicine is typically for the duration of tuberculosis treatment, usually 6 to 9 months. Prolonged use can increase the risk of liver toxicity, peripheral neuropathy, and drug interactions. Regular monitoring of liver function and clinical assessments are essential. After completing treatment, most side effects resolve, but liver damage may persist if not detected early. Follow-up care is important to monitor for relapse.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthcare worker observes the patient taking each dose to ensure adherence and improve outcomes.
Evidence: Well-establishedAdequate nutrition helps improve immune response and treatment outcomes.
Evidence: EstablishedVitamin B6 can prevent isoniazid-induced peripheral neuropathy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live vaccines such as BCG. If you need any vaccinations, inform your doctor that you are taking this medicine. In general, inactivated vaccines are safe, but the immune response may be reduced. Discuss timing with your healthcare provider.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container or pouch
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually under medical advice. Carry enough supply for your entire trip, as refills may be difficult. Check customs regulations for carrying prescription medicines. Inform airport security if you have liquid forms or needles, though this medicine is oral.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within a few weeks, but the full course of treatment usually lasts 6 months or more. It is important to complete the entire course to ensure the infection is fully cured.
A: No, you must complete the full course as prescribed. Stopping early can lead to relapse and drug-resistant tuberculosis, which is much harder to treat.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is generally considered safe during pregnancy when clinically indicated for tuberculosis, but it must be supervised by a specialist. The benefits of treating active tuberculosis outweigh the risks.
A: Yes, rifampicin can make hormonal contraceptives less effective. Use a backup non-hormonal method during treatment and for at least 4 weeks after stopping.
🤔 Common Patient Concerns
🔄 Substitutes for scc 3 lw 300 mg/150 mg/550 mg tablet
View AllAlternative brands with exact same active ingredient:
-
Scc 2 LW 300mg/150mg PouchManeesh Pharmaceuticals Ltd ₹12.19 75.6% CHEAPER
-
scc 3 lw 300mg/150mg/550mg pouchManeesh Pharmaceuticals Ltd ₹17.53 64.9% CHEAPER
-
Scc 2 LW 300 mg/150 mg TabletManeesh Pharmaceuticals Ltd ₹36.09 27.7% CHEAPER
-
vicox 2 lw tabletShrinivas Gujarat Laboratories Pvt Ltd ₹58.00 16.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed for the full duration prescribed, even if you feel better, to prevent relapse and drug resistance. - Myth: This medicine is only for lung tuberculosis.
Fact: It is effective for tuberculosis in other parts of the body as well, such as lymph nodes, bones, and brain. - Myth: Orange urine means the medicine is not working.
Fact: Orange-red discoloration of urine is a harmless and expected side effect of rifampicin, not a sign of treatment failure. - Myth: You can take this medicine with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided completely during treatment.
🔄 Alternative Options
Generic Alternatives
- Rifampicin and isoniazid fixed-dose combination (generic)
- Rifampicin and isoniazid separate tablets (generic)
Brand Alternatives
- Rifampicin and isoniazid combination products available under various brand names