Letrozole 2.5 mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden chest pain or difficulty breathing
- Severe headache with vision changes
- Yellowing of skin or eyes
- Dark urine or severe abdominal pain
- Sudden weakness or numbness on one side of the body
- Severe allergic reaction with swelling of face, lips, or throat
- Unusual vaginal bleeding
If experiencing severe symptoms, call emergency services immediately.
What is anolet 2.5mg tablet used for?
Letrozole 2.5 mg is an oral aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women and to induce ovulation in infertility. It works by lowering estrogen levels in the body.
- Generic Name: Letrozole
- Manufacturer: Maneesh Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anolet 2.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से पोस्टमेनोपॉज़ल महिलाओं में हार्मोन रिसेप्टर-पॉज़िटिव ब्रेस्ट कैंसर के इलाज के लिए और बांझपन में ओव्यूलेशन को प्रेरित करने के लिए उपयोग की जाती है। यह शरीर में एस्ट्रोजन के स्तर को कम करके काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में गर्म चमक, जोड़ों में दर्द, थकान, सिरदर्द, मतली और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में हड्डी का फ्रैक्चर, हृदय संबंधी समस्याएं और लीवर की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गर्भावस्था के दौरान इसका सेवन न करें। यदि आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं तो डॉक्टर को बताएं। शराब से बचें। अन्य दवाओं के साथ इसका सेवन करने से पहले डॉक्टर से सलाह लें। नियमित जांच कराते रहें।
💊 anolet 2.5mg tablet Uses & Benefits
[{"condition":"Hormone receptor-positive breast cancer in postmenopausal women","description":"Used as adjuvant therapy to reduce the risk of recurrence and as first-line treatment for advanced disease.","evidence":"Well-established"},{"condition":"Ovulation induction in infertility","description":"Used to stimulate ovulation in women with polycystic ovary syndrome or other ovulatory disorders.","evidence":"Well-established"},{"condition":"Breast cancer prevention in high-risk postmenopausal women","description":"May be used to reduce the risk of developing breast cancer in women at high risk.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Endometriosis","description":"Sometimes prescribed off-label to reduce estrogen levels and alleviate symptoms.","evidence":"Limited"},{"condition":"Uterine fibroids","description":"May be used off-label to shrink fibroids by lowering estrogen.","evidence":"Limited"}]
Primary treatment for: Hormone receptor-positive breast cancer
Also treats: Infertility due to ovulation disorders, Breast cancer prevention in high-risk women
📋 Drug Information
| Generic Name(s) | Letrozole |
| Brand Name | Anolet |
| Manufacturer | Maneesh Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Aromatase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a potent and selective non-steroidal aromatase inhibitor. It works by binding reversibly to the aromatase enzyme, which is responsible for converting androgens (such as testosterone and androstenedione) into estrogens (such as estrone and estradiol). By inhibiting aromatase, this medicine significantly reduces circulating estrogen levels in postmenopausal women, where estrogen is primarily produced through peripheral conversion in adipose tissue and other sites. In breast cancer, many tumors are hormone receptor-positive and depend on estrogen for growth. By lowering estrogen, this medicine starves these cancer cells of their growth stimulus, leading to reduced tumor growth and improved survival. In fertility treatment, the reduction in estrogen feedback leads to increased secretion of follicle-stimulating hormone (FSH) from the pituitary, which stimulates ovarian follicles and induces ovulation.
Mechanism Steps
💡 How to Take anolet 2.5mg tablet
Strength: Letrozole 2.5 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose for breast cancer is 2.5 mg once daily, with or without food. For ovulation induction, the dose is typically 2.5 mg once daily for 5 days, starting on day 3 to 5 of the menstrual cycle. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects; monitor closely. |
| Renal Impairment | No dose adjustment is needed for mild to moderate renal impairment. In severe renal impairment (creatinine clearance <10 mL/min), use with caution as letrozole has not been studied extensively. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is needed. In severe hepatic impairment, dose reduction may be necessary; use with caution. |
| Maximum Daily Dose | The maximum recommended daily dose is 2.5 mg. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anolet 2.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tamoxifen | Major | |
| Estrogens | Major | |
| Rifampicin | Moderate | |
| Ketoconazole | Moderate | |
| Warfarin | Minor |
🚨 Major Interactions
- Tamoxifen
- Estrogen-containing products
⚡ Moderate Interactions
- CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and worsen side effects such as dizziness and fatigue. It is advisable to limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Breastfeeding","Premenopausal women (unless used for fertility)","Known hypersensitivity to letrozole or any excipient","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Use with caution in patients with hepatic impairment; dose reduction may be needed.","May cause dizziness and fatigue; avoid driving or operating machinery until you know how it affects you.","May reduce bone mineral density; consider calcium and vitamin D supplementation.","May increase cholesterol levels; monitor lipid profile.","Not for use in premenopausal women with breast cancer unless ovarian suppression is achieved.","May cause fetal harm; use effective contraception."]
🤱 Lactation Safety
It is not known whether letrozole is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended during treatment.
💊 Overdose Management
There is limited experience with letrozole overdose. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine is not for use during pregnancy. If you are pregnant or planning to become pregnant, inform your doctor immediately. Use effective contraception while taking this medicine if you are of childbearing potential. Avoid alcohol as it may increase the risk of liver problems. Inform your doctor about all other medications, supplements, and herbal products you are taking. Regular monitoring of bone density, liver function, and cholesterol may be required. Do not drive or operate heavy machinery if you feel dizzy or fatigued. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as bone loss and cardiovascular events. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
Letrozole is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to discuss alternative treatments. Use effective contraception while on letrozole.
🏥 Post-Surgery Considerations
Letrozole may be prescribed after breast cancer surgery. Follow your surgeon's and oncologist's instructions regarding when to start and any precautions.
🦷 Dental Procedures
Inform your dentist that you are taking letrozole. No specific precautions are usually needed, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience joint pain or fatigue, modify your exercise routine. Low-impact activities are generally safe. Avoid high-impact exercises if you have bone pain or fractures.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Letrozole may cause dizziness and fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take breaks and manage stress.
🛑 When to Stop This Medicine
Do not stop taking letrozole without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor will decide if dose adjustment or discontinuation is necessary.
📅 Long-Term Use Effects
Long-term use of letrozole may lead to decreased bone mineral density, increased risk of fractures, and cardiovascular events. Regular monitoring of bone density, lipid profile, and liver function is recommended. It is important to discuss with your doctor about calcium and vitamin D supplementation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another aromatase inhibitor used for breast cancer.
Evidence: Well-establishedA selective estrogen receptor modulator used for breast cancer.
Evidence: Well-establishedAnother medication for ovulation induction.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines while on letrozole.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry your letrozole tablets in their original packaging with a copy of your prescription. Keep them in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, maintain your dosing schedule as close to usual as possible. Check customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For breast cancer, it may take several weeks to months to see full effects. For ovulation induction, it usually works within one cycle.
A: Weight gain is a possible side effect but not everyone experiences it. Maintaining a healthy diet and exercise can help.
A: No, letrozole is contraindicated during pregnancy as it can harm the fetus.
🤔 Common Patient Concerns
🔄 Substitutes for anolet 2.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
anzen 2.5mg tabletSanzyme Ltd ₹23.32 85.9% CHEAPER
-
davaindia letrozole 2.5mg tabletDavaindia Generic Pharmacy ₹28.13 82.9% CHEAPER
-
letfem tabletNeon Laboratories Ltd ₹29.06 82.4% CHEAPER
-
fertolet tabletCipla Ltd ₹39.99 75.7% CHEAPER
-
ceolet 2.5mg tabletCieo Remedie ₹42.19 74.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Letrozole is a hormone replacement therapy.
Fact: Letrozole is an aromatase inhibitor that lowers estrogen levels, not a hormone replacement. - Myth: Letrozole can be taken during pregnancy.
Fact: Letrozole is contraindicated in pregnancy as it can harm the fetus. - Myth: Letrozole is safe for premenopausal women with breast cancer.
Fact: Letrozole is generally not used in premenopausal women with breast cancer unless ovarian suppression is achieved.
🔄 Alternative Options
Generic Alternatives
- Letrozole 2.5 mg tablet (generic)
Brand Alternatives
- Femara
- Letroz
- Ovaril