SCC 2 400 mg/225 mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the eyes or skin, or dark brown urine, which may indicate liver injury.
- Severe nausea, persistent vomiting, or severe pain in the upper right abdomen.
- Sudden swelling of the face, lips, or throat, or difficulty breathing, which may indicate a severe allergic reaction.
- Unusual bruising or bleeding, such as nosebleeds or blood in the stool.
- New numbness, tingling, or weakness in the hands and feet.
- Confusion, hallucinations, seizures, or sudden vision changes.
- Decreased urine output or swelling of the legs and feet.
- Fever with rash or joint pain that does not settle.
If experiencing severe symptoms, call emergency services immediately.
What is scc 2 400 mg/225 mg tablet used for?
This medicine is a fixed-dose combination of rifampicin 400 mg and isoniazid 225 mg, two first-line antitubercular antibiotics. It is used as part of a multi-drug regimen to treat tuberculosis. It works by blocking bacterial RNA synthesis and mycolic acid production, and it must be taken exactly as prescribed for the full duration to prevent resistance.
- Generic Name: Rifampicin (400mg) + Isoniazid (225mg)
- Manufacturer: Maneesh Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 scc 2 400 mg/225 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रिफैम्पिसिन 400 मिलीग्राम और आइसोनियाजिड 225 मिलीग्राम का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज में किया जाता है। यह दवा टीबी के कीटाणुओं को दो अलग-अलग तरीकों से मारती है, जिससे इलाज जल्दी और प्रभावी होता है। यह दवा अकेले नहीं, बल्कि डॉक्टर द्वारा बताए गए पूरे टीबी इलाज के हिस्से के रूप में ली जाती है। इसे रोज एक ही समय पर लेना बहुत जरूरी है। इलाज बीच में रोकना खतरनाक हो सकता है, क्योंकि इससे टीबी की दवाओं के प्रति प्रतिरोधक क्षमता विकसित हो सकती है। इस दवा को लेते समय शराब बिल्कुल न लें और डॉक्टर से सभी दवाओं के बारे में जानकारी दें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में असहजता, भूख कम लगना और हल्का सिरदर्द शामिल हैं। रिफैम्पिसिन के कारण पेशाब, पसीना और थूक का रंग नारंगी-लाल हो सकता है, जो आमतौर पर हानिकारक नहीं होता और इसे खून समझने की गलती नहीं करनी चाहिए। आइसोनियाजिड से हाथ-पैरों में झनझनाहट या सुन्नपन हो सकता है, खासकर डायबिटीज, कुपोषण या शराब सेवन करने वालों में। कभी-कभी लिवर पर असर हो सकता है, इसलिए आंखों या त्वचा का पीलापन, गहरे रंग का पेशाब, लगातार उल्टी या पेट के ऊपरी हिस्से में दर्द होने पर तुरंत डॉक्टर से मिलें। गंभीर एलर्जी, खून की समस्या या दौरे जैसे गंभीर दुष्प्रभाव कम होते हैं, लेकिन इन्हें नजरअंदाज न करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और इलाज का पूरा कोर्स पूरा करें। बीच में दवा छोड़ना या खुराक भूलना खतरनाक हो सकता है, क्योंकि इससे टीबी के कीटाणु दवाओं के प्रति प्रतिरोधक हो सकते हैं। दवा को पानी के साथ निगलें और शराब बिल्कुल न लें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर एचआईवी की दवाएं, खून पतला करने वाली दवाएं, मधुमेह की दवाएं और गर्भनिरोधक गोलियां। इस दवा के साथ हार्मोनल गर्भनिरोधक कम असरदार हो सकते हैं, इसलिए अतिरिक्त गर्भनिरोधक तरीका अपनाएं। आंखों या त्वचा का पीलापन, गहरे पेशाब, लगातार उल्टी, हाथ-पैरों में झनझनाहट या असामान्य खून आना दिखे तो तुरंत डॉक्टर से संपर्क करें। नियमित जांच और फॉलो-अप जरूर कराएं।
💊 scc 2 400 mg/225 mg tablet Uses & Benefits
[{"condition":"Active pulmonary tuberculosis","description":"Used as part of a multi-drug regimen to treat drug-susceptible pulmonary tuberculosis, helping to kill actively multiplying Mycobacterium tuberculosis and prevent relapse.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Included in treatment regimens for tuberculosis affecting lymph nodes, bones, joints, meninges, and other sites, under specialist supervision.","evidence":"Well-established"},{"condition":"Latent tuberculosis infection (selected protocols)","description":"May be used in specific short-course rifampicin-based regimens for latent tuberculosis in certain patients, as determined by a tuberculosis specialist.","evidence":"Established in specific guideline-based regimens"},{"condition":"Tuberculosis in patients co-infected with HIV","description":"Forms part of antitubercular therapy in people living with HIV, but requires careful adjustment of antiretroviral therapy because of significant drug interactions.","evidence":"Well-established with specialist management"}]
Off-label uses: [{"condition":"Brucellosis","description":"Rifampicin combined with doxycycline is sometimes used for brucellosis, but this combination tablet is not the standard formulation for that indication.","evidence":"Limited, specialist use only"},{"condition":"Atypical mycobacterial infections","description":"Selected non-tuberculous mycobacterial infections may be treated with rifampicin-containing regimens, but isoniazid is not always included.","evidence":"Limited, specialist use only"}]
Primary treatment for: Tuberculosis
Also treats: Extrapulmonary tuberculosis, Latent tuberculosis infection in selected protocols, Tuberculosis in people living with HIV, with specialist management
📋 Drug Information
| Generic Name(s) | Rifampicin (400mg) + Isoniazid (225mg) |
| Brand Name | scc 2 400 mg/225 mg tablet |
| Manufacturer | Maneesh Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature, between 15°C and 30°C, in a dry place. Keep it in the original container, tightly closed, away from direct sunlight and moisture. Do not store it in the bathroom. Keep all medicines out of the reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but the exact expiry date is printed on the pack. Do not use the medicine after the expiry date, and do not use it if the tablet is discolored, cracked, or damaged. |
| WHO Guideline | The World Health Organization recommends rifampicin and isoniazid as first-line antitubercular medicines in standardized treatment regimens for drug-susceptible tuberculosis. Fixed-dose combination tablets containing these medicines are endorsed to simplify treatment and improve adherence. The exact regimen and duration depend on the site of disease, drug susceptibility, and national program guidelines. |
| ICMR Guideline | The Indian Council of Medical Research and India's National Tuberculosis Elimination Program recommend rifampicin and isoniazid as core first-line drugs in daily fixed-dose combination regimens for drug-susceptible tuberculosis. Treatment is weight-based, given daily, and supported by monitoring for liver toxicity and adherence. Patients should follow the regimen prescribed by their treating physician or program officer. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular antibiotics with complementary mechanisms. Rifampicin binds to the beta subunit of bacterial DNA-dependent RNA polymerase, blocking transcription and preventing the synthesis of messenger RNA, which stops bacterial protein production and leads to bacterial death. Isoniazid is a prodrug activated by the mycobacterial enzyme KatG; the activated form inhibits InhA, an enoyl-acyl carrier protein reductase involved in mycolic acid synthesis, and also affects other pathways, weakening the mycobacterial cell wall and making the organism more vulnerable. Because the two drugs attack different essential targets, the combination helps slow the emergence of resistant mutants and improves overall killing of Mycobacterium tuberculosis.
Mechanism Steps
💡 How to Take scc 2 400 mg/225 mg tablet
Strength: Immediate-release oral tablet containing rifampicin 400 mg and isoniazid 225 mg.
Dosage Information
| Adult Dosage | The adult dose of this medicine is determined by the treating tuberculosis specialist based on the patient's weight, the specific treatment phase, and national tuberculosis program guidelines. This tablet provides rifampicin 400 mg and isoniazid 225 mg in a single fixed-dose combination, and it is usually taken once daily on an empty stomach or as directed. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Never adjust the dose yourself, and never stop treatment early, because doing so can lead to treatment failure and drug resistance. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific strength and combination tablet. Children with tuberculosis require weight-based dosing using pediatric formulations, and treatment must be supervised by a pediatrician or pediatric tuberculosis specialist. Do not give this adult tablet to a child unless specifically instructed by a qualified clinician. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially liver-related effects and nerve symptoms. The dose is generally similar to that used in younger adults, but liver and kidney function should be checked more closely, and vitamin B6 supplementation may be needed. The treating clinician will individualize the dose based on overall health, other medicines, and organ function. |
| Renal Impairment | Rifampicin and isoniazid are both eliminated partly by the kidneys, and dose adjustment may be needed in severe kidney disease. People with reduced kidney function should have their kidney function monitored, and the treating clinician will decide whether the dose or dosing interval needs to be changed. Do not adjust the dose yourself. |
| Hepatic Impairment | This medicine should be used with great caution in people with liver disease, because both rifampicin and isoniazid can affect the liver. In mild liver impairment, the clinician may continue treatment with close monitoring of liver function tests. In severe liver disease or active hepatitis, this medicine is usually avoided or used only under specialist supervision with alternative regimens considered. |
| Maximum Daily Dose | The maximum daily dose must be determined by the treating clinician based on the patient's weight, treatment phase, and national tuberculosis program guidelines. Do not exceed the prescribed dose. For educational reference only, this fixed-dose combination tablet is typically taken once daily as part of a multi-drug regimen. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of scc 2 400 mg/225 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ritonavir-boosted protease inhibitors | Major | |
| Warfarin | Major | |
| Hormonal contraceptives | Major | |
| Ketoconazole | Major | |
| Phenytoin | Major | |
| Sulfonylureas | Moderate | |
| Corticosteroids | Moderate | |
| Methadone | Moderate | |
| Paracetamol (high dose) | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Ritonavir-boosted protease inhibitors and some other antiretrovirals
- Warfarin and other vitamin K antagonists
- Hormonal contraceptives
- Ketoconazole, itraconazole, and other azole antifungals
- Some anticonvulsants such as phenytoin and carbamazepine
⚡ Moderate Interactions
- Oral diabetes medicines such as sulfonylureas
- Corticosteroids
- Methadone
- Paracetamol (acetaminophen) in high doses
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided completely while taking this medicine. Both rifampicin and isoniazid can stress the liver, and alcohol increases the risk of drug-induced hepatitis, especially with isoniazid. Alcohol also raises the chance of peripheral neuropathy and can worsen nausea and vomiting. If you have an alcohol use disorder, tell your doctor so that liver monitoring and vitamin B6 supplementation can be arranged.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergic reaction to rifampicin, isoniazid, or any component of this tablet","Acute liver disease or severe active hepatitis","Previous isoniazid-related liver injury","Concomitant use with certain antiretrovirals without specialist adjustment","Acute porphyria","Severe kidney disease without specialist supervision"]
⚠️ Warnings & Precautions
["This medicine must only be used as part of a full antitubercular regimen prescribed by a specialist.","Do not stop or skip doses, because incomplete treatment can lead to drug-resistant tuberculosis.","Avoid alcohol completely during treatment.","Use additional non-hormonal contraception while taking this medicine.","Report any yellowing of eyes or skin, dark urine, or severe nausea immediately.","Inform all healthcare providers, including dentists and surgeons, that you are taking this medicine.","People with diabetes, malnutrition, or alcohol use may need vitamin B6 supplementation to prevent nerve symptoms.","This medicine can cause orange-red discoloration of body fluids, which is harmless but may stain contact lenses and clothing.","Regular follow-up and laboratory monitoring are essential throughout treatment."]
🤱 Lactation Safety
Both rifampicin and isoniazid pass into breast milk in small amounts. Breastfeeding is usually considered compatible with this medicine when the mother is being treated for tuberculosis, but the baby should be monitored for jaundice, poor feeding, or unusual sleepiness. Discuss breastfeeding with your doctor, and ensure the baby receives any recommended preventive therapy or vaccination as advised.
💊 Overdose Management
Overdose with this medicine can cause severe nausea, vomiting, abdominal pain, dizziness, drowsiness, seizures, and liver injury. If an overdose is suspected, seek emergency medical care immediately. Do not try to induce vomiting unless instructed by a healthcare professional. Treatment is supportive, with monitoring of liver and kidney function, control of seizures, and management of any metabolic abnormalities. Bring the medicine packaging to the hospital so the treating team knows exactly what was taken.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the usual dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss doses repeatedly, tell your doctor, because consistent daily dosing is essential for curing tuberculosis and preventing resistance.
Additional Safety Advice
Take this medicine exactly as prescribed by your tuberculosis specialist, at the same time each day, and never skip doses or stop early, because incomplete treatment can allow the infection to return in a resistant form. Swallow the tablet with water, preferably on an empty stomach or as directed by your clinician, and avoid alcohol completely because both ingredients can stress the liver. Inform your doctor about all other medicines, including antiretrovirals, blood thinners, diabetes drugs, and hormonal contraceptives, since rifampicin strongly affects liver enzymes and can change how these drugs work. Use barrier contraception in addition to any hormonal method while on this medicine. Report promptly any yellowing of the eyes or skin, dark urine, persistent vomiting, numbness or tingling in the hands and feet, or unexplained bruising or bleeding. Keep all follow-up appointments for liver tests, sputum checks, and clinical review, and do not share this medicine with anyone else.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to experience liver-related side effects and drug interactions with this medicine. Liver and kidney function should be checked before and during treatment, and the dose may need adjustment. Vitamin B6 supplementation may be considered to reduce the risk of nerve symptoms. Falls risk should be assessed if dizziness or weakness occurs, and all other medicines should be reviewed for interactions.
🤰 Pregnancy Planning (TTC)
If you are planning a pregnancy, discuss your tuberculosis treatment with your doctor before conception. Rifampicin and isoniazid are generally considered acceptable when needed to treat active tuberculosis, but treatment should be supervised by a specialist. Effective contraception is important during treatment because rifampicin can reduce the effectiveness of hormonal contraceptives. If you become pregnant while taking this medicine, contact your doctor promptly for review and monitoring.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Rifampicin can interact with anesthetic agents and other medicines used during and after surgery, and it can affect liver function. Your treatment team may need to adjust other medicines or monitor you more closely. Do not stop this medicine unless your tuberculosis specialist advises it.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. Rifampicin can interact with some medicines used for pain or infection, and it may affect how your body handles certain drugs. Good oral hygiene is important, and any mouth ulcers or unusual bleeding should be evaluated. Do not stop your tuberculosis treatment for a dental appointment without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise is usually safe while taking this medicine, but you should avoid strenuous activity if you feel very tired, breathless, or dizzy. If you develop nerve symptoms such as tingling in the feet, avoid activities that require fine balance until you have been evaluated. Always consult your doctor before starting a new exercise program during tuberculosis treatment.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their usual work and daily activities while taking this medicine, but fatigue, nausea, or dizziness may affect concentration in some cases. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Tuberculosis can be contagious until you have been on effective treatment for a period determined by your doctor, so follow infection-control advice at work and in public. Inform your employer if required, and take sick leave if your doctor advises it.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. It should only be stopped when your treating clinician decides that the full course is complete or that a change in treatment is needed because of side effects or resistance. If you experience serious side effects such as liver problems, severe allergic reactions, or nerve symptoms, contact your doctor immediately; they will decide whether to adjust or stop the medicine. Stopping early can lead to treatment failure and drug-resistant tuberculosis.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the duration of tuberculosis treatment, which is usually several months. The main long-term concern is liver injury, so liver function is monitored during therapy. Isoniazid can cause peripheral neuropathy, especially in people with diabetes, malnutrition, or alcohol use, and vitamin B6 may be prescribed to prevent this. Rifampicin can affect many other medicines and can cause orange discoloration of body fluids, which is harmless. After completing treatment, most side effects resolve, but any persistent symptoms should be evaluated by a doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthcare worker or trained observer watches the patient take each dose to improve adherence and outcomes.
Evidence: Well-establishedAdequate nutrition helps the immune system and improves treatment outcomes in tuberculosis.
Evidence: Well-establishedCovering the mouth, good ventilation, and isolating during the infectious period help prevent spread.
Evidence: Well-establishedPyridoxine can prevent or reduce isoniazid-related peripheral neuropathy in at-risk patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not replace tuberculosis vaccination or other routine vaccines. If you are due for vaccines, tell your healthcare provider that you are taking this medicine, because rifampicin can affect how some vaccines work. Live vaccines may need to be timed differently. Household contacts, especially children, should be screened and may need preventive treatment or vaccination as advised by the tuberculosis program.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specifically instructed
✅ DO
Keep in the original container with the label intact
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of the reach of children and pets
❌ DON'T
Do not use after the expiry date
✅ DO
Check the tablet for damage or discoloration before use
❌ DON'T
Do not use damaged or discolored tablets
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a letter from your doctor stating that you are being treated for tuberculosis, especially for international travel. Carry enough medicine for the entire trip, plus extra in case of delays. Store the tablets in a cool, dry place, away from direct sunlight, and do not leave them in a hot car. If you are crossing time zones, keep taking the medicine at the same interval as prescribed; ask your doctor how to adjust the timing if needed. Declare the medicine at customs if required, and keep it in your hand luggage rather than checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The medicine starts killing tuberculosis bacteria within hours, but you may not feel better for several weeks. It is important to continue the full course as prescribed.
A: No. Stopping early can allow the infection to return in a resistant form. Complete the full course exactly as prescribed.
A: Rifampicin causes harmless orange-red discoloration of urine, sweat, tears, and saliva. It is not blood and does not mean something is wrong.
A: It is usually taken on an empty stomach for better absorption. If it upsets your stomach, ask your doctor whether you can take it with a small snack.
A: Yes, rifampicin can make hormonal contraceptives less effective. Use an additional non-hormonal method during treatment and for a period after stopping, as advised by your doctor.
A: If less than half the dosing interval has passed, take it as soon as you remember. If more than half has passed, skip the missed dose and continue your regular schedule. Do not double dose.
A: It is generally considered acceptable when needed to treat active tuberculosis, but it must be supervised by a specialist. Untreated tuberculosis is more dangerous than the medicine.
A: No. Alcohol increases the risk of liver damage and nerve side effects. Avoid it completely during treatment.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Stopping early can allow the infection to return in a drug-resistant form. The full course must be completed exactly as prescribed. - Myth: Orange-red urine means there is blood in the urine.
Fact: This discoloration is a harmless and expected effect of rifampicin. It is not blood. - Myth: This medicine can be shared with family members who have similar symptoms.
Fact: Antitubercular medicines must never be shared. Each patient needs a proper diagnosis and an individualized regimen. - Myth: Alcohol in small amounts is safe during treatment.
Fact: Alcohol increases the risk of liver damage and nerve side effects, so it should be avoided completely. - Myth: This medicine makes hormonal contraception ineffective only for the first few days.
Fact: Rifampicin can reduce the effectiveness of hormonal contraception throughout treatment and for a period after stopping, so additional contraception is needed.
🔄 Alternative Options
Generic Alternatives
- Rifampicin and isoniazid fixed-dose combination tablets
Brand Alternatives
- SCC 2 400 mg/225 mg tablet