Anxiflu 0.25 mg/20 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Severe agitation, confusion, fever, muscle twitching, or diarrhea suggesting serotonin syndrome
- Difficulty breathing, slow or shallow breathing, or extreme drowsiness
- Rash, hives, swelling of the face, lips, tongue, or throat
- Unusual bleeding or bruising, blood in stool or urine
- Seizures or loss of consciousness
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Irregular or rapid heartbeat, chest pain, or fainting
- Severe headache with visual changes
- Inability to urinate or severe dizziness on standing
If experiencing severe symptoms, call emergency services immediately.
What is sanprax f 0.25mg/20mg tablet used for?
This medicine is a prescription combination of alprazolam 0.25 mg and fluoxetine 20 mg used to treat anxiety disorders, panic disorder, and depression with prominent anxiety. Alprazolam provides rapid calming effects, while fluoxetine works gradually to restore serotonin balance. It must be taken exactly as prescribed and should not be stopped suddenly.
- Generic Name: Alprazolam (0.25mg) + Fluoxetine (20mg)
- Manufacturer: Sanity Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sanprax f 0.25mg/20mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अल्प्राजोलम 0.25 मिलीग्राम और फ्लुओक्सेटीन 20 मिलीग्राम का संयोजन है, जिसका उपयोग चिंता विकार, पैनिक डिसऑर्डर, और अवसाद के साथ चिंता के इलाज के लिए किया जाता है। अल्प्राजोलम तुरंत शांति प्रदान करता है, जबकि फ्लुओक्सेटीन धीरे-धीरे मूड और चिंता को नियंत्रित करता है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और डॉक्टर की सलाह के बिना इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, मुँह सूखना, मतली, दस्त, कब्ज, भूख में कमी, नींद न आना, और यौन समस्याएँ शामिल हैं। गंभीर दुष्प्रभावों में सेरोटोनिन सिंड्रोम, गंभीर एलर्जी, असामान्य रक्तस्राव, दौरे, और आत्महत्या के विचार शामिल हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ पूरा निगलें, चबाएँ या तोड़ें नहीं। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह आप पर कैसा असर करती है। शराब का सेवन बिल्कुल न करें। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। नियमित रूप से डॉक्टर से मिलते रहें और सभी दुष्प्रभावों की जानकारी दें।
💊 sanprax f 0.25mg/20mg tablet Uses & Benefits
[{"condition":"Generalized anxiety disorder with depressive symptoms","description":"This combination is used when anxiety is prominent and a rapid calming effect from alprazolam is needed while fluoxetine provides longer-term mood and anxiety control.","evidence":"Moderate"},{"condition":"Panic disorder with or without agoraphobia","description":"Fluoxetine reduces the frequency and intensity of panic attacks over time, while the short-term alprazolam component helps manage acute panic symptoms during the initial weeks.","evidence":"Moderate"},{"condition":"Major depressive disorder with anxious distress","description":"This medicine may be prescribed when depression is accompanied by significant anxiety, restlessness, or tension that interferes with daily functioning.","evidence":"Limited"},{"condition":"Obsessive-compulsive disorder with anxiety","description":"Fluoxetine is an established treatment for obsessive-compulsive disorder, and the alprazolam component may be added briefly for severe anxiety while fluoxetine takes effect.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premenstrual dysphoric disorder with severe anxiety","description":"Fluoxetine is sometimes used for premenstrual dysphoric disorder, and the addition of alprazolam may be considered for short-term anxiety control in selected cases.","evidence":"Limited"},{"condition":"Post-traumatic stress disorder with prominent anxiety","description":"This combination may be used off-label when anxiety and depressive symptoms dominate the clinical picture, although trauma-focused therapy remains the first-line approach.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders with or without depression
Also treats: Panic disorder, Major depressive disorder with anxious distress, Obsessive-compulsive disorder with anxiety, Generalized anxiety disorder
📋 Drug Information
| Generic Name(s) | Alprazolam (0.25mg) + Fluoxetine (20mg) |
| Brand Name | sanprax f 0.25mg/20mg tablet |
| Manufacturer | Sanity Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C in its original container. Protect it from moisture, heat, and direct sunlight. Do not refrigerate unless specifically instructed. Keep it out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture, but the exact expiry date is printed on the packaging. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different but complementary mechanisms. Alprazolam binds to the benzodiazepine site on gamma-aminobutyric acid type A receptors in the brain, which increases the frequency of chloride channel opening and enhances the inhibitory effect of gamma-aminobutyric acid. This results in reduced neuronal excitability, producing anxiolytic, sedative, muscle relaxant, and anticonvulsant effects within a short time. Fluoxetine selectively inhibits the serotonin transporter in presynaptic neurons, blocking the reuptake of serotonin into nerve terminals. This increases serotonin availability in the synaptic cleft and gradually enhances serotonergic neurotransmission, which over several weeks leads to adaptive changes in serotonin receptors and improved mood, reduced anxiety, and better control of obsessive thoughts. The combination provides rapid symptom relief through the alprazolam component while the fluoxetine component addresses the underlying neurochemical imbalance.
Mechanism Steps
💡 How to Take sanprax f 0.25mg/20mg tablet
Strength: This medicine is available as an immediate-release tablet containing alprazolam 0.25 mg and fluoxetine 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably in the morning, but the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, kidney function, liver function, and response to treatment. Some patients may be started on a lower dose or a different schedule. Do not adjust the dose without your doctor's advice. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative effects of alprazolam and the hyponatremic effects of fluoxetine. Treatment should be started at the lowest effective dose and increased gradually under close medical supervision. Regular monitoring for falls, confusion, and electrolyte imbalances is recommended. |
| Renal Impairment | Dose adjustment may be necessary in patients with significant renal impairment. Alprazolam and fluoxetine are excreted by the kidneys, and accumulation can increase the risk of side effects. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose reduction is recommended in patients with liver impairment because both alprazolam and fluoxetine undergo extensive liver metabolism. In severe liver disease, this medicine is contraindicated. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of this medicine must be determined by a qualified clinician based on the individual patient's condition and response to treatment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sanprax f 0.25mg/20mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Monoamine oxidase inhibitors | Major | |
| Thioridazine | Major | |
| Pimozide | Major | |
| Opioids | Major | |
| Warfarin | Major | |
| Tramadol | Major | |
| CYP3A4 inhibitors | Moderate | |
| Nonsteroidal anti-inflammatory drugs | Moderate | |
| Aspirin | Moderate | |
| Alcohol | Major |
🚨 Major Interactions
- Monoamine oxidase inhibitors
- Thioridazine
- Pimozide
- CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Opioids
- Tramadol
- Warfarin
⚡ Moderate Interactions
- Nonsteroidal anti-inflammatory drugs
- Aspirin
- Other benzodiazepines
- Alcohol
- CYP2D6 inhibitors such as quinidine, terbinafine, and bupropion
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative and central nervous system depressant effects of alprazolam, which can lead to excessive drowsiness, impaired coordination, difficulty breathing, and increased risk of accidents. Alcohol can also worsen depression and anxiety symptoms and may increase the risk of serotonin syndrome when combined with fluoxetine. If you accidentally consume alcohol, do not drive or operate machinery, and contact your doctor if you feel unusually sedated or unwell.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to alprazolam, fluoxetine, or any component of this medicine","Concurrent use with monoamine oxidase inhibitors or within 14 days of stopping a monoamine oxidase inhibitor","Concurrent use with thioridazine or pimozide","Narrow-angle glaucoma","Severe liver disease","Acute alcohol intoxication or concurrent use of other central nervous system depressants","Myasthenia gravis","Severe respiratory insufficiency","Pregnancy and breastfeeding unless specifically advised by a specialist"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness, dizziness, and impaired coordination. Avoid driving or operating heavy machinery until you know how it affects you.","Do not stop this medicine suddenly, as abrupt discontinuation can cause withdrawal symptoms including anxiety, insomnia, tremors, and seizures.","Antidepressants, including fluoxetine, may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults, especially during the first few weeks of treatment. Close monitoring is required.","This medicine can interact dangerously with monoamine oxidase inhibitors, opioids, alcohol, and other central nervous system depressants.","Use with caution in elderly patients, who are more sensitive to the sedative effects of alprazolam and the hyponatremic effects of fluoxetine.","Inform your doctor if you have a history of substance abuse, as alprazolam has a potential for dependence and misuse.","This medicine may affect blood sugar control in people with diabetes. Monitor blood sugar levels regularly.","Avoid excessive sun exposure and use sunscreen, as fluoxetine may increase sensitivity to sunlight.","Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep all follow-up appointments so your doctor can monitor your response and adjust the dose if needed."]
🤱 Lactation Safety
Both alprazolam and fluoxetine are excreted in human breast milk. Alprazolam can cause sedation, poor feeding, and weight loss in breastfed infants. Fluoxetine and its active metabolite norfluoxetine can also pass into breast milk and may cause irritability, poor feeding, or sleep disturbances in the infant. Breastfeeding while taking this medicine is generally not recommended unless the benefits clearly outweigh the risks and the infant is monitored closely. Consult your doctor or a lactation specialist before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, impaired coordination, slow or shallow breathing, rapid or irregular heartbeat, low blood pressure, seizures, and loss of consciousness. Serotonin syndrome may also occur, with symptoms such as agitation, fever, muscle rigidity, and sweating. If you suspect an overdose, call emergency services immediately or go to the nearest emergency department. Do not try to induce vomiting unless instructed by a medical professional. Treatment is supportive and may include activated charcoal, intravenous fluids, and medications to control seizures or agitation. Inform the treating team about all medicines and substances taken.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half of the dosing interval has passed. If more than half of the dosing interval has passed, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily in the morning for the fluoxetine component, while the alprazolam component may be divided into smaller doses depending on your doctor's instructions. Swallow the tablet whole with water and do not crush, chew, or break it unless your doctor or pharmacist has advised otherwise. Avoid driving, operating heavy machinery, or performing activities that require full alertness until you know how this medicine affects you, because drowsiness and dizziness are common. Do not drink alcohol while taking this medicine, as alcohol can dangerously increase sedation, impair breathing, and worsen mood symptoms. Do not stop this medicine suddenly, especially after long-term use, because abrupt discontinuation can cause withdrawal symptoms such as anxiety, insomnia, irritability, sweating, tremors, and in severe cases seizures. If you need to stop, your doctor will reduce the dose gradually. Inform all your healthcare providers, including dentists and surgeons, that you are taking this medicine before any procedure. Keep regular follow-up appointments so your doctor can monitor your mood, anxiety level, blood pressure, and any side effects. Store this medicine in its original container at room temperature, away from moisture, heat, and direct light, and keep it out of reach of children and pets.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative effects of alprazolam and the hyponatremic effects of fluoxetine. They are at higher risk of falls, confusion, and electrolyte imbalances. Treatment should be started at the lowest effective dose and increased gradually. Regular monitoring of kidney function, sodium levels, and mental status is recommended. Elderly patients should also be monitored for drug interactions, as they often take multiple medicines.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before trying to conceive. Both alprazolam and fluoxetine may pose risks to the developing baby. Your doctor may recommend switching to a safer alternative or gradually tapering the medicine. Do not stop the medicine suddenly on your own. If you become pregnant while taking this medicine, contact your doctor immediately for guidance.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Alprazolam can increase the sedative effects of anesthesia and other medications used during surgery. Fluoxetine may increase bleeding risk and interact with certain pain medicines. Your doctor may advise you to temporarily adjust or stop the medicine before surgery, but never do so without medical advice. After surgery, follow your doctor's instructions regarding when to resume the medicine.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Alprazolam can increase drowsiness and interact with sedatives or anesthetics used in dentistry. Fluoxetine may increase bleeding risk during dental procedures. Your dentist may need to take extra precautions or coordinate with your doctor. Do not stop the medicine before a dental procedure without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial while taking this medicine, but caution is needed because alprazolam can cause drowsiness, dizziness, and impaired coordination. Avoid high-risk activities such as rock climbing, contact sports, or heavy weightlifting until you know how the medicine affects you. Stay well hydrated during exercise, especially if you sweat heavily. If you feel dizzy, lightheaded, or unusually tired during exercise, stop and rest. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can significantly affect your ability to work and perform daily activities, especially during the first few weeks of treatment. Drowsiness, dizziness, and impaired concentration are common and can affect driving, operating machinery, or performing tasks that require full alertness. You should avoid driving or operating heavy machinery until you know how this medicine affects you. If your job requires such activities, discuss with your doctor about adjusting the dose or timing. The medicine may also affect your mood and energy levels, but with regular use, many people find that their anxiety and depression symptoms improve, which can enhance work performance and relationships. Communicate openly with your employer if you need temporary accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If your doctor decides to stop the medicine, they will gradually reduce the dose over several weeks to prevent withdrawal symptoms and relapse of anxiety or depression. You may need to stop if you experience serious side effects such as serotonin syndrome, severe allergic reactions, or liver injury. If you become pregnant or plan to become pregnant, consult your doctor immediately to discuss the risks and benefits. Never stop the medicine abruptly on your own.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring. The alprazolam component can lead to tolerance, dependence, and withdrawal symptoms, so it is usually prescribed for short periods or at the lowest effective dose. The fluoxetine component is often used for longer periods to prevent relapse of depression or anxiety. Long-term effects may include sexual dysfunction, weight changes, sleep disturbances, and rarely, low sodium levels or liver enzyme abnormalities. Regular follow-up with your doctor is essential to assess the ongoing need for treatment, monitor side effects, and adjust the dose. Do not stop the medicine on your own.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured form of talk therapy that helps change negative thought patterns and behaviors associated with anxiety and depression.
Evidence: Well-establishedPractices that help reduce stress and improve emotional regulation, often used alongside medicine.
Evidence: ModeratePhysical activity can improve mood and reduce anxiety through various biological and psychological mechanisms.
Evidence: Well-establishedDeep breathing, progressive muscle relaxation, and guided imagery can help manage acute anxiety symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific contraindications to receiving vaccines while taking this medicine. However, if you are scheduled for any vaccination, inform the healthcare provider about all medicines you are taking. Live vaccines should be avoided if you have a severely weakened immune system, but this medicine does not typically cause significant immunosuppression. Follow your doctor's advice regarding routine vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container with the label intact
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not share this medicine with others
✅ DO
Check the expiry date before use
❌ DON'T
Do not use expired medicine
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a letter from your doctor stating the medicine name, dose, and reason for use, especially for international travel. Carry enough supply for the entire trip plus extra in case of delays. Store the medicine in your hand luggage, away from extreme heat or cold, and do not leave it in a hot car. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Check the customs regulations of your destination country regarding controlled medicines, as alprazolam may be regulated. Never pack this medicine in checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The alprazolam component may start reducing anxiety within 30 to 60 minutes, but the fluoxetine component usually takes 1 to 2 weeks to begin working and 4 to 6 weeks for full benefits.
A: No. Stopping suddenly can cause withdrawal symptoms such as anxiety, insomnia, tremors, and seizures. Always taper under your doctor's supervision.
A: No. Alcohol can dangerously increase sedation, impair breathing, and worsen mood symptoms. Avoid alcohol completely.
A: Drowsiness is a common side effect, especially in the first few weeks. Avoid driving or operating machinery until you know how it affects you.
A: This medicine should only be used during pregnancy if the potential benefit clearly outweighs the risk, and only under specialist supervision. Consult your doctor immediately if you are pregnant or planning to become pregnant.
A: Weight changes can occur with fluoxetine, but the effect varies. Some people gain weight, while others lose weight. Discuss any concerns with your doctor.
A: If less than half the dosing interval has passed, take the missed dose as soon as you remember. If more than half has passed, skip it and continue with your regular schedule. Do not double dose.
A: Some medicines can interact dangerously with this medicine, including monoamine oxidase inhibitors, opioids, and blood thinners. Always inform your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for sanprax f 0.25mg/20mg tablet
View AllAlternative brands with exact same active ingredient:
-
albiz-fx 0.25mg/20mg tabletUbit Pharmaceuticals Pvt Ltd ₹2.50 93.1% CHEAPER
-
faxtin a 0.25 mg/20 mg tabletInd Swift Laboratories Ltd ₹7.50 79.2% CHEAPER
-
altin 0.25mg/20mg tabletZee Laboratories ₹23.44 35.1% CHEAPER
-
depoxit plus 0.25mg/20mg tabletPsycormedies ₹23.44 35.1% CHEAPER
-
ateez f 0.25mg/20mg tabletEast African (India) Overseas ₹25.00 30.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is not a sleeping pill. It is a combination of an anti-anxiety medicine and an antidepressant used to treat anxiety and depression. - Myth: This medicine works immediately for depression.
Fact: The alprazolam component may calm anxiety quickly, but the fluoxetine component takes several weeks to improve depression and long-term anxiety. - Myth: I can stop this medicine whenever I feel better.
Fact: Stopping suddenly can cause withdrawal symptoms and a return of anxiety or depression. Always taper under medical supervision. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol can dangerously increase sedation and breathing problems when combined with this medicine. It should be avoided completely. - Myth: This medicine is addictive for everyone.
Fact: The alprazolam component carries a risk of dependence, especially with long-term use, but the risk can be managed with careful prescribing and monitoring.
🔄 Alternative Options
Generic Alternatives
- Alprazolam 0.25 mg tablet
- Fluoxetine 20 mg capsule or tablet