roll on tablet - Paracetamol (500mg) + Pseudoephedrine (30mg) medicine

LC Plus Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety

No reviews yet
🏭 Gufic Bioscience Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of nasal congestion and associated symptoms.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction (rash, itching, swelling, difficulty breathing)
  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain or dark urine
  • Chest pain or irregular heartbeat
  • Severe headache with blurred vision
  • Difficulty urinating
  • Seizures or hallucinations

If experiencing severe symptoms, call emergency services immediately.

What is roll on tablet used for?

This medicine is a combination of Paracetamol and Pseudoephedrine used to relieve nasal congestion, fever, and mild pain associated with colds, allergies, and sinusitis. It works by reducing swelling in the nasal passages and lowering fever. It should be used for short-term relief only and not exceed the recommended dose.

  • Generic Name: Paracetamol (500mg) + Pseudoephedrine (30mg)
  • Manufacturer: Gufic Bioscience Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 roll on tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और स्यूडोएफेड्रिन का संयोजन है, जिसका उपयोग सर्दी, एलर्जी और साइनसाइटिस से जुड़ी नाक की भीड़, बुखार और हल्के दर्द से राहत के लिए किया जाता है। यह नाक के रक्त वाहिकाओं को सिकोड़कर भीड़ को कम करती है और पैरासिटामोल बुखार और दर्द को कम करता है। इसका उपयोग केवल अल्पकालिक राहत के लिए किया जाना चाहिए और डॉक्टर की सलाह के बिना 5-7 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बेचैनी, अनिद्रा, चक्कर आना, सिरदर्द, मतली और मुंह सूखना शामिल हैं। कुछ लोगों को दिल की धड़कन तेज हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, उच्च रक्तचाप, अनियमित दिल की धड़कन और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई गंभीर या लगातार दुष्प्रभाव महसूस हो, तो दवा बंद करें और तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। शराब का सेवन न करें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ जाता है। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह या थायरॉइड की समस्या है, तो डॉक्टर से सलाह लें। चक्कर आने पर वाहन न चलाएं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 roll on tablet Uses & Benefits

[{"condition":"Common cold with nasal congestion","description":"Relieves nasal stuffiness and associated headache, body ache, and fever.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces nasal congestion and sinus pressure caused by allergies.","evidence":"Well-established"},{"condition":"Sinusitis","description":"Helps relieve sinus congestion and pain.","evidence":"Well-established"},{"condition":"Upper respiratory tract infections","description":"Provides symptomatic relief of congestion, fever, and mild pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Eustachian tube dysfunction","description":"Sometimes used to relieve ear pressure and congestion.","evidence":"Limited"},{"condition":"Altitude sickness","description":"Pseudoephedrine may help with nasal congestion at high altitudes.","evidence":"Limited"}]

Primary treatment for: Common cold with nasal congestion

Also treats: Allergic rhinitis, Sinusitis, Upper respiratory tract infections

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Pseudoephedrine (30mg)
Brand Nameroll on tablet
ManufacturerGufic Bioscience Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the recommended dose of 4 tablets in 24 hours.
3
Avoid alcohol while taking this medicine to prevent liver damage.
4
Do not use for more than 5-7 days without consulting a doctor.
5
If you have high blood pressure or heart disease, consult your doctor before use.
6
Report any unusual symptoms like palpitations or severe dizziness immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Nasal congestion
This medicine is commonly used for this symptom.
Likely Use
Fever
Paracetamol in this medicine helps reduce fever.
Likely Use
Headache
Paracetamol provides relief from mild headache.
Likely Use
Sore throat
Paracetamol helps relieve sore throat pain.
Likely Use
Cough
This medicine does not treat cough.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Pseudoephedrine is also well absorbed from the gastrointestinal tract. Food may delay the absorption of Paracetamol but does not significantly affect the overall extent of absorption.
DistributionParacetamol distributes widely into most body tissues, with relatively low protein binding. Pseudoephedrine distributes into body tissues and crosses the blood-brain barrier and placenta.
Protein BindingParacetamol: approximately 10-25% bound to plasma proteins. Pseudoephedrine: Not established from the available information.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by cytochrome P450 2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Pseudoephedrine undergoes minimal hepatic metabolism.
Half-LifeParacetamol: 2-3 hours in adults. Pseudoephedrine: 3-6 hours, depending on urine pH.
ExcretionParacetamol is excreted in urine as metabolites. Pseudoephedrine is excreted largely unchanged in urine, with excretion dependent on urine pH.
BioavailabilityParacetamol: approximately 80-100%. Pseudoephedrine: Not established from the available information.
Onset of ActionParacetamol: 30-60 minutes. Pseudoephedrine: 15-30 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours. Pseudoephedrine: 1-2 hours.
Duration of ActionParacetamol: 4-6 hours. Pseudoephedrine: 4-6 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Paracetamol acts primarily in the central nervous system to reduce fever and pain by inhibiting prostaglandin synthesis. Pseudoephedrine is a sympathomimetic amine that directly and indirectly stimulates alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, which reduces swelling and congestion. The combination provides relief from both congestion and pain/fever.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the central nervous system, reducing fever and pain perception.
2
Pseudoephedrine alpha-adrenergic stimulation: Pseudoephedrine binds to alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction.
3
Reduced nasal congestion: Vasoconstriction decreases blood flow and swelling in the nasal mucosa, relieving congestion.
4
Symptom relief: The combined effects provide relief from nasal congestion, fever, headache, and body aches.

💡 How to Take roll on tablet

Strength: Tablet: Paracetamol 500 mg + Pseudoephedrine 30 mg

1Take this medicine orally with a glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at regular intervals as directed by your doctor.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 4 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use for the shortest duration necessary.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of Pseudoephedrine, especially on blood pressure and heart rate. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult a doctor for appropriate dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult a doctor for appropriate dosing.
Maximum Daily DoseMaximum daily dose: 4 tablets in 24 hours. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or milk
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage.
Caffeine
Limit
May increase nervousness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of roll on tablet

✅ Common Side Effects

Nervousness (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Insomnia (Common (5-10%))
Avoid taking close to bedtime. Consult doctor if severe.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Dry mouth (Common (5-10%))
Sip water or chew sugarless gum.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling, severe dizziness, or trouble breathing.
Liver damage (Rare (<0.1%))
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, blurred vision, chest pain, or difficulty breathing.
Irregular heartbeat (Rare (<0.1%))
Consult a doctor immediately if you feel palpitations or irregular pulse.

⚠️ Rare Side Effects

Hallucinations
Stop the medicine and seek immediate medical attention.
Difficulty urinating
Consult a doctor if you have trouble passing urine.
Seizures
Seek emergency medical help immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Beta-blockers Major
Tricyclic antidepressants Major
Warfarin Moderate
Digoxin Moderate
Ergot alkaloids Moderate
Antacids Minor
Caffeine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Beta-blockers
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Warfarin
  • Digoxin
  • Ergot alkaloids

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from Paracetamol and may worsen the central nervous system effects of Pseudoephedrine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Paracetamol or Pseudoephedrine","Severe hypertension or coronary artery disease","Use within 14 days of MAOI therapy","Severe liver or kidney disease","Pheochromocytoma","Hyperthyroidism","Closed-angle glaucoma","Urinary retention"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose of Paracetamol; overdose can cause severe liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with high blood pressure, heart disease, diabetes, or thyroid disorders.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 5-7 days without consulting a doctor.","Pseudoephedrine may cause rebound congestion if used for prolonged periods.","Consult a doctor before use in pregnancy or breastfeeding."]

🤱 Lactation Safety

Paracetamol is considered safe during breastfeeding. Pseudoephedrine passes into breast milk and may cause irritability or sleep disturbances in the infant. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of Paracetamol can cause severe liver damage, which may be delayed. Symptoms of overdose may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention even if you feel well. The antidote for Paracetamol overdose is N-acetylcysteine, which is most effective when given within 8-10 hours of ingestion. Pseudoephedrine overdose may cause severe hypertension, tachycardia, and nervousness. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of use. Avoid taking other products containing Paracetamol while on this medicine to prevent overdose. Do not use this medicine for more than 5-7 days without medical advice. Avoid alcohol consumption as it increases the risk of liver damage. If you have high blood pressure, heart disease, diabetes, thyroid disorder, or prostate problems, consult your doctor before taking this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the cardiovascular effects of Pseudoephedrine. Use with caution and monitor blood pressure and heart rate. Lower doses may be required.

🤰 Pregnancy Planning (TTC)

Consult your doctor before using this medicine if you are planning pregnancy. Paracetamol is generally considered safe, but Pseudoephedrine should be used with caution, especially during the first trimester.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you are taking other medications or have underlying conditions.

🦷 Dental Procedures

This medicine can be taken for pain after dental procedures, but consult your dentist or doctor for appropriate use. Pseudoephedrine may interact with anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Get plenty of rest to support recovery.
😴
Use a humidifier to ease nasal congestion.
💧
Avoid exposure to allergens and irritants.
🧘
Wash hands frequently to prevent infections.
🌞
Avoid smoking and secondhand smoke.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have fever or feel weak. Pseudoephedrine may increase heart rate, so monitor how you feel during exercise. Consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid cold and sugary drinks.
Eat light, easily digestible meals.
Limit caffeine intake.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause insomnia if taken late in the day, affecting sleep and work performance.

🛑 When to Stop This Medicine

Stop taking this medicine if your symptoms improve or after 5-7 days of use. If symptoms persist or worsen, consult a doctor. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of Pseudoephedrine can cause rebound congestion. Prolonged high-dose Paracetamol can lead to liver damage. Use only for short-term relief and consult a doctor if symptoms persist beyond 5-7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal irrigation

Helps clear nasal passages and reduce congestion.

Evidence: Well-established
Steam inhalation

Provides temporary relief from nasal congestion.

Evidence: Limited
Antihistamines

May help if congestion is due to allergies.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications. Do not leave in hot cars or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with common cold and nasal congestion
He took this medicine as prescribed for 3 days. His nasal congestion and fever improved significantly. He experienced mild insomnia, so he avoided taking it close to bedtime. He was advised not to exceed the dose and to stay hydrated.
💡 Lesson: Taking this medicine as prescribed and avoiding late-night doses can minimize side effects like insomnia.
👤 A 50-year-old woman with allergic rhinitis
She used this medicine for seasonal allergies. It relieved her nasal congestion and sinus pressure. However, she noticed increased heart rate, so her doctor reduced the dose and monitored her blood pressure. She was advised to use it only when needed.
💡 Lesson: Patients with underlying conditions should use this medicine under medical supervision and report any unusual symptoms.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe for children?

A: This medicine is not recommended for children under 12 years unless directed by a doctor.

Q: Can I take it with other cold medicines?

A: Do not take other medicines containing Paracetamol or Pseudoephedrine without consulting your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood pressure?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for roll on tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only provides symptomatic relief; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for weeks.
    Fact: Prolonged use can lead to rebound congestion and other side effects. It should be used for short-term relief only.
  • Myth: More tablets mean faster relief.
    Fact: Taking more than the recommended dose can cause serious side effects, including liver damage. Always follow the recommended dose.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Pseudoephedrine combination tablets

Brand Alternatives

  • Sinarest
  • Coldarin
  • Actifed
  • Sudafed

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 500 mg + Pseudoephedrine 30 mg","uses":"Nasal congestion, fever, mild pain","notes":"Combination product"},{"medicine":"Paracetamol + Phenylephrine","composition":"Paracetamol 500 mg + Phenylephrine 5 mg","uses":"Nasal congestion, fever, mild pain","notes":"Phenylephrine is less likely to cause stimulation"},{"medicine":"Ibuprofen + Pseudoephedrine","composition":"Ibuprofen 200 mg + Pseudoephedrine 30 mg","uses":"Nasal congestion, pain, fever","notes":"Ibuprofen may cause stomach upset"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory