Applevit-PM SR Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Sudden swelling of the face, lips, tongue, or throat, or difficulty breathing.
- New or worsening thoughts of self-harm or suicide.
- Severe muscle pain, weakness, or dark-colored urine.
- Chest pain, shortness of breath, or sudden weight gain due to fluid retention.
- Severe abdominal pain radiating to the back, with nausea and vomiting.
- Yellowing of the skin or eyes, dark urine, or severe fatigue.
- Unusual bruising or bleeding.
- Confusion, extreme drowsiness, or slow, shallow breathing.
If experiencing severe symptoms, call emergency services immediately.
What is reneurop 1500mcg/75mg tablet sr used for?
This medicine is a combination of Methylcobalamin 1500 mcg and Pregabalin 75 mg used to treat neuropathic pain. It works by reducing abnormal nerve signals and supporting nerve health. It is taken orally, usually once or twice daily, and should not be stopped suddenly.
- Generic Name: Methylcobalamin (1500mcg) + Pregabalin (75mg)
- Manufacturer: Motif Health Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 reneurop 1500mcg/75mg tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन 1500 माइक्रोग्राम और प्रेगाबालिन 75 मिलीग्राम का संयोजन है। इसका उपयोग मुख्य रूप से न्यूरोपैथिक दर्द (तंत्रिका दर्द) के इलाज के लिए किया जाता है, जैसे कि मधुमेह के कारण होने वाला तंत्रिका दर्द, दाद के बाद बचा हुआ दर्द, और विटामिन बी12 की कमी से जुड़ी तंत्रिका समस्याएं। यह दवा तंत्रिकाओं को स्वस्थ रखने और दर्द के संकेतों को कम करने में मदद करती है। इसे डॉक्टर के परामर्श के बिना शुरू या बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, धुंधली दृष्टि, मुंह सूखना, और हाथ-पैरों में सूजन शामिल हैं। कुछ लोगों को ध्यान केंद्रित करने में कठिनाई या चलने में अस्थिरता महसूस हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, या मांसपेशियों में गंभीर दर्द हो सकता है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण जैसे बेचैनी, अनिद्रा, मतली या सिरदर्द हो सकता है। दवा लेते समय शराब न पिएं और वाहन चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको किडनी की समस्या है, तो डॉक्टर को बताएं। दवा को ठंडी और सूखी जगह पर रखें।
💊 reneurop 1500mcg/75mg tablet sr Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps reduce burning, tingling, and shooting pain in the feet and hands caused by nerve damage from diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It is used to relieve persistent nerve pain that remains after a shingles infection has healed.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency with neurological symptoms","description":"Methylcobalamin in this medicine helps correct B12 deficiency and supports nerve repair when deficiency contributes to neuropathy.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Pregabalin, a component of this medicine, is sometimes prescribed to reduce widespread muscle pain and improve sleep in fibromyalgia.","evidence":"Moderate"},{"condition":"Spinal cord injury-related neuropathic pain","description":"This medicine may be used to manage chronic nerve pain following spinal cord injury.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Pregabalin is sometimes used off-label for short-term anxiety management, but this is not a primary approved use.","evidence":"Limited"},{"condition":"Chronic low back pain with neuropathic features","description":"May be prescribed off-label when back pain has a significant nerve-pain component.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Pregabalin has been studied off-label for reducing symptoms of restless legs syndrome.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Fibromyalgia, Vitamin B12 deficiency with neurological symptoms, Spinal cord injury pain
📋 Drug Information
| Generic Name(s) | Methylcobalamin (1500mcg) + Pregabalin (75mg) |
| Brand Name | reneurop 1500mcg/75mg tablet sr |
| Manufacturer | Motif Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified by the manufacturer. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Methylcobalamin is a coenzyme form of vitamin B12 that participates in methylation reactions essential for myelin synthesis and nerve cell maintenance. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. The result is decreased abnormal nerve firing and reduced neuropathic pain perception. Methylcobalamin supports the structural integrity of nerves, while pregabalin dampens excessive pain signalling. Together, they address both the nutritional and neurological aspects of nerve pain.
Mechanism Steps
💡 How to Take reneurop 1500mcg/75mg tablet sr
Strength: Each tablet contains Methylcobalamin 1500 mcg and Pregabalin 75 mg. The tablet is intended for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your physician. The exact dose and frequency depend on the indication, severity of symptoms, and your kidney function. For neuropathic pain, the typical starting dose of pregabalin is 75 mg twice daily or 150 mg once daily, which may be increased gradually up to a maximum of 600 mg per day in divided doses. Methylcobalamin 1500 mcg is usually taken once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and confusion. Doses should be started low and increased gradually. Renal function should be assessed before starting and monitored periodically. Dose must be individualized by a qualified clinician based on renal function and overall health status. |
| Renal Impairment | Pregabalin is primarily excreted by the kidneys, so dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the dose may be reduced by 50%. For creatinine clearance 15-30 mL/min, the dose may be reduced by 75%. For creatinine clearance less than 15 mL/min, the dose may need to be reduced by 87.5% or given less frequently. Methylcobalamin does not require renal dose adjustment. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Pregabalin undergoes negligible hepatic metabolism, so no dose adjustment is typically required for hepatic impairment. Methylcobalamin is also not significantly affected by liver disease. However, dose must be individualized by a qualified clinician based on overall clinical status. |
| Maximum Daily Dose | The maximum recommended daily dose of pregabalin is 600 mg per day in divided doses. The maximum daily dose of methylcobalamin in this combination is 1500 mcg. Do not exceed the prescribed dose without consulting your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of reneurop 1500mcg/75mg tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Morphine | Major | |
| Diazepam | Major | |
| Alcohol | Major | |
| Furosemide | Moderate | |
| Pioglitazone | Moderate | |
| Lisinopril | Moderate | |
| Antacids | Minor | |
| Oral contraceptives | Minor | |
| Metformin | Minor | |
| Warfarin | Minor |
🚨 Major Interactions
- Opioid analgesics (e.g., morphine, oxycodone)
- Benzodiazepines (e.g., diazepam, lorazepam)
- Alcohol
⚡ Moderate Interactions
- Antihypertensives
- Thiazolidinediones (e.g., pioglitazone)
- Loop diuretics (e.g., furosemide)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and pregabalin depress the central nervous system, leading to increased drowsiness, dizziness, impaired coordination, and a higher risk of accidents. Combining them can also increase the risk of respiratory depression, especially if other sedatives are used. If you consume alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pregabalin, methylcobalamin, or any component of the formulation.","Severe renal impairment (creatinine clearance less than 15 mL/min) unless dose is adjusted and monitored.","Concurrent use with strong opioids or benzodiazepines without close monitoring.","Pregnancy, unless clearly needed and advised by a specialist.","Breastfeeding, unless advised by a doctor.","Children under 18 years of age, unless prescribed by a paediatric neurologist."]
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not stop this medicine suddenly; withdrawal symptoms may occur. Taper gradually under medical supervision.","May increase the risk of suicidal thoughts; report any mood changes to your doctor immediately.","Use with caution in elderly patients due to increased risk of falls and confusion.","May cause peripheral edema; monitor for swelling of hands and feet.","Inform your doctor if you have kidney disease, as dose adjustment may be needed.","Avoid alcohol and other central nervous system depressants while taking this medicine.","May impair fertility in some men; discuss with your doctor if you are planning to father a child."]
🤱 Lactation Safety
Pregabalin is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Methylcobalamin is present in breast milk and is considered safe. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine may cause excessive drowsiness, confusion, agitation, dizziness, blurred vision, and in severe cases, respiratory depression, coma, or seizures. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal if taken recently, monitoring of vital signs, and management of symptoms. There is no specific antidote for pregabalin; hemodialysis may be considered in severe cases with renal failure. Methylcobalamin overdose is unlikely to cause serious harm due to its low toxicity.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it suddenly, as this can cause withdrawal symptoms such as anxiety, insomnia, nausea, or headache. Avoid driving or operating dangerous machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine because it can increase drowsiness and dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medicines you take, especially opioids, sedatives, or other pain medicines. If you have kidney problems, your doctor may need to adjust your dose. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight. Do not use it after the expiry date. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; never double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as dizziness, drowsiness, confusion, and falls. Doses should be started low and increased slowly. Renal function should be assessed before and during treatment. Elderly patients may also be more sensitive to the effects of pregabalin on balance and cognition. Regular monitoring and dose adjustments are important.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Pregabalin may increase the risk of birth defects. Effective contraception should be used during treatment. If you become pregnant while taking this medicine, contact your doctor immediately. Do not stop the medicine abruptly without medical advice.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Pregabalin can interact with anesthetic agents and increase sedation. Your doctor may advise you to stop the medicine temporarily before surgery. Do not stop it on your own. After surgery, follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Pregabalin may interact with sedatives or anesthetics used during dental work, increasing drowsiness. Your dentist may need to adjust the dose of other medicines. Do not stop this medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness, drowsiness, or unsteadiness. Avoid high-impact or balance-demanding exercises until you know how the medicine affects you. Start with gentle activities and gradually increase intensity. If you feel dizzy or weak, stop and rest. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy equipment. Take regular breaks if you have a desk job, and practice good posture. The medicine may also cause mood changes; seek support if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe allergic reactions, suicidal thoughts, or signs of liver or kidney problems, seek immediate medical attention. Your doctor may decide to stop the medicine or adjust the dose based on your condition and response. If you wish to discontinue, your doctor will gradually taper the dose to prevent withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Pregabalin can cause weight gain, peripheral edema, and cognitive effects. Regular monitoring of kidney function, mood, and side effects is recommended. The need for continued therapy should be reassessed periodically. Methylcobalamin is generally safe for long-term use, but excessive doses should be avoided. Do not use for longer than prescribed without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve strength, balance, and reduce pain in neuropathic conditions.
Evidence: Well-establishedHelps patients cope with chronic pain and reduce distress.
Evidence: ModerateMay provide temporary relief from neuropathic pain.
Evidence: LimitedSome patients report pain relief, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking. Live vaccines should be avoided if you have a weakened immune system, but this medicine does not typically cause immunosuppression.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust the dosing schedule gradually in consultation with your doctor. Do not pack it in checked baggage. Check local customs regulations regarding controlled substances, as pregabalin may be regulated in some countries.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start noticing some relief within a few days, but the full effect on neuropathic pain usually takes 2 to 4 weeks of regular use.
A: No, you should not stop suddenly. Your doctor will gradually reduce the dose to prevent withdrawal symptoms.
A: If you remember within a few hours, take it. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine can cause dizziness and drowsiness. Avoid driving until you know how it affects you.
A: Consult your doctor before taking any other painkillers, especially opioids, as they can increase sedation and breathing problems.
🤔 Common Patient Concerns
🔄 Substitutes for reneurop 1500mcg/75mg tablet sr
View AllAlternative brands with exact same active ingredient:
-
davaindia methylcobalamin+pregabalin 1500mcg/75mg tablet srDavaindia Generic Pharmacy ₹50.00 66.9% CHEAPER
-
nervigesic pg 1500mcg/75mg tabletIndian Pharmaceuticals ₹65.53 56.6% CHEAPER
-
aconerv-p tablet srAcmedix Pharma LLP ₹67.50 55.3% CHEAPER
-
binerve 1500 tablet srFreedom Healthcare Pvt Ltd ₹79.69 47.2% CHEAPER
-
nurotek-pg tablet srMacsys LifeSciences ₹79.69 47.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a simple painkiller for any type of pain.
Fact: This medicine is specifically for neuropathic pain and is not effective for ordinary headaches or muscle pain. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: Stopping suddenly can cause withdrawal symptoms. Always taper gradually under medical supervision. - Myth: This medicine is safe to take during pregnancy.
Fact: Pregabalin may increase the risk of birth defects. Consult your doctor if you are pregnant or planning pregnancy. - Myth: Taking more than the prescribed dose will relieve pain faster.
Fact: Taking more can increase side effects and does not provide faster relief. Always follow the prescribed dose.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin 1500 mcg + Pregabalin 75 mg tablet (generic versions may be available)
Brand Alternatives
- Pregeb M 75 Tablet
- Nurokind-G 75 Tablet
- Maxgalin M 75 Tablet
- Pregabid M 75 Tablet
- Gabapin ME 75 Tablet