Neocalm Plus Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity and confusion (possible neuroleptic malignant syndrome).
- Involuntary repetitive movements of the face, tongue, or limbs (tardive dyskinesia).
- Severe allergic reaction with rash, swelling, or difficulty breathing.
- Yellowing of skin or eyes (jaundice).
- Irregular heartbeat or palpitations.
- Seizures or loss of consciousness.
- Severe abdominal pain or difficulty urinating.
If experiencing severe symptoms, call emergency services immediately.
What is relicalm plus 5 mg/2 mg tablet used for?
This medicine is a combination of trifluoperazine (an antipsychotic) and trihexyphenidyl (an anticholinergic) used to treat schizophrenia and other psychotic disorders. Trihexyphenidyl helps reduce movement side effects caused by trifluoperazine.
- Generic Name: Trifluoperazine (5mg) + Trihexyphenidyl (2mg)
- Manufacturer: Reliance Formulation Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 relicalm plus 5 mg/2 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्राइफ्लुओपेराज़िन और ट्राईहेक्सीफेनिडाइल का संयोजन है, जिसका उपयोग सिज़ोफ्रेनिया और अन्य मानसिक विकारों के इलाज के लिए किया जाता है। यह मतिभ्रम, भ्रम और आंदोलन को कम करने में मदद करती है। ट्राईहेक्सीफेनिडाइल ट्राइफ्लुओपेराज़िन के कारण होने वाले मांसपेशियों में अकड़न और कंपन जैसे दुष्प्रभावों को कम करता है।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में मुँह सूखना, धुंधली दृष्टि, कब्ज, नींद आना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में टार्डिव डिस्किनेसिया (अनैच्छिक हरकतें), न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम (तेज बुखार, मांसपेशियों में अकड़न, भ्रम) और गंभीर एलर्जी प्रतिक्रियाएँ शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, क्योंकि इससे मतली, उल्टी और अनिद्रा हो सकती है। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाते या मशीन चलाते समय सावधानी बरतें। मुँह सूखने से राहत के लिए पानी पिएँ और शुगर-फ्री गम चबाएँ। नियमित रूप से रक्त जांच, लीवर फंक्शन और आँखों की जांच करवाएँ।
💊 relicalm plus 5 mg/2 mg tablet Uses & Benefits
- [{"condition":"Schizophrenia","description":"Helps reduce hallucinations, delusions, and disorganized thinking.
- The trihexyphenidyl component minimizes extrapyramidal side effects.","evidence":"Well-established"},{"condition":"Psychotic disorders","description":"Used for short-term management of acute psychosis and agitation.","evidence":"Well-established"},{"condition":"Severe anxiety","description":"May be used as an adjunct for severe anxiety when other treatments are ineffective.","evidence":"Limited"}]
Off-label uses: [{"condition":"Nausea and vomiting","description":"Trifluoperazine has antiemetic properties, but this combination is not typically used for this purpose.","evidence":"Limited"},{"condition":"Huntington's disease","description":"Sometimes used to control chorea, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Schizophrenia
Also treats: Psychotic disorders, Severe anxiety, Agitation
📋 Drug Information
| Generic Name(s) | Trifluoperazine (5mg) + Trihexyphenidyl (2mg) |
| Brand Name | relicalm plus 5 mg/2 mg tablet |
| Manufacturer | Reliance Formulation Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Trifluoperazine blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing psychotic symptoms. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking effects. Trihexyphenidyl is a centrally acting anticholinergic that restores the balance between dopamine and acetylcholine in the striatum, thereby reducing extrapyramidal symptoms caused by dopamine blockade.
Mechanism Steps
💡 How to Take relicalm plus 5 mg/2 mg tablet
Strength: Each tablet contains Trifluoperazine 5 mg and Trihexyphenidyl 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 1 tablet taken 1 to 2 times daily, but the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and renal/hepatic function. Do not self-adjust the dose. Take with food to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Use with caution due to increased risk of tardive dyskinesia, anticholinergic effects, and falls. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be needed. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed 10 mg of trifluoperazine and 4 mg of trihexyphenidyl, but this must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of relicalm plus 5 mg/2 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CNS depressants | Major | |
| Anticholinergics | Major | |
| CYP1A2 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Antacids | Moderate | |
| Antihistamines | Minor | |
| Tricyclic antidepressants | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (alcohol, benzodiazepines, opioids)
- Anticholinergics (e.g., atropine, benztropine)
⚡ Moderate Interactions
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- CYP3A4 inducers (e.g., carbamazepine, rifampin)
- Antacids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase sedation, dizziness, and the risk of respiratory depression. It may also worsen the underlying psychiatric condition.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Parkinson's disease","Glaucoma (narrow-angle)","Urinary retention","Severe liver disease","Severe kidney disease","Elderly patients with dementia-related psychosis","Known hypersensitivity to trifluoperazine or trihexyphenidyl"]
⚠️ Warnings & Precautions
["May cause tardive dyskinesia, which can be irreversible.","Risk of neuroleptic malignant syndrome; seek emergency care if symptoms occur.","May impair ability to drive or operate machinery.","Avoid alcohol and other CNS depressants.","Use with caution in patients with cardiovascular disease.","May lower seizure threshold; use with caution in epileptic patients.","Anticholinergic effects can worsen glaucoma, urinary retention, and constipation.","Do not stop abruptly; taper under medical supervision."]
🤱 Lactation Safety
Not established from the available information. Both drugs may pass into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose can cause severe drowsiness, coma, seizures, hypotension, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and ECG.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly, as withdrawal can cause nausea, vomiting, and insomnia. Avoid alcohol and other central nervous system depressants. Use caution while driving or operating machinery until you know how this medicine affects you. Stay hydrated and maintain good oral hygiene to manage dry mouth. Inform your doctor if you have glaucoma, prostate enlargement, or heart problems. Regular monitoring of blood counts, liver function, and eye exams may be needed during long-term therapy. Do not take antacids or antidiarrheal medicines without consulting your doctor, as they can affect absorption.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Increased risk of tardive dyskinesia, anticholinergic effects, falls, and confusion. Use with caution in dementia-related psychosis due to increased mortality risk.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Discuss alternative treatments with your doctor.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and increase the risk of complications. Your doctor may advise temporary dose adjustments.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental caries and gum disease. Regular dental check-ups are recommended.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms such as nausea, vomiting, insomnia, and relapse of psychiatric symptoms. Your doctor will gradually reduce the dose if needed.
📅 Long-Term Use Effects
Long-term use may increase the risk of tardive dyskinesia, which can be irreversible. Regular monitoring of blood counts, liver function, and eye exams is recommended. Metabolic side effects such as weight gain and diabetes may occur. Periodic assessment of extrapyramidal symptoms is necessary. Dose reduction or discontinuation should be done gradually under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for managing psychotic symptoms.
Evidence: Well-establishedHelps family members support the patient and understand the condition.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can improve overall well-being.
Evidence: Emerging💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust dosing times gradually under medical advice. Store at room temperature and protect from direct sunlight. Check customs regulations for controlled substances before traveling internationally. Always carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Antipsychotic effects may take several days to weeks. Anticholinergic effects occur within 1-2 hours.
A: Yes, take it with food to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop suddenly as it can cause withdrawal symptoms and relapse. Consult your doctor for a gradual taper.
A: Not established from the available information. Use only if clearly needed and prescribed by a doctor.
🤔 Common Patient Concerns
🔄 Substitutes for relicalm plus 5 mg/2 mg tablet
View AllAlternative brands with exact same active ingredient:
-
wipetri 5mg/2mg tabletNexus India ₹5.95 81.4% CHEAPER
-
sycot 5mg/2mg tabletStadmed Pvt Ltd ₹7.07 77.9% CHEAPER
-
hexyzine 5 mg/2 mg tabletRKG Pharma ₹7.51 76.5% CHEAPER
-
Selocalm Plus 5mg/2mg TabletOsho Pharma Pvt Ltd ₹8.44 73.6% CHEAPER
-
Tercam 5 mg/2 mg TabletGujarat Terce Laboratories Ltd ₹9.82 69.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered under medical supervision. - Myth: This medicine can cure schizophrenia permanently.
Fact: This medicine manages symptoms but does not cure schizophrenia. Long-term treatment is often needed. - Myth: You can stop taking this medicine once you feel better.
Fact: Stopping suddenly can cause relapse of symptoms and withdrawal effects. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Trifluoperazine + Trihexyphenidyl combination (generic)
Brand Alternatives
- Neocalm Plus Tablet