relicalm plus 10 mg/2 mg tablet - Trifluoperazine (10mg) + Trihexyphenidyl (2mg) medicine

Elicalm Plus 10mg/2mg Tablet: Complete Information

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🏭 Reliance Formulation Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for schizophrenia; limited for off-label uses.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • High fever with muscle rigidity and confusion
  • Uncontrollable movements of face, tongue, or limbs
  • Irregular heartbeat or fainting
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Yellowing of skin or eyes
  • Unusual bleeding or bruising
  • Seizures

If experiencing severe symptoms, call emergency services immediately.

What is relicalm plus 10 mg/2 mg tablet used for?

This medicine is a combination of trifluoperazine (an antipsychotic) and trihexyphenidyl (an anticholinergic) used to treat schizophrenia and other psychotic disorders. Trihexyphenidyl helps reduce movement side effects caused by trifluoperazine.

  • Generic Name: Trifluoperazine (10mg) + Trihexyphenidyl (2mg)
  • Manufacturer: Reliance Formulation Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 relicalm plus 10 mg/2 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा ट्राइफ्लुओपेराज़िन और ट्राइहेक्सीफेनिडाइल का संयोजन है, जिसका उपयोग सिज़ोफ्रेनिया और अन्य मानसिक विकारों के इलाज के लिए किया जाता है। यह मतिभ्रम, भ्रम और आंदोलन को कम करने में मदद करती है। ट्राइहेक्सीफेनिडाइल ट्राइफ्लुओपेराज़िन के कारण होने वाले मांसपेशियों की अकड़न और कंपन को कम करता है।

साइड इफेक्ट्स: सामान्य दुष्प्रभावों में मुंह सूखना, धुंधली दृष्टि, कब्ज, नींद आना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में अनैच्छिक मांसपेशीय हलचल, उच्च बुखार, मांसपेशियों में अकड़न और अनियमित दिल की धड़कन शामिल हो सकते हैं। इन्हें तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अचानक बंद न करें। शराब न पिएं। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इसका असर पता न चल जाए। नियमित रूप से रक्त जांच और लीवर फंक्शन की जांच कराएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 relicalm plus 10 mg/2 mg tablet Uses & Benefits

  • [{"condition":"Schizophrenia","description":"This medicine helps manage symptoms such as hallucinations, delusions, and disorganized thinking.
  • Trihexyphenidyl reduces drug-induced movement disorders.","evidence":"Well-established"},{"condition":"Psychosis","description":"Used to control psychotic symptoms in conditions like schizoaffective disorder and brief psychotic disorder.","evidence":"Well-established"},{"condition":"Agitation and aggression","description":"May be used short-term to manage severe agitation in psychiatric emergencies.","evidence":"Limited"}]

Off-label uses: [{"condition":"Tourette syndrome","description":"Sometimes prescribed off-label to reduce tics, though not first-line.","evidence":"Limited"},{"condition":"Severe anxiety with psychotic features","description":"May be used off-label when other treatments fail.","evidence":"Limited"}]

Primary treatment for: Schizophrenia

Also treats: Psychosis, Schizoaffective disorder, Bipolar disorder with psychotic features

📋 Drug Information

Generic Name(s)Trifluoperazine (10mg) + Trihexyphenidyl (2mg)
Brand Namerelicalm plus 10 mg/2 mg tablet
ManufacturerReliance Formulation Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid alcohol completely while on this medicine.
3
Do not drive or operate machinery until you know how it affects you.
4
Take it at the same time each day to maintain steady levels.
5
Do not stop abruptly; consult your doctor for a gradual taper.
6
Report any unusual movements, fever, or muscle stiffness immediately.
7
Keep all follow-up appointments for blood tests and eye exams.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Hallucinations
This medicine is commonly prescribed for this.
Likely Use
Delusions
This medicine is commonly prescribed for this.
Likely Use
Muscle stiffness
Trihexyphenidyl component helps reduce this.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTrifluoperazine is well absorbed from the gastrointestinal tract. Trihexyphenidyl is also well absorbed orally. Food may slightly delay absorption but does not significantly affect overall bioavailability.
DistributionBoth drugs are widely distributed in body tissues. Trifluoperazine is highly protein-bound. Trihexyphenidyl crosses the blood-brain barrier and placenta.
Protein BindingTrifluoperazine: approximately 90-99% bound to plasma proteins. Trihexyphenidyl: approximately 80% bound.
MetabolismTrifluoperazine is metabolized in the liver by cytochrome P450 enzymes, primarily CYP1A2 and CYP3A4. Trihexyphenidyl is also metabolized in the liver.
Half-LifeTrifluoperazine: approximately 10-20 hours. Trihexyphenidyl: approximately 3-4 hours.
ExcretionBoth drugs and their metabolites are excreted primarily in urine and feces.
BioavailabilityTrifluoperazine: approximately 40-50% due to first-pass metabolism. Trihexyphenidyl: approximately 80-90%.
Onset of ActionAntipsychotic effects may take several days to weeks to fully manifest. Anticholinergic effects occur within 1-2 hours.
Peak Plasma TimeTrifluoperazine: 2-4 hours. Trihexyphenidyl: 1-2 hours.
Duration of ActionTrifluoperazine: 12-24 hours. Trihexyphenidyl: 6-12 hours.

How It Works

Trifluoperazine blocks dopamine D2 receptors in the brain, reducing psychotic symptoms. Trihexyphenidyl blocks acetylcholine receptors, helping to balance dopamine and acetylcholine activity, which reduces extrapyramidal side effects caused by trifluoperazine.

Mechanism Steps

1
Dopamine D2 receptor blockade: Trifluoperazine binds to and blocks dopamine D2 receptors in the mesolimbic pathway, reducing positive symptoms of psychosis.
2
Anticholinergic action: Trihexyphenidyl blocks muscarinic acetylcholine receptors in the striatum, restoring the dopamine-acetylcholine balance and reducing extrapyramidal symptoms.
3
Combined effect: The combination allows for effective antipsychotic treatment with fewer movement-related side effects.

💡 How to Take relicalm plus 10 mg/2 mg tablet

Strength: Tablet containing Trifluoperazine 10 mg and Trihexyphenidyl 2 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with food to reduce stomach upset.
4Take at the same time each day.
5Follow your doctor's instructions exactly.

Dosage Information

Adult DosageThe dosage is individualized by a qualified clinician based on the condition, severity, and patient response. Typically, treatment is started at a low dose and gradually increased. The usual maintenance dose may range from 1 to 2 tablets daily, but this must be confirmed by your doctor. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for side effects such as confusion, falls, and extrapyramidal symptoms.
Renal ImpairmentUse with caution in renal impairment. Dose adjustment may be necessary. Consult a doctor.
Hepatic ImpairmentUse with caution in hepatic impairment. Dose adjustment may be necessary. Consult a doctor.
Maximum Daily DoseThe maximum daily dose is determined by the prescribing doctor based on the patient's condition and tolerance. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Alcohol
Avoid
Increases sedation and CNS depression.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of relicalm plus 10 mg/2 mg tablet

✅ Common Side Effects

Dry mouth (Common (10-30%))
Chew sugar-free gum or sip water. Consult doctor if severe.
Blurred vision (Common (10-20%))
Usually temporary. Avoid driving if affected.
Constipation (Common (10-20%))
Increase fiber and fluid intake. Use laxatives if needed after consulting doctor.
Drowsiness (Common (10-20%))
Avoid driving or operating machinery until effects wear off.
Dizziness (Common (5-15%))
Rise slowly from sitting or lying position.

🚨 Serious Side Effects

Tardive dyskinesia (Uncommon (1-5%))
Report involuntary movements to doctor immediately. May be irreversible.
Neuroleptic malignant syndrome (Rare (<0.1%))
Seek emergency care for high fever, muscle rigidity, confusion, or irregular pulse.
Severe allergic reaction (Rare (<0.1%))
Get emergency help for rash, swelling, or difficulty breathing.
Blood dyscrasias (Rare (<0.1%))
Report unusual bruising, bleeding, or infections.

⚠️ Rare Side Effects

Jaundice
Seek medical attention if skin or eyes yellow.
Seizures
Seek emergency care.
QT prolongation
Report palpitations or fainting.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
CNS depressants Major
Anticholinergics Major
Levodopa Moderate
Antihypertensives Moderate
Metoclopramide Moderate
Antacids Minor
Caffeine Minor

🚨 Major Interactions

  • MAO inhibitors
  • CNS depressants (e.g., alcohol, benzodiazepines, opioids)
  • Anticholinergics (e.g., atropine, benztropine)

⚡ Moderate Interactions

  • Levodopa
  • Antihypertensives
  • Metoclopramide

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of other central nervous system side effects. It may also worsen the underlying psychiatric condition.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to trifluoperazine or trihexyphenidyl","Severe central nervous system depression","Comatose states","Blood dyscrasias","Severe liver disease","Glaucoma","Enlarged prostate","Myasthenia gravis"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol.","Do not stop abruptly; taper gradually.","Use with caution in elderly patients.","May lower seizure threshold.","May cause anticholinergic effects; use with caution in patients with glaucoma, urinary retention, or constipation.","May cause photosensitivity; use sunscreen.","Regular monitoring of blood counts and liver function is advised."]

🤱 Lactation Safety

Not established from the available information. Both drugs may pass into breast milk. Consult a doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe drowsiness, coma, seizures, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not stop abruptly, as withdrawal symptoms may occur. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine, as it can increase drowsiness and other side effects. Inform your doctor if you have glaucoma, enlarged prostate, or heart problems. Regular monitoring of blood counts, liver function, and eye exams may be necessary during long-term treatment. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for confusion, falls, and extrapyramidal symptoms. Increased risk of mortality in elderly with dementia-related psychosis.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine may not be safe during pregnancy. Effective contraception is advised while taking this medicine.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthetic agents and affect recovery.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It can cause dry mouth and may interact with dental anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through diet and exercise.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good sleep hygiene.
💧
Avoid alcohol and recreational drugs.
🧘
Stay socially active and attend follow-up appointments.
🌞
Manage stress with relaxation techniques.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you, as it can cause drowsiness and dizziness. Stay hydrated during exercise.

🥗 Diet Recommendations

Include fiber-rich foods to prevent constipation.
Stay well hydrated to reduce dry mouth.
Limit caffeine and sugary drinks.
Eat a balanced diet to support overall health.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and blurred vision, which may affect your ability to drive or operate machinery. Avoid these activities until you know how it affects you. Discuss with your employer if your job requires such tasks.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms or relapse of psychiatric symptoms. Your doctor will gradually reduce the dose if needed.

📅 Long-Term Use Effects

Long-term use may increase the risk of tardive dyskinesia, metabolic syndrome, and anticholinergic effects. Regular monitoring of blood counts, liver function, and eye exams is recommended. Periodic reassessment of the need for continued treatment is advised.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy

Can complement medicine for schizophrenia.

Evidence: Well-established
Psychosocial rehabilitation

Helps improve social and vocational skills.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, consult your doctor before receiving any live vaccines while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage. Store at room temperature and avoid extreme heat. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for controlled substances before travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with schizophrenia
He was started on this medicine after experiencing hallucinations and agitation. Within a few weeks, his symptoms improved significantly. He experienced dry mouth initially, which was managed by sipping water. He continues regular follow-ups and has not had any severe side effects.
💡 Lesson: Consistent use and regular monitoring help manage symptoms effectively.
👤 A 50-year-old woman with schizoaffective disorder
She had severe muscle stiffness from a previous antipsychotic. Her doctor switched her to this combination. The stiffness reduced considerably, and she was able to resume her daily activities. She was advised to avoid alcohol and driving.
💡 Lesson: The addition of trihexyphenidyl can improve tolerability of antipsychotic treatment.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Antipsychotic effects may take several days to weeks to fully manifest. Anticholinergic effects occur within 1-2 hours.

Q: Can I stop taking this medicine suddenly?

A: No, stopping abruptly can cause withdrawal symptoms or relapse. Consult your doctor for a gradual taper.

Q: Is it safe during pregnancy?

A: Not established from the available information. Consult your doctor before use.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for relicalm plus 10 mg/2 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is addictive.
    Fact: It is not addictive, but it should not be stopped abruptly without medical advice.
  • Myth: It can cure schizophrenia permanently.
    Fact: It manages symptoms but does not cure the condition. Long-term treatment may be needed.
  • Myth: It is safe to drive while taking this medicine.
    Fact: It can cause drowsiness and blurred vision, so avoid driving until you know how it affects you.

🔄 Alternative Options

Generic Alternatives

  • Trifluoperazine + Trihexyphenidyl combination generics

Brand Alternatives

  • Elicalm Plus 10mg/2mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Trifluoperazine alone","difference":"Lacks trihexyphenidyl, so higher risk of extrapyramidal symptoms."},{"medicine":"Haloperidol + Trihexyphenidyl","difference":"Different antipsychotic; may have different side effect profile."}]

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