refacold tablet - Ambroxol (30mg) + Guaifenesin (100mg) medicine

Bronk X Syrup: Complete Guide to Uses, Dosage, Side Effects, and Safety

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🏭 Trans Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for productive cough; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in sputum or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Persistent fever or rash

If experiencing severe symptoms, call emergency services immediately.

What is refacold tablet used for?

This medicine is a combination of Ambroxol and Guaifenesin used to treat productive cough by thinning mucus and making it easier to cough up. It is taken orally every 4-6 hours as needed, but not for more than 7 days without medical advice.

  • Generic Name: Ambroxol (30mg) + Guaifenesin (100mg)
  • Manufacturer: Trans Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 refacold tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एक कफ सिरप है जिसमें एम्ब्रोक्सोल और गुआइफेनेसिन दो सक्रिय तत्व होते हैं। यह गीले खांसी (जिसमें बलगम आता है) के इलाज के लिए इस्तेमाल की जाती है। यह बलगम को पतला करके और उसे बाहर निकालने में मदद करके छाती की जकड़न को कम करती है। यह दवा सूखी खांसी के लिए नहीं है। इसका इस्तेमाल डॉक्टर की सलाह के अनुसार ही करें।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट में गड़बड़ी, सिरदर्द और नींद आना शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको त्वचा पर चकत्ते, सूजन, सांस लेने में कठिनाई, या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से ज्यादा न लें। हर बार उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही माप के लिए मापने वाला कप या चम्मच इस्तेमाल करें। सूखी खांसी के लिए इसका इस्तेमाल न करें। 7 दिन से ज्यादा इसका इस्तेमाल न करें। अगर आपको नींद या चक्कर आते हैं तो गाड़ी न चलाएं। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 refacold tablet Uses & Benefits

[{"condition":"Productive cough (wet cough)","description":"Helps to loosen and thin mucus in the airways, making it easier to cough out and providing relief from chest congestion.","evidence":"Well-established"},{"condition":"Bronchitis","description":"Used as a supportive treatment to clear mucus in acute or chronic bronchitis.","evidence":"Moderate"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"May be used to help clear mucus in COPD patients, but only under medical supervision.","evidence":"Limited"}]

Off-label uses: []

Primary treatment for: Productive cough

Also treats: Bronchitis, COPD, Chest congestion

📋 Drug Information

Generic Name(s)Ambroxol (30mg) + Guaifenesin (100mg)
Brand Namerefacold tablet
ManufacturerTrans Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not refrigerate. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine only for productive cough, not for dry cough.
2
Advise patients to take it with food if they experience stomach upset.
3
Warn patients about the possibility of drowsiness and advise caution while driving.
4
Instruct patients not to use this medicine for more than 7 days without reassessment.
5
Caution patients to avoid alcohol while taking this medicine.
6
For pediatric use, calculate the dose based on weight and age, and do not exceed recommended limits.
7
Monitor for allergic reactions, especially in patients with a history of allergy.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Productive cough
This medicine is commonly prescribed for this.
Likely Use
Dry cough
This medicine is not effective for dry cough.
Not Primary
Chest congestion
This medicine helps to clear mucus and relieve congestion.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmbroxol is rapidly absorbed from the gastrointestinal tract after oral administration. Guaifenesin is also absorbed from the gastrointestinal tract. The presence of food may slightly delay the absorption of guaifenesin but does not significantly affect the overall effect.
DistributionAmbroxol is widely distributed in the body, including the lungs, and crosses the blood-brain barrier and placental barrier. Guaifenesin is also distributed to various tissues. Protein binding information is not well established for both ingredients.
Protein BindingNot established from the available information.
MetabolismAmbroxol is metabolized in the liver primarily by conjugation to glucuronides and sulfates. Guaifenesin is metabolized in the liver by oxidation and conjugation.
Half-LifeThe elimination half-life of Ambroxol is approximately 7 to 12 hours. The half-life of Guaifenesin is about 1 hour.
ExcretionAmbroxol and its metabolites are excreted mainly in the urine. Guaifenesin and its metabolites are also excreted in the urine.
BioavailabilityThe oral bioavailability of Ambroxol is about 70-80% due to first-pass metabolism. The bioavailability of Guaifenesin is approximately 50%.
Onset of ActionThe onset of action for Ambroxol is typically within 30 minutes to 1 hour after oral administration. Guaifenesin may start working within 30 minutes.
Peak Plasma TimePeak plasma concentrations of Ambroxol are reached about 1 to 2.5 hours after oral administration. For Guaifenesin, peak levels occur within 15 to 30 minutes.
Duration of ActionThe effects of Ambroxol last for about 6 to 12 hours. Guaifenesin effects last for about 4 to 6 hours. However, the exact duration may vary.

How It Works

This medicine works through two complementary mechanisms. Ambroxol is a mucolytic that breaks down acidic mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to clear. It also stimulates the production of surfactant in the lungs, which helps to keep airways open. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of bronchial secretions by drawing water into the mucus, making it less sticky and easier to cough up. Together, they help to relieve chest congestion and make coughing more productive.

Mechanism Steps

1
Ambroxol breaks down mucus fibers: Ambroxol hydrolyzes acidic mucopolysaccharide fibers in the mucus, reducing its viscosity and making it less thick.
2
Ambroxol stimulates surfactant production: It promotes the production of surfactant in the alveoli, which helps to keep the airways open and improves mucus transport.
3
Guaifenesin increases mucus water content: Guaifenesin draws water into the bronchial secretions, further thinning the mucus and increasing its volume.
4
Enhanced mucus clearance: The combined effect makes the mucus easier to cough up, leading to a productive cough that clears the airways.

💡 How to Take refacold tablet

Strength: Each 5 mL of syrup contains Ambroxol 30 mg and Guaifenesin 100 mg.

1Shake the bottle well before each use.
2Measure the correct dose using the measuring cup or spoon provided.
3Take the medicine orally, with or without food.
4If it upsets your stomach, take it with a meal or snack.
5Drink a glass of water after taking the medicine.
6Wash the measuring cup after each use.
7Close the bottle tightly after use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5-10 mL (one to two teaspoons) taken orally every 4 to 6 hours, up to a maximum of 6 doses in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the recommended dose. Always use a proper measuring cup or spoon.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, such as drowsiness and dizziness. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentDose adjustment may be needed in patients with kidney disease. Consult a doctor for guidance.
Hepatic ImpairmentDose adjustment may be needed in patients with liver disease. Consult a doctor for guidance.
Maximum Daily DoseThe maximum daily dose of this medicine should not exceed 60 mL (12 teaspoons) in 24 hours for adults, unless otherwise directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Water
Drink plenty of water
Helps to thin mucus and soothe the throat.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of refacold tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (1-10%))
Stay hydrated. If vomiting is severe or persistent, seek medical advice.
Stomach upset (Common (1-10%))
Take with meals. Avoid spicy foods. Consult doctor if it continues.
Diarrhea (Common (1-10%))
Drink plenty of fluids. If diarrhea is severe or bloody, seek medical help.
Headache (Common (1-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Drowsiness (Uncommon (0.1-1%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face, lips, or throat, difficulty breathing, or dizziness.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Stop the medicine and seek immediate medical help if you notice skin rash, blisters, or peeling skin.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools, vomiting blood, or severe abdominal pain.

⚠️ Rare Side Effects

Kidney problems
Report decreased urine output, swelling in legs, or fatigue to your doctor immediately.
Liver problems
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Dextromethorphan Major
Atropine Moderate
Amoxicillin Moderate
Furosemide Minor

🚨 Major Interactions

  • Cough suppressants (e.g., codeine, dextromethorphan)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, hyoscyamine)
  • Antibiotics (e.g., amoxicillin, cefuroxime)

🍷 Alcohol Interaction

Alcohol may increase the risk of drowsiness, dizziness, and stomach upset when taken with this medicine. It is advisable to avoid alcohol while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to Ambroxol, Guaifenesin, or any other ingredient in this medicine.","Children under 2 years of age.","Use in patients with a dry, non-productive cough.","Use in patients with severe liver or kidney disease without medical supervision."]

⚠️ Warnings & Precautions

["Do not use this medicine for more than 7 days without consulting a doctor.","If cough persists or worsens, or is accompanied by fever, rash, or persistent headache, consult a doctor.","Avoid driving or operating machinery if you feel drowsy or dizzy.","Avoid alcohol while taking this medicine.","Consult your doctor before use if you are pregnant, planning to become pregnant, or breastfeeding.","Use with caution in patients with liver or kidney disease.","Keep out of reach of children.","Do not exceed the recommended dose."]

🤱 Lactation Safety

It is not known whether Ambroxol and Guaifenesin pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

If you suspect an overdose, seek immediate medical attention. Symptoms of overdose may include severe nausea, vomiting, diarrhea, and abdominal pain. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Shake the bottle well before each use. Use a proper measuring cup or spoon to ensure accurate dosing. Do not use this medicine for a dry cough or for more than 7 days without consulting a doctor. Avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking this medicine. Do not drink alcohol while taking this medicine as it may increase drowsiness and stomach upset. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Store it at room temperature, away from direct sunlight and moisture. Do not use it after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, particularly drowsiness, dizziness, and stomach upset. They may also have reduced liver and kidney function, which can affect drug clearance. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. The safety of this medicine during pregnancy is not well established, and it should only be used if clearly needed and prescribed by a doctor.

🏥 Post-Surgery Considerations

If you have recently undergone surgery, consult your doctor before using this medicine. It may interact with other medications or affect your recovery. Do not self-medicate.

🦷 Dental Procedures

This medicine does not typically interfere with dental procedures. However, inform your dentist that you are taking it, especially if you are scheduled for surgery or have a history of allergies.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated by drinking plenty of fluids, especially water and warm liquids.
🥗
Use a humidifier or take steamy showers to help loosen mucus.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid alcohol and caffeine, which can dehydrate you.

🏋️ Exercise Considerations

If you experience drowsiness or dizziness after taking this medicine, avoid exercising or operating heavy machinery. Light activity like walking may be fine if you feel up to it, but listen to your body and rest when needed.

🥗 Diet Recommendations

Drink warm fluids like herbal tea, soup, and broth.
Include honey and ginger in your diet, which can soothe the throat.
Avoid cold, sugary, and processed foods that can thicken mucus.
Eat plenty of fruits and vegetables rich in vitamin C.
Avoid dairy products if they seem to increase mucus for you.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. If affected, avoid driving, operating machinery, or performing tasks that require alertness. Otherwise, it should not significantly impact your daily work life. Take it as prescribed and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, worsens, or is accompanied by fever, rash, or persistent headache. Also stop if you experience any severe side effects such as allergic reactions or gastrointestinal bleeding.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to increased side effects such as stomach upset, drowsiness, and rarely, kidney or liver problems. It is important to review with your doctor if you need to use it for more than 7 days. Regular monitoring of liver and kidney function may be advised in patients with underlying conditions.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Inhaling steam can help to loosen mucus and relieve chest congestion.

Evidence: Well-established
Saline nasal irrigation

Using a saline nasal spray or rinse can help to clear nasal passages and reduce postnasal drip.

Evidence: Moderate
Honey

A spoonful of honey can help soothe a cough and throat irritation.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it at room temperature and protect it from direct sunlight. If you are crossing time zones, continue taking the medicine as prescribed, but adjust the timing gradually to avoid missing doses. Do not leave it in a hot car or checked luggage. If you have any doubts, consult a pharmacist before your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He had a persistent productive cough with thick yellow mucus. His doctor prescribed this medicine. After taking it for 3 days, he noticed that the mucus became thinner and easier to cough out. He took it with food to avoid stomach upset and avoided alcohol. He felt significant relief within a week.
💡 Lesson: Taking this medicine as prescribed and with food improves tolerability and effectiveness.
👤 A 60-year-old woman with COPD
She experienced frequent chest congestion and difficulty clearing mucus. Her doctor added this medicine to her regimen. She found that her cough became more productive and her breathing felt easier. She was advised not to use it for more than 7 days without review.
💡 Lesson: This medicine can be helpful in COPD for mucus clearance, but it should be used under medical supervision and for short periods.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 minutes to 1 hour after taking it. You may notice that your cough becomes more productive and mucus is easier to cough out.

Q: Can I take this medicine with antibiotics?

A: Yes, this medicine can be taken with antibiotics. In fact, Ambroxol may increase the concentration of some antibiotics in the lungs, which can be beneficial. However, always consult your doctor before combining any medicines.

Q: Is this medicine safe for children?

A: This medicine is not recommended for children under 2 years of age. For older children, the dose must be determined by a pediatrician based on weight and age.

Q: Can I take this medicine if I am pregnant?

A: The safety of this medicine during pregnancy is not well established. Consult your doctor before using it if you are pregnant or planning to become pregnant.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for children?
  • Can I take it with other cough medicines?

🔄 Substitutes for refacold tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with mucus. It is not effective for dry cough.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can increase side effects and does not provide faster relief.
  • Myth: It is safe to take this medicine for weeks.
    Fact: This medicine should not be used for more than 7 days without consulting a doctor.

🔄 Alternative Options

Generic Alternatives

  • Ambroxol + Guaifenesin syrup (generic)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Ambroxol 30mg + Guaifenesin 100mg per 5mL","onset":"30-60 minutes","duration":"6-12 hours"},{"medicine":"Ambroxol alone","composition":"Ambroxol 30mg per 5mL","onset":"30-60 minutes","duration":"6-12 hours"},{"medicine":"Guaifenesin alone","composition":"Guaifenesin 100mg per 5mL","onset":"30 minutes","duration":"4-6 hours"}]

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