Binex Z 150mg/750mg Tablet: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the right upper quadrant
- Persistent nausea and vomiting
- Sudden severe joint pain, especially in the big toe
- Swelling of the face, lips, or throat, or difficulty breathing
- Seizures or confusion
- Unusual bleeding or bruising
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is r-cinex z tablet used for?
This medicine is a combination of isoniazid and pyrazinamide used to treat tuberculosis. It works by killing the bacteria that cause tuberculosis and is always used with other antitubercular medicines to prevent resistance. It must be taken exactly as prescribed, and regular liver function monitoring is important.
- Generic Name: Isoniazid (150mg) + Pyrazinamide (750mg)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 r-cinex z tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इंसोनियाजिड और पायराजिनामाइड का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज के लिए किया जाता है। यह टीबी के बैक्टीरिया को मारती है और हमेशा अन्य टीबी-रोधी दवाओं के साथ मिलकर दी जाती है ताकि दवा प्रतिरोध न हो। यह दवा मुख्य रूप से फेफड़ों की टीबी और शरीर के अन्य हिस्सों की टीबी के इलाज के लिए इस्तेमाल की जाती है। इसे डॉक्टर के बताए अनुसार नियमित रूप से लेना बहुत जरूरी है, और इलाज बीच में नहीं रोकना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, भूख न लगना, पेट में असहजता और थकान शामिल हैं। कुछ लोगों को जोड़ों में दर्द या मांसपेशियों में दर्द हो सकता है। इंसोनियाजिड के कारण हाथ-पैरों में झुनझुनी या सुन्नपन हो सकता है। गंभीर दुष्प्रभावों में लिवर की सूजन, पीलिया, गहरे रंग का पेशाब, त्वचा पर गंभीर दाने और सांस लेने में कठिनाई शामिल हैं। अगर ऐसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, नियमित समय पर लें और बीच में न रोकें। इलाज के दौरान शराब बिल्कुल न पिएं क्योंकि इससे लिवर को गंभीर नुकसान हो सकता है। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। लिवर की जांच नियमित रूप से कराते रहें। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं तो डॉक्टर को बताएं। आंखों या त्वचा का पीलापन, गहरे रंग का पेशाब, लगातार उल्टी या पेट में तेज दर्द होने पर तुरंत डॉक्टर से मिलें।
💊 r-cinex z tablet Uses & Benefits
[{"condition":"Active pulmonary tuberculosis","description":"Used in the intensive phase of treatment for drug-susceptible pulmonary tuberculosis as part of a multi-drug regimen.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Used for tuberculosis affecting lymph nodes, pleura, bones, joints, and other sites outside the lungs, always in combination with other antitubercular drugs.","evidence":"Well-established"},{"condition":"Tuberculous meningitis","description":"Included in the initial intensive phase of treatment for tuberculosis of the central nervous system under specialist supervision.","evidence":"Well-established"},{"condition":"Tuberculosis in HIV-infected patients","description":"Used as part of a tailored regimen for tuberculosis in people living with HIV, with careful attention to drug interactions and immune reconstitution.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Latent tuberculosis infection","description":"Isoniazid alone is used for latent tuberculosis, but this combination is not standard for latent infection and should not be used off-label without specialist guidance.","evidence":"Not established from the available information."},{"condition":"Atypical mycobacterial infections","description":"Occasionally considered by specialists for certain non-tuberculous mycobacterial infections, but evidence is limited and susceptibility testing is required.","evidence":"Limited"}]
Primary treatment for: Tuberculosis
Also treats: Extrapulmonary tuberculosis, Tuberculous meningitis, Tuberculosis in HIV-infected patients
📋 Drug Information
| Generic Name(s) | Isoniazid (150mg) + Pyrazinamide (750mg) |
| Brand Name | r-cinex z tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C, in its original container, away from moisture, heat, and direct sunlight. Do not refrigerate unless specifically instructed. Keep out of reach of children. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | The World Health Organization recommends isoniazid and pyrazinamide as part of first-line treatment for drug-susceptible tuberculosis during the intensive phase. This fixed-dose combination should be used in accordance with national tuberculosis program guidelines. |
| ICMR Guideline | The Indian Council of Medical Research and the Revised National Tuberculosis Control Program (RNTCP) recommend weight-based dosing of isoniazid and pyrazinamide in fixed-dose combinations for the treatment of drug-susceptible tuberculosis, with regular monitoring for adverse effects. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular agents with complementary mechanisms. Isoniazid is a prodrug activated by the mycobacterial enzyme KatG and then inhibits InhA, an enoyl-acyl carrier protein reductase, blocking the synthesis of mycolic acid, which is essential for the bacterial cell wall. Pyrazinamide is also a prodrug converted by mycobacterial pyrazinamidase to pyrazinoic acid, which disrupts membrane transport, depletes cellular energy, and inhibits fatty acid synthase type I, particularly in the acidic environment of inflamed tuberculosis lesions. Together, these actions kill actively dividing and semi-dormant Mycobacterium tuberculosis, reducing the bacterial burden during the intensive phase of treatment.
Mechanism Steps
💡 How to Take r-cinex z tablet
Strength: This medicine is available as an immediate-release tablet containing isoniazid 150 mg and pyrazinamide 750 mg.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's weight, age, kidney and liver function, and the specific type of tuberculosis being treated. In standard adult tuberculosis regimens, isoniazid is usually given as 5 mg/kg once daily (maximum 300 mg) and pyrazinamide as 15 to 30 mg/kg once daily (maximum 2 g), but the exact dose and duration depend on the treatment protocol. This fixed-dose combination is typically taken once daily, preferably on an empty stomach, but it may be taken with food if it causes stomach upset. Never adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific fixed-dose combination. Children with tuberculosis require weight-based dosing and specialized pediatric formulations. Consult a pediatrician or tuberculosis specialist for appropriate dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially liver toxicity and peripheral neuropathy. Kidney and liver function should be assessed before starting treatment, and doses may need adjustment. Close monitoring is recommended. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance less than 30 mL/min), dose reduction or extended dosing intervals may be necessary for pyrazinamide. Isoniazid generally does not require dose adjustment in renal impairment but should be used with caution. Consult a specialist for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with acute liver disease or severe hepatic impairment. In patients with mild to moderate liver impairment, use with extreme caution and frequent monitoring of liver function. Dose reduction may be necessary. Consult a hepatologist or tuberculosis specialist. |
| Maximum Daily Dose | The maximum daily dose should not exceed the standard adult doses: isoniazid 300 mg per day and pyrazinamide 2 g per day, unless otherwise directed by a specialist. Never exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of r-cinex z tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Alcohol | Major | |
| Phenytoin | Major | |
| Carbamazepine | Major | |
| Warfarin | Major | |
| Paracetamol | Moderate | |
| Ketoconazole | Moderate | |
| Diazepam | Moderate | |
| Theophylline | Moderate | |
| Levodopa | Moderate |
🚨 Major Interactions
- Rifampicin
- Alcohol
- Phenytoin
- Carbamazepine
- Warfarin
⚡ Moderate Interactions
- Paracetamol (acetaminophen)
- Ketoconazole
- Benzodiazepines (e.g., diazepam)
- Theophylline
- Levodopa
🍷 Alcohol Interaction
Alcohol must be completely avoided while taking this medicine. Both isoniazid and pyrazinamide are processed by the liver, and alcohol increases the risk of severe liver injury, including hepatitis and liver failure. Alcohol can also worsen isoniazid-related peripheral neuropathy and increase the risk of seizures. If you drink alcohol regularly, discuss this with your doctor before starting treatment, and seek help to stop drinking during the course.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isoniazid or pyrazinamide","Acute liver disease or severe hepatic impairment","Acute gout or severe hyperuricemia","Severe renal impairment without specialist supervision","Previous isoniazid-induced hepatitis","Concurrent use of alcohol"]
⚠️ Warnings & Precautions
["This medicine must never be used alone for tuberculosis; it must be part of a multi-drug regimen to prevent resistance.","Liver function should be monitored before and during treatment, especially in people with a history of liver disease or alcohol use.","Patients with diabetes may experience changes in blood sugar control and should monitor glucose more frequently.","Pyridoxine (vitamin B6) supplementation is often recommended to prevent peripheral neuropathy, especially in high-risk patients.","Patients with seizure disorders should be monitored closely, as isoniazid can lower the seizure threshold.","Avoid alcohol completely during treatment to reduce the risk of liver damage.","Use effective contraception during treatment, and inform your doctor if you become pregnant.","Do not stop treatment early, even if you feel better, as this can lead to relapse and drug resistance."]
🤱 Lactation Safety
Isoniazid and pyrazinamide are excreted in breast milk in small amounts. Breastfeeding is generally considered safe while taking these medicines, but the baby should be monitored for jaundice or unusual drowsiness. Pyridoxine supplementation is recommended for the mother and may be considered for the infant. Consult your doctor for personalized advice.
💊 Overdose Management
Overdose of this medicine can cause severe liver injury, seizures, metabolic acidosis, and coma. If an overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal if taken recently, management of seizures with benzodiazepines, correction of acidosis, and administration of pyridoxine for isoniazid toxicity. Hemodialysis may be considered in severe cases. Do not attempt to treat an overdose at home.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for guidance, as consistent dosing is critical for curing tuberculosis and preventing resistance.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, at the same time each day, and never skip doses or stop early, because incomplete treatment can lead to drug-resistant tuberculosis. Avoid alcohol completely while taking this medicine, as alcohol increases the risk of liver damage. Tell your doctor about all other medicines you take, including over-the-counter painkillers, herbal products, and supplements, because interactions can be serious. Do not take this medicine if you have active liver disease or a history of severe liver problems unless your doctor specifically approves it. Use effective contraception during treatment if you are of childbearing age, and inform your doctor immediately if you become pregnant. Keep all follow-up appointments for liver function tests, sputum tests, and eye checks. If you notice yellowing of the eyes or skin, dark urine, persistent vomiting, or severe stomach pain, stop the medicine and seek medical help right away. Store this medicine in its original container, away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver toxicity, peripheral neuropathy, and drug interactions. Kidney and liver function should be assessed before starting treatment, and doses may need adjustment. Close monitoring for side effects is recommended, and fall precautions should be taken if dizziness occurs.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before starting or continuing this medicine. Tuberculosis treatment is important for both mother and baby, but the regimen may need adjustment. Use effective contraception during treatment if you are of childbearing age. If you become pregnant while taking this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
If you have surgery while taking this medicine, inform your surgeon and anesthesiologist about your treatment. This medicine can interact with some anesthetic agents and may affect liver function. Your treatment should be continued during the perioperative period unless otherwise advised by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can interact with some antibiotics and anesthetics, and may affect liver function. Your dentist may need to adjust medications or take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel fatigued or dizzy. Avoid strenuous exercise until you feel fully recovered. Start with light activities like walking and gradually increase as tolerated. If you experience joint pain, avoid high-impact exercises and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving if you feel drowsy or unwell. You can continue working if you feel up to it, but ensure you take your medicine regularly and attend all medical appointments. Inform your employer about your treatment if necessary, especially if you work in healthcare or food handling.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Treatment must be completed for the full prescribed duration to cure tuberculosis and prevent resistance. If you experience severe side effects such as jaundice, severe rash, or persistent vomiting, stop the medicine and seek immediate medical attention. Your doctor will decide whether to adjust or change your treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the duration of tuberculosis treatment, usually several months. Prolonged use can increase the risk of liver toxicity, peripheral neuropathy, and hyperuricemia. Regular monitoring of liver function, uric acid levels, and neurological symptoms is essential. Most side effects are reversible after stopping the medicine, but liver damage can be serious if not detected early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthy diet with adequate protein, vitamins, and minerals can support recovery and reduce side effects.
Evidence: Well-establishedVitamin B6 can prevent or treat isoniazid-induced peripheral neuropathy.
Evidence: Well-establishedSupervised treatment programs improve adherence and outcomes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with tuberculosis should complete their treatment before receiving live vaccines if possible. The BCG vaccine is used for tuberculosis prevention and is not a treatment. Discuss vaccination timing with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, maintain your dosing schedule as close to every 24 hours as possible; consult your doctor for specific advice. Store at room temperature and avoid leaving it in hot cars or direct sunlight. Check customs regulations for carrying prescription medicines internationally, and carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1 to 2 weeks, but you must complete the full course of treatment, which usually lasts several months, to fully cure the infection and prevent resistance.
A: No, you must complete the entire prescribed course even if you feel better. Stopping early can lead to relapse and drug-resistant tuberculosis.
A: Avoid alcohol completely, limit caffeine, and avoid large amounts of tyramine-rich foods. Also, inform your doctor about all other medicines you take.
A: Yes, this medicine can affect the liver. Regular liver function tests are important, and you should report symptoms like yellowing of eyes, dark urine, or abdominal pain immediately.
🤔 Common Patient Concerns
🔄 Substitutes for r-cinex z tablet
View AllAlternative brands with exact same active ingredient:
-
binex z 150mg/750mg/225mg tabletAlbert David Ltd ₹9.57 52.5% CHEAPER
-
orif 3 forte tabletOsho Pharma Pvt Ltd ₹39.60 96.5% COSTLIER
-
montorip forte tabletShreya Life Sciences Pvt Ltd ₹39.84 97.7% COSTLIER
-
Ripcox TabletSuzikem Drugs Pvt Ltd ₹46.00 128.3% COSTLIER
-
TRICINEX-PZ 150MG/750MG/225MG TABLETZee Laboratories ₹49.69 146.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed for the full duration prescribed, even if you feel better, to prevent relapse and drug resistance. - Myth: This medicine can be taken alone for tuberculosis.
Fact: This medicine must always be part of a multi-drug regimen; using it alone can lead to drug-resistant tuberculosis. - Myth: Alcohol in moderation is safe while taking this medicine.
Fact: Alcohol should be completely avoided because it increases the risk of severe liver damage. - Myth: Tuberculosis is hereditary.
Fact: Tuberculosis is an infectious disease caused by bacteria, not a hereditary condition.
🔄 Alternative Options
Generic Alternatives
- Isoniazid and Pyrazinamide Tablets
Brand Alternatives
- Binex Z 150mg/750mg/225mg Tablet