Placidin 400mg Tablet XR (Quetiapine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, muscle stiffness, confusion, or irregular heartbeat (signs of neuroleptic malignant syndrome).
- Uncontrollable movements of face, tongue, or limbs (tardive dyskinesia).
- Severe allergic reaction: rash, swelling, difficulty breathing.
- Irregular heartbeat, palpitations, or fainting.
- Excessive thirst, frequent urination, or blurred vision (high blood sugar).
- Yellowing of skin or eyes (liver problems).
- Thoughts of harming yourself or others.
If experiencing severe symptoms, call emergency services immediately.
What is quticalm 400mg tablet sr used for?
This medicine contains quetiapine 400 mg extended-release tablets. It is used to treat schizophrenia and bipolar disorder by balancing brain chemicals. Take it once daily in the evening, swallow whole, and avoid alcohol. Common side effects include drowsiness and weight gain.
- Generic Name: Quetiapine (400mg)
- Manufacturer: Ryon Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 quticalm 400mg tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा क्वेटियापिन 400 मिलीग्राम एक्सटेंडेड-रिलीज़ टैबलेट है। इसका उपयोग सिज़ोफ्रेनिया और बाइपोलर डिसऑर्डर के इलाज के लिए किया जाता है। यह मस्तिष्क में रसायनों को संतुलित करके मनोविकार और मूड स्विंग्स को कम करती है। इसे रोज एक बार शाम को लें, पूरी गोली निगलें, और शराब से बचें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, वजन बढ़ना और भूख बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, अनियमित दिल की धड़कन, या न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम हो सकता है। इन्हें तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को हर दिन एक ही समय पर लें, बेहतर होगा शाम को। गोली को चबाएं नहीं, पूरा निगलें। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। गर्भवती होने या स्तनपान कराने से पहले डॉक्टर को बताएं। दवा अचानक बंद न करें। नियमित जांच कराएं।
💊 quticalm 400mg tablet sr Uses & Benefits
[{"condition":"Schizophrenia","description":"Helps reduce hallucinations, delusions, and disorganized thinking, improving overall functioning.","evidence":"Well-established"},{"condition":"Bipolar disorder (manic episodes)","description":"Stabilizes mood and reduces the severity of manic episodes.","evidence":"Well-established"},{"condition":"Bipolar disorder (depressive episodes)","description":"Helps alleviate depressive symptoms in bipolar disorder.","evidence":"Well-established"},{"condition":"Major depressive disorder (adjunctive)","description":"Used as an add-on treatment for major depressive disorder when other treatments are insufficient.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Sometimes prescribed off-label for severe anxiety when other treatments fail.","evidence":"Limited"},{"condition":"Insomnia","description":"Low doses may be used off-label for sleep problems, but not recommended for long-term use.","evidence":"Limited"},{"condition":"Post-traumatic stress disorder (PTSD)","description":"May be used off-label for PTSD symptoms, but evidence is mixed.","evidence":"Limited"}]
Primary treatment for: Schizophrenia
Also treats: Bipolar disorder, Major depressive disorder
📋 Drug Information
| Generic Name(s) | Quetiapine (400mg) |
| Brand Name | quticalm 400mg tablet sr |
| Manufacturer | Ryon Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) away from moisture and heat. Keep in original container. |
| Shelf Life | 24 months from date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Quetiapine works by blocking dopamine D2 and serotonin 5-HT2A receptors in the brain. This helps to rebalance neurotransmitter activity, reducing psychotic symptoms and stabilizing mood. It also interacts with histamine H1 and adrenergic alpha-1 receptors, which contributes to side effects like sedation and orthostatic hypotension.
Mechanism Steps
💡 How to Take quticalm 400mg tablet sr
Strength: Extended-release tablet, 400 mg
Dosage Information
| Adult Dosage | The usual starting dose for schizophrenia is 25 mg twice daily, titrated up to 300-400 mg daily in divided doses. For extended-release, 300 mg once daily, increased to 400 mg once daily if needed. For bipolar mania, 50-200 mg twice daily, titrated to 400-800 mg daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Start with lower doses (e.g., 25 mg/day) and titrate slowly. Increased risk of orthostatic hypotension, sedation, and falls. Monitor closely. |
| Renal Impairment | No dose adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | Start with lower doses (e.g., 25 mg/day) and titrate slowly. Monitor liver function. |
| Maximum Daily Dose | 800 mg per day for immediate-release; 800 mg per day for extended-release. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of quticalm 400mg tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Carbamazepine | Major | |
| Rifampin | Major | |
| Clarithromycin | Major | |
| Antihypertensives | Moderate | |
| Benzodiazepines | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., carbamazepine, rifampin)
- Other antipsychotics
⚡ Moderate Interactions
- Antihypertensives
- Benzodiazepines
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and impair your ability to think clearly. It may also worsen the side effects of quetiapine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to quetiapine or any component of the formulation","Concomitant use with strong CYP3A4 inhibitors","History of neuroleptic malignant syndrome","Severe cardiovascular disease","Elderly patients with dementia-related psychosis (increased risk of death)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","May cause orthostatic hypotension; rise slowly from sitting or lying position.","May increase blood sugar and cholesterol; monitor regularly.","May cause weight gain; monitor weight and diet.","May cause QT prolongation; use with caution in patients with heart disease.","Do not stop abruptly; taper gradually under medical supervision.","May increase risk of falls in elderly patients.","Use with caution in patients with a history of seizures.","May impair cognitive and motor skills.","Avoid alcohol and other CNS depressants."]
🤱 Lactation Safety
Quetiapine is excreted in breast milk. Limited data. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, rapid heartbeat, low blood pressure, and unconsciousness. Seek emergency medical help immediately. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine at the same time each day, preferably in the evening, to reduce daytime drowsiness. Swallow the tablet whole; do not crush or chew. Avoid alcohol as it can increase drowsiness and dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not stop this medicine abruptly as it can cause withdrawal symptoms or relapse. Keep all appointments for monitoring, including blood tests for sugar and cholesterol. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of orthostatic hypotension, sedation, and falls. Start with lower doses and monitor closely. Increased risk of death in elderly with dementia-related psychosis.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. Use effective contraception while on this medicine. If you become pregnant, inform your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine. It may interact with anesthesia and affect blood pressure.
🦷 Dental Procedures
Inform your dentist about this medicine. It may cause dry mouth, increasing risk of dental problems. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise until you know how it affects you. Stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, affecting your ability to drive or operate machinery. It may also impact concentration. Discuss with your doctor about work adjustments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms or relapse. Your doctor will guide you on a gradual taper.
📅 Long-Term Use Effects
Long-term use may increase risk of weight gain, diabetes, high cholesterol, and tardive dyskinesia. Regular monitoring of weight, blood sugar, lipids, and eye exams is recommended. Do not stop without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for schizophrenia and bipolar disorder.
Evidence: Well-establishedRegular exercise, healthy diet, and sleep hygiene can improve overall well-being.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust the timing gradually. Store at room temperature and avoid extreme heat. Check customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Sedation may occur within 1-2 hours, but full therapeutic effects for psychosis may take several weeks.
A: No, stopping suddenly can cause withdrawal symptoms or relapse. Always consult your doctor for a gradual taper.
A: This medicine may cause drowsiness. Avoid driving until you know how it affects you.
A: Consult your doctor. Use only if benefits outweigh risks.
🤔 Common Patient Concerns
🔄 Substitutes for quticalm 400mg tablet sr
View AllAlternative brands with exact same active ingredient:
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placidin 400mg tablet xrLupin Ltd ₹39.86 83% CHEAPER
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quezo 400mg tablet srSalas Pharmaceuticals ₹210.00 10.4% CHEAPER
-
qutaford 400mg tablet srOxford Pharmaceuticals Pvt Ltd ₹210.94 10% CHEAPER
-
qtripil 400mg tablet srArinna Lifescience Pvt Ltd ₹214.00 8.7% CHEAPER
-
qtajas 400mg tablet srIshjas Pharma Pvt Ltd ₹231.56 1.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Quetiapine is only for severe mental illness.
Fact: It is also used for bipolar depression and as an add-on for major depressive disorder. - Myth: Quetiapine is addictive.
Fact: It is not addictive in the traditional sense, but it can cause dependence and withdrawal if stopped abruptly. - Myth: You can stop taking quetiapine once you feel better.
Fact: Stopping suddenly can cause relapse or withdrawal symptoms. Always consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Quetiapine fumarate extended-release tablets
Brand Alternatives
- Seroquel XR
- Qutipin XR
- Quetia XR