quadrovax sd vaccine - Diphtheria Toxoid (30IU) + Haemophilus Type B Conjugate Vaccine (10mcg) medicine

Easyfour-TT Paediatric Vaccine: A Complete Guide

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🏭 Serum Institute Of India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swallowing
  • Swelling of the face, lips, or throat
  • High fever that does not respond to medication
  • Inconsolable crying lasting more than 3 hours
  • Seizures or convulsions
  • Limpness or unresponsiveness
  • Severe rash or hives

If experiencing severe symptoms, call emergency services immediately.

What is quadrovax sd vaccine used for?

This medicine is a combination vaccine that protects children against diphtheria and Haemophilus influenzae type b (Hib) infections. It is given as an injection by a healthcare professional.

  • Generic Name: Diphtheria Toxoid (30IU) + Haemophilus Type B Conjugate Vaccine (10mcg)
  • Manufacturer: Serum Institute Of India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 quadrovax sd vaccine के बारे में (Hindi Summary)

उपयोग: यह दवा एक शिशु टीका है जो डिप्थीरिया और हीमोफिलस इन्फ्लुएंजा टाइप बी (Hib) संक्रमण से बचाव के लिए दी जाती है। यह इंजेक्शन के रूप में दी जाती है और शिशुओं और छोटे बच्चों को गंभीर बीमारियों से बचाती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, हल्का बुखार, चिड़चिड़ापन, नींद आना और भूख में कमी शामिल हैं। ये आमतौर पर 1-2 दिनों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन तेज बुखार, लगातार रोना, दौरे या गंभीर एलर्जी हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह टीका केवल योग्य स्वास्थ्य पेशेवर द्वारा ही लगाया जाना चाहिए। डॉक्टर को किसी भी एलर्जी, पिछले टीकाकरण प्रतिक्रियाओं या वर्तमान बीमारी के बारे में बताएं। टीकाकरण के बाद हल्का बुखार सामान्य है; डॉक्टर की सलाह अनुसार पैरासिटामोल दें। इंजेक्शन की जगह पर मालिश न करें। बच्चे को पर्याप्त तरल पदार्थ दें। किसी भी असामान्य लक्षण की तुरंत रिपोर्ट करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 quadrovax sd vaccine Uses & Benefits

[{"condition":"Diphtheria prevention","description":"Protects against diphtheria, a serious bacterial infection affecting the throat and sometimes skin, which can lead to breathing problems, heart failure, and paralysis.","evidence":"Well-established"},{"condition":"Haemophilus influenzae type b (Hib) disease prevention","description":"Protects against Hib infections that can cause meningitis, pneumonia, epiglottitis, and other invasive diseases.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Diphtheria and Haemophilus influenzae type b disease prevention

📋 Drug Information

Generic Name(s)Diphtheria Toxoid (30IU) + Haemophilus Type B Conjugate Vaccine (10mcg)
Brand Namequadrovax sd vaccine
ManufacturerSerum Institute Of India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVACCINES
Action Class
Route of AdministrationParenteral (intramuscular injection)
StorageStore in a refrigerator at 2-8°C. Do not freeze. Protect from light. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineThe World Health Organization recommends Hib and diphtheria vaccination in routine immunisation schedules for children.
ICMR GuidelineThe Indian Council of Medical Research supports the inclusion of Hib and diphtheria vaccines in the national immunisation schedule.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Administer the vaccine intramuscularly in the anterolateral thigh of infants and deltoid of older children.
2
Observe the child for at least 15-20 minutes after vaccination to monitor for allergic reactions.
3
Advise parents to give paracetamol for fever as needed and to keep the child hydrated.
4
Do not massage the injection site; this can increase local reactions.
5
Ensure the child is up to date with other vaccines as per the national schedule.
6
Document the vaccine lot number and date in the immunisation record.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Prevention of diphtheria
This vaccine is used to prevent diphtheria.
Likely Use
Prevention of Hib disease
This vaccine is used to prevent Haemophilus influenzae type b infections.
Likely Use
Active infection
This vaccine is not used to treat active infections.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNot applicable. This vaccine is administered by injection and does not undergo absorption like oral medicines.
DistributionNot applicable. The vaccine antigens act locally at the injection site and in nearby lymph nodes; they are not distributed systemically in the same way as conventional drugs.
Protein BindingNot established from the available information.
MetabolismNot applicable. The vaccine components are not metabolised by the liver; they are processed by the immune system.
Half-LifeNot applicable. The vaccine antigens are cleared by the immune system over time, but this does not follow classic pharmacokinetic parameters.
ExcretionNot applicable. The vaccine components are degraded and cleared by normal cellular processes.
BioavailabilityNot applicable. The vaccine is injected directly, so bioavailability is not a relevant concept.
Onset of ActionImmune response begins within days but protective immunity typically develops over 2-4 weeks after the primary series.
Peak Plasma TimeNot applicable. The vaccine does not achieve a plasma concentration; instead, antibody titres peak several weeks after vaccination.
Duration of ActionProtection lasts for years, but booster doses are required to maintain immunity according to the recommended schedule.

How It Works

This vaccine contains diphtheria toxoid, which is a modified toxin that retains its ability to stimulate an immune response but lacks toxicity. It also contains Haemophilus influenzae type b capsular polysaccharide conjugated to a carrier protein. After injection, the immune system recognises these antigens as foreign and produces specific antibodies. It also creates memory B cells, so that upon future exposure to the actual bacteria or toxin, the body can mount a rapid and strong immune response, providing protection.

Mechanism Steps

1
Antigen recognition: Dendritic cells and macrophages at the injection site capture the vaccine antigens (diphtheria toxoid and Hib polysaccharide-carrier protein conjugate).
2
Antigen presentation: These cells process the antigens and present them to T cells in the lymph nodes, initiating an adaptive immune response.
3
B cell activation and antibody production: B cells recognise the antigens, with help from T cells, and differentiate into plasma cells that produce specific antibodies against diphtheria toxin and Hib polysaccharide.
4
Memory formation: Some B cells become memory B cells, which persist in the body and enable a rapid response upon future exposure to the actual pathogens.

💡 How to Take quadrovax sd vaccine

Strength: Injection: Diphtheria Toxoid 30 IU and Haemophilus Type B Conjugate Vaccine 10 mcg per dose.

1This vaccine is given by a healthcare professional as an intramuscular injection, usually in the thigh or upper arm.
2No special preparation is needed before vaccination.
3After the injection, keep the child under observation for 15-20 minutes.
4Follow the doctor's advice regarding fever management and care of the injection site.

Dosage Information

Adult DosageNot applicable. This vaccine is intended for paediatric use only. Dose must be individualized by a qualified clinician based on the child's age and vaccination history.
Pediatric DosageThe dosage is determined by the paediatrician based on the child's age and national immunisation schedule. Typically, it is given as a 0.5 mL intramuscular injection. The exact number of doses and timing must be individualized by a qualified clinician.
Elderly DosageNot applicable. This vaccine is not intended for elderly patients.
Renal ImpairmentNo dosage adjustment is required for renal impairment as the vaccine is not cleared by the kidneys.
Hepatic ImpairmentNo dosage adjustment is required for hepatic impairment as the vaccine is not metabolised by the liver.
Maximum Daily DoseNot applicable. This vaccine is given as a single dose per schedule, not daily.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 A scheduled dose is missed by a few days
→ Contact your paediatrician to reschedule the missed dose as soon as possible.
💡 Do not skip the dose; the schedule can be resumed without restarting the series.
📌 A scheduled dose is missed by weeks or months
→ Consult the paediatrician for a catch-up schedule.
💡 Do not restart the series from the beginning; the doctor will advise on the appropriate catch-up plan.

⚠️ Side Effects of quadrovax sd vaccine

✅ Common Side Effects

Injection site pain, redness, or swelling (Common (up to 25%))
Apply a cool compress if needed. Do not massage the site. It usually resolves within 1-2 days.
Mild fever (Common (up to 10%))
Give paracetamol as advised by the doctor. Ensure plenty of fluids.
Irritability or fussiness (Common (up to 20%))
Comfort the child. It usually subsides within 24-48 hours.
Drowsiness (Common (up to 10%))
Allow the child to rest. It typically resolves on its own.
Loss of appetite (Common (up to 10%))
Offer small, frequent feeds. Consult doctor if it persists beyond 48 hours.

🚨 Serious Side Effects

High fever (above 39°C) (Uncommon (0.1-1%))
Seek medical attention if fever is high or does not respond to paracetamol.
Persistent crying (more than 3 hours) (Rare (<0.1%))
Contact a doctor immediately if the child cries inconsolably for more than 3 hours.
Seizures or convulsions (Rare (<0.1%))
Seek emergency medical care if the child has a seizure.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services immediately if there is difficulty breathing, swelling of face or throat, or a severe rash.

⚠️ Rare Side Effects

Hypotonic-hyporesponsive episode
Seek immediate medical attention if the child becomes limp, pale, and unresponsive.
Thrombocytopenia
Consult a doctor if unusual bruising or bleeding occurs.

Consult your doctor if you experience any unusual symptoms.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe allergic reaction to a previous dose of this vaccine or any of its components.","Known hypersensitivity to diphtheria toxoid, Haemophilus influenzae type b conjugate vaccine, or any excipient.","Moderate to severe acute illness with fever; vaccination should be deferred until recovery."]

⚠️ Warnings & Precautions

["This vaccine should be given by a healthcare professional only.","Have epinephrine available in case of anaphylaxis.","Inform the doctor of any bleeding disorders or anticoagulant therapy before injection.","Immunocompromised children may have a reduced immune response.","Do not mix with other vaccines in the same syringe unless approved.","Use with caution in children with a history of seizures."]

🤱 Lactation Safety

Not applicable. This vaccine is for children and not used during lactation.

💊 Overdose Management

Overdose is unlikely as the vaccine is administered by a healthcare professional. In case of accidental overdose, monitor the child for any adverse reactions and provide symptomatic treatment.

⏰ Missed Dose

If a dose is missed, contact your paediatrician to reschedule as soon as possible. Do not skip doses; complete the recommended schedule for full protection.

Additional Safety Advice

General Safety

This vaccine should be administered by a qualified healthcare professional only. Inform the doctor about any allergies, previous vaccine reactions, or current illnesses. A mild fever after vaccination is normal; use paracetamol as advised by the doctor. Do not massage the injection site. Keep the child well hydrated. Report any unusual symptoms immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Not applicable. This vaccine is for paediatric use only.

🤰 Pregnancy Planning (TTC)

Not applicable. This vaccine is not given during pregnancy.

🏥 Post-Surgery Considerations

Vaccination can be given after surgery once the child has recovered and is stable. Consult the paediatrician.

🦷 Dental Procedures

No specific considerations for dental procedures. Inform the dentist about the child's vaccination status.

💚 Lifestyle Tips for Better Results

🏃
Ensure your child completes all recommended vaccines on time.
🥗
Maintain a healthy diet and hygiene to support overall immunity.
😴
Keep a record of your child's vaccinations.
💧
Follow up with the paediatrician for booster doses.
🧘
Encourage regular handwashing to prevent infections.

🏋️ Exercise Considerations

No specific exercise restrictions after vaccination. However, if the child has a fever or is unwell, allow rest and avoid strenuous activities.

🥗 Diet Recommendations

Offer plenty of fluids to keep the child hydrated.
Continue normal feeding; no dietary restrictions are needed.
If the child has a fever, offer light, easily digestible foods.

💼 Impact on Daily Work & Life

The vaccine may cause mild drowsiness or irritability in the child, which can affect sleep patterns for a day. Parents may need to comfort the child. It does not affect the parents' work life directly, but they may need to take time off for the vaccination visit.

🛑 When to Stop This Medicine

Do not stop the vaccination series without consulting a paediatrician. If a serious adverse reaction occurs, the doctor will advise whether to continue with subsequent doses.

📅 Long-Term Use Effects

Long-term protection against diphtheria and Hib disease is achieved with completion of the vaccination schedule. Booster doses are needed to maintain immunity. No long-term adverse effects are known.

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This vaccine is part of the routine immunisation schedule. It can be given simultaneously with other vaccines at different sites. Live vaccines should be given at least 4 weeks apart if not on the same day.

📦 Storage Guide

✅ DO

Store in a refrigerator at 2-8°C

❌ DON'T

Do not freeze the vaccine

✅ DO

Keep in the original packaging

❌ DON'T

Do not expose to direct sunlight

✅ DO

Maintain the cold chain during transport

❌ DON'T

Do not use if the vaccine has been frozen or looks discoloured

✈️ Traveling with This Medicine

When travelling with a child who needs this vaccine, carry the vaccine in its original packaging in a cool bag with ice packs to maintain the cold chain (2-8°C). Carry a copy of the prescription and immunisation record. Check with the airline about carrying medical items. If travelling across time zones, consult a paediatrician to adjust the vaccination schedule if needed. Do not freeze the vaccine.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 2-month-old infant brought for routine vaccination
The baby received Easyfour-TT as part of the primary immunisation series. The mother was advised to give paracetamol drops for mild fever and to apply a cool compress for injection site pain. The baby had mild fussiness for a day but was back to normal by the next day.
💡 Lesson: Mild side effects are common and self-limiting. Proper counselling helps parents manage them at home.
👤 A 6-month-old infant with a history of preterm birth
The paediatrician reviewed the baby's health and confirmed that vaccination was safe. The vaccine was given, and the baby experienced no serious adverse effects. The parents were reassured about the importance of completing the schedule.
💡 Lesson: Preterm infants should receive vaccines according to their chronological age, with careful assessment by a paediatrician.

💬 Questions Patients Often Ask

Q: How long does it take for the vaccine to work?

A: Protective immunity usually develops within 2-4 weeks after the primary series, but full protection requires completion of the recommended schedule including boosters.

Q: Can my child get the disease from the vaccine?

A: No, the vaccine contains inactivated or non-infectious components, so it cannot cause the disease.

Q: What if my child misses a dose?

A: Contact your paediatrician to reschedule. Do not skip doses; the series can be resumed without starting over.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can my child receive this vaccine if they have a cold?
  • What should I do if my child has a fever after vaccination?
  • Is it safe to give this vaccine with other vaccines?
  • How long does protection last?
  • Are there any long-term side effects?

🔄 Substitutes for quadrovax sd vaccine

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Vaccines cause autism.
    Fact: Extensive research has shown no link between vaccines and autism.
  • Myth: It is better to get the disease than the vaccine.
    Fact: Vaccines provide immunity without the risks of serious complications from the disease.
  • Myth: Multiple vaccines overwhelm the immune system.
    Fact: Children's immune systems can safely handle multiple vaccines at once.

📊 Comparison with Similar Medicines

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