Avumol MF Plus Oral Suspension: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is pyre mef oral suspension used for?
This medicine is a combination of mefenamic acid and paracetamol used for short-term relief of mild to moderate pain and fever. It works by reducing inflammation and pain through mefenamic acid and lowering fever through paracetamol. It should be taken with food and not exceeding the recommended dose.
- Generic Name: Mefenamic Acid (100mg) + Paracetamol (250mg)
- Manufacturer: SanoreX Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pyre mef oral suspension के बारे में (Hindi Summary)
उपयोग: यह दवा मेफेनामिक एसिड और पैरासिटामोल का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और बुखार से राहत के लिए किया जाता है। यह दांत दर्द, सिरदर्द, मासिक धर्म में होने वाले दर्द, मांसपेशियों के दर्द और सर्जरी के बाद के दर्द में प्रभावी है। यह बुखार को कम करने में भी मदद करती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर द्वारा बताई गई मात्रा से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द, अपच, दस्त या कब्ज शामिल हैं। कुछ लोगों को चक्कर आना या सिरदर्द हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में अल्सर या रक्तस्राव, एलर्जी प्रतिक्रिया, गुर्दे या यकृत की समस्या हो सकती है। यदि आपको काला मल, उल्टी में खून, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं। इसे भोजन या दूध के साथ लें। शराब का सेवन न करें। पैरासिटामोल युक्त अन्य दवाओं के साथ न लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के 3 दिन से अधिक बुखार या 5 दिन से अधिक दर्द के लिए न लें। बच्चों की पहुंच से दूर रखें।
💊 pyre mef oral suspension Uses & Benefits
[{"condition":"Dental pain","description":"Relieves mild to moderate pain following tooth extraction or other dental procedures.","evidence":"Well-established"},{"condition":"Headache","description":"Provides relief from tension headaches and mild migraines.","evidence":"Well-established"},{"condition":"Menstrual cramps","description":"Reduces pain and inflammation associated with dysmenorrhea.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Eases pain from sprains, strains, and minor injuries.","evidence":"Well-established"},{"condition":"Fever","description":"Lowers elevated body temperature due to infections or other causes.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgery.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Osteoarthritis pain","description":"May be used for short-term relief of osteoarthritis pain, though not first-line.","evidence":"Limited"}]
Primary treatment for: Pain and fever
Also treats: Dental pain, Headache, Menstrual cramps, Musculoskeletal pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Mefenamic Acid (100mg) + Paracetamol (250mg) |
| Brand Name | pyre mef oral suspension |
| Manufacturer | SanoreX Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from direct sunlight and moisture. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Mefenamic acid is a non-steroidal anti-inflammatory drug that reversibly inhibits the cyclooxygenase enzymes, leading to decreased production of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also affect the hypothalamic heat-regulating center to reduce fever. The combination provides additive pain relief and fever reduction.
Mechanism Steps
💡 How to Take pyre mef oral suspension
Strength: Each 5 mL of oral suspension contains Mefenamic Acid 100 mg and Paracetamol 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this oral suspension is 5 to 10 mL (providing 100 mg mefenamic acid and 250 mg paracetamol per 5 mL) taken every 6 to 8 hours as needed for pain or fever. Do not exceed 4 doses in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Use the lowest effective dose for the shortest duration possible. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. Avoid in severe kidney disease. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe liver disease. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed 4 doses of 10 mL each (providing 400 mg mefenamic acid and 1000 mg paracetamol) in 24 hours. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pyre mef oral suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Probenecid | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Lithium
- Phenytoin
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen liver damage, especially with paracetamol. It may also increase drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to mefenamic acid, paracetamol, or any other ingredients","Active or history of peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Asthma triggered by aspirin or other NSAIDs","Heart failure","Third trimester of pregnancy","Children under 12 years (unless specifically prescribed by a doctor)"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Take with food or milk to reduce stomach upset.","Use with caution in the elderly due to increased risk of side effects.","Consult a doctor before use if you have a history of stomach ulcers, kidney or liver disease, asthma, or heart problems.","Do not use for more than 3 days for fever or 5 days for pain without medical advice.","Keep out of reach of children.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not take other medicines containing paracetamol while on this medicine.","Stop use and seek medical help if you experience signs of allergic reaction or severe side effects."]
🤱 Lactation Safety
Mefenamic acid and paracetamol are excreted in breast milk in small amounts. Consult your doctor before using this medicine while breastfeeding. Short-term use at the lowest effective dose is generally considered acceptable, but medical advice is recommended.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, kidney failure, and blood disorders. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and drowsiness. If you suspect an overdose, seek emergency medical attention immediately. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or heart problems. Do not take this medicine with other products containing paracetamol to avoid exceeding the safe daily limit. Avoid alcohol while taking this medicine, as it increases the risk of stomach bleeding and liver damage. Take this medicine with food or milk to reduce stomach upset. Do not lie down immediately after taking it; stay upright for at least 30 minutes. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Do not use it for more than 3 days for fever or 5 days for pain without consulting a doctor. Keep out of reach of children. Store at room temperature, away from direct sunlight and moisture. Do not use after the expiry date. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events with this medicine. Use the lowest effective dose for the shortest duration. Monitor kidney function and blood pressure regularly. Avoid long-term use unless specifically advised by a doctor.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like mefenamic acid may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered safer but should still be used only when necessary.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain relief after minor surgery. However, it can increase the risk of bleeding, so inform your surgeon if you are taking it. It is usually stopped before major surgery. Follow your doctor's instructions regarding its use in the post-operative period.
🦷 Dental Procedures
This medicine is often prescribed for dental pain. Inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk. It can be taken after dental extraction for pain relief, but follow the dentist's instructions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue with your normal exercise routine if you feel well. However, if you experience dizziness or fatigue, avoid strenuous activities or exercises that require balance. Listen to your body and rest if needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily work or activities.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 3 days for fever or 5 days for pain, or if you experience any serious side effects such as stomach bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney problems, and cardiovascular events. It should only be used for short periods unless specifically directed by a doctor. Regular monitoring of kidney and liver function may be required if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage chronic pain and improve mobility without medication.
Evidence: Well-establishedMay provide local pain relief for muscle aches and injuries.
Evidence: Well-establishedStress reduction can help manage tension headaches and chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, it is best to postpone vaccination until you recover, as fever may complicate the assessment of vaccine side effects.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep the bottle tightly closed
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust your dosing schedule to maintain the recommended interval between doses. Do not leave it in a hot car or checked luggage. Always pack it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: Do not use it for more than 3 days for fever or 5 days for pain without consulting your doctor.
A: Consult your doctor before using this medicine during pregnancy. It is generally avoided in the third trimester.
A: Inform your doctor about all other medicines you are taking, as this medicine can interact with several drugs.
🤔 Common Patient Concerns
🔄 Substitutes for pyre mef oral suspension
View AllAlternative brands with exact same active ingredient:
-
drmef p syrupDR Best pharmaceuticals Pvt Ltd ₹28.13 45.3% CHEAPER
-
mefpa-p oral suspensionMclaine Pharmaceutical ₹30.94 39.8% CHEAPER
-
erimol mf oral suspensionErika Remedies ₹33.75 34.3% CHEAPER
-
varnmic p dry syrupSB Lifesciences ₹34.69 32.5% CHEAPER
-
nikopar-mds oral suspension orangeUniark Healthcare Pvt Ltd ₹34.92 32.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce stomach upset. - Myth: It is safe to take this medicine for long periods without medical supervision.
Fact: Prolonged use can cause serious side effects like stomach bleeding and kidney problems. Use only as prescribed. - Myth: This medicine is safe to take with other paracetamol-containing products.
Fact: Taking multiple paracetamol products can lead to overdose and liver damage. Always check labels.
🔄 Alternative Options
Generic Alternatives
- Mefenamic acid + Paracetamol oral suspension