Endogest 200 SR Tablet: Complete Guide to Uses, Side Effects, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Sudden swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Chest pain, sudden shortness of breath, or coughing up blood.
- Pain, swelling, or redness in one leg, especially the calf.
- Severe headache with vision changes, confusion, or weakness on one side of the body.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Heavy vaginal bleeding with large clots or dizziness and fainting.
- Severe depression or thoughts of harming yourself.
- High fever with a rash or severe allergic reaction.
If experiencing severe symptoms, call emergency services immediately.
What is pregsure 200mg capsule used for?
This medicine is an oral tablet containing natural micronized progesterone 200 mg. It is used to support pregnancy, treat menstrual problems, and protect the uterine lining during hormone replacement therapy. It works by binding to progesterone receptors in the body. Take it exactly as prescribed, usually at bedtime, and avoid driving until you know how it affects you.
- Generic Name: Progesterone (Natural Micronized) (200mg)
- Manufacturer: Serene Life Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pregsure 200mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा प्राकृतिक माइक्रोनाइज़्ड प्रोजेस्टेरोन 200 मिलीग्राम की एक ओरल टैबलेट है। इसका इस्तेमाल मुख्य रूप से उन महिलाओं में किया जाता है जिनमें प्रोजेस्टेरोन हार्मोन की कमी होती है। यह गर्भावस्था को सहारा देने, माहवारी की समस्याओं जैसे पीरियड्स न आना या अनियमित होना, और असामान्य रक्तस्राव को नियंत्रित करने में मदद करती है। यह उन महिलाओं में भी दी जाती है जो हार्मोन रिप्लेसमेंट थेरेपी ले रही हैं और जिनका गर्भाशय अभी भी मौजूद है। यह दवा गर्भाशय की परत को मजबूत बनाती है और गर्भावस्था को बनाए रखने में सहायता करती है। इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर रात को सोने से पहले। इसे लेने के बाद नींद और चक्कर आ सकते हैं, इसलिए गाड़ी चलाने से बचें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, स्तनों में कोमलता, जी मिचलाना, पेट में गैस बनना और माहवारी में बदलाव शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के सामान्य होने पर कम हो जाते हैं। कुछ महिलाओं को मूड में बदलाव या चिड़चिड़ापन भी महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर चेहरे, होंठ या गले में सूजन, सांस लेने में तकलीफ, सीने में दर्द, पैर में दर्द या सूजन, आंखों या त्वचा का पीला पड़ना, या बहुत ज्यादा रक्तस्राव हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या रात को सोने से पहले लेने से चक्कर और जी मिचलाना कम हो सकता है। अपने आप दवा शुरू, बंद या डोज बदलें नहीं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। अपनी सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में डॉक्टर को जानकारी दें। इस दवा के साथ शराब न लें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। दवा को ठंडी, सूखी जगह पर, धूप से दूर, बच्चों की पहुंच से बाहर रखें।
💊 pregsure 200mg capsule Uses & Benefits
[{"condition":"Luteal phase support in assisted reproduction","description":"This medicine is used to support the lining of the uterus after fertility treatments such as IVF, helping to improve the chance of implantation and pregnancy.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage due to luteal phase defect","description":"This medicine may be prescribed to support early pregnancy when the body is not producing enough progesterone on its own.","evidence":"Established in selected cases"},{"condition":"Secondary amenorrhea","description":"This medicine can help restart menstrual periods in women whose periods have stopped due to low progesterone or hormonal imbalance.","evidence":"Well-established"},{"condition":"Abnormal uterine bleeding due to hormonal imbalance","description":"This medicine helps stabilize the uterine lining and reduce irregular or heavy bleeding caused by hormonal imbalance.","evidence":"Well-established"},{"condition":"Hormone replacement therapy in women with a uterus","description":"This medicine is used along with estrogen to protect the uterine lining in women going through menopause who still have a uterus.","evidence":"Well-established"},{"condition":"Luteal phase support in infertility","description":"This medicine is used to support the second half of the menstrual cycle in women undergoing fertility treatment.","evidence":"Established"}]
Off-label uses: [{"condition":"Preterm birth prevention","description":"This medicine is sometimes used off-label to help prevent premature birth in women at risk, but evidence is mixed and it is not a standard first-line treatment.","evidence":"Limited and conflicting"},{"condition":"Catamenial epilepsy","description":"This medicine has been studied off-label for seizures that worsen around menstrual periods, but it is not a routine treatment.","evidence":"Limited"},{"condition":"Menopausal hot flashes","description":"This medicine is occasionally used off-label to help with hot flashes, but it is not a first-choice treatment for this symptom.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency and related conditions
Also treats: Infertility, Recurrent miscarriage, Secondary amenorrhea, Abnormal uterine bleeding, Menopausal symptoms in women with a uterus
📋 Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) (200mg) |
| Brand Name | pregsure 200mg capsule |
| Manufacturer | Serene Life Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C. Keep it in its original packaging, away from moisture, heat, and direct sunlight. Do not refrigerate unless your pharmacist has advised you to do so. Keep it out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is usually 24 to 36 months from the date of manufacture, depending on the batch. Always check the expiry date on the pack before taking it. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains natural micronized progesterone, which is chemically identical to the progesterone produced by the ovaries and placenta. It works by binding to progesterone receptors in the nucleus of target cells, especially in the uterus, breast, and brain. Once bound, it changes the way certain genes are read, which helps prepare and maintain the uterine lining for pregnancy, supports the normal menstrual cycle, and balances the effects of estrogen. In the brain, it can have a mild calming effect, which explains why some women feel drowsy after taking it. Because it is micronized, the particles are very small, which helps the body absorb the hormone more effectively when taken by mouth.
Mechanism Steps
💡 How to Take pregsure 200mg capsule
Strength: This medicine is available as an oral tablet containing 200 mg of natural micronized progesterone.
Dosage Information
| Adult Dosage | The dose of this medicine depends on the condition being treated, your age, your medical history, and how you respond to treatment. For luteal support in fertility treatment, a common dose is 200 mg to 400 mg per day, often taken as one or more doses. For hormone replacement therapy, the dose is usually 200 mg at bedtime for 12 to 14 days each month. For other conditions, your doctor will decide the right dose for you. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose on your own. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly women can usually take this medicine at the same doses as younger adults, but they may be more sensitive to side effects such as drowsiness and dizziness. Start with the lowest effective dose and monitor closely. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Renal Impairment | This medicine is mainly excreted by the kidneys. Women with mild to moderate kidney disease usually do not need a dose change, but those with severe kidney disease should be monitored closely. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Hepatic Impairment | This medicine is processed by the liver. Women with mild to moderate liver disease may need a lower dose or less frequent dosing. This medicine should not be used in women with severe liver disease. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Maximum Daily Dose | The maximum daily dose of this medicine depends on the condition being treated and should be determined by your doctor. In general, doses above 400 mg per day are not commonly used without specialist supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pregsure 200mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Major | |
| Diazepam | Moderate | |
| Levothyroxine | Moderate | |
| Amlodipine | Moderate | |
| Grapefruit juice | Minor | |
| Paracetamol | Minor | |
| St. John's wort | Major | |
| Carbamazepine | Major |
🚨 Major Interactions
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Strong CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin, and St. John's wort
- Warfarin and other anticoagulants
⚡ Moderate Interactions
- Benzodiazepines and other sedatives
- Antihypertensive medicines
- Thyroid hormone (levothyroxine)
🍷 Alcohol Interaction
Alcohol can increase the drowsiness and dizziness caused by this medicine. It is best to avoid alcohol while taking this medicine, especially if you need to drive or operate machinery. If you choose to drink, do so only occasionally and in small amounts, and never right after taking your dose.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to progesterone or any ingredient in this medicine","Unexplained vaginal bleeding that has not been evaluated by a doctor","Known or suspected breast cancer","Known or suspected progesterone-sensitive tumors","Active liver disease or severe liver problems","History of blood clots in the legs, lungs, or brain","Known or suspected pregnancy loss with retained products of conception","Severe kidney disease without medical supervision"]
⚠️ Warnings & Precautions
["This medicine can cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you.","Take this medicine at bedtime if your doctor advises, to reduce daytime drowsiness.","Inform your doctor if you have a history of depression, liver disease, kidney disease, heart disease, or blood clots.","Do not use this medicine if you are allergic to progesterone or any of its ingredients.","Tell your doctor about all other medicines, supplements, and herbal products you are taking.","Avoid alcohol while taking this medicine because it can increase drowsiness.","Use reliable contraception if you are taking this medicine for a non-pregnancy reason and do not wish to conceive.","Keep all follow-up appointments and report any unusual symptoms promptly."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is generally considered compatible with breastfeeding when prescribed by a doctor, but the benefits and risks should be discussed with your clinician. Monitor the baby for any unusual drowsiness or poor feeding and report these to your doctor.
💊 Overdose Management
If you or someone else takes too much of this medicine, seek medical help immediately. Symptoms of overdose may include severe drowsiness, dizziness, nausea, vomiting, and in women, withdrawal bleeding. Treatment is supportive and based on symptoms. Do not try to vomit unless a healthcare professional tells you to do so. Carry the medicine packaging with you to the hospital so the medical team knows exactly what was taken.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is less than half the time until your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with water; do not crush, chew, or break it unless your doctor or pharmacist has advised you to do so. Taking this medicine with food, especially at bedtime, can reduce dizziness and drowsiness. Do not start, stop, or change the dose on your own. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding, because the dose and suitability depend on your situation. Tell your doctor about all other medicines, including blood thinners, antifungals, antibiotics, seizure medicines, and herbal products, as some can interact with this medicine. Avoid alcohol while taking this medicine because it can increase drowsiness and dizziness. Use reliable contraception if you are taking this medicine for a non-pregnancy reason and do not wish to conceive. Keep all follow-up appointments and report any unusual bleeding, severe headache, vision changes, leg pain, or breathing difficulty immediately. Store this medicine in its original packaging, away from moisture, heat, and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Women above 65 years of age may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. They may also have a higher risk of blood clots and liver problems. The dose should be individualized by a qualified clinician, and regular monitoring is recommended. Falls and accidents related to dizziness should be avoided by taking the medicine at bedtime and getting up slowly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, talk to your doctor before starting or continuing this medicine. This medicine is often used to support early pregnancy in women who need extra progesterone. Your doctor will decide the right dose and duration based on your fertility treatment plan or history of miscarriage. Do not start or stop this medicine on your own while trying to conceive.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, tell your surgeon and anesthesiologist that you are taking this medicine. This medicine may increase the risk of blood clots, so your doctor may advise you to stop it for a short period before surgery or take extra precautions. Do not stop the medicine on your own; follow your doctor's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no major interaction with common dental anesthetics, but your dentist should know about all medicines you take. If you are taking blood thinners along with this medicine, tell your dentist because of the increased risk of bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, especially in the first few days of treatment. Avoid heavy lifting, high-intensity workouts, or activities that require balance until you know how the medicine affects you. If you feel dizzy or weak during exercise, stop immediately and rest. Light to moderate exercise such as walking or stretching is usually safe and can help with overall well-being.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks that require concentration. It is best to take the dose at bedtime so that the sedative effect wears off by morning. If you still feel drowsy during the day, avoid driving and inform your employer if your work involves operating heavy equipment. Most women can continue their normal daily activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine on your own. Your doctor will decide when it is safe to stop based on your condition and response to treatment. If you experience serious side effects such as severe allergic reactions, blood clots, liver problems, or severe mood changes, seek medical help immediately and follow your doctor's advice about stopping the medicine. If you are pregnant or undergoing fertility treatment, stopping suddenly can be harmful, so always consult your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken under medical supervision. However, prolonged use may increase the risk of blood clots, liver problems, and mood changes in some women. Regular follow-up visits are important so your doctor can monitor your response and check for any side effects. Your doctor may order blood tests to check liver function and other parameters if you take this medicine for a long time. Do not continue this medicine for longer than prescribed without a review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A synthetic progestin that can be used for similar conditions, often with less sedation.
Evidence: Well-establishedA synthetic progestin used for menstrual problems and hormone replacement therapy.
Evidence: Well-establishedProgesterone given vaginally may be an option for luteal support with different side effect profiles.
Evidence: Well-establishedWeight management, regular exercise, and a balanced diet can help support hormonal balance.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine unless your doctor advises otherwise. If you are pregnant, discuss the timing of any vaccines with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless your pharmacist has advised you to do so.
✅ DO
Keep the medicine in its original container with the label intact.
❌ DON'T
Do not transfer the tablets to an unmarked container.
✅ DO
Keep the medicine away from direct sunlight and moisture.
❌ DON'T
Do not store it in the bathroom cabinet or near a sink.
✅ DO
Keep the medicine out of reach of children and pets.
❌ DON'T
Do not leave the medicine where children can see or reach it.
✅ DO
Check the expiry date before taking the medicine.
❌ DON'T
Do not use the medicine after the expiry date.
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Keep a copy of your prescription or a letter from your doctor in case you need to show it at customs or security. Store the medicine in your hand luggage, away from direct sunlight and extreme heat. If you are crossing time zones, ask your doctor how to adjust the timing of your doses so that you maintain steady hormone levels. Do not leave the medicine in a hot car or checked luggage. If you are travelling for a long period, carry enough medicine for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The time it takes to work depends on the condition being treated. For menstrual problems, you may notice changes within one or two cycles. For luteal support in fertility treatment, the effect on the uterine lining develops over several days. For sleep-related effects, drowsiness may occur within a few hours of taking the dose.
A: Yes, you can take this medicine with food. Taking it with a meal, especially one that contains some fat, improves absorption and reduces dizziness and nausea. Many women find it helpful to take it at bedtime.
A: If you miss a dose, take it as soon as you remember if it is less than half the time until your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
A: It is best to avoid alcohol while taking this medicine because it can increase drowsiness and dizziness. If you choose to drink, do so only occasionally and in small amounts, and never right after taking your dose.
A: This medicine is used to support pregnancy in specific situations and is generally considered acceptable when prescribed by a doctor. However, the decision to use it during pregnancy should be made by a qualified clinician based on your individual condition and needs.
A: No, do not stop taking this medicine suddenly, especially during pregnancy or fertility treatment, without talking to your doctor first. Stopping suddenly can cause hormonal changes or bleeding. Your doctor will advise you on how to stop safely if needed.
A: Yes, this medicine can interact with some other medicines, including antifungals, antibiotics, seizure medicines, blood thinners, and herbal products such as St. John's wort. Always tell your doctor about all medicines and supplements you are taking.
A: Some women may notice mild fluid retention or bloating, but not everyone gains weight. A healthy diet and regular physical activity can help manage this. If you notice sudden weight gain or swelling, contact your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for pregsure 200mg capsule
View AllAlternative brands with exact same active ingredient:
-
miprogen 200mg pessariesBharat Serums & Vaccines Ltd ₹68.00 27.5% CHEAPER
-
unogest 200mg vaginal pessariesUvb Healthcare Pvt Ltd ₹70.31 25% CHEAPER
-
placentone 200mg injectionSymbiotic Drugs ₹80.00 14.7% CHEAPER
-
wisrone 200mg injectionWisdom Pharma Pvt. Ltd ₹82.50 12% CHEAPER
-
hilgestrone 200mg injectionHindustan Latex Ltd ₹94.28 0.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a contraceptive pill.
Fact: This medicine is not a contraceptive. It is used for hormonal support and other conditions. If you need contraception, talk to your doctor about suitable options. - Myth: This medicine can be taken at any time of day without any effect.
Fact: This medicine can cause drowsiness, so it is often taken at bedtime. Taking it at the same time each day helps keep hormone levels steady. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine is a prescription medicine. It should only be taken under the supervision of a qualified doctor. - Myth: This medicine will cause weight gain in everyone.
Fact: Some women may notice mild fluid retention or bloating, but not everyone gains weight. A healthy diet and regular activity can help. - Myth: This medicine can be stopped suddenly without any problem.
Fact: Stopping this medicine suddenly can cause hormonal changes or bleeding. Always talk to your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Natural micronized progesterone 200 mg tablet
Brand Alternatives
- Endogest 200 SR Tablet