Pre Aldonil 75 Tablet SR: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, throat, or tongue
- Difficulty breathing or swallowing
- Severe skin rash, blisters, or peeling skin
- Unexplained muscle pain, tenderness, or dark urine
- Yellowing of the skin or eyes
- Severe dizziness or fainting
- Suicidal thoughts or self-harm ideation
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is prealdonil 150mg/75mg tablet used for?
This medicine is a combination of Epalrestat and Pregabalin used to treat painful diabetic peripheral neuropathy. It works by reducing nerve damage and calming overactive nerves to relieve burning, tingling, and shooting pain.
- Generic Name: Epalrestat (150mg) + Pregabalin (75mg)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 prealdonil 150mg/75mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एपलरेस्टैट 150 मिलीग्राम और प्रीगैबलिन 75 मिलीग्राम का संयोजन है, जिसका उपयोग मधुमेह के कारण होने वाले दर्दनाक न्यूरोपैथी (तंत्रिका क्षति) के इलाज के लिए किया जाता है। यह पैरों और हाथों में जलन, झुनझुनी, सुन्नपन और दर्द को कम करने में मदद करती है। यह दवा तंत्रिकाओं को होने वाले नुकसान को धीमा करने और दर्द के संकेतों को शांत करने का काम करती है। इसे डॉक्टर के परामर्श के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, धुंधली दृष्टि, मुँह सूखना और वजन बढ़ना शामिल हैं। कुछ लोगों में पैरों में सूजन भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन चेहरे, होंठ या गले में सूजन, मांसपेशियों में दर्द, या त्वचा पर गंभीर दाने होने पर तुरंत डॉक्टर से संपर्क करें। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। दवा लेते समय गाड़ी चलाने या मशीनरी चलाने से बचें, क्योंकि इससे नींद और चक्कर आ सकते हैं। शराब का सेवन बिल्कुल न करें। अगर आपको किडनी, लीवर या हृदय की समस्या है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। नियमित रूप से किडनी और लीवर की जांच कराते रहें। दवा को ठंडी और सूखी जगह पर, बच्चों से दूर रखें।
💊 prealdonil 150mg/75mg tablet Uses & Benefits
- [{"condition":"Painful diabetic peripheral neuropathy","description":"This medicine is used to relieve burning, tingling, and shooting pain caused by nerve damage in diabetes.
- Epalrestat targets the metabolic cause while Pregabalin reduces pain signaling.","evidence":"Well-established for Pregabalin; Epalrestat has supportive evidence in diabetic neuropathy."},{"condition":"Diabetic neuropathy prevention progression","description":"Epalrestat may help slow the progression of nerve damage by inhibiting aldose reductase, though its effect on long-term outcomes is still being studied.","evidence":"Moderate evidence for Epalrestat in slowing nerve conduction deficits."}]
Off-label uses: [{"condition":"Postherpetic neuralgia","description":"Pregabalin component may be used off-label for nerve pain after shingles, but the combination is not formally approved for this.","evidence":"Limited for the combination; Pregabalin alone has evidence."},{"condition":"Fibromyalgia","description":"Pregabalin is sometimes prescribed off-label for fibromyalgia pain, but the combination with Epalrestat is not standard.","evidence":"Limited for the combination."}]
Primary treatment for: Painful diabetic peripheral neuropathy
Also treats: Diabetic neuropathy, Neuropathic pain, Postherpetic neuralgia (off-label)
📋 Drug Information
| Generic Name(s) | Epalrestat (150mg) + Pregabalin (75mg) |
| Brand Name | prealdonil 150mg/75mg tablet |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Epalrestat is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol in nerve tissues, reducing osmotic stress and oxidative damage that contribute to diabetic neuropathy. Pregabalin is an alpha-2-delta ligand that binds to voltage-gated calcium channels in the central nervous system, decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This reduces neuronal hyperexcitability and dampens pain transmission. Together, they address both the metabolic and neuropathic components of diabetic nerve pain.
Mechanism Steps
💡 How to Take prealdonil 150mg/75mg tablet
Strength: Tablet containing Epalrestat 150 mg and Pregabalin 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, as prescribed by your doctor. The exact dose and frequency depend on your kidney function, the severity of your symptoms, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without medical advice. Take it with or without food, but taking it with food may reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and confusion. Dose adjustment may be necessary based on kidney function. Regular monitoring is advised. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. Pregabalin is primarily excreted by the kidneys, and the dose should be reduced according to creatinine clearance. Epalrestat may also require caution. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Pregabalin undergoes minimal hepatic metabolism, so dose adjustment may not be necessary in mild to moderate liver impairment. Epalrestat is metabolized in the liver, and caution is advised in severe hepatic impairment. Consult your doctor for guidance. |
| Maximum Daily Dose | The maximum daily dose of this medicine is generally one tablet twice daily, but the exact maximum must be determined by your doctor based on your condition and kidney function. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of prealdonil 150mg/75mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| Alcohol | Major | |
| Antihypertensives | Moderate | |
| Thiazolidinediones | Moderate | |
| ACE inhibitors | Moderate | |
| Antacids | Minor | |
| Loop diuretics | Minor |
🚨 Major Interactions
- Opioids (e.g., morphine, oxycodone)
- Benzodiazepines (e.g., diazepam, alprazolam)
- Alcohol
⚡ Moderate Interactions
- Antihypertensives
- Thiazolidinediones (e.g., pioglitazone)
- ACE inhibitors
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both Pregabalin and alcohol depress the central nervous system, leading to increased drowsiness, dizziness, impaired coordination, and a higher risk of accidents. Combining them can also increase the risk of respiratory depression and other serious side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Epalrestat, Pregabalin, or any component of the formulation","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until effects are known.","Do not stop abruptly; taper gradually under medical supervision to avoid withdrawal symptoms.","Use with caution in patients with a history of substance abuse due to dependence potential.","May cause peripheral edema and weight gain; monitor in patients with heart failure.","Rare risk of angioedema and severe skin reactions; seek immediate help if symptoms occur.","May increase suicidal thoughts; monitor mood closely, especially in patients with depression.","Dose adjustment needed in renal impairment; regular monitoring of kidney function is advised.","Avoid alcohol and other CNS depressants while taking this medicine."]
🤱 Lactation Safety
Pregabalin is excreted in breast milk and may cause sedation in the infant. Epalrestat safety during breastfeeding is not established. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause excessive sedation, confusion, dizziness, blurred vision, and respiratory depression. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including monitoring of vital signs and airway management. There is no specific antidote for Pregabalin or Epalrestat. Hemodialysis may be considered for Pregabalin overdose in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop it on your own, as abrupt discontinuation of Pregabalin can cause withdrawal symptoms such as anxiety, insomnia, and sweating. Avoid driving or operating heavy machinery until you know how this medicine affects you, because it can cause dizziness and drowsiness. Do not consume alcohol while taking this medicine, as it can increase sedation and impair your ability to think clearly. Inform your doctor if you have kidney disease, liver disease, heart failure, or a history of drug or alcohol abuse. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this medicine. Keep all follow-up appointments and get regular blood tests to monitor your kidney and liver function. Store this medicine in its original container at room temperature, away from moisture and direct sunlight. Keep it out of reach of children and pets. Never share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dizziness, drowsiness, and confusion. Dose adjustment based on kidney function is often necessary. Regular monitoring for falls and cognitive changes is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Pregabalin may harm the fetus, and Epalrestat is not recommended during pregnancy. Effective contraception should be used while on this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and increase sedation. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can cause dry mouth and increase the risk of dental problems. Also, it may interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness and drowsiness. Avoid high-risk activities like heavy lifting or balance-intensive exercises until you know how the medicine affects you. Low-impact exercises are generally safe and beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how it affects you. Desk jobs are usually fine, but caution is needed for jobs requiring alertness.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or your pain improves significantly, your doctor may gradually reduce the dose. Abrupt discontinuation can cause withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Pregabalin can cause weight gain and peripheral edema over time. Regular monitoring of kidney and liver function, as well as mood, is recommended. The benefits of improved pain control and potential slowing of neuropathy progression should be weighed against these risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay provide additional pain relief for some patients.
Evidence: ModerateSome patients report benefit for neuropathic pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Store it at room temperature and avoid leaving it in a hot car or checked luggage. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pregabalin may start relieving pain within a few days, but full effects may take 2 to 4 weeks. Epalrestat's effect on nerve metabolism may take longer.
A: No, do not stop suddenly. Consult your doctor for a gradual taper to avoid withdrawal symptoms and rebound pain.
A: Pregabalin requires dose adjustment in kidney disease. Your doctor will monitor your kidney function and adjust the dose accordingly.
A: No, alcohol should be strictly avoided as it increases sedation and the risk of serious side effects.
🤔 Common Patient Concerns
🔄 Substitutes for prealdonil 150mg/75mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetic neuropathy completely.
Fact: This medicine helps manage symptoms and may slow nerve damage, but it does not cure the underlying condition. Lifestyle and blood sugar control are essential. - Myth: It is safe to stop this medicine abruptly once pain improves.
Fact: Stopping suddenly can cause withdrawal symptoms and rebound pain. Always taper under medical supervision. - Myth: This medicine is a simple painkiller like paracetamol.
Fact: It is a specialized combination for nerve pain and requires a prescription and monitoring.
🔄 Alternative Options
Generic Alternatives
- Epalrestat 150 mg + Pregabalin 75 mg tablet (generic versions may be available)
Brand Alternatives
- Pre Aldonil 75 Tablet SR