Fibrodone 801mg Tablet (Pirfenidone): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe nausea, vomiting, or abdominal pain
- Unexplained fatigue or weakness
- Severe skin rash, blistering, or peeling
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Blood in vomit or stool
- Chest pain or palpitations
- Sudden decrease in urine output
If experiencing severe symptoms, call emergency services immediately.
What is pirfenex 801mg tablet used for?
This medicine is an antifibrotic medicine used to treat idiopathic pulmonary fibrosis by slowing the scarring of lung tissue and preserving lung function.
- Generic Name: Pirfenidone (801mg)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pirfenex 801mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पिरफेनिडोन नामक सक्रिय तत्व से बनी है और मुख्य रूप से इडियोपैथिक पल्मोनरी फाइब्रोसिस (आईपीएफ) नामक फेफड़ों की बीमारी के इलाज में उपयोग की जाती है। इस बीमारी में फेफड़ों के ऊतकों में निशान पड़ने लगते हैं और सांस लेने में कठिनाई होती है। यह दवा फेफड़ों में निशान बनने की प्रक्रिया को धीमा करती है और फेफड़ों की कार्यक्षमता को बनाए रखने में मदद करती है। यह दवा बीमारी को पूरी तरह ठीक नहीं करती, लेकिन इसके बढ़ने की गति को कम कर सकती है। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए और नियमित रूप से लिवर की जांच करानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में गड़बड़ी, सिरदर्द, थकान, और धूप के प्रति त्वचा की संवेदनशीलता शामिल हैं। कुछ लोगों को चक्कर आना, नींद न आना, या भूख में कमी भी हो सकती है। गंभीर दुष्प्रभावों में लिवर की क्षति, त्वचा पर गंभीर प्रतिक्रियाएं, और एलर्जी शामिल हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, त्वचा पर चकत्ते, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। इलाज के दौरान नियमित रूप से लिवर की जांच करानी चाहिए। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें। शराब का सेवन न करें। दवा को भोजन के साथ लें ताकि पेट की गड़बड़ी कम हो। दवा को चबाएं या तोड़ें नहीं, पूरा निगल लें। डॉक्टर की सलाह के बिना दवा बंद न करें।
💊 pirfenex 801mg tablet Uses & Benefits
[{"condition":"Idiopathic pulmonary fibrosis","description":"This medicine is used to slow the decline in lung function in adults with idiopathic pulmonary fibrosis, a chronic progressive lung disease characterised by scarring of the lungs.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Other fibrotic lung diseases","description":"This medicine has been studied in other interstitial lung diseases with fibrosis, but its use in these conditions is not universally approved and remains investigational.","evidence":"Limited"},{"condition":"Liver fibrosis","description":"Some research has explored the use of this medicine in liver fibrosis, but evidence is insufficient to support routine use.","evidence":"Limited"},{"condition":"Kidney fibrosis","description":"Preliminary studies have investigated this medicine in kidney fibrosis, but it is not an established treatment for this condition.","evidence":"Limited"}]
Primary treatment for: Idiopathic pulmonary fibrosis
Also treats: Interstitial lung diseases with fibrosis (off-label), Liver fibrosis (investigational), Kidney fibrosis (investigational)
📋 Drug Information
| Generic Name(s) | Pirfenidone (801mg) |
| Brand Name | pirfenex 801mg tablet |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Idiopathic pulmonary fibrosis (IPF) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed, and protect them from moisture and light. Do not store in the bathroom. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the production and activity of transforming growth factor beta, a key cytokine that drives the formation of fibrous scar tissue. It also reduces the proliferation of fibroblasts and the deposition of collagen in lung tissue. By interfering with these processes, this medicine helps to slow the progression of fibrosis in the lungs.
Mechanism Steps
💡 How to Take pirfenex 801mg tablet
Strength: This medicine is available as an 801 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 801 mg taken three times a day with food, for a total daily dose of 2403 mg. However, treatment is typically started at a lower dose and increased gradually over a period of days to weeks to improve tolerability. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and tolerability. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based solely on age. However, elderly patients may be more sensitive to the effects of this medicine and should be monitored closely for side effects. Dose should be individualized by a qualified clinician. |
| Renal Impairment | This medicine should be used with caution in patients with mild to moderate kidney impairment. In patients with severe kidney impairment (creatinine clearance less than 30 mL/min), the use of this medicine is not recommended. Dose adjustment may be necessary in patients with moderate kidney impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver impairment (Child-Pugh Class C). In patients with mild to moderate liver impairment, the dose may need to be reduced or the medicine used with caution. Regular monitoring of liver function is required. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 2403 mg, taken as 801 mg three times a day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pirfenex 801mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Fluvoxamine | Major | |
| Tobacco smoking | Major | |
| Omeprazole | Moderate | |
| Rifampicin | Moderate | |
| Phenytoin | Moderate | |
| Paracetamol | Minor | |
| Warfarin | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Fluvoxamine
- Tobacco smoking
⚡ Moderate Interactions
- Omeprazole
- Rifampicin
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because both alcohol and this medicine can stress the liver. Drinking alcohol may increase the risk of liver injury and worsen side effects such as nausea and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to pirfenidone or any of the other ingredients in this medicine.","Severe liver impairment (Child-Pugh Class C).","Severe kidney impairment (creatinine clearance less than 30 mL/min).","Concomitant use with fluvoxamine.","Pregnancy and breastfeeding, unless the potential benefit outweighs the risk.","Children and adolescents under 18 years of age."]
⚠️ Warnings & Precautions
["This medicine can cause liver injury. Regular liver function tests are essential. Stop the medicine and consult your doctor immediately if you develop symptoms of liver injury.","This medicine can cause photosensitivity reactions. Avoid sun exposure and use protective clothing and sunscreen.","Serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported. Stop the medicine and seek immediate medical attention if you develop a severe rash.","This medicine may cause dizziness and fatigue. Do not drive or operate machinery until you know how this medicine affects you.","Avoid alcohol while taking this medicine to reduce the risk of liver problems.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not stop taking this medicine without consulting your doctor, as stopping suddenly may worsen your condition.","Keep all appointments for monitoring and follow-up.","Store this medicine in its original container at room temperature, away from moisture and heat.","Keep this medicine out of the reach of children."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many medicines are excreted in breast milk, a decision should be made whether to discontinue breastfeeding or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
There is limited information on overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be supportive and symptomatic. Contact a poison control centre or emergency department for guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially if you have liver or kidney problems, or if you have ever had an allergic reaction to any medicine. You must have regular blood tests to check your liver function before and during treatment, as this medicine can cause liver injury. Avoid exposure to sunlight and ultraviolet light, including tanning beds, because this medicine can make your skin more sensitive to the sun. Wear protective clothing and use a broad-spectrum sunscreen with a high sun protection factor when you go outdoors. Do not drink alcohol while taking this medicine, as alcohol may increase the risk of liver problems. If you experience nausea, vomiting, or stomach upset, taking the tablet with food may help. Do not crush, chew, or split the tablet; swallow it whole with a glass of water. If you miss a dose, follow your doctor's instructions on what to do. Never take a double dose to make up for a missed one. Keep all your appointments with your doctor and the laboratory so that your progress can be monitored. Do not stop taking this medicine without first talking to your doctor, as stopping suddenly may worsen your condition. Inform any healthcare professional you see that you are taking this medicine, especially before surgery or dental procedures. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and fatigue. Close monitoring for side effects is recommended. Dose adjustment is not routinely required based on age alone, but individualised dosing is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. Effective contraception should be used during treatment. This medicine may harm the unborn baby.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are usually needed, but your dentist may consult your doctor if you have any concerns.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally encouraged, but you should avoid strenuous activity if you feel breathless or fatigued. Consult your doctor before starting any new exercise programme. Stop and rest if you experience chest pain, severe breathlessness, or dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is important to take your doses at regular intervals, which may require planning around your work schedule. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as liver injury or severe skin reactions, your doctor may advise you to stop. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may help slow the progression of idiopathic pulmonary fibrosis, but it requires regular monitoring of liver function and skin. Some patients may experience persistent side effects such as nausea or photosensitivity. Regular follow-up with your doctor is essential to manage any long-term effects and adjust treatment as needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrotic medicine that can be used for idiopathic pulmonary fibrosis.
Evidence: Well-establishedA programme of exercise and education that can improve symptoms and quality of life.
Evidence: Well-establishedMay be used if blood oxygen levels are low.
Evidence: Well-establishedConsidered for eligible patients with advanced disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with idiopathic pulmonary fibrosis should receive annual influenza vaccination and pneumococcal vaccination as recommended by their doctor. Live vaccines should be avoided if the immune system is compromised. Discuss with your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working gradually. It may take several weeks to months to see a noticeable effect on lung function. It is important to continue taking it as prescribed.
A: No, you should not stop taking this medicine without consulting your doctor. Stopping suddenly may cause your condition to worsen.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Avoid grapefruit juice and limit caffeine intake. Take the medicine with food to reduce stomach upset.
A: Some medicines can interact with this medicine. Always inform your doctor about all medicines you are taking, including over-the-counter products and herbal supplements.
🤔 Common Patient Concerns
🔄 Substitutes for pirfenex 801mg tablet
View AllAlternative brands with exact same active ingredient:
-
fiboresp forte tabletGlenmark Pharmaceuticals Ltd ₹609.38 24.3% CHEAPER
-
pirfact 801 tabletSun Pharmaceutical Industries Ltd ₹609.38 24.3% CHEAPER
-
fibrodone 801mg tabletLupin Ltd ₹744.25 7.5% CHEAPER
-
pulmofib 801mg tabletMSN Laboratories ₹747.65 7.1% CHEAPER
-
pirfetab 801mg tabletZydus Cadila ₹822.94 2.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure idiopathic pulmonary fibrosis.
Fact: This medicine does not cure the disease but can slow its progression and help preserve lung function. - Myth: This medicine can be stopped once symptoms improve.
Fact: This medicine is usually taken long-term. Stopping it without medical advice may lead to worsening of the condition. - Myth: This medicine is safe to take without regular blood tests.
Fact: Regular liver function tests are essential because this medicine can cause liver injury. - Myth: This medicine can be taken with any other medicine without concern.
Fact: This medicine interacts with several medicines, especially those affecting CYP1A2. Always inform your doctor about all medicines you take.
🔄 Alternative Options
Generic Alternatives
- Pirfenidone 801 mg tablet
Brand Alternatives
- Fibrodone 801 mg tablet